Incidental Mutation 'R8766:Or9a7'
ID 667880
Institutional Source Beutler Lab
Gene Symbol Or9a7
Ensembl Gene ENSMUSG00000068259
Gene Name olfactory receptor family 9 subfamily A member 7
Synonyms GA_x6K02T2P3E9-6973252-6974193, Olfr461, MOR120-3
MMRRC Submission 068600-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R8766 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 40520970-40521911 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 40521485 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 143 (M143V)
Ref Sequence ENSEMBL: ENSMUSP00000150632 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089490] [ENSMUST00000215009]
AlphaFold Q8VF30
Predicted Effect probably benign
Transcript: ENSMUST00000089490
AA Change: M143V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000086917
Gene: ENSMUSG00000068259
AA Change: M143V

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 2e-41 PFAM
Pfam:7tm_1 40 289 1.3e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215009
AA Change: M143V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr10 T G 12: 71,001,430 (GRCm39) probably null Het
Amz1 A G 5: 140,733,921 (GRCm39) N166D probably benign Het
Armh4 T A 14: 50,011,497 (GRCm39) N70I probably damaging Het
Asah2 A G 19: 32,035,280 (GRCm39) F15S possibly damaging Het
Axin2 A G 11: 108,814,657 (GRCm39) M182V probably damaging Het
Cacna1s T C 1: 136,002,881 (GRCm39) L326P probably damaging Het
Ccdc169 T C 3: 55,058,245 (GRCm39) probably null Het
Cct8 A T 16: 87,285,756 (GRCm39) V234D probably damaging Het
Cdh19 T C 1: 110,817,844 (GRCm39) R633G probably benign Het
Clca3a1 A T 3: 144,714,939 (GRCm39) probably benign Het
Crat G A 2: 30,297,075 (GRCm39) P293S probably benign Het
Crybg3 G A 16: 59,375,696 (GRCm39) R139C probably benign Het
Ctbs A G 3: 146,165,588 (GRCm39) N301S possibly damaging Het
Cyp4x1 T C 4: 114,967,262 (GRCm39) H438R probably damaging Het
Dglucy C A 12: 100,837,706 (GRCm39) H616Q probably benign Het
Dync1i1 T A 6: 5,767,142 (GRCm39) L74Q possibly damaging Het
Epn1 T C 7: 5,095,860 (GRCm39) S167P possibly damaging Het
Fbxw28 T C 9: 109,155,749 (GRCm39) E341G probably benign Het
Gk2 T A 5: 97,604,110 (GRCm39) M243L probably benign Het
Grhl3 T A 4: 135,300,724 (GRCm39) E4D probably benign Het
Hsd17b13 T C 5: 104,125,009 (GRCm39) K58R probably benign Het
Ighd5-7 G A 12: 113,428,148 (GRCm39) Q9* probably null Het
Izumo1 G A 7: 45,276,496 (GRCm39) S353N probably benign Het
Klhl31 T C 9: 77,557,445 (GRCm39) S54P possibly damaging Het
Lonp2 T C 8: 87,363,198 (GRCm39) M272T probably benign Het
Ltbp1 T A 17: 75,603,250 (GRCm39) C682* probably null Het
Magi2 A G 5: 20,400,123 (GRCm39) K52E probably benign Het
Nab2 C T 10: 127,502,417 (GRCm39) probably benign Het
Ncapg2 T A 12: 116,390,356 (GRCm39) V435D probably damaging Het
Nid2 A G 14: 19,802,340 (GRCm39) D87G probably benign Het
Or10a3 A G 7: 108,480,453 (GRCm39) M120T probably benign Het
Pamr1 T C 2: 102,380,538 (GRCm39) M1T probably null Het
Pard3b T C 1: 62,198,637 (GRCm39) C242R probably benign Het
Pcif1 T A 2: 164,727,346 (GRCm39) V106E probably benign Het
Pitx2 T A 3: 129,012,223 (GRCm39) F218I probably damaging Het
Ppip5k1 G T 2: 121,166,919 (GRCm39) Y877* probably null Het
Prkch A G 12: 73,749,312 (GRCm39) N354S probably benign Het
Psen2 T A 1: 180,073,201 (GRCm39) D40V probably benign Het
Rfx7 T A 9: 72,524,021 (GRCm39) S404T possibly damaging Het
Ryr2 T A 13: 11,683,855 (GRCm39) T3070S probably damaging Het
Slc24a4 A G 12: 102,196,711 (GRCm39) D263G probably benign Het
Tox T C 4: 6,823,047 (GRCm39) E90G probably damaging Het
Unc13b C T 4: 43,174,722 (GRCm39) S1850L unknown Het
Vmn1r5 T A 6: 56,963,100 (GRCm39) D258E possibly damaging Het
Vmn2r84 C T 10: 130,222,241 (GRCm39) V660M probably damaging Het
Yju2b C T 8: 84,988,423 (GRCm39) R68H probably damaging Het
Zfp592 A T 7: 80,674,353 (GRCm39) H439L probably benign Het
Zfp775 A T 6: 48,597,113 (GRCm39) H329L probably damaging Het
Zswim5 T C 4: 116,816,004 (GRCm39) L364P probably damaging Het
Other mutations in Or9a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02232:Or9a7 APN 6 40,520,980 (GRCm39) missense probably damaging 0.96
IGL03245:Or9a7 APN 6 40,521,076 (GRCm39) missense probably damaging 0.98
R0325:Or9a7 UTSW 6 40,521,057 (GRCm39) missense possibly damaging 0.95
R0835:Or9a7 UTSW 6 40,521,272 (GRCm39) missense probably benign 0.01
R1594:Or9a7 UTSW 6 40,521,281 (GRCm39) missense probably benign 0.00
R2437:Or9a7 UTSW 6 40,521,856 (GRCm39) missense probably benign 0.37
R6360:Or9a7 UTSW 6 40,521,647 (GRCm39) missense possibly damaging 0.83
R6970:Or9a7 UTSW 6 40,521,590 (GRCm39) missense probably benign 0.31
R7252:Or9a7 UTSW 6 40,521,703 (GRCm39) missense probably benign 0.06
R7326:Or9a7 UTSW 6 40,521,829 (GRCm39) missense probably damaging 0.97
R9201:Or9a7 UTSW 6 40,521,293 (GRCm39) missense probably benign 0.00
RF003:Or9a7 UTSW 6 40,521,296 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CAGAAGCTGAGGGGATCTTG -3'
(R):5'- CCTTATATGCTCCAGGGGCTTC -3'

Sequencing Primer
(F):5'- AATTGTAAGGATCATGGAACCAAC -3'
(R):5'- CTTCTTCGACAGACGCAGATAATATC -3'
Posted On 2021-03-08