Mutagenetix > Incidental Mutation

Incidental Mutation 'R9097:Vmn1r16'

691411

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r16

Ensembl Gene

ENSMUSG00000115792

Gene Name

vomeronasal 1 receptor 16

Synonyms

V1rc29

MMRRC Submission

068912-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

R9097 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

57297724-57300620 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 57300250 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 124 (I124N)

Ref Sequence

ENSEMBL: ENSMUSP00000154001 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000227168] [ENSMUST00000227283] [ENSMUST00000228356]

AlphaFold

K7N775

Predicted Effect

probably benign
Transcript: ENSMUST00000227168
AA Change: I124N

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Predicted Effect

probably benign
Transcript: ENSMUST00000227283
AA Change: I124N

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Predicted Effect

probably benign
Transcript: ENSMUST00000228356
AA Change: I124N

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.1%

Validation Efficiency

96% (50/52)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Antxrl	G	A	14: 33,793,660 (GRCm39)	V463I	probably benign	Het
Aox1	T	A	1: 58,326,887 (GRCm39)	L162Q	possibly damaging	Het
Arhgap40	A	T	2: 158,389,584 (GRCm39)	M586L	probably benign	Het
Arnt	G	T	3: 95,397,588 (GRCm39)	S535I	probably benign	Het
Bsx	G	T	9: 40,785,636 (GRCm39)	G55C	probably damaging	Het
Ccdc168	T	C	1: 44,098,049 (GRCm39)	I1016M	possibly damaging	Het
Col9a1	A	T	1: 24,224,207 (GRCm39)	I130F	unknown	Het
Cyp51	G	T	5: 4,149,172 (GRCm39)	T235N	possibly damaging	Het
Depdc1a	T	A	3: 159,204,117 (GRCm39)	D55E	probably benign	Het
Dlc1	A	T	8: 37,080,721 (GRCm39)	I10N	probably benign	Het
Dzank1	G	T	2: 144,316,882 (GRCm39)	L767I	possibly damaging	Het
Eif3k	A	T	7: 28,671,660 (GRCm39)	*193K	probably null	Het
Eprs1	C	A	1: 185,139,303 (GRCm39)	A896E	probably benign	Het
Evc2	T	A	5: 37,550,505 (GRCm39)	F840I	possibly damaging	Het
Fut2	G	T	7: 45,300,375 (GRCm39)	H132Q	probably benign	Het
Gbp11	T	C	5: 105,474,347 (GRCm39)	*443W	probably null	Het
Gimd1	T	A	3: 132,340,661 (GRCm39)	M59K	probably benign	Het
Glis2	A	G	16: 4,429,640 (GRCm39)	T228A	probably damaging	Het
Gm21663	G	C	5: 26,147,167 (GRCm39)	C46W	probably benign	Het
Gpr162	A	G	6: 124,836,570 (GRCm39)	I367T	probably benign	Het
Grik1	G	A	16: 87,732,796 (GRCm39)	T692I		Het
Igf2r	G	T	17: 12,910,100 (GRCm39)	A2043D	probably damaging	Het
Il12b	C	A	11: 44,301,107 (GRCm39)	L208M	probably benign	Het
Il12b	T	A	11: 44,301,108 (GRCm39)	L208Q	probably damaging	Het
Lrrk2	C	T	15: 91,557,459 (GRCm39)		probably benign	Het
Map3k9	T	C	12: 81,819,855 (GRCm39)	D133G	possibly damaging	Het
Mrc2	A	G	11: 105,231,398 (GRCm39)	D777G	probably damaging	Het
Mtrr	A	G	13: 68,723,441 (GRCm39)	L157P	probably benign	Het
Nol4l	C	A	2: 153,312,630 (GRCm39)	R226L	probably damaging	Het
Nsmaf	CAAACTTTTAAACTT	CAAACTT	4: 6,416,543 (GRCm39)		probably null	Het
Or4f7	T	A	2: 111,644,196 (GRCm39)	K292*	probably null	Het
Or51f23c-ps1	A	G	7: 102,431,475 (GRCm39)	H264R	probably damaging	Het
Or5p73	A	T	7: 108,064,815 (GRCm39)	I95F	probably damaging	Het
Or6c7	T	A	10: 129,323,647 (GRCm39)	M256K	possibly damaging	Het
Or7g22	G	A	9: 19,048,670 (GRCm39)	C127Y	probably damaging	Het
Or9g8	T	A	2: 85,607,669 (GRCm39)	V247E	probably damaging	Het
Pkn2	C	T	3: 142,515,249 (GRCm39)	R695Q	probably benign	Het
Ppp1r9a	A	G	6: 4,906,012 (GRCm39)	D189G	probably damaging	Het
Prkca	A	G	11: 107,905,061 (GRCm39)	S226P	probably benign	Het
Ptpru	T	C	4: 131,499,843 (GRCm39)	N1267S	probably damaging	Het
Retnlb	T	A	16: 48,638,980 (GRCm39)		probably benign	Het
Rrp12	A	T	19: 41,878,577 (GRCm39)	D189E	probably benign	Het
Serpinb7	G	A	1: 107,377,907 (GRCm39)	C200Y	probably damaging	Het
Sez6	G	A	11: 77,865,121 (GRCm39)	E623K	possibly damaging	Het
Stk32a	A	T	18: 43,446,497 (GRCm39)	M316L	possibly damaging	Het
Supt6	G	T	11: 78,113,100 (GRCm39)	H948N	probably benign	Het
Sycp2l	A	T	13: 41,300,070 (GRCm39)	D428V	possibly damaging	Het
Tasp1	A	T	2: 139,725,690 (GRCm39)		probably null	Het
Telo2	T	C	17: 25,324,066 (GRCm39)	T550A	probably benign	Het
Tmem131l	A	T	3: 83,850,122 (GRCm39)	N225K	probably damaging	Het
Tnc	T	C	4: 63,888,622 (GRCm39)	T1724A	possibly damaging	Het
Tyk2	C	A	9: 21,020,072 (GRCm39)	E1029*	probably null	Het
Uhmk1	C	T	1: 170,042,879 (GRCm39)		probably benign	Het
Vav2	G	A	2: 27,181,850 (GRCm39)	R330W	probably damaging	Het
Vmn1r181	A	G	7: 23,684,444 (GRCm39)	N303S	probably benign	Het
Vmn1r50	G	A	6: 90,085,022 (GRCm39)	V256I	probably benign	Het

Other mutations in Vmn1r16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01350:Vmn1r16	APN	6	57,299,716 (GRCm39)	missense	possibly damaging	0.74
IGL02027:Vmn1r16	APN	6	57,300,044 (GRCm39)	missense	possibly damaging	0.49
IGL02804:Vmn1r16	APN	6	57,300,467 (GRCm39)	missense	probably benign	0.18
IGL03329:Vmn1r16	APN	6	57,300,603 (GRCm39)	missense	probably damaging	0.99
IGL03392:Vmn1r16	APN	6	57,299,879 (GRCm39)	missense	probably damaging	1.00
I1329:Vmn1r16	UTSW	6	57,300,519 (GRCm39)	missense	probably damaging	0.97
PIT4581001:Vmn1r16	UTSW	6	57,299,858 (GRCm39)	missense	probably benign	0.12
R0750:Vmn1r16	UTSW	6	57,299,812 (GRCm39)	missense	probably benign	0.00
R1137:Vmn1r16	UTSW	6	57,300,221 (GRCm39)	missense	probably damaging	1.00
R1239:Vmn1r16	UTSW	6	57,300,618 (GRCm39)	start codon destroyed	probably null	1.00
R1796:Vmn1r16	UTSW	6	57,300,256 (GRCm39)	missense	probably benign	0.03
R1858:Vmn1r16	UTSW	6	57,299,884 (GRCm39)	missense	probably damaging	1.00
R1895:Vmn1r16	UTSW	6	57,299,885 (GRCm39)	missense	probably benign	0.31
R1946:Vmn1r16	UTSW	6	57,299,885 (GRCm39)	missense	probably benign	0.31
R3832:Vmn1r16	UTSW	6	57,300,212 (GRCm39)	missense	probably benign	0.00
R4801:Vmn1r16	UTSW	6	57,300,175 (GRCm39)	missense	probably benign	0.03
R4802:Vmn1r16	UTSW	6	57,300,175 (GRCm39)	missense	probably benign	0.03
R6658:Vmn1r16	UTSW	6	57,300,091 (GRCm39)	nonsense	probably null
R6981:Vmn1r16	UTSW	6	57,300,473 (GRCm39)	missense	probably benign	0.30
R6991:Vmn1r16	UTSW	6	57,299,869 (GRCm39)	nonsense	probably null
R7915:Vmn1r16	UTSW	6	57,300,380 (GRCm39)	missense	probably damaging	1.00
R8214:Vmn1r16	UTSW	6	57,300,424 (GRCm39)	missense	noncoding transcript
R8459:Vmn1r16	UTSW	6	57,300,347 (GRCm39)	missense	probably benign	0.12
R8531:Vmn1r16	UTSW	6	57,299,900 (GRCm39)	missense	probably damaging	1.00
R8676:Vmn1r16	UTSW	6	57,299,814 (GRCm39)	missense	probably benign	0.01
R9096:Vmn1r16	UTSW	6	57,300,250 (GRCm39)	missense	probably benign	0.02
X0061:Vmn1r16	UTSW	6	57,300,349 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CATGTATGCGCTTGTAGTCAGC -3'
(R):5'- TGAGACACTGAACATTGAGAATGAC -3'

Sequencing Primer
(F):5'- ACATCTCTGGACATTGTCACAG -3'
(R):5'- CTGAACATTGAGAATGACTTCAAATG -3'

Posted On

2021-12-30