Incidental Mutation 'R8449:Zfp202'
| ID |
654667 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp202
|
| Ensembl Gene |
ENSMUSG00000025602 |
| Gene Name |
zinc finger protein 202 |
| Synonyms |
C130037E22Rik |
| MMRRC Submission |
067829-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8449 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
40103612-40124900 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 40118976 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 130
(R130*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000026693
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026693]
[ENSMUST00000168691]
[ENSMUST00000168832]
|
| AlphaFold |
Q8C879 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000026693
AA Change: R130*
|
| SMART Domains |
Protein: ENSMUSP00000026693
Gene: ENSMUSG00000025602
AA Change: R130*
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
154 |
1.19e-75 |
SMART |
|
KRAB
|
237 |
297 |
1.7e-17 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
473 |
495 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
501 |
523 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
529 |
551 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
557 |
579 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
585 |
607 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
613 |
635 |
3.39e-3 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000168691
AA Change: R130*
|
| SMART Domains |
Protein: ENSMUSP00000130163
Gene: ENSMUSG00000025602
AA Change: R130*
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
132 |
1.03e-56 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000168832
AA Change: R130*
|
| SMART Domains |
Protein: ENSMUSP00000132131
Gene: ENSMUSG00000025602
AA Change: R130*
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
154 |
1.19e-75 |
SMART |
|
KRAB
|
237 |
277 |
5.32e-2 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ace3 |
A |
G |
11: 105,885,768 (GRCm39) |
E58G |
probably damaging |
Het |
| Ank1 |
T |
A |
8: 23,629,302 (GRCm39) |
F4I |
possibly damaging |
Het |
| Arih2 |
T |
C |
9: 108,488,872 (GRCm39) |
D282G |
possibly damaging |
Het |
| Atp7b |
C |
T |
8: 22,503,556 (GRCm39) |
V733I |
probably damaging |
Het |
| Avil |
A |
G |
10: 126,845,861 (GRCm39) |
D370G |
probably benign |
Het |
| Ccdc88b |
T |
C |
19: 6,833,213 (GRCm39) |
E278G |
probably damaging |
Het |
| Cdkl3 |
A |
G |
11: 51,975,260 (GRCm39) |
H74R |
|
Het |
| Clec9a |
C |
A |
6: 129,387,292 (GRCm39) |
A49E |
probably damaging |
Het |
| Cntn5 |
A |
G |
9: 9,666,840 (GRCm39) |
|
probably null |
Het |
| Cyp11b2 |
A |
G |
15: 74,723,428 (GRCm39) |
M412T |
possibly damaging |
Het |
| Dhrs7l |
T |
C |
12: 72,659,340 (GRCm39) |
N145D |
probably damaging |
Het |
| Dync1i1 |
A |
G |
6: 5,966,815 (GRCm39) |
Q399R |
possibly damaging |
Het |
| Fam47e |
C |
A |
5: 92,702,990 (GRCm39) |
R21S |
probably benign |
Het |
| Gimap4 |
A |
G |
6: 48,667,694 (GRCm39) |
I150V |
probably damaging |
Het |
| Gm7361 |
T |
A |
5: 26,465,387 (GRCm39) |
M128K |
possibly damaging |
Het |
| Gtf3c3 |
C |
T |
1: 54,468,068 (GRCm39) |
E190K |
probably damaging |
Het |
| Hells |
T |
C |
19: 38,940,286 (GRCm39) |
S396P |
probably damaging |
Het |
| Hrg |
T |
A |
16: 22,780,286 (GRCm39) |
S521R |
unknown |
Het |
| Itih5 |
A |
G |
2: 10,191,800 (GRCm39) |
T112A |
probably benign |
Het |
| Ly9 |
T |
A |
1: 171,421,586 (GRCm39) |
N555I |
probably damaging |
Het |
| Morc2b |
C |
T |
17: 33,355,775 (GRCm39) |
E666K |
probably benign |
Het |
| Mup8 |
C |
A |
4: 60,222,382 (GRCm39) |
V30L |
probably benign |
Het |
| Nebl |
T |
A |
2: 17,418,593 (GRCm39) |
E268D |
probably damaging |
Het |
| Nr4a3 |
G |
T |
4: 48,052,170 (GRCm39) |
R308L |
probably benign |
Het |
| Or10k2 |
A |
T |
8: 84,268,301 (GRCm39) |
H176L |
probably damaging |
Het |
| Or14j1 |
A |
G |
17: 38,146,561 (GRCm39) |
R224G |
probably damaging |
Het |
| Or4c10 |
A |
T |
2: 89,760,878 (GRCm39) |
I242L |
possibly damaging |
Het |
| Or6d14 |
G |
T |
6: 116,534,289 (GRCm39) |
R301L |
probably damaging |
Het |
| Or8k33 |
T |
G |
2: 86,383,980 (GRCm39) |
I163L |
probably benign |
Het |
| Plcd3 |
A |
G |
11: 102,965,496 (GRCm39) |
Y530H |
probably damaging |
Het |
| Pou2af1 |
A |
T |
9: 51,144,326 (GRCm39) |
E80V |
probably damaging |
Het |
| Scgb2b18 |
C |
T |
7: 32,872,656 (GRCm39) |
D50N |
probably benign |
Het |
| Shisa6 |
G |
C |
11: 66,416,556 (GRCm39) |
Q79E |
probably benign |
Het |
| Sis |
C |
T |
3: 72,810,984 (GRCm39) |
G1679D |
probably damaging |
Het |
| Sorcs2 |
A |
T |
5: 36,386,519 (GRCm39) |
M173K |
possibly damaging |
Het |
| Ston2 |
T |
C |
12: 91,608,649 (GRCm39) |
D817G |
probably damaging |
Het |
| Ticrr |
T |
A |
7: 79,344,428 (GRCm39) |
F1431Y |
probably benign |
Het |
| Uevld |
T |
A |
7: 46,595,055 (GRCm39) |
N179I |
probably damaging |
Het |
| Utp6 |
G |
T |
11: 79,836,610 (GRCm39) |
Q375K |
probably benign |
Het |
| Vmn2r68 |
T |
A |
7: 84,882,785 (GRCm39) |
E322D |
probably damaging |
Het |
| Wnt5a |
A |
G |
14: 28,235,108 (GRCm39) |
M51V |
probably benign |
Het |
| Zfp949 |
G |
T |
9: 88,449,302 (GRCm39) |
V36L |
possibly damaging |
Het |
|
| Other mutations in Zfp202 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00662:Zfp202
|
APN |
9 |
40,122,339 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01862:Zfp202
|
APN |
9 |
40,123,124 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL03069:Zfp202
|
APN |
9 |
40,122,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0028:Zfp202
|
UTSW |
9 |
40,123,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0158:Zfp202
|
UTSW |
9 |
40,120,212 (GRCm39) |
nonsense |
probably null |
|
|
R0278:Zfp202
|
UTSW |
9 |
40,119,778 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1132:Zfp202
|
UTSW |
9 |
40,122,318 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1404:Zfp202
|
UTSW |
9 |
40,122,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1404:Zfp202
|
UTSW |
9 |
40,122,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Zfp202
|
UTSW |
9 |
40,121,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1928:Zfp202
|
UTSW |
9 |
40,121,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2929:Zfp202
|
UTSW |
9 |
40,122,984 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3153:Zfp202
|
UTSW |
9 |
40,119,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3948:Zfp202
|
UTSW |
9 |
40,119,721 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4190:Zfp202
|
UTSW |
9 |
40,122,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4273:Zfp202
|
UTSW |
9 |
40,118,790 (GRCm39) |
nonsense |
probably null |
|
|
R6181:Zfp202
|
UTSW |
9 |
40,118,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Zfp202
|
UTSW |
9 |
40,118,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Zfp202
|
UTSW |
9 |
40,123,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Zfp202
|
UTSW |
9 |
40,121,531 (GRCm39) |
splice site |
probably null |
|
|
R7382:Zfp202
|
UTSW |
9 |
40,122,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7493:Zfp202
|
UTSW |
9 |
40,118,640 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7542:Zfp202
|
UTSW |
9 |
40,122,443 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7689:Zfp202
|
UTSW |
9 |
40,121,829 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7832:Zfp202
|
UTSW |
9 |
40,121,758 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8084:Zfp202
|
UTSW |
9 |
40,122,538 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8349:Zfp202
|
UTSW |
9 |
40,118,976 (GRCm39) |
nonsense |
probably null |
|
|
R8879:Zfp202
|
UTSW |
9 |
40,123,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9135:Zfp202
|
UTSW |
9 |
40,120,237 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9411:Zfp202
|
UTSW |
9 |
40,118,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9785:Zfp202
|
UTSW |
9 |
40,120,233 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0012:Zfp202
|
UTSW |
9 |
40,122,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCTCATCAGACTTCGAGAG -3'
(R):5'- GCCTAGAAAGTCACACTCGC -3'
Sequencing Primer
(F):5'- CAGACTTCGAGAGCTTTGTCATCAG -3'
(R):5'- TCGCACACATCCATCCCGG -3'
|
| Posted On |
2020-10-20 |
Incidental Mutation