Incidental Mutation 'R9473:Tas2r114'
ID 715569
Institutional Source Beutler Lab
Gene Symbol Tas2r114
Ensembl Gene ENSMUSG00000063478
Gene Name taste receptor, type 2, member 114
Synonyms mt2r46, mGR14, T2R14, Tas2r14
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R9473 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 131666097-131667026 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 131666104 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 308 (D308G)
Ref Sequence ENSEMBL: ENSMUSP00000079453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053652] [ENSMUST00000072404] [ENSMUST00000080619]
AlphaFold Q7M722
Predicted Effect probably benign
Transcript: ENSMUST00000053652
SMART Domains Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 9.4e-109 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000072404
SMART Domains Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.3e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080619
AA Change: D308G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478
AA Change: D308G

DomainStartEndE-ValueType
Pfam:TAS2R 1 298 8.1e-104 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik C T 5: 144,980,912 (GRCm39) P107L probably benign Het
Abcc10 T C 17: 46,617,609 (GRCm39) N1142S probably benign Het
Accsl T C 2: 93,686,092 (GRCm39) H575R probably benign Het
Adgra2 T A 8: 27,610,943 (GRCm39) L964Q probably damaging Het
Akap5 T C 12: 76,376,632 (GRCm39) L688P probably damaging Het
Anapc10 A G 8: 80,501,673 (GRCm39) N147S probably damaging Het
Atm C T 9: 53,410,272 (GRCm39) E1059K probably benign Het
Bltp2 G A 11: 78,174,983 (GRCm39) R1706H probably damaging Het
Bmf A C 2: 118,363,104 (GRCm39) F251V probably benign Het
Capn3 G T 2: 120,326,535 (GRCm39) E576* probably null Het
Capns2 T C 8: 93,628,854 (GRCm39) *248R probably null Het
Ceacam13 G T 7: 17,747,281 (GRCm39) V245L probably benign Het
Clcn3 T C 8: 61,407,651 (GRCm39) D2G probably benign Het
Dcstamp G A 15: 39,617,972 (GRCm39) C127Y probably damaging Het
Dnmt3l C T 10: 77,886,022 (GRCm39) Q36* probably null Het
Dpys A G 15: 39,687,583 (GRCm39) I405T possibly damaging Het
Duoxa1 A G 2: 122,134,326 (GRCm39) I309T probably benign Het
Eif2b1 G A 5: 124,712,677 (GRCm39) Q156* probably null Het
Eif3l T A 15: 78,970,704 (GRCm39) M326K probably damaging Het
Fbxl13 T C 5: 21,790,243 (GRCm39) N267D possibly damaging Het
Fip1l1 C T 5: 74,745,719 (GRCm39) T372I probably damaging Het
Galt A G 4: 41,757,575 (GRCm39) N249S probably benign Het
Gm17324 G T 9: 78,355,839 (GRCm39) R47S unknown Het
Gm45871 T G 18: 90,609,093 (GRCm39) D110E probably benign Het
Gtf2ird1 T A 5: 134,433,534 (GRCm39) T298S probably benign Het
Ighv7-4 T C 12: 114,186,722 (GRCm39) I17V probably benign Het
Krt7 C T 15: 101,318,409 (GRCm39) R299W probably damaging Het
Macc1 A G 12: 119,297,990 (GRCm39) probably benign Het
Mturn G A 6: 54,666,009 (GRCm39) E61K probably benign Het
Nol11 T C 11: 107,075,581 (GRCm39) D149G probably null Het
Nr4a3 A T 4: 48,052,143 (GRCm39) N299I probably damaging Het
Pip5k1b A T 19: 24,335,590 (GRCm39) I351N probably damaging Het
Plce1 G A 19: 38,766,337 (GRCm39) E2121K possibly damaging Het
Pramel11 T G 4: 143,620,815 (GRCm39) T468P probably benign Het
Rdh19 A G 10: 127,696,177 (GRCm39) T310A probably benign Het
Rflnb T A 11: 75,913,064 (GRCm39) Y108F probably damaging Het
Rfx1 A T 8: 84,819,903 (GRCm39) I713F probably damaging Het
Saxo5 G A 8: 3,529,232 (GRCm39) C239Y probably benign Het
Scgn T C 13: 24,143,731 (GRCm39) probably null Het
Serpina1d T C 12: 103,729,939 (GRCm39) *414W probably null Het
Slc18a3 T C 14: 32,185,913 (GRCm39) I157V probably benign Het
Steap1 T C 5: 5,790,378 (GRCm39) Y190C probably damaging Het
Svep1 A G 4: 58,064,243 (GRCm39) S3247P probably benign Het
Syne1 T C 10: 5,198,258 (GRCm39) I3778V probably benign Het
Tpm2 A T 4: 43,514,813 (GRCm39) L274* probably null Het
Ttc39b A G 4: 83,181,977 (GRCm39) F81L possibly damaging Het
Ttn A G 2: 76,547,338 (GRCm39) V32236A probably damaging Het
Ubr5 A G 15: 38,002,617 (GRCm39) V1472A Het
Ugt2b1 A T 5: 87,065,539 (GRCm39) V500D possibly damaging Het
Vpreb1b G A 16: 17,798,565 (GRCm39) C17Y probably benign Het
Wscd1 A G 11: 71,679,644 (GRCm39) N506D probably damaging Het
Other mutations in Tas2r114
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01777:Tas2r114 APN 6 131,666,664 (GRCm39) nonsense probably null
IGL02971:Tas2r114 APN 6 131,666,243 (GRCm39) missense probably benign 0.00
R0561:Tas2r114 UTSW 6 131,666,758 (GRCm39) missense probably benign 0.30
R3034:Tas2r114 UTSW 6 131,666,611 (GRCm39) missense probably benign 0.15
R3687:Tas2r114 UTSW 6 131,666,231 (GRCm39) missense probably benign 0.25
R4411:Tas2r114 UTSW 6 131,666,585 (GRCm39) missense probably benign 0.06
R4826:Tas2r114 UTSW 6 131,666,800 (GRCm39) missense probably damaging 0.99
R4889:Tas2r114 UTSW 6 131,666,758 (GRCm39) missense probably damaging 0.96
R5084:Tas2r114 UTSW 6 131,666,251 (GRCm39) nonsense probably null
R5258:Tas2r114 UTSW 6 131,666,504 (GRCm39) missense probably benign 0.03
R6038:Tas2r114 UTSW 6 131,666,444 (GRCm39) missense possibly damaging 0.89
R6038:Tas2r114 UTSW 6 131,666,444 (GRCm39) missense possibly damaging 0.89
R6499:Tas2r114 UTSW 6 131,666,099 (GRCm39) makesense probably null
R7164:Tas2r114 UTSW 6 131,666,728 (GRCm39) missense possibly damaging 0.74
R7276:Tas2r114 UTSW 6 131,666,310 (GRCm39) missense probably damaging 0.96
R7745:Tas2r114 UTSW 6 131,666,401 (GRCm39) missense probably damaging 1.00
R7851:Tas2r114 UTSW 6 131,666,888 (GRCm39) missense probably damaging 1.00
R8002:Tas2r114 UTSW 6 131,666,102 (GRCm39) missense probably damaging 1.00
R8901:Tas2r114 UTSW 6 131,666,914 (GRCm39) missense probably damaging 0.99
R9297:Tas2r114 UTSW 6 131,666,287 (GRCm39) missense probably damaging 0.96
R9380:Tas2r114 UTSW 6 131,666,381 (GRCm39) missense probably benign 0.00
R9402:Tas2r114 UTSW 6 131,666,894 (GRCm39) missense possibly damaging 0.49
R9513:Tas2r114 UTSW 6 131,666,746 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AACGAGTTGGAGACTGACTG -3'
(R):5'- TGTCTGTTAATCCCAGAAAGCAAC -3'

Sequencing Primer
(F):5'- CTGAACAAATTAACCTGTACATGGG -3'
(R):5'- CCCAGAAAGCAACTTGTTATTCATG -3'
Posted On 2022-06-15