Mutagenetix > Incidental Mutation

Incidental Mutation 'R9786:Or5p72'

734333

Institutional Source

Beutler Lab

Gene Symbol

Or5p72

Ensembl Gene

ENSMUSG00000095239

Gene Name

olfactory receptor family 5 subfamily P member 72

Synonyms

MOR204-9, GA_x6K02T2PBJ9-10752603-10753547, Olfr497

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R9786 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

108021780-108022724 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 108021924 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 49 (I49F)

Ref Sequence

ENSEMBL: ENSMUSP00000150439 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076406] [ENSMUST00000213521]

AlphaFold

Q8VG08

Predicted Effect

probably benign
Transcript: ENSMUST00000076406
AA Change: I49F

PolyPhen 2 Score 0.277 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000075741
Gene: ENSMUSG00000095239
AA Change: I49F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	311	5.5e-55	PFAM
Pfam:7tm_1	44	293	1.4e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213521
AA Change: I49F

PolyPhen 2 Score 0.277 (Sensitivity: 0.91; Specificity: 0.88)

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.2%
20x: 97.9%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4gnt	T	A	9: 99,502,536 (GRCm39)	M232K	possibly damaging	Het
Abcc1	T	C	16: 14,222,927 (GRCm39)	S243P	probably damaging	Het
Acsl1	T	C	8: 46,974,486 (GRCm39)	Y320H	probably damaging	Het
Adam11	A	G	11: 102,653,090 (GRCm39)	S61G	probably benign	Het
Adamts1	G	A	16: 85,592,302 (GRCm39)	T965I	probably benign	Het
Adcyap1r1	T	A	6: 55,456,182 (GRCm39)	M190K	probably damaging	Het
Ankrd2	T	A	19: 42,033,358 (GRCm39)	L300Q		Het
Ankrd27	A	T	7: 35,291,294 (GRCm39)	Q30L	possibly damaging	Het
Atp8b5	T	A	4: 43,305,798 (GRCm39)	I114K	probably damaging	Het
Atrn	A	T	2: 130,786,809 (GRCm39)	I205F	probably damaging	Het
BC035947	A	G	1: 78,488,561 (GRCm39)		probably benign	Het
Boc	C	T	16: 44,311,692 (GRCm39)	R677H		Het
Calhm6	A	G	10: 34,003,643 (GRCm39)	F88S	probably benign	Het
Ccdc121rt3	T	A	5: 112,502,939 (GRCm39)	E255V	probably benign	Het
Dpysl3	G	T	18: 43,462,922 (GRCm39)	T485K	probably damaging	Het
Esyt3	T	C	9: 99,194,038 (GRCm39)	D867G	possibly damaging	Het
Fam178b	G	A	1: 36,603,517 (GRCm39)	T478I	probably damaging	Het
Foxd2	G	T	4: 114,764,850 (GRCm39)	T390K	possibly damaging	Het
Furin	A	G	7: 80,040,645 (GRCm39)	V731A	probably benign	Het
Grin2a	T	A	16: 9,471,466 (GRCm39)	I601F	possibly damaging	Het
Hat1	G	A	2: 71,250,959 (GRCm39)	R169Q	possibly damaging	Het
Ighe	G	C	12: 113,236,851 (GRCm39)	Q6E		Het
Ighv8-2	T	C	12: 114,426,179 (GRCm39)	I31V	probably benign	Het
Klk1	A	G	7: 43,878,104 (GRCm39)	D120G	probably damaging	Het
Kmt2e	A	G	5: 23,702,982 (GRCm39)	D1054G	probably benign	Het
Lamp5	A	T	2: 135,910,998 (GRCm39)	I244F	probably damaging	Het
Maco1	A	T	4: 134,557,993 (GRCm39)	Y173*	probably null	Het
Mcm5	C	T	8: 75,844,168 (GRCm39)	S313F	probably benign	Het
Mfsd4b1	T	C	10: 39,878,865 (GRCm39)	E344G	probably damaging	Het
Mns1	A	G	9: 72,346,556 (GRCm39)	K13R	probably benign	Het
Mrpl43	C	T	19: 44,994,346 (GRCm39)	S91N	probably benign	Het
Mtbp	T	C	15: 55,481,032 (GRCm39)	S706P	probably benign	Het
Nelfb	A	T	2: 25,095,145 (GRCm39)	V348D	probably damaging	Het
Or1l8	T	A	2: 36,817,416 (GRCm39)	K237*	probably null	Het
Or7g20	C	T	9: 18,947,241 (GRCm39)	A274V	possibly damaging	Het
Or8k18	G	A	2: 86,085,428 (GRCm39)	S203L	probably benign	Het
Or8s8	T	C	15: 98,354,713 (GRCm39)	I174T	possibly damaging	Het
Pde6c	T	C	19: 38,140,009 (GRCm39)	I324T	possibly damaging	Het
Phlpp2	T	A	8: 110,660,655 (GRCm39)	L770*	probably null	Het
Pik3c2b	T	A	1: 133,019,338 (GRCm39)	F1029I	possibly damaging	Het
Rfx2	A	T	17: 57,087,890 (GRCm39)	S500R	probably benign	Het
Sarm1	T	C	11: 78,365,743 (GRCm39)	M761V	probably benign	Het
Serpina1a	A	G	12: 103,822,140 (GRCm39)	L264P	possibly damaging	Het
Slc37a1	G	T	17: 31,556,965 (GRCm39)	G377V	probably damaging	Het
Slc38a4	T	A	15: 96,906,378 (GRCm39)	M364L	probably damaging	Het
Slc7a15	A	G	12: 8,580,280 (GRCm39)	F384S	probably benign	Het
Smyd4	T	C	11: 75,281,625 (GRCm39)	V366A	probably benign	Het
Spata31d1b	T	A	13: 59,866,155 (GRCm39)	V1101D	possibly damaging	Het
Spata31d1e	C	T	13: 59,890,498 (GRCm39)	D441N	possibly damaging	Het
Stab2	C	A	10: 86,757,997 (GRCm39)	M1090I	probably benign	Het
Tex15	C	T	8: 34,062,457 (GRCm39)	T903I	probably damaging	Het
Tgds	A	T	14: 118,368,049 (GRCm39)	Y41*	probably null	Het
Tle4	G	T	19: 14,495,304 (GRCm39)	H142N	probably benign	Het
Tlx2	T	C	6: 83,046,274 (GRCm39)		probably null	Het
Tmem151a	C	G	19: 5,131,869 (GRCm39)	A446P	probably damaging	Het
Tmem205	A	T	9: 21,832,496 (GRCm39)	D138E	probably damaging	Het
Tmprss9	A	G	10: 80,734,042 (GRCm39)	K1009E	unknown	Het
Tnk2	T	A	16: 32,498,875 (GRCm39)	C729*	probably null	Het
Trim46	T	A	3: 89,142,399 (GRCm39)	D696V	probably damaging	Het
Tuba3b	G	A	6: 145,564,482 (GRCm39)	R84Q	probably benign	Het
Unc119b	C	T	5: 115,263,521 (GRCm39)	D228N	probably damaging	Het
Usp17la	A	G	7: 104,510,864 (GRCm39)	T490A	probably benign	Het
Zfp267	T	A	3: 36,219,853 (GRCm39)	C625*	probably null	Het
Zfp687	C	T	3: 94,919,768 (GRCm39)	M1I	probably null	Het
Zfp729a	T	C	13: 67,768,628 (GRCm39)	T534A	possibly damaging	Het
Zfp985	A	T	4: 147,668,047 (GRCm39)	H305L	probably benign	Het
Zscan10	C	T	17: 23,828,330 (GRCm39)	Q291*	probably null	Het

Other mutations in Or5p72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01448:Or5p72	APN	7	108,022,235 (GRCm39)	nonsense	probably null
IGL03145:Or5p72	APN	7	108,021,806 (GRCm39)	missense	probably benign	0.00
R0732:Or5p72	UTSW	7	108,021,784 (GRCm39)	missense	probably benign	0.00
R1892:Or5p72	UTSW	7	108,022,147 (GRCm39)	missense	possibly damaging	0.61
R2008:Or5p72	UTSW	7	108,022,389 (GRCm39)	missense	probably benign	0.01
R3721:Or5p72	UTSW	7	108,022,326 (GRCm39)	missense	probably damaging	1.00
R4497:Or5p72	UTSW	7	108,022,122 (GRCm39)	missense	probably benign	0.37
R4674:Or5p72	UTSW	7	108,022,309 (GRCm39)	missense	possibly damaging	0.65
R4675:Or5p72	UTSW	7	108,022,309 (GRCm39)	missense	possibly damaging	0.65
R4695:Or5p72	UTSW	7	108,022,196 (GRCm39)	missense	probably benign	0.18
R5265:Or5p72	UTSW	7	108,022,609 (GRCm39)	missense	possibly damaging	0.94
R5656:Or5p72	UTSW	7	108,021,825 (GRCm39)	missense	probably benign	0.03
R5758:Or5p72	UTSW	7	108,022,369 (GRCm39)	missense	probably benign	0.02
R6124:Or5p72	UTSW	7	108,022,725 (GRCm39)	splice site	probably null
R6787:Or5p72	UTSW	7	108,021,889 (GRCm39)	missense	possibly damaging	0.52
R7174:Or5p72	UTSW	7	108,022,367 (GRCm39)	missense	probably benign	0.01
R7222:Or5p72	UTSW	7	108,021,844 (GRCm39)	missense	probably benign	0.00
R7240:Or5p72	UTSW	7	108,022,140 (GRCm39)	missense	probably damaging	1.00
R8752:Or5p72	UTSW	7	108,022,480 (GRCm39)	missense	probably benign
R9548:Or5p72	UTSW	7	108,022,416 (GRCm39)	missense	possibly damaging	0.75

Predicted Primers

PCR Primer
(F):5'- ACAGCCTTAATCTAGTAGCAGCTAC -3'
(R):5'- TAAGCCATGGCAGCCAGAAG -3'

Sequencing Primer
(F):5'- AGCTACACTGTCCCATGGC -3'
(R):5'- AGAAATCAGCCAGGCTCTGCTG -3'

Posted On

2022-11-14