Mutagenetix > Incidental Mutation

Incidental Mutation 'R8531:Vmn1r16'

659044

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r16

Ensembl Gene

ENSMUSG00000115792

Gene Name

vomeronasal 1 receptor 16

Synonyms

V1rc29

MMRRC Submission

068501-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

R8531 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

57297724-57300620 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 57299900 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 241 (Y241H)

Ref Sequence

ENSEMBL: ENSMUSP00000154643 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000227168] [ENSMUST00000227283] [ENSMUST00000228356]

AlphaFold

K7N775

Predicted Effect

probably damaging
Transcript: ENSMUST00000227168
AA Change: Y241H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000227283
AA Change: Y241H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228356
AA Change: Y241H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930407I10Rik	A	T	15: 81,950,622 (GRCm39)	R1506S	probably benign	Het
Acox2	T	C	14: 8,247,960 (GRCm38)	T441A	probably damaging	Het
Adam6a	A	G	12: 113,508,917 (GRCm39)	E430G	probably damaging	Het
Afg3l2	T	C	18: 67,540,439 (GRCm39)	E690G	probably damaging	Het
Alb	A	G	5: 90,611,873 (GRCm39)	I101V	probably benign	Het
Arhgef19	T	C	4: 140,976,903 (GRCm39)	I493T	possibly damaging	Het
Btnl2	T	C	17: 34,577,028 (GRCm39)	M61T	probably benign	Het
Cyp2d11	A	G	15: 82,273,429 (GRCm39)	Y481H	probably benign	Het
Dennd4c	T	C	4: 86,744,319 (GRCm39)		probably null	Het
Dhx9	C	A	1: 153,334,182 (GRCm39)	V993F	possibly damaging	Het
Dlk1	A	G	12: 109,424,066 (GRCm39)	Q110R	probably null	Het
Dmp1	A	C	5: 104,360,269 (GRCm39)	D315A	probably damaging	Het
Dnah3	T	C	7: 119,550,591 (GRCm39)	K3243E	probably damaging	Het
Dsc3	T	C	18: 20,101,449 (GRCm39)	N648S	probably benign	Het
Dsc3	C	T	18: 20,114,274 (GRCm39)	D327N	probably damaging	Het
Egr4	T	C	6: 85,489,106 (GRCm39)	D318G	probably damaging	Het
Fiz1	A	T	7: 5,012,163 (GRCm39)	C118*	probably null	Het
Flad1	A	C	3: 89,310,517 (GRCm39)	Y479D	probably damaging	Het
Flnb	T	C	14: 7,929,939 (GRCm38)	F2023S	probably damaging	Het
Glp1r	T	C	17: 31,143,531 (GRCm39)	L189P	probably damaging	Het
Grm5	A	T	7: 87,779,724 (GRCm39)	T1055S	probably benign	Het
Gucy1a1	A	G	3: 82,018,468 (GRCm39)	I123T	probably benign	Het
Ifnar1	T	A	16: 91,292,344 (GRCm39)	C199*	probably null	Het
Lepr	A	T	4: 101,622,612 (GRCm39)	Y464F	probably damaging	Het
Mamdc4	G	T	2: 25,457,730 (GRCm39)	Q452K	possibly damaging	Het
Map2k6	A	G	11: 110,290,175 (GRCm39)		probably benign	Het
Mphosph10	T	C	7: 64,034,076 (GRCm39)	I429V	possibly damaging	Het
Neb	T	A	2: 52,181,074 (GRCm39)	M1178L	possibly damaging	Het
Nherf4	T	C	9: 44,159,670 (GRCm39)	E442G	probably damaging	Het
Npc2	C	A	12: 84,807,612 (GRCm39)	R82L	probably benign	Het
Olfm5	A	T	7: 103,803,029 (GRCm39)	M478K	probably benign	Het
Or5aq6	G	T	2: 86,923,670 (GRCm39)	Q24K	probably benign	Het
Or5k14	A	C	16: 58,693,016 (GRCm39)	L166V	probably damaging	Het
Osbpl9	T	C	4: 109,013,908 (GRCm39)	D62G	probably damaging	Het
Otog	C	T	7: 45,901,473 (GRCm39)	R391C	probably damaging	Het
Plppr4	T	C	3: 117,115,592 (GRCm39)	Y755C	probably damaging	Het
Pnpla8	T	A	12: 44,358,368 (GRCm39)	F708I	possibly damaging	Het
Pom121l12	A	T	11: 14,549,932 (GRCm39)	T213S	probably benign	Het
Pramel27	T	A	4: 143,579,601 (GRCm39)	D395E	probably benign	Het
Rabep1	T	C	11: 70,799,332 (GRCm39)	S278P	probably benign	Het
Rigi	A	G	4: 40,225,596 (GRCm39)		probably null	Het
Rnf213	C	G	11: 119,365,031 (GRCm39)	Q4563E	probably benign	Het
Rttn	C	A	18: 89,131,467 (GRCm39)	R1949S	probably benign	Het
Rwdd3	T	C	3: 120,952,788 (GRCm39)	I140V	probably benign	Het
Serpinb6a	A	T	13: 34,115,462 (GRCm39)	M53K	probably damaging	Het
Serpinb9g	A	T	13: 33,676,896 (GRCm39)	D226V	possibly damaging	Het
Serpind1	A	T	16: 17,160,847 (GRCm39)	Y459F	probably damaging	Het
Skor2	T	C	18: 76,946,569 (GRCm39)	V97A	unknown	Het
Slc26a4	C	T	12: 31,599,911 (GRCm39)		probably null	Het
Slc4a10	T	C	2: 62,097,851 (GRCm39)	Y517H	probably damaging	Het
Sphkap	A	G	1: 83,254,909 (GRCm39)	W947R	probably damaging	Het
Sult3a2	T	C	10: 33,653,239 (GRCm39)	D167G	probably damaging	Het
Supt16	A	T	14: 52,410,020 (GRCm39)	M729K	probably damaging	Het
Tmem176b	A	G	6: 48,811,538 (GRCm39)	I37T	possibly damaging	Het
Tmem259	A	G	10: 79,813,819 (GRCm39)	V423A	probably damaging	Het
Tmem62	G	T	2: 120,837,533 (GRCm39)	L483F	probably damaging	Het
Tnfrsf13b	T	C	11: 61,031,777 (GRCm39)		probably null	Het
Tut7	A	T	13: 59,937,074 (GRCm39)	I1191K	probably damaging	Het
Txk	C	A	5: 72,893,720 (GRCm39)	C20F	possibly damaging	Het
Ube2w	A	C	1: 16,672,542 (GRCm39)	N46K	probably benign	Het
Unc79	A	T	12: 103,013,922 (GRCm39)	H300L	probably damaging	Het
Unc79	T	A	12: 103,049,855 (GRCm39)	H920Q	probably benign	Het
Vmn2r100	A	T	17: 19,742,459 (GRCm39)	I278F	possibly damaging	Het
Zfp260	T	A	7: 29,804,884 (GRCm39)	H261Q	probably damaging	Het

Other mutations in Vmn1r16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01350:Vmn1r16	APN	6	57,299,716 (GRCm39)	missense	possibly damaging	0.74
IGL02027:Vmn1r16	APN	6	57,300,044 (GRCm39)	missense	possibly damaging	0.49
IGL02804:Vmn1r16	APN	6	57,300,467 (GRCm39)	missense	probably benign	0.18
IGL03329:Vmn1r16	APN	6	57,300,603 (GRCm39)	missense	probably damaging	0.99
IGL03392:Vmn1r16	APN	6	57,299,879 (GRCm39)	missense	probably damaging	1.00
I1329:Vmn1r16	UTSW	6	57,300,519 (GRCm39)	missense	probably damaging	0.97
PIT4581001:Vmn1r16	UTSW	6	57,299,858 (GRCm39)	missense	probably benign	0.12
R0750:Vmn1r16	UTSW	6	57,299,812 (GRCm39)	missense	probably benign	0.00
R1137:Vmn1r16	UTSW	6	57,300,221 (GRCm39)	missense	probably damaging	1.00
R1239:Vmn1r16	UTSW	6	57,300,618 (GRCm39)	start codon destroyed	probably null	1.00
R1796:Vmn1r16	UTSW	6	57,300,256 (GRCm39)	missense	probably benign	0.03
R1858:Vmn1r16	UTSW	6	57,299,884 (GRCm39)	missense	probably damaging	1.00
R1895:Vmn1r16	UTSW	6	57,299,885 (GRCm39)	missense	probably benign	0.31
R1946:Vmn1r16	UTSW	6	57,299,885 (GRCm39)	missense	probably benign	0.31
R3832:Vmn1r16	UTSW	6	57,300,212 (GRCm39)	missense	probably benign	0.00
R4801:Vmn1r16	UTSW	6	57,300,175 (GRCm39)	missense	probably benign	0.03
R4802:Vmn1r16	UTSW	6	57,300,175 (GRCm39)	missense	probably benign	0.03
R6658:Vmn1r16	UTSW	6	57,300,091 (GRCm39)	nonsense	probably null
R6981:Vmn1r16	UTSW	6	57,300,473 (GRCm39)	missense	probably benign	0.30
R6991:Vmn1r16	UTSW	6	57,299,869 (GRCm39)	nonsense	probably null
R7915:Vmn1r16	UTSW	6	57,300,380 (GRCm39)	missense	probably damaging	1.00
R8214:Vmn1r16	UTSW	6	57,300,424 (GRCm39)	missense	noncoding transcript
R8459:Vmn1r16	UTSW	6	57,300,347 (GRCm39)	missense	probably benign	0.12
R8676:Vmn1r16	UTSW	6	57,299,814 (GRCm39)	missense	probably benign	0.01
R9096:Vmn1r16	UTSW	6	57,300,250 (GRCm39)	missense	probably benign	0.02
R9097:Vmn1r16	UTSW	6	57,300,250 (GRCm39)	missense	probably benign	0.02
X0061:Vmn1r16	UTSW	6	57,300,349 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AACATTCTGGAGGTGCTTTGAC -3'
(R):5'- CCCCATGAACTACATCATTAGGG -3'

Sequencing Primer
(F):5'- TGACTGCCTGTTTTTCAACATAG -3'
(R):5'- CCATGAACTACATCATTAGGGGATTG -3'

Posted On

2021-01-18