Mutagenetix > Incidental Mutations

Incidental Mutation 'R6906:Vmn1r171'

538777

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r171

Ensembl Gene

ENSMUSG00000062483

Gene Name

vomeronasal 1 receptor 171

Synonyms

V3R7, V1rd7

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R6906 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

23630722-23634370 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 23632379 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 10 (V10I)

Ref Sequence

ENSEMBL: ENSMUSP00000077552 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078458] [ENSMUST00000226128] [ENSMUST00000226321] [ENSMUST00000226733] [ENSMUST00000226771] [ENSMUST00000227386] [ENSMUST00000227774] [ENSMUST00000227866] [ENSMUST00000228228] [ENSMUST00000228484] [ENSMUST00000228559] [ENSMUST00000228674] [ENSMUST00000228681]

Predicted Effect

probably benign
Transcript: ENSMUST00000078458
AA Change: V10I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000077552
Gene: ENSMUSG00000062483
AA Change: V10I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	20	307	1.7e-14	PFAM
Pfam:7tm_1	42	300	3.4e-7	PFAM
Pfam:V1R	53	307	1.1e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226128

Predicted Effect

probably benign
Transcript: ENSMUST00000226321

Predicted Effect

probably benign
Transcript: ENSMUST00000226733

Predicted Effect

probably benign
Transcript: ENSMUST00000226771

Predicted Effect

probably benign
Transcript: ENSMUST00000227386

Predicted Effect

probably benign
Transcript: ENSMUST00000227774

Predicted Effect

probably benign
Transcript: ENSMUST00000227866

Predicted Effect

probably benign
Transcript: ENSMUST00000228228

Predicted Effect

probably benign
Transcript: ENSMUST00000228484

Predicted Effect

probably benign
Transcript: ENSMUST00000228559

Predicted Effect

probably benign
Transcript: ENSMUST00000228674

Predicted Effect

probably benign
Transcript: ENSMUST00000228681

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 97.3%

Validation Efficiency

98% (45/46)

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf2	A	G	5: 24,568,842	F350L	possibly damaging	Het
Ahnak2	T	A	12: 112,785,313	T305S	probably benign	Het
Anp32a	A	G	9: 62,377,569		probably benign	Het
Aplf	A	G	6: 87,630,086	S449P	possibly damaging	Het
Arl6ip4	A	G	5: 124,116,551	R36G	possibly damaging	Het
Ascc1	G	A	10: 60,004,852	D12N	probably benign	Het
Bin1	C	A	18: 32,421,925	H243Q	probably benign	Het
Ccdc7a	C	A	8: 128,935,681	V547L	unknown	Het
Cntnap5c	T	A	17: 58,395,307	N1207K	probably benign	Het
Coro7	C	A	16: 4,633,304	R507L	probably benign	Het
Crtap	T	A	9: 114,381,632	K291N	probably benign	Het
Csmd3	T	C	15: 47,847,173	T1569A	probably benign	Het
Dmrta1	A	G	4: 89,691,966	T388A	probably benign	Het
Ehd3	T	C	17: 73,830,338	F501L	probably damaging	Het
Fam126a	A	T	5: 23,999,958	W12R	probably damaging	Het
Fam160a2	G	A	7: 105,388,269	T369I	probably damaging	Het
Fbn2	A	C	18: 58,071,819	L1184R	possibly damaging	Het
Gm8251	C	T	1: 44,056,013	S1975N	probably benign	Het
Hsf1	T	C	15: 76,477,719		probably null	Het
Kansl1l	T	C	1: 66,723,278	H810R	possibly damaging	Het
Lrp5	A	T	19: 3,622,638	I557N	probably damaging	Het
Lypd1	T	C	1: 125,910,459	E41G	probably damaging	Het
Mgam	A	G	6: 40,747,919	Y443C	probably damaging	Het
Muc2	A	G	7: 141,698,733	D871G	probably damaging	Het
Nup85	T	A	11: 115,580,943	Y198N	probably damaging	Het
Obscn	T	A	11: 59,032,918	M6578L	possibly damaging	Het
Olfr1097	T	C	2: 86,890,747	T143A	probably benign	Het
Osbpl5	G	C	7: 143,694,328	Q667E	probably damaging	Het
Ovgp1	T	A	3: 105,986,873		probably benign	Het
Prl8a2	T	A	13: 27,348,917	N37K	probably benign	Het
Ptprf	A	T	4: 118,269,277	I93N	possibly damaging	Het
Rnf112	T	C	11: 61,450,389	S457G	probably null	Het
Sema3e	A	G	5: 14,240,587	D562G	probably damaging	Het
Sesn3	A	G	9: 14,325,641	M472V	probably damaging	Het
Sfpq	GCCGCCGCAGCAGCCTCCGCCGCAGCAGCC	GCCGCCGCAGCAGCC	4: 127,021,626		probably benign	Het
Shc3	T	C	13: 51,466,559	T144A	probably damaging	Het
Sis	A	G	3: 72,919,485	L1287P	probably damaging	Het
Srrm2	C	T	17: 23,820,363	P2090S	probably damaging	Het
Syne2	T	G	12: 75,995,986	D3910E	possibly damaging	Het
Tcaim	C	T	9: 122,834,774	T443I	probably benign	Het
Tex19.1	T	C	11: 121,147,122	V102A	probably benign	Het
Tpd52l1	T	G	10: 31,332,954	T168P	possibly damaging	Het
Trdn	G	A	10: 33,233,948	C294Y	probably benign	Het
Trmt1l	T	C	1: 151,452,175	Y479H	probably benign	Het
Zbtb41	T	A	1: 139,423,390	D80E	possibly damaging	Het
Zcchc4	A	G	5: 52,823,634	K473E	possibly damaging	Het

Other mutations in Vmn1r171

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01088:Vmn1r171	APN	7	23632827	missense	probably damaging	1.00
IGL02963:Vmn1r171	APN	7	23632688	missense	possibly damaging	0.62
FR4304:Vmn1r171	UTSW	7	23632680	missense	probably benign	0.26
R0412:Vmn1r171	UTSW	7	23632655	missense	possibly damaging	0.81
R0602:Vmn1r171	UTSW	7	23633177	missense	probably benign	0.01
R0710:Vmn1r171	UTSW	7	23633001	missense	probably damaging	1.00
R1758:Vmn1r171	UTSW	7	23632356	missense	probably benign	0.25
R2007:Vmn1r171	UTSW	7	23632587	missense	probably damaging	1.00
R4153:Vmn1r171	UTSW	7	23632652	missense	probably damaging	1.00
R4799:Vmn1r171	UTSW	7	23632944	missense	probably benign	0.31
R5038:Vmn1r171	UTSW	7	23632763	missense	probably benign	0.00
R6087:Vmn1r171	UTSW	7	23633004	missense	probably damaging	1.00
R7745:Vmn1r171	UTSW	7	23632610	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- ACACACAGATCTATCATGAGGAAAG -3'
(R):5'- ATCAAGGTATTGCCCACAGC -3'

Sequencing Primer
(F):5'- GATCTATCATGAGGAAAGAAAGAGC -3'
(R):5'- ATTGCCCACAGCTAAGTTGG -3'

Posted On

2018-11-06