Incidental Mutation 'R7891:Or10ag54'
ID 609312
Institutional Source Beutler Lab
Gene Symbol Or10ag54
Ensembl Gene ENSMUSG00000070855
Gene Name olfactory receptor family 10 subfamily AG member 54
Synonyms MOR264-21P, Olfr1116-ps, Olfr1521-ps1, GA_x6K02T2Q125-48753766-48754734, MOR264-8P, Olfr1116
MMRRC Submission 045943-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.094) question?
Stock # R7891 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87099190-87100113 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87099421 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 99 (T99S)
Ref Sequence ENSEMBL: ENSMUSP00000149674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090717] [ENSMUST00000216364]
AlphaFold A0A1L1SRZ5
Predicted Effect possibly damaging
Transcript: ENSMUST00000090717
AA Change: T78S

PolyPhen 2 Score 0.836 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000132837
Gene: ENSMUSG00000070855
AA Change: T78S

DomainStartEndE-ValueType
Pfam:7tm_4 22 298 1.1e-53 PFAM
Pfam:7tm_1 32 281 1.1e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216364
AA Change: T99S

PolyPhen 2 Score 0.836 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700025C18Rik T G 2: 164,920,864 (GRCm39) E56D unknown Het
9930111J21Rik2 T C 11: 48,910,543 (GRCm39) Q630R probably benign Het
Abca9 A G 11: 110,054,098 (GRCm39) V68A probably benign Het
Acnat1 G A 4: 49,449,181 (GRCm39) A195V possibly damaging Het
Acsl3 C T 1: 78,681,305 (GRCm39) A612V probably benign Het
Adam12 A T 7: 133,599,961 (GRCm39) D115E probably benign Het
Adam3 T A 8: 25,197,513 (GRCm39) probably null Het
Aif1 G A 17: 35,391,600 (GRCm39) probably benign Het
Ank3 A G 10: 69,824,139 (GRCm39) D154G probably damaging Het
Arid3b A G 9: 57,717,442 (GRCm39) C233R probably benign Het
Ccdc7b T A 8: 129,799,146 (GRCm39) D74E unknown Het
Cckbr T A 7: 105,084,557 (GRCm39) D430E probably benign Het
Chpf T C 1: 75,451,939 (GRCm39) H667R probably benign Het
Dnah8 A G 17: 30,931,263 (GRCm39) E1426G probably benign Het
Dync1h1 A G 12: 110,609,590 (GRCm39) I2791V probably benign Het
Ehd3 A G 17: 74,123,387 (GRCm39) N130S probably benign Het
Fgfr4 A G 13: 55,306,964 (GRCm39) T218A probably benign Het
Foxe1 G A 4: 46,344,599 (GRCm39) E136K possibly damaging Het
Frmpd1 A G 4: 45,284,478 (GRCm39) S1100G probably benign Het
Gask1b G A 3: 79,793,591 (GRCm39) A20T probably benign Het
Gm21886 T G 18: 80,132,972 (GRCm39) Q62P probably null Het
Golga4 A G 9: 118,385,434 (GRCm39) E852G probably damaging Het
Gprin3 T C 6: 59,330,696 (GRCm39) D537G probably benign Het
Gpx5 C A 13: 21,472,918 (GRCm39) D139Y probably damaging Het
Hmcn1 T C 1: 150,468,940 (GRCm39) Y5007C probably damaging Het
Igsf10 G A 3: 59,235,832 (GRCm39) R1450* probably null Het
Kif21a G A 15: 90,840,517 (GRCm39) P1200S probably damaging Het
Kmt2c G A 5: 25,505,109 (GRCm39) R3400C probably damaging Het
Miox A C 15: 89,220,742 (GRCm39) M216L probably benign Het
Mphosph9 T C 5: 124,428,967 (GRCm39) Y687C probably damaging Het
Mxi1 T A 19: 53,299,192 (GRCm39) V21D probably benign Het
Nbeal1 T C 1: 60,299,591 (GRCm39) L1309P probably benign Het
Onecut2 T A 18: 64,474,046 (GRCm39) M180K possibly damaging Het
Or13c25 C T 4: 52,911,663 (GRCm39) V44I probably benign Het
Or4c100 G A 2: 88,356,289 (GRCm39) V121I probably benign Het
Or7g22 T C 9: 19,049,141 (GRCm39) M284T possibly damaging Het
Polq A G 16: 36,848,244 (GRCm39) T284A probably damaging Het
Polrmt A T 10: 79,577,714 (GRCm39) M295K probably damaging Het
Pou2af1 G T 9: 51,144,297 (GRCm39) M70I probably damaging Het
Pou3f1 G A 4: 124,552,232 (GRCm39) E245K probably damaging Het
Psmb1 C T 17: 15,714,748 (GRCm39) V50I probably benign Het
Ptgis T C 2: 167,069,434 (GRCm39) D50G probably damaging Het
R3hdm2 A G 10: 127,334,443 (GRCm39) I955M probably benign Het
Rasef G A 4: 73,677,935 (GRCm39) T97I probably benign Het
Rasef T C 4: 73,709,201 (GRCm39) T11A probably benign Het
Sema4c C A 1: 36,588,995 (GRCm39) L710F probably damaging Het
Slc39a10 C T 1: 46,851,328 (GRCm39) A721T probably damaging Het
Sltm C G 9: 70,493,955 (GRCm39) P802R possibly damaging Het
Spata31d1a A G 13: 59,848,139 (GRCm39) C1330R possibly damaging Het
Susd1 T C 4: 59,349,915 (GRCm39) D560G possibly damaging Het
Tnfrsf1b T C 4: 144,955,660 (GRCm39) Y32C probably damaging Het
Trhr2 C A 8: 123,084,083 (GRCm39) V306F probably damaging Het
Trpm6 A T 19: 18,754,074 (GRCm39) Q35L probably benign Het
Ttbk2 A G 2: 120,616,510 (GRCm39) S197P probably damaging Het
Uggt2 T A 14: 119,280,059 (GRCm39) E806D probably benign Het
Ushbp1 T G 8: 71,841,422 (GRCm39) Q469P possibly damaging Het
Vmn1r73 G A 7: 11,491,036 (GRCm39) V285I possibly damaging Het
Zfp934 A C 13: 62,668,003 (GRCm39) S63R probably benign Het
Other mutations in Or10ag54
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5427:Or10ag54 UTSW 2 87,099,858 (GRCm39) missense probably benign 0.04
R5557:Or10ag54 UTSW 2 87,099,736 (GRCm39) missense possibly damaging 0.95
R6038:Or10ag54 UTSW 2 87,099,611 (GRCm39) missense possibly damaging 0.80
R6038:Or10ag54 UTSW 2 87,099,611 (GRCm39) missense possibly damaging 0.80
R7536:Or10ag54 UTSW 2 87,099,943 (GRCm39) nonsense probably null
R8230:Or10ag54 UTSW 2 87,099,545 (GRCm39) missense probably benign 0.03
R8832:Or10ag54 UTSW 2 87,099,743 (GRCm39) missense probably benign 0.02
R9004:Or10ag54 UTSW 2 87,099,695 (GRCm39) missense possibly damaging 0.54
R9200:Or10ag54 UTSW 2 87,100,055 (GRCm39) missense probably benign 0.02
R9267:Or10ag54 UTSW 2 87,099,326 (GRCm39) missense possibly damaging 0.95
R9318:Or10ag54 UTSW 2 87,099,271 (GRCm39) missense possibly damaging 0.92
Z1088:Or10ag54 UTSW 2 87,099,919 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AATGTTCCTCATTTGCAGTGGG -3'
(R):5'- TGGAATCCCACTGATCCAGGAG -3'

Sequencing Primer
(F):5'- AGTGGGTGCTGTTTATGGTATTTTTG -3'
(R):5'- ACTGATCCAGGAGGCAGCTAC -3'
Posted On 2019-12-20