Incidental Mutation 'R6500:Or10al5'
ID 519702
Institutional Source Beutler Lab
Gene Symbol Or10al5
Ensembl Gene ENSMUSG00000060017
Gene Name olfactory receptor family 10 subfamily AL member 5
Synonyms Olfr121, GA_x6K02T2PSCP-2211113-2212078, MOR263-4
MMRRC Submission 044632-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R6500 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38059757-38063895 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 38063577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 277 (D277E)
Ref Sequence ENSEMBL: ENSMUSP00000084377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074555] [ENSMUST00000174675]
AlphaFold Q5CZY0
Predicted Effect probably damaging
Transcript: ENSMUST00000074555
AA Change: D277E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000084377
Gene: ENSMUSG00000060017
AA Change: D277E

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.9e-56 PFAM
Pfam:7TM_GPCR_Srsx 41 311 2.1e-5 PFAM
Pfam:7tm_1 47 296 8.3e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174675
AA Change: D277E

PolyPhen 2 Score 0.224 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000133865
Gene: ENSMUSG00000060017
AA Change: D277E

DomainStartEndE-ValueType
transmembrane domain 33 55 N/A INTRINSIC
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam21 A G 12: 81,606,380 (GRCm39) F461L probably benign Het
Adamtsl3 C A 7: 82,227,818 (GRCm39) H1334Q probably benign Het
Adgrf1 A G 17: 43,621,263 (GRCm39) N500S probably damaging Het
Afdn A G 17: 14,042,634 (GRCm39) D335G possibly damaging Het
Arhgap19 G A 19: 41,775,077 (GRCm39) T178M probably damaging Het
Chac2 T C 11: 30,927,625 (GRCm39) D86G probably damaging Het
Clhc1 T C 11: 29,510,542 (GRCm39) S209P possibly damaging Het
Col1a2 G A 6: 4,515,517 (GRCm39) G127S unknown Het
Coro2b A G 9: 62,396,606 (GRCm39) F51L probably benign Het
Cux2 A G 5: 122,002,789 (GRCm39) S1139P probably benign Het
Cyth3 A T 5: 143,693,595 (GRCm39) I379F probably damaging Het
Dock2 A T 11: 34,312,822 (GRCm39) L240H possibly damaging Het
Ercc6 A G 14: 32,248,780 (GRCm39) K444E probably damaging Het
Fam3b A G 16: 97,302,101 (GRCm39) L52P possibly damaging Het
Fat4 T G 3: 39,035,418 (GRCm39) Y3023* probably null Het
Gad1 A T 2: 70,423,780 (GRCm39) N396Y probably damaging Het
Gbp2b A G 3: 142,317,252 (GRCm39) E536G probably benign Het
Gm11564 G A 11: 99,706,061 (GRCm39) T123I unknown Het
Herc2 G T 7: 55,796,393 (GRCm39) E1922* probably null Het
Hrh4 G T 18: 13,155,525 (GRCm39) V355F probably damaging Het
Isyna1 A G 8: 71,047,339 (GRCm39) I21V probably damaging Het
Jak1 T C 4: 101,039,130 (GRCm39) D165G probably benign Het
Klhl38 C A 15: 58,185,809 (GRCm39) G307* probably null Het
Krt77 T C 15: 101,772,772 (GRCm39) N269S probably damaging Het
Lrp4 T A 2: 91,322,765 (GRCm39) I1118N possibly damaging Het
Ly6i T C 15: 74,853,833 (GRCm39) Y30C probably damaging Het
Magi2 A G 5: 20,807,345 (GRCm39) E620G possibly damaging Het
Mbl2 A G 19: 30,216,839 (GRCm39) D217G possibly damaging Het
Mogat2 T A 7: 98,871,553 (GRCm39) I253F probably benign Het
Mpped2 T C 2: 106,691,925 (GRCm39) L210P probably damaging Het
Nav3 C A 10: 109,600,617 (GRCm39) A1337S probably damaging Het
Ncaph2 T A 15: 89,248,407 (GRCm39) V206E probably benign Het
Nlgn1 T C 3: 25,488,094 (GRCm39) E747G possibly damaging Het
Nlrc3 C T 16: 3,770,308 (GRCm39) G237D possibly damaging Het
Nsun7 A G 5: 66,452,827 (GRCm39) D514G probably benign Het
Pals2 A G 6: 50,175,146 (GRCm39) K500E possibly damaging Het
Pcnx2 C A 8: 126,480,224 (GRCm39) V2028F probably damaging Het
Pdx1 G T 5: 147,207,440 (GRCm39) W131L probably damaging Het
Pkdrej C T 15: 85,703,747 (GRCm39) V730I probably damaging Het
Plcg1 T A 2: 160,596,487 (GRCm39) Y669N probably damaging Het
Plpp1 G T 13: 113,003,454 (GRCm39) W226L probably damaging Het
Sfxn1 G A 13: 54,242,918 (GRCm39) V59I probably benign Het
Shank1 T C 7: 43,976,645 (GRCm39) I581T unknown Het
Slc35f6 A C 5: 30,814,164 (GRCm39) K150N possibly damaging Het
Slc5a7 A T 17: 54,591,231 (GRCm39) S234T probably benign Het
Smg6 C T 11: 74,821,331 (GRCm39) T534I possibly damaging Het
Ush2a C T 1: 188,573,724 (GRCm39) T3649I probably benign Het
Vmn1r158 T C 7: 22,490,078 (GRCm39) T44A possibly damaging Het
Vmn1r217 A T 13: 23,298,073 (GRCm39) Y276* probably null Het
Vmn2r100 T A 17: 19,742,355 (GRCm39) I243N probably damaging Het
Vwde T C 6: 13,208,404 (GRCm39) probably null Het
Washc4 C A 10: 83,394,687 (GRCm39) P306T probably damaging Het
Wdhd1 C T 14: 47,488,217 (GRCm39) probably null Het
Xpo6 T C 7: 125,770,262 (GRCm39) probably benign Het
Other mutations in Or10al5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01348:Or10al5 APN 17 38,063,177 (GRCm39) missense probably benign 0.03
R0100:Or10al5 UTSW 17 38,063,594 (GRCm39) missense probably benign 0.12
R0328:Or10al5 UTSW 17 38,063,284 (GRCm39) missense possibly damaging 0.57
R1641:Or10al5 UTSW 17 38,062,916 (GRCm39) missense possibly damaging 0.90
R2358:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R3711:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R3712:Or10al5 UTSW 17 38,063,271 (GRCm39) nonsense probably null
R4658:Or10al5 UTSW 17 38,063,054 (GRCm39) missense probably damaging 1.00
R4913:Or10al5 UTSW 17 38,063,315 (GRCm39) missense possibly damaging 0.86
R5229:Or10al5 UTSW 17 38,063,192 (GRCm39) missense probably benign 0.00
R5611:Or10al5 UTSW 17 38,062,975 (GRCm39) missense possibly damaging 0.94
R6159:Or10al5 UTSW 17 38,063,038 (GRCm39) missense probably damaging 1.00
R6375:Or10al5 UTSW 17 38,062,990 (GRCm39) missense probably benign
R6818:Or10al5 UTSW 17 38,063,315 (GRCm39) missense possibly damaging 0.86
R7027:Or10al5 UTSW 17 38,063,300 (GRCm39) missense probably damaging 1.00
R7498:Or10al5 UTSW 17 38,063,242 (GRCm39) missense probably damaging 0.96
R7888:Or10al5 UTSW 17 38,062,888 (GRCm39) missense probably damaging 1.00
R8299:Or10al5 UTSW 17 38,062,891 (GRCm39) nonsense probably null
R9497:Or10al5 UTSW 17 38,062,942 (GRCm39) missense probably damaging 1.00
Z1176:Or10al5 UTSW 17 38,063,658 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATCTTCGTGGCAGCAATTC -3'
(R):5'- GGCTCATTGCACATTTTCATTAGC -3'

Sequencing Primer
(F):5'- GCATATCTAGCCCATTTTTGTTGATC -3'
(R):5'- GCACATTTTCATTAGCCAGCAG -3'
Posted On 2018-06-06