Mutagenetix > Incidental Mutation

Incidental Mutation 'R9610:Or51f1'

724145

Institutional Source

Beutler Lab

Gene Symbol

Or51f1

Ensembl Gene

ENSMUSG00000060888

Gene Name

olfactory receptor family 51 subfamily F member 1

Synonyms

MOR14-7P, Olfr566, GA_x6K02T2PBJ9-5560696-5559746

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

R9610 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

102505528-102507972 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 102506147 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Proline at position 114 (H114P)

Ref Sequence

ENSEMBL: ENSMUSP00000148058 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071393] [ENSMUST00000209952] [ENSMUST00000213481]

AlphaFold

A0A1B0GST0

Predicted Effect

probably damaging
Transcript: ENSMUST00000071393
AA Change: H111P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000071344
Gene: ENSMUSG00000060888
AA Change: H111P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	316	1e-110	PFAM
Pfam:7TM_GPCR_Srsx	42	313	3.5e-6	PFAM
Pfam:7tm_1	47	298	9.3e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000209952
AA Change: H114P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000213481
AA Change: H114P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts19	A	T	18: 59,023,399 (GRCm39)	T265S	probably benign	Het
Arhgef5	A	G	6: 43,257,890 (GRCm39)	I1311M	probably damaging	Het
Bcr	T	A	10: 74,990,743 (GRCm39)	Y750N	probably damaging	Het
Bcr	T	A	10: 74,990,745 (GRCm39)	Y750*	probably null	Het
Btbd16	T	A	7: 130,407,595 (GRCm39)	M295K	probably benign	Het
Ccdc88a	T	C	11: 29,427,316 (GRCm39)	L1007P	possibly damaging	Het
Cnep1r1	A	G	8: 88,860,457 (GRCm39)	*126W	probably null	Het
Cstf1	T	A	2: 172,214,984 (GRCm39)	I35N	probably benign	Het
Cstpp1	T	C	2: 91,135,127 (GRCm39)	D111G	probably damaging	Het
Cul9	A	G	17: 46,830,823 (GRCm39)	L1690P	possibly damaging	Het
Dnm2	A	T	9: 21,414,973 (GRCm39)	K677*	probably null	Het
Dscaml1	C	A	9: 45,579,522 (GRCm39)	N356K	possibly damaging	Het
Dvl3	A	G	16: 20,346,008 (GRCm39)	D446G	probably damaging	Het
Ecm2	A	G	13: 49,668,518 (GRCm39)	N74D	probably benign	Het
Ecm2	A	G	13: 49,681,216 (GRCm39)	I450M	probably damaging	Het
Emc1	T	A	4: 139,091,035 (GRCm39)	D460E	probably benign	Het
Fhip2b	T	C	14: 70,824,258 (GRCm39)	Y493C	probably benign	Het
Fuom	T	A	7: 139,679,828 (GRCm39)	E121V	possibly damaging	Het
Fyco1	T	C	9: 123,657,585 (GRCm39)	T864A	possibly damaging	Het
Galk2	T	C	2: 125,817,218 (GRCm39)	Y336H	probably damaging	Het
Gcsh	T	A	8: 117,720,125 (GRCm39)	Y14F	probably benign	Het
Grip1	G	A	10: 119,874,569 (GRCm39)	E778K	possibly damaging	Het
Gucy2g	T	C	19: 55,194,605 (GRCm39)	I937M	probably damaging	Het
Hsp90ab1	T	C	17: 45,880,600 (GRCm39)	I370M	possibly damaging	Het
Hypk	T	C	2: 121,288,154 (GRCm39)	S72P	probably damaging	Het
Izumo1r	T	G	9: 14,811,840 (GRCm39)	I183L	possibly damaging	Het
Kctd13	G	T	7: 126,544,180 (GRCm39)	G293C	probably damaging	Het
Kmt2d	CTGTTG	CTG	15: 98,743,057 (GRCm39)		probably benign	Het
Krt13	T	C	11: 100,012,318 (GRCm39)	S2G	probably benign	Het
Mark4	C	A	7: 19,167,338 (GRCm39)	R467L	possibly damaging	Het
Mrps33	T	A	6: 39,779,422 (GRCm39)	K91M	probably damaging	Het
Muc5ac	T	A	7: 141,350,078 (GRCm39)	V608D	possibly damaging	Het
Myb	G	A	10: 21,030,627 (GRCm39)	Q57*	probably null	Het
Peg10	GCAC	GCACCAC	6: 4,756,452 (GRCm39)		probably benign	Het
Phldb3	G	A	7: 24,328,372 (GRCm39)	V639M	probably damaging	Het
Pip4k2c	A	C	10: 127,036,069 (GRCm39)	L266R	probably damaging	Het
Plg	T	C	17: 12,609,213 (GRCm39)	Y173H	probably benign	Het
Pmp22	G	T	11: 63,024,065 (GRCm39)	V25F	probably benign	Het
Ppp1r16b	T	A	2: 158,537,998 (GRCm39)	Y40N	probably damaging	Het
Prl5a1	A	G	13: 28,329,492 (GRCm39)	E57G	possibly damaging	Het
Psmb10	A	G	8: 106,664,144 (GRCm39)	F75S	probably benign	Het
Ptprm	C	A	17: 67,000,483 (GRCm39)	R1167M	probably damaging	Het
Rbm46	T	C	3: 82,771,541 (GRCm39)	H358R	probably benign	Het
Rgl1	A	G	1: 152,397,115 (GRCm39)	S684P	probably benign	Het
Rmnd5b	T	C	11: 51,517,869 (GRCm39)	I162V	probably damaging	Het
Sh3d19	T	C	3: 86,014,529 (GRCm39)	V440A	possibly damaging	Het
Sik1	T	A	17: 32,073,246 (GRCm39)	K70M	probably damaging	Het
Slc44a4	C	T	17: 35,147,793 (GRCm39)	S611F	probably benign	Het
Stk32a	A	G	18: 43,430,620 (GRCm39)	I177V	probably benign	Het
Syt7	G	A	19: 10,421,459 (GRCm39)	D548N	probably benign	Het
Tcf7l2	A	G	19: 55,899,038 (GRCm39)	D215G	probably null	Het
Tex14	T	A	11: 87,377,084 (GRCm39)	F143I	probably damaging	Het
Tjp3	A	G	10: 81,119,411 (GRCm39)	V26A	possibly damaging	Het
Tpx2	T	A	2: 152,715,124 (GRCm39)	V115D	probably benign	Het
Tubb2b	C	A	13: 34,311,742 (GRCm39)	K350N	probably damaging	Het
Usf3	T	C	16: 44,036,936 (GRCm39)	V472A	probably benign	Het
Vps13b	G	T	15: 35,642,555 (GRCm39)	G1389V	possibly damaging	Het
Vps39	T	C	2: 120,172,485 (GRCm39)	R183G	probably damaging	Het
Wnk4	G	T	11: 101,159,250 (GRCm39)	E556*	probably null	Het
Xpo7	T	A	14: 70,925,617 (GRCm39)	E474V	probably benign	Het
Zbtb18	A	G	1: 177,275,341 (GRCm39)	R234G	probably null	Het
Zc3h14	T	A	12: 98,737,663 (GRCm39)	I50N	possibly damaging	Het
Zfat	A	G	15: 68,051,655 (GRCm39)	V713A	possibly damaging	Het
Zfp462	T	C	4: 55,009,545 (GRCm39)	S504P	possibly damaging	Het
Zmiz1	T	C	14: 25,651,022 (GRCm39)	V502A	probably benign	Het

Other mutations in Or51f1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02295:Or51f1	APN	7	102,506,031 (GRCm39)	missense	probably benign
IGL03336:Or51f1	APN	7	102,505,823 (GRCm39)	missense	probably benign	0.38
PIT4382001:Or51f1	UTSW	7	102,505,809 (GRCm39)	missense	probably damaging	1.00
R1337:Or51f1	UTSW	7	102,506,078 (GRCm39)	missense	probably benign	0.03
R1791:Or51f1	UTSW	7	102,505,569 (GRCm39)	nonsense	probably null
R3953:Or51f1	UTSW	7	102,505,824 (GRCm39)	missense	probably damaging	0.97
R3954:Or51f1	UTSW	7	102,505,824 (GRCm39)	missense	probably damaging	0.97
R3955:Or51f1	UTSW	7	102,505,824 (GRCm39)	missense	probably damaging	0.97
R3957:Or51f1	UTSW	7	102,505,824 (GRCm39)	missense	probably damaging	0.97
R4734:Or51f1	UTSW	7	102,506,186 (GRCm39)	missense	probably damaging	0.99
R5182:Or51f1	UTSW	7	102,506,176 (GRCm39)	missense	probably benign	0.07
R5394:Or51f1	UTSW	7	102,505,686 (GRCm39)	missense	probably damaging	1.00
R5559:Or51f1	UTSW	7	102,506,414 (GRCm39)	missense	possibly damaging	0.94
R6023:Or51f1	UTSW	7	102,506,169 (GRCm39)	missense	possibly damaging	0.95
R6310:Or51f1	UTSW	7	102,506,412 (GRCm39)	missense	probably benign	0.01
R7312:Or51f1	UTSW	7	102,505,706 (GRCm39)	missense	probably damaging	1.00
R7493:Or51f1	UTSW	7	102,506,278 (GRCm39)	nonsense	probably null
R8409:Or51f1	UTSW	7	102,506,477 (GRCm39)	missense	probably benign	0.01
R8476:Or51f1	UTSW	7	102,506,152 (GRCm39)	missense	probably benign	0.22
R8747:Or51f1	UTSW	7	102,506,139 (GRCm39)	missense	probably benign	0.05
R8946:Or51f1	UTSW	7	102,505,725 (GRCm39)	nonsense	probably null
R9382:Or51f1	UTSW	7	102,506,014 (GRCm39)	missense	probably benign	0.01
R9611:Or51f1	UTSW	7	102,506,147 (GRCm39)	missense	probably damaging	1.00
R9625:Or51f1	UTSW	7	102,505,636 (GRCm39)	missense	probably benign	0.01
R9800:Or51f1	UTSW	7	102,506,093 (GRCm39)	missense	probably benign	0.14
Z1177:Or51f1	UTSW	7	102,505,581 (GRCm39)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- GGCTCGAGTGTCTGAACATG -3'
(R):5'- TTGTGACCCAGCATAGTCTG -3'

Sequencing Primer
(F):5'- GCTCGAGTGTCTGAACATGCTAAC -3'
(R):5'- GTCTGCATGAACCTATGTACTATTTC -3'

Posted On

2022-09-12