Incidental Mutation 'IGL01323:Or1o1'
ID 74110
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1o1
Ensembl Gene ENSMUSG00000063188
Gene Name olfactory receptor family 1 subfamily O member 1
Synonyms MOR156-3, GA_x6K02T2PSCP-1867165-1868094, Olfr107
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # IGL01323
Quality Score
Status
Chromosome 17
Chromosomal Location 37716368-37717400 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 37717031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 197 (M197I)
Ref Sequence ENSEMBL: ENSMUSP00000148879 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077008] [ENSMUST00000215894] [ENSMUST00000215947] [ENSMUST00000215974] [ENSMUST00000216844]
AlphaFold Q7TRK4
Predicted Effect probably benign
Transcript: ENSMUST00000077008
AA Change: M197I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000076267
Gene: ENSMUSG00000063188
AA Change: M197I

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.3e-54 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.3e-5 PFAM
Pfam:7tm_1 38 287 3.7e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174238
Predicted Effect probably benign
Transcript: ENSMUST00000215894
AA Change: M197I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215947
AA Change: M197I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215974
AA Change: M197I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216844
AA Change: M197I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef2 A G 2: 166,713,415 (GRCm39) D1272G probably damaging Het
Ascl2 A G 7: 142,522,125 (GRCm39) S108P probably benign Het
B3gat1 T C 9: 26,667,206 (GRCm39) V146A possibly damaging Het
Barhl1 C T 2: 28,805,558 (GRCm39) S45N probably benign Het
Birc6 C T 17: 74,929,920 (GRCm39) A2370V probably damaging Het
C1qtnf7 A G 5: 43,766,602 (GRCm39) D67G possibly damaging Het
Cand2 A G 6: 115,762,086 (GRCm39) T171A probably benign Het
Ccdc77 T C 6: 120,311,757 (GRCm39) Q247R probably benign Het
Cenpp A T 13: 49,801,118 (GRCm39) V100D probably damaging Het
Cep135 A G 5: 76,739,612 (GRCm39) T3A probably benign Het
Eef2k T C 7: 120,484,038 (GRCm39) probably benign Het
Fga T C 3: 82,937,518 (GRCm39) S132P probably damaging Het
Gpr6 T A 10: 40,947,555 (GRCm39) N9I possibly damaging Het
Gvin2 A G 7: 105,546,009 (GRCm39) S2348P possibly damaging Het
Hacd3 A G 9: 64,905,587 (GRCm39) F184L probably damaging Het
Heatr1 T C 13: 12,413,819 (GRCm39) I132T possibly damaging Het
Igfbp7 A G 5: 77,499,884 (GRCm39) probably benign Het
Ighv8-6 T C 12: 115,129,477 (GRCm39) D93G possibly damaging Het
Izumo3 A G 4: 92,034,627 (GRCm39) probably benign Het
Jade2 T C 11: 51,716,165 (GRCm39) T347A possibly damaging Het
Kif18a A G 2: 109,128,787 (GRCm39) T419A probably benign Het
Krt34 A G 11: 99,929,606 (GRCm39) S267P possibly damaging Het
Krt4 T G 15: 101,828,716 (GRCm39) K383Q probably damaging Het
Lgals7 G T 7: 28,564,989 (GRCm39) E42D probably benign Het
Morc2b A G 17: 33,356,293 (GRCm39) V493A possibly damaging Het
Mtif2 T A 11: 29,491,447 (GRCm39) S557R probably damaging Het
Nup43 T A 10: 7,545,320 (GRCm39) F83I probably benign Het
Oosp2 A G 19: 11,624,825 (GRCm39) L155S probably damaging Het
Plxnd1 T A 6: 115,943,760 (GRCm39) T1180S possibly damaging Het
Prpf39 T A 12: 65,089,498 (GRCm39) F79I possibly damaging Het
Prph G A 15: 98,956,517 (GRCm39) S465N possibly damaging Het
Purg A T 8: 33,876,631 (GRCm39) I90L probably damaging Het
Pxdn C A 12: 30,037,136 (GRCm39) Q305K probably benign Het
R3hdm1 G A 1: 128,144,280 (GRCm39) S816N probably benign Het
Src G A 2: 157,311,423 (GRCm39) G461R probably damaging Het
Tmem201 G A 4: 149,804,045 (GRCm39) probably benign Het
Tnfrsf22 G A 7: 143,197,111 (GRCm39) P76L probably damaging Het
Triml1 T C 8: 43,591,600 (GRCm39) probably null Het
Upp1 A G 11: 9,086,100 (GRCm39) *312W probably null Het
Wdfy3 G T 5: 102,042,930 (GRCm39) S1940R probably damaging Het
Xpc T C 6: 91,469,335 (GRCm39) Y804C probably damaging Het
Xrn2 C T 2: 146,876,767 (GRCm39) probably benign Het
Zfp106 A T 2: 120,354,945 (GRCm39) D1275E possibly damaging Het
Other mutations in Or1o1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01614:Or1o1 APN 17 37,716,529 (GRCm39) missense probably benign 0.00
IGL02390:Or1o1 APN 17 37,716,986 (GRCm39) missense probably benign 0.04
R1051:Or1o1 UTSW 17 37,717,341 (GRCm39) missense possibly damaging 0.74
R4767:Or1o1 UTSW 17 37,717,091 (GRCm39) nonsense probably null
R4849:Or1o1 UTSW 17 37,716,589 (GRCm39) missense probably benign 0.16
R6182:Or1o1 UTSW 17 37,716,883 (GRCm39) missense possibly damaging 0.65
R6550:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6551:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6552:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6555:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6584:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6586:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6588:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6688:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6758:Or1o1 UTSW 17 37,716,586 (GRCm39) missense probably damaging 0.97
R7024:Or1o1 UTSW 17 37,717,095 (GRCm39) missense probably benign 0.04
R7083:Or1o1 UTSW 17 37,717,063 (GRCm39) missense probably benign 0.00
R8350:Or1o1 UTSW 17 37,717,260 (GRCm39) missense probably benign 0.00
Posted On 2013-10-07