Incidental Mutation 'R8420:Rap2b'
ID 653133
Institutional Source Beutler Lab
Gene Symbol Rap2b
Ensembl Gene ENSMUSG00000036894
Gene Name RAP2B, member of RAS oncogene family
Synonyms 4021402C18Rik
MMRRC Submission 067773-MU
Accession Numbers
Essential gene? Not available question?
Stock # R8420 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 61271928-61276124 bp(+) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) A to G at 61271805 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000070175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049064] [ENSMUST00000066298]
AlphaFold P61226
Predicted Effect probably benign
Transcript: ENSMUST00000049064
SMART Domains Protein: ENSMUSP00000038841
Gene: ENSMUSG00000036894

DomainStartEndE-ValueType
RAS 1 167 3.08e-111 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000066298
SMART Domains Protein: ENSMUSP00000070175
Gene: ENSMUSG00000053706

DomainStartEndE-ValueType
low complexity region 95 103 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A G 11: 119,937,746 (GRCm39) S11P unknown Het
Adrb2 T C 18: 62,312,004 (GRCm39) T274A probably damaging Het
Aph1b A G 9: 66,701,503 (GRCm39) S45P probably damaging Het
Atp9b A T 18: 80,887,806 (GRCm39) D321E Het
C1qbp A G 11: 70,869,543 (GRCm39) V180A possibly damaging Het
C4b G T 17: 34,953,513 (GRCm39) A990D probably damaging Het
Ccdc80 T A 16: 44,915,612 (GRCm39) S123T possibly damaging Het
Cdh18 A C 15: 23,474,138 (GRCm39) E669D possibly damaging Het
Ceacam3 T A 7: 16,895,608 (GRCm39) V526D Het
Cenpf C T 1: 189,404,782 (GRCm39) C349Y probably damaging Het
Dmrt2 T C 19: 25,655,379 (GRCm39) V326A probably damaging Het
Dock9 T C 14: 121,783,454 (GRCm39) Q2023R probably damaging Het
Exd2 A G 12: 80,522,771 (GRCm39) R77G probably benign Het
Exph5 A T 9: 53,287,148 (GRCm39) K1410* probably null Het
Eya2 A G 2: 165,608,988 (GRCm39) T443A probably damaging Het
Fam135a G A 1: 24,067,569 (GRCm39) T1100M probably benign Het
Foxp2 G T 6: 15,403,866 (GRCm39) R381L unknown Het
Grm7 T G 6: 111,057,315 (GRCm39) V305G probably benign Het
Gzma G A 13: 113,237,464 (GRCm39) R8W probably benign Het
H6pd T C 4: 150,066,133 (GRCm39) E759G probably benign Het
Ift27 A G 15: 78,048,391 (GRCm39) V154A probably benign Het
Kif1a A T 1: 92,950,141 (GRCm39) S1429T probably benign Het
Lrrn1 T A 6: 107,546,294 (GRCm39) D697E probably benign Het
Mcrs1 A T 15: 99,141,575 (GRCm39) I387N probably damaging Het
Muc16 T C 9: 18,448,807 (GRCm39) T7675A probably damaging Het
Naf1 GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC 8: 67,313,200 (GRCm39) probably benign Het
Nid1 C A 13: 13,612,416 (GRCm39) L44I possibly damaging Het
Or2f2 A T 6: 42,767,644 (GRCm39) T224S possibly damaging Het
Or4m1 T C 14: 50,558,233 (GRCm39) T20A probably benign Het
Or5h27 A G 16: 59,006,117 (GRCm39) I243T unknown Het
Or8k1 T A 2: 86,047,457 (GRCm39) E199V probably damaging Het
Pde11a C T 2: 75,889,354 (GRCm39) D707N probably damaging Het
Pigf A T 17: 87,327,910 (GRCm39) L119* probably null Het
Pkd1l1 A T 11: 8,820,277 (GRCm39) C1679* probably null Het
Prnp A G 2: 131,778,669 (GRCm39) N107S probably benign Het
Ptgfr C T 3: 151,541,053 (GRCm39) V152M possibly damaging Het
Rtn4 A G 11: 29,657,300 (GRCm39) T485A probably damaging Het
Sec23b A G 2: 144,401,234 (GRCm39) T32A probably benign Het
Skint5 A T 4: 113,437,679 (GRCm39) probably null Het
Slc13a5 A G 11: 72,148,210 (GRCm39) L275P probably damaging Het
Slc20a1 C T 2: 129,041,784 (GRCm39) A49V probably damaging Het
Slc35g2 A G 9: 100,435,224 (GRCm39) I149T probably benign Het
Syk T A 13: 52,778,763 (GRCm39) I283K probably benign Het
Taf7l2 T C 10: 115,948,440 (GRCm39) Y362C probably benign Het
Tnfsf13b G A 8: 10,056,795 (GRCm39) probably benign Het
Ubr1 A G 2: 120,701,476 (GRCm39) V1592A probably benign Het
Vopp1 T C 6: 57,739,379 (GRCm39) *123W probably null Het
Xpo4 T A 14: 57,841,913 (GRCm39) Q467H probably damaging Het
Zdhhc22 A C 12: 87,035,143 (GRCm39) V103G possibly damaging Het
Zfp868 A G 8: 70,064,160 (GRCm39) S392P probably damaging Het
Other mutations in Rap2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02544:Rap2b APN 3 61,272,560 (GRCm39) missense probably damaging 1.00
R1715:Rap2b UTSW 3 61,272,611 (GRCm39) missense probably damaging 0.98
R2117:Rap2b UTSW 3 61,272,512 (GRCm39) missense probably damaging 1.00
R8217:Rap2b UTSW 3 61,272,551 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- AGTGTACGATCCTGAGAGGC -3'
(R):5'- TCGCCAACAGACTAGCAGAG -3'

Sequencing Primer
(F):5'- ATCCTGAGAGGCGCGCAG -3'
(R):5'- AAGACAACGGCTGGAGCTCTTC -3'
Posted On 2020-10-20