Incidental Mutation 'R6286:Pramel20'
ID |
508226 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Pramel20
|
Ensembl Gene |
ENSMUSG00000070618 |
Gene Name |
PRAME like 20 |
Synonyms |
BC080695 |
MMRRC Submission |
044456-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.073)
|
Stock # |
R6286 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
4 |
Chromosomal Location |
143294045-143300368 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 143297796 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Aspartic acid
at position 72
(V72D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000101400
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105765]
[ENSMUST00000105774]
|
AlphaFold |
Q66JY9 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000105765
AA Change: V72D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000101391 Gene: ENSMUSG00000070618 AA Change: V72D
Domain | Start | End | E-Value | Type |
SCOP:d1a4ya_
|
210 |
414 |
5e-12 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000105774
AA Change: V72D
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000101400 Gene: ENSMUSG00000070618 AA Change: V72D
Domain | Start | End | E-Value | Type |
SCOP:d1a4ya_
|
210 |
414 |
5e-12 |
SMART |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.7%
|
Validation Efficiency |
98% (40/41) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Alk |
T |
A |
17: 72,187,842 (GRCm39) |
M1300L |
probably damaging |
Het |
C3 |
A |
T |
17: 57,531,118 (GRCm39) |
I356N |
probably damaging |
Het |
Cntnap5b |
T |
A |
1: 100,182,798 (GRCm39) |
S276T |
possibly damaging |
Het |
Cts7 |
C |
T |
13: 61,500,584 (GRCm39) |
G321E |
probably damaging |
Het |
Cyp11a1 |
G |
A |
9: 57,924,701 (GRCm39) |
|
probably benign |
Het |
Ddx4 |
T |
C |
13: 112,750,269 (GRCm39) |
T421A |
probably damaging |
Het |
Dnttip2 |
A |
G |
3: 122,078,049 (GRCm39) |
T694A |
probably damaging |
Het |
Eif3b |
G |
T |
5: 140,405,566 (GRCm39) |
D151Y |
probably damaging |
Het |
Fhad1 |
T |
A |
4: 141,648,209 (GRCm39) |
E219V |
probably damaging |
Het |
Gdf2 |
C |
T |
14: 33,667,057 (GRCm39) |
R260C |
probably damaging |
Het |
Gm14295 |
T |
C |
2: 176,501,361 (GRCm39) |
Y284H |
possibly damaging |
Het |
Gm45861 |
A |
G |
8: 28,019,619 (GRCm39) |
T745A |
unknown |
Het |
Grin2a |
G |
A |
16: 9,579,639 (GRCm39) |
T208I |
possibly damaging |
Het |
Ide |
T |
A |
19: 37,255,409 (GRCm39) |
Y798F |
unknown |
Het |
Llgl1 |
G |
A |
11: 60,600,358 (GRCm39) |
G569D |
probably damaging |
Het |
Mrpl9 |
G |
C |
3: 94,351,097 (GRCm39) |
E92D |
probably benign |
Het |
Muc16 |
T |
A |
9: 18,555,685 (GRCm39) |
H3536L |
unknown |
Het |
Nasp |
T |
C |
4: 116,461,985 (GRCm39) |
Y526C |
probably damaging |
Het |
Nfx1 |
A |
G |
4: 40,986,728 (GRCm39) |
N404D |
probably damaging |
Het |
Nsrp1 |
A |
G |
11: 76,940,269 (GRCm39) |
I112T |
probably damaging |
Het |
Or6c7 |
T |
C |
10: 129,323,497 (GRCm39) |
L206P |
probably damaging |
Het |
Or8b8 |
A |
T |
9: 37,809,074 (GRCm39) |
I125F |
probably damaging |
Het |
Oxsr1 |
A |
G |
9: 119,093,948 (GRCm39) |
V235A |
probably damaging |
Het |
Pamr1 |
C |
T |
2: 102,471,293 (GRCm39) |
Q539* |
probably null |
Het |
Ptpn4 |
A |
G |
1: 119,649,592 (GRCm39) |
|
probably null |
Het |
Ranbp2 |
C |
T |
10: 58,315,394 (GRCm39) |
A2038V |
probably benign |
Het |
Rsf1 |
G |
GACGGCGGCA |
7: 97,229,116 (GRCm39) |
|
probably benign |
Homo |
Septin5 |
A |
G |
16: 18,442,127 (GRCm39) |
V253A |
probably damaging |
Het |
Skic3 |
T |
C |
13: 76,291,359 (GRCm39) |
L993P |
probably damaging |
Het |
Slc22a13 |
C |
A |
9: 119,037,778 (GRCm39) |
E117* |
probably null |
Het |
Slc9c1 |
T |
C |
16: 45,398,194 (GRCm39) |
I653T |
probably benign |
Het |
Slco6c1 |
T |
A |
1: 97,053,445 (GRCm39) |
H152L |
possibly damaging |
Het |
Sp2 |
A |
C |
11: 96,852,372 (GRCm39) |
V184G |
probably benign |
Het |
Taok1 |
T |
A |
11: 77,444,599 (GRCm39) |
H492L |
probably benign |
Het |
Tas2r110 |
G |
A |
6: 132,845,490 (GRCm39) |
D174N |
probably benign |
Het |
Trim24 |
G |
A |
6: 37,896,426 (GRCm39) |
|
probably null |
Het |
Ttn |
G |
A |
2: 76,581,321 (GRCm39) |
R21445* |
probably null |
Het |
Ttn |
A |
G |
2: 76,605,967 (GRCm39) |
Y16502H |
probably damaging |
Het |
Vmn2r84 |
A |
C |
10: 130,226,737 (GRCm39) |
M367R |
possibly damaging |
Het |
Zfp46 |
T |
C |
4: 136,018,320 (GRCm39) |
S385P |
probably damaging |
Het |
|
Other mutations in Pramel20 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02118:Pramel20
|
APN |
4 |
143,297,726 (GRCm39) |
missense |
probably benign |
0.42 |
IGL02533:Pramel20
|
APN |
4 |
143,297,572 (GRCm39) |
utr 5 prime |
probably benign |
|
R0352:Pramel20
|
UTSW |
4 |
143,297,878 (GRCm39) |
splice site |
probably benign |
|
R1600:Pramel20
|
UTSW |
4 |
143,298,537 (GRCm39) |
missense |
possibly damaging |
0.78 |
R3121:Pramel20
|
UTSW |
4 |
143,297,583 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R4005:Pramel20
|
UTSW |
4 |
143,298,839 (GRCm39) |
missense |
probably benign |
0.00 |
R4477:Pramel20
|
UTSW |
4 |
143,297,732 (GRCm39) |
missense |
probably benign |
0.21 |
R4639:Pramel20
|
UTSW |
4 |
143,298,467 (GRCm39) |
missense |
probably benign |
0.22 |
R4791:Pramel20
|
UTSW |
4 |
143,297,559 (GRCm39) |
start gained |
probably benign |
|
R5118:Pramel20
|
UTSW |
4 |
143,297,697 (GRCm39) |
missense |
probably damaging |
1.00 |
R5353:Pramel20
|
UTSW |
4 |
143,297,807 (GRCm39) |
missense |
probably benign |
0.00 |
R5861:Pramel20
|
UTSW |
4 |
143,297,810 (GRCm39) |
missense |
probably benign |
|
R6163:Pramel20
|
UTSW |
4 |
143,298,605 (GRCm39) |
missense |
probably damaging |
1.00 |
R6958:Pramel20
|
UTSW |
4 |
143,297,829 (GRCm39) |
missense |
probably damaging |
1.00 |
R7391:Pramel20
|
UTSW |
4 |
143,298,876 (GRCm39) |
missense |
probably damaging |
1.00 |
R7625:Pramel20
|
UTSW |
4 |
143,298,821 (GRCm39) |
missense |
probably benign |
0.00 |
R8189:Pramel20
|
UTSW |
4 |
143,298,530 (GRCm39) |
missense |
probably benign |
|
R8190:Pramel20
|
UTSW |
4 |
143,298,530 (GRCm39) |
missense |
probably benign |
|
R8192:Pramel20
|
UTSW |
4 |
143,298,530 (GRCm39) |
missense |
probably benign |
|
R8219:Pramel20
|
UTSW |
4 |
143,298,530 (GRCm39) |
missense |
probably benign |
|
R8221:Pramel20
|
UTSW |
4 |
143,298,530 (GRCm39) |
missense |
probably benign |
|
R8223:Pramel20
|
UTSW |
4 |
143,298,530 (GRCm39) |
missense |
probably benign |
|
R8226:Pramel20
|
UTSW |
4 |
143,298,530 (GRCm39) |
missense |
probably benign |
|
R9005:Pramel20
|
UTSW |
4 |
143,298,425 (GRCm39) |
missense |
probably benign |
0.11 |
R9150:Pramel20
|
UTSW |
4 |
143,298,531 (GRCm39) |
missense |
probably benign |
|
R9295:Pramel20
|
UTSW |
4 |
143,298,704 (GRCm39) |
missense |
possibly damaging |
0.51 |
R9307:Pramel20
|
UTSW |
4 |
143,299,314 (GRCm39) |
missense |
probably damaging |
1.00 |
R9691:Pramel20
|
UTSW |
4 |
143,299,328 (GRCm39) |
missense |
probably benign |
0.09 |
Z1176:Pramel20
|
UTSW |
4 |
143,298,822 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- CTGAGCTTGGCAGTACAGAG -3'
(R):5'- ACTGTCCAGGACACTGTAACTC -3'
Sequencing Primer
(F):5'- GCAGTACAGAGCCTGGC -3'
(R):5'- TGTCCAGGACACTGTAACTCTTCAAG -3'
|
Posted On |
2018-03-15 |