Incidental Mutation 'R8428:Prokr1'
ID 653594
Institutional Source Beutler Lab
Gene Symbol Prokr1
Ensembl Gene ENSMUSG00000049409
Gene Name prokineticin receptor 1
Synonyms Pkr1, Gpr73, EG-VEGFR1
MMRRC Submission 067822-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8428 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 87555573-87567725 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87565756 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 30 (T30A)
Ref Sequence ENSEMBL: ENSMUSP00000059034 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050887] [ENSMUST00000203636] [ENSMUST00000204682]
AlphaFold Q9JKL1
Predicted Effect probably benign
Transcript: ENSMUST00000050887
AA Change: T30A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000059034
Gene: ENSMUSG00000049409
AA Change: T30A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 73 360 8.8e-8 PFAM
Pfam:7tm_1 79 342 7.2e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203636
AA Change: T30A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000145476
Gene: ENSMUSG00000049409
AA Change: T30A

DomainStartEndE-ValueType
low complexity region 100 113 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000204682
AA Change: T30A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000144999
Gene: ENSMUSG00000049409
AA Change: T30A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 73 360 8.8e-8 PFAM
Pfam:7tm_1 79 342 7.2e-47 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]
PHENOTYPE: Mice homozygous for one null allele exhibit abnormal nociceptions and hypoalgesia. Mice homozygous for another null allele exhibit decreased capillary density in the heart. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agap2 A G 10: 126,923,175 (GRCm39) I670V unknown Het
Bcan G T 3: 87,904,405 (GRCm39) T117K probably damaging Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Cbx8 C A 11: 118,929,754 (GRCm39) V280F probably damaging Het
Ccdc117 A T 11: 5,484,350 (GRCm39) S163R possibly damaging Het
Ccdc17 A T 4: 116,456,823 (GRCm39) I509F probably damaging Het
Cdon T C 9: 35,403,163 (GRCm39) V1091A probably benign Het
Cntnap5b C T 1: 100,311,310 (GRCm39) T972I probably damaging Het
Dlg2 T C 7: 90,740,240 (GRCm39) L9P possibly damaging Het
Dnah6 T A 6: 73,051,634 (GRCm39) R3053S probably benign Het
Dnah7a T A 1: 53,512,112 (GRCm39) N2983I probably damaging Het
Dnah7c T C 1: 46,711,536 (GRCm39) Y2588H probably damaging Het
Dpysl5 A G 5: 30,902,811 (GRCm39) D81G probably damaging Het
Dscaml1 A G 9: 45,653,884 (GRCm39) D1387G probably benign Het
Exd1 G T 2: 119,369,348 (GRCm39) T89K possibly damaging Het
Ezh2 T A 6: 47,522,745 (GRCm39) R364* probably null Het
Fam161b C T 12: 84,404,369 (GRCm39) D104N probably benign Het
Fbxw8 C A 5: 118,215,763 (GRCm39) V416L probably benign Het
Flnc A T 6: 29,450,849 (GRCm39) D1499V probably benign Het
Fmc1 A T 6: 38,516,115 (GRCm39) R54* probably null Het
Fzr1 A G 10: 81,206,942 (GRCm39) F61S probably damaging Het
Get4 T G 5: 139,251,393 (GRCm39) C160G probably benign Het
Gm32742 G A 9: 51,055,675 (GRCm39) R1330* probably null Het
Gnat3 G A 5: 18,220,312 (GRCm39) A225T possibly damaging Het
Gucy2c A G 6: 136,704,892 (GRCm39) Y541H probably damaging Het
Hand2 A G 8: 57,775,461 (GRCm39) T174A probably benign Het
Helb T C 10: 119,927,522 (GRCm39) T863A probably damaging Het
Hoxa7 A T 6: 52,194,993 (GRCm39) V2D unknown Het
Ifi44 G A 3: 151,444,978 (GRCm39) R325* probably null Het
Igfn1 C T 1: 135,895,520 (GRCm39) G1682E probably damaging Het
Itch A G 2: 155,010,627 (GRCm39) N32D probably benign Het
Kif26b T C 1: 178,744,923 (GRCm39) V1673A probably benign Het
Map1a A T 2: 121,135,418 (GRCm39) D2078V probably benign Het
Mgat4b G T 11: 50,121,512 (GRCm39) V35L probably benign Het
Micu3 G A 8: 40,761,205 (GRCm39) M38I probably benign Het
Myo15a A T 11: 60,387,241 (GRCm39) H706L probably damaging Het
Ndc1 A G 4: 107,226,017 (GRCm39) T42A probably benign Het
Nfat5 T A 8: 108,095,152 (GRCm39) M1131K probably damaging Het
Nop14 G A 5: 34,798,784 (GRCm39) S648L probably damaging Het
Or51k1 G T 7: 103,661,632 (GRCm39) Y92* probably null Het
Otogl A G 10: 107,634,597 (GRCm39) V1413A probably damaging Het
Palb2 T A 7: 121,711,224 (GRCm39) M967L possibly damaging Het
Pira12 G A 7: 3,898,257 (GRCm39) T355I probably benign Het
Ppa2 A G 3: 133,053,904 (GRCm39) K198R probably damaging Het
Prss50 C T 9: 110,687,128 (GRCm39) R24C unknown Het
Rbm17 T C 2: 11,605,441 (GRCm39) T38A possibly damaging Het
Rps6ka5 G A 12: 100,541,500 (GRCm39) Q420* probably null Het
Senp6 G T 9: 80,025,794 (GRCm39) R448L probably damaging Het
Senp7 T C 16: 55,999,391 (GRCm39) I838T probably damaging Het
Sf3b2 C T 19: 5,337,242 (GRCm39) S329N possibly damaging Het
Slc13a4 A T 6: 35,245,814 (GRCm39) D610E probably benign Het
Slc24a2 A G 4: 87,145,337 (GRCm39) L239P probably damaging Het
Slc39a5 T A 10: 128,232,884 (GRCm39) H389L probably damaging Het
Syt4 A G 18: 31,577,072 (GRCm39) L94P probably damaging Het
Tgm5 A G 2: 120,879,356 (GRCm39) V560A probably benign Het
Thoc5 A G 11: 4,876,115 (GRCm39) T623A probably damaging Het
Tm7sf2 C T 19: 6,113,074 (GRCm39) V376I probably benign Het
Tmem268 T A 4: 63,496,141 (GRCm39) V194E probably damaging Het
Tpr C A 1: 150,290,564 (GRCm39) R798S probably damaging Het
Trpv5 G T 6: 41,630,182 (GRCm39) T685K possibly damaging Het
Ttn A T 2: 76,584,774 (GRCm39) N22141K probably damaging Het
Txnrd2 T C 16: 18,275,048 (GRCm39) I353T unknown Het
Upk1a A G 7: 30,303,043 (GRCm39) Y252H probably damaging Het
Vmn2r118 A G 17: 55,915,642 (GRCm39) I436T probably benign Het
Vmn2r76 T A 7: 85,874,479 (GRCm39) I833F possibly damaging Het
Zfp277 T C 12: 40,379,577 (GRCm39) H319R probably damaging Het
Other mutations in Prokr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Prokr1 APN 6 87,565,593 (GRCm39) missense probably damaging 1.00
IGL00838:Prokr1 APN 6 87,565,675 (GRCm39) missense possibly damaging 0.94
IGL01083:Prokr1 APN 6 87,565,766 (GRCm39) missense probably benign 0.41
IGL02677:Prokr1 APN 6 87,565,350 (GRCm39) splice site probably benign
IGL03344:Prokr1 APN 6 87,565,482 (GRCm39) missense possibly damaging 0.95
R1953:Prokr1 UTSW 6 87,565,575 (GRCm39) missense probably benign 0.18
R2065:Prokr1 UTSW 6 87,565,695 (GRCm39) missense probably damaging 0.98
R3161:Prokr1 UTSW 6 87,565,413 (GRCm39) missense probably damaging 1.00
R4777:Prokr1 UTSW 6 87,565,842 (GRCm39) start codon destroyed probably null 0.98
R4828:Prokr1 UTSW 6 87,558,224 (GRCm39) missense probably benign 0.07
R4890:Prokr1 UTSW 6 87,565,678 (GRCm39) missense probably benign 0.00
R4943:Prokr1 UTSW 6 87,558,806 (GRCm39) missense possibly damaging 0.90
R6134:Prokr1 UTSW 6 87,565,837 (GRCm39) missense possibly damaging 0.54
R6183:Prokr1 UTSW 6 87,565,834 (GRCm39) missense possibly damaging 0.94
R6329:Prokr1 UTSW 6 87,558,774 (GRCm39) missense possibly damaging 0.94
R6794:Prokr1 UTSW 6 87,565,675 (GRCm39) missense possibly damaging 0.94
R6922:Prokr1 UTSW 6 87,565,455 (GRCm39) missense probably damaging 1.00
R8478:Prokr1 UTSW 6 87,558,330 (GRCm39) missense probably benign 0.01
R9369:Prokr1 UTSW 6 87,558,407 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- AGTCTGAAATGGCCAGGTTG -3'
(R):5'- AAGATCTGACTCACCGAGGGAG -3'

Sequencing Primer
(F):5'- AGCTTTTTGTAGCGGGCCAG -3'
(R):5'- CTCACCGAGGGAGAGCCAAG -3'
Posted On 2020-10-20