Incidental Mutation 'R9590:Cyp2j11'
| ID |
722959 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cyp2j11
|
| Ensembl Gene |
ENSMUSG00000066097 |
| Gene Name |
cytochrome P450, family 2, subfamily j, polypeptide 11 |
| Synonyms |
Cyp2j11-ps |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
R9590 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
96182745-96236899 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 96195614 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 361
(M361L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132180
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015368]
|
| AlphaFold |
Q3UNV2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000015368
AA Change: M361L
PolyPhen 2
Score 0.109 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000132180
Gene: ENSMUSG00000066097
AA Change: M361L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
Pfam:p450
|
44 |
500 |
4.3e-133 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ace |
A |
G |
11: 105,876,506 (GRCm39) |
T1087A |
probably benign |
Het |
| Aopep |
A |
G |
13: 63,208,923 (GRCm39) |
T347A |
probably benign |
Het |
| Atp8b2 |
A |
T |
3: 89,865,693 (GRCm39) |
L69* |
probably null |
Het |
| Bnip3l |
G |
A |
14: 67,246,214 (GRCm39) |
P7L |
possibly damaging |
Het |
| C130073F10Rik |
G |
A |
4: 101,747,618 (GRCm39) |
T137I |
probably benign |
Het |
| C9orf72 |
C |
T |
4: 35,218,557 (GRCm39) |
G101R |
|
Het |
| Cacna1a |
C |
T |
8: 85,328,610 (GRCm39) |
Q1683* |
probably null |
Het |
| Calml4 |
A |
G |
9: 62,782,810 (GRCm39) |
Y139C |
probably benign |
Het |
| Cd33 |
T |
A |
7: 43,179,637 (GRCm39) |
I264F |
probably benign |
Het |
| Cfi |
A |
T |
3: 129,642,461 (GRCm39) |
H105L |
probably benign |
Het |
| Cnr1 |
G |
T |
4: 33,944,849 (GRCm39) |
M412I |
probably benign |
Het |
| Dnase2b |
A |
T |
3: 146,290,323 (GRCm39) |
V216D |
probably benign |
Het |
| Eif1 |
C |
T |
11: 100,210,867 (GRCm39) |
|
probably benign |
Het |
| Faap100 |
G |
A |
11: 120,269,545 (GRCm39) |
|
probably benign |
Het |
| Fkbp10 |
A |
T |
11: 100,306,785 (GRCm39) |
Q59L |
probably damaging |
Het |
| Galnt13 |
G |
T |
2: 54,747,973 (GRCm39) |
V285F |
probably benign |
Het |
| Gm32742 |
A |
G |
9: 51,050,461 (GRCm39) |
F1510S |
possibly damaging |
Het |
| Klhl33 |
T |
G |
14: 51,130,042 (GRCm39) |
D224A |
probably benign |
Het |
| Man1a |
A |
G |
10: 53,784,060 (GRCm39) |
F607S |
probably damaging |
Het |
| Mcc |
T |
C |
18: 44,592,977 (GRCm39) |
N686S |
possibly damaging |
Het |
| Mlip |
A |
G |
9: 77,045,834 (GRCm39) |
M882T |
probably benign |
Het |
| Mmp9 |
T |
A |
2: 164,790,834 (GRCm39) |
M74K |
probably benign |
Het |
| Nek10 |
C |
A |
14: 14,853,888 (GRCm38) |
S358Y |
probably damaging |
Het |
| Or51a7 |
T |
C |
7: 102,614,553 (GRCm39) |
L82P |
probably benign |
Het |
| Or5b12b |
T |
C |
19: 12,861,980 (GRCm39) |
V245A |
probably benign |
Het |
| Or8g29-ps1 |
A |
T |
9: 39,201,076 (GRCm39) |
C37S |
unknown |
Het |
| Padi1 |
T |
C |
4: 140,544,552 (GRCm39) |
D547G |
probably damaging |
Het |
| Pcbp4 |
T |
C |
9: 106,340,400 (GRCm39) |
S332P |
possibly damaging |
Het |
| Pde2a |
A |
G |
7: 101,160,757 (GRCm39) |
I909V |
probably benign |
Het |
| Ppil6 |
T |
C |
10: 41,366,478 (GRCm39) |
M1T |
probably null |
Het |
| Proser2 |
A |
G |
2: 6,105,794 (GRCm39) |
S257P |
probably benign |
Het |
| Prr27 |
C |
A |
5: 87,990,994 (GRCm39) |
P202Q |
probably benign |
Het |
| Rsf1 |
CGGCGGCGG |
CGGCGGCGGGGGCGGCGG |
7: 97,229,118 (GRCm39) |
|
probably benign |
Het |
| Scn9a |
A |
G |
2: 66,314,328 (GRCm39) |
F1797L |
probably benign |
Het |
| Sfmbt1 |
T |
C |
14: 30,512,727 (GRCm39) |
L360P |
probably damaging |
Het |
| Tab1 |
A |
T |
15: 80,040,097 (GRCm39) |
N306Y |
probably damaging |
Het |
| Tob2 |
A |
C |
15: 81,735,068 (GRCm39) |
F300L |
possibly damaging |
Het |
|
| Other mutations in Cyp2j11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01101:Cyp2j11
|
APN |
4 |
96,227,332 (GRCm39) |
missense |
probably benign |
|
|
IGL01816:Cyp2j11
|
APN |
4 |
96,183,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02406:Cyp2j11
|
APN |
4 |
96,236,776 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
E7848:Cyp2j11
|
UTSW |
4 |
96,207,602 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0020:Cyp2j11
|
UTSW |
4 |
96,195,641 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0020:Cyp2j11
|
UTSW |
4 |
96,195,641 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1298:Cyp2j11
|
UTSW |
4 |
96,195,497 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1411:Cyp2j11
|
UTSW |
4 |
96,233,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1428:Cyp2j11
|
UTSW |
4 |
96,183,117 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1740:Cyp2j11
|
UTSW |
4 |
96,207,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1818:Cyp2j11
|
UTSW |
4 |
96,185,976 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1819:Cyp2j11
|
UTSW |
4 |
96,185,976 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1917:Cyp2j11
|
UTSW |
4 |
96,228,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Cyp2j11
|
UTSW |
4 |
96,227,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2146:Cyp2j11
|
UTSW |
4 |
96,204,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2148:Cyp2j11
|
UTSW |
4 |
96,204,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2150:Cyp2j11
|
UTSW |
4 |
96,204,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4963:Cyp2j11
|
UTSW |
4 |
96,204,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5335:Cyp2j11
|
UTSW |
4 |
96,195,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5450:Cyp2j11
|
UTSW |
4 |
96,228,113 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5688:Cyp2j11
|
UTSW |
4 |
96,233,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5978:Cyp2j11
|
UTSW |
4 |
96,207,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6061:Cyp2j11
|
UTSW |
4 |
96,236,853 (GRCm39) |
start gained |
probably benign |
|
|
R6075:Cyp2j11
|
UTSW |
4 |
96,233,322 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6912:Cyp2j11
|
UTSW |
4 |
96,183,108 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7338:Cyp2j11
|
UTSW |
4 |
96,195,524 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7394:Cyp2j11
|
UTSW |
4 |
96,204,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7464:Cyp2j11
|
UTSW |
4 |
96,233,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7972:Cyp2j11
|
UTSW |
4 |
96,185,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8152:Cyp2j11
|
UTSW |
4 |
96,195,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8328:Cyp2j11
|
UTSW |
4 |
96,236,605 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8383:Cyp2j11
|
UTSW |
4 |
96,236,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8519:Cyp2j11
|
UTSW |
4 |
96,207,539 (GRCm39) |
missense |
probably benign |
0.44 |
|
R8789:Cyp2j11
|
UTSW |
4 |
96,227,405 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9268:Cyp2j11
|
UTSW |
4 |
96,207,781 (GRCm39) |
intron |
probably benign |
|
|
R9323:Cyp2j11
|
UTSW |
4 |
96,195,619 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9457:Cyp2j11
|
UTSW |
4 |
96,195,596 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Cyp2j11
|
UTSW |
4 |
96,195,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Cyp2j11
|
UTSW |
4 |
96,195,540 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTCAGATAATGCCAAGGATATAC -3'
(R):5'- TGCAAACTTTATATGCCCCAGTAC -3'
Sequencing Primer
(F):5'- TGCCAAGGATATACTGGAGTTTAG -3'
(R):5'- CCAGTACAGGGTAACGCCAG -3'
|
| Posted On |
2022-08-09 |
Incidental Mutation