Incidental Mutation 'R0847:Olfm2'
ID 77019
Institutional Source Beutler Lab
Gene Symbol Olfm2
Ensembl Gene ENSMUSG00000032172
Gene Name olfactomedin 2
Synonyms A030009A06Rik
MMRRC Submission 039026-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.547) question?
Stock # R0847 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 20578986-20657645 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20579953 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 266 (V266A)
Ref Sequence ENSEMBL: ENSMUSP00000034692 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034689] [ENSMUST00000034692] [ENSMUST00000215999] [ENSMUST00000217198]
AlphaFold Q8BM13
Predicted Effect probably benign
Transcript: ENSMUST00000034689
SMART Domains Protein: ENSMUSP00000034689
Gene: ENSMUSG00000032171

DomainStartEndE-ValueType
WW 6 39 3.57e-14 SMART
Pfam:Rotamase_3 45 165 1.6e-23 PFAM
Pfam:Rotamase 61 165 1.4e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000034692
AA Change: V266A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000034692
Gene: ENSMUSG00000032172
AA Change: V266A

DomainStartEndE-ValueType
Pfam:Noelin-1 19 118 3.8e-44 PFAM
Blast:OLF 132 177 2e-18 BLAST
OLF 190 440 4.32e-123 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215039
Predicted Effect probably damaging
Transcript: ENSMUST00000215999
AA Change: V274A

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000217198
AA Change: V296A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit moderate locomotor and anxiety-related behavioral abnormalities, altered visual evoked potential, and reduced compactness of myelin sheaths in the optic nerve. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b T C 5: 8,895,764 (GRCm39) I899T probably damaging Het
Ahnak C T 19: 8,983,797 (GRCm39) Q1694* probably null Het
Cblc A T 7: 19,524,459 (GRCm39) Y260* probably null Het
Ccn4 T G 15: 66,791,124 (GRCm39) C309G probably damaging Het
Ceacam5 A G 7: 17,491,762 (GRCm39) T711A possibly damaging Het
Cep63 A G 9: 102,465,957 (GRCm39) S690P probably benign Het
Chia1 A T 3: 106,039,253 (GRCm39) I448F probably benign Het
Dmxl2 A T 9: 54,313,112 (GRCm39) F1712I probably damaging Het
Ecpas G A 4: 58,841,439 (GRCm39) T645I probably benign Het
Exosc3 A G 4: 45,319,695 (GRCm39) V109A probably damaging Het
Fxyd7 A G 7: 30,744,029 (GRCm39) C60R probably damaging Het
Gm17349 C A 15: 99,600,289 (GRCm39) probably benign Het
Gpn2 A G 4: 133,315,906 (GRCm39) N199D probably benign Het
Ints12 C T 3: 132,814,603 (GRCm39) T270M possibly damaging Het
Kdm4a C T 4: 118,021,695 (GRCm39) E266K probably damaging Het
Kremen2 G T 17: 23,963,634 (GRCm39) T50N probably damaging Het
Macf1 A T 4: 123,293,159 (GRCm39) D1249E probably benign Het
Mdga2 T A 12: 66,769,854 (GRCm39) K146N probably damaging Het
Med20 G A 17: 47,922,618 (GRCm39) probably null Het
Myo18b T C 5: 113,022,354 (GRCm39) probably benign Het
Nav3 T A 10: 109,739,718 (GRCm39) T84S possibly damaging Het
Or5b101 A T 19: 13,005,095 (GRCm39) Y199* probably null Het
Or5b123 C T 19: 13,596,915 (GRCm39) H87Y probably benign Het
Or6c69b T A 10: 129,627,327 (GRCm39) I44F probably damaging Het
Pthlh A T 6: 147,164,766 (GRCm39) probably null Het
Rpap3 C T 15: 97,601,082 (GRCm39) probably null Het
Rprd2 A G 3: 95,672,725 (GRCm39) S893P probably benign Het
Sacm1l G A 9: 123,377,927 (GRCm39) G69D probably damaging Het
Slc27a4 T C 2: 29,701,261 (GRCm39) S351P probably benign Het
Sobp C G 10: 42,898,415 (GRCm39) R390P probably damaging Het
Spata7 T A 12: 98,614,689 (GRCm39) M107K possibly damaging Het
Sri G A 5: 8,113,755 (GRCm39) probably null Het
Stab2 T C 10: 86,805,735 (GRCm39) I204V probably benign Het
Synm T C 7: 67,384,804 (GRCm39) I511V probably damaging Het
Tbr1 T C 2: 61,635,373 (GRCm39) S108P probably benign Het
Tln1 A G 4: 43,555,333 (GRCm39) F197S probably damaging Het
Tmem167b C T 3: 108,467,537 (GRCm39) G46R probably benign Het
Tmprss11g T C 5: 86,638,585 (GRCm39) K301R probably benign Het
Tnfrsf21 C T 17: 43,349,104 (GRCm39) H239Y probably benign Het
Trpm2 C T 10: 77,765,122 (GRCm39) V960M possibly damaging Het
Ube3a G A 7: 58,926,334 (GRCm39) D371N possibly damaging Het
Vmn2r57 A T 7: 41,078,225 (GRCm39) F78I probably benign Het
Other mutations in Olfm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02105:Olfm2 APN 9 20,583,476 (GRCm39) missense probably damaging 1.00
IGL03276:Olfm2 APN 9 20,580,083 (GRCm39) splice site probably benign
IGL03352:Olfm2 APN 9 20,580,019 (GRCm39) missense probably damaging 1.00
R0015:Olfm2 UTSW 9 20,580,037 (GRCm39) missense probably damaging 1.00
R1051:Olfm2 UTSW 9 20,579,759 (GRCm39) missense probably damaging 1.00
R3730:Olfm2 UTSW 9 20,584,063 (GRCm39) missense probably damaging 1.00
R5366:Olfm2 UTSW 9 20,579,708 (GRCm39) missense probably benign 0.04
R5665:Olfm2 UTSW 9 20,579,840 (GRCm39) splice site probably null
R5986:Olfm2 UTSW 9 20,586,946 (GRCm39) missense probably damaging 1.00
R6046:Olfm2 UTSW 9 20,579,824 (GRCm39) missense probably damaging 1.00
R6709:Olfm2 UTSW 9 20,584,009 (GRCm39) missense probably damaging 1.00
R7020:Olfm2 UTSW 9 20,579,864 (GRCm39) missense probably damaging 1.00
R7636:Olfm2 UTSW 9 20,579,593 (GRCm39) missense possibly damaging 0.72
R8341:Olfm2 UTSW 9 20,583,918 (GRCm39) splice site probably null
R8782:Olfm2 UTSW 9 20,579,501 (GRCm39) missense probably damaging 1.00
R9743:Olfm2 UTSW 9 20,579,785 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCCCACTCTCGTCTACCATGAAG -3'
(R):5'- GCGACATGCTGATAATGGCTGACC -3'

Sequencing Primer
(F):5'- TACCATGAAGTCCATGTCCGAG -3'
(R):5'- CTGATAATGGCTGACCATGATTG -3'
Posted On 2013-10-16