Incidental Mutation 'R0845:Ctsw'
ID 77350
Institutional Source Beutler Lab
Gene Symbol Ctsw
Ensembl Gene ENSMUSG00000024910
Gene Name cathepsin W
Synonyms lymphopain
MMRRC Submission 039024-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0845 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 5515071-5518535 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 5515489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153409 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025844] [ENSMUST00000025847] [ENSMUST00000225141]
AlphaFold P56203
Predicted Effect probably benign
Transcript: ENSMUST00000025844
SMART Domains Protein: ENSMUSP00000025844
Gene: ENSMUSG00000024910

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Inhibitor_I29 40 97 2.21e-12 SMART
Pept_C1 126 357 1.58e-79 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000025847
SMART Domains Protein: ENSMUSP00000025847
Gene: ENSMUSG00000024911

DomainStartEndE-ValueType
Pfam:FIBP 3 363 7.6e-171 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224005
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224422
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224944
Predicted Effect probably benign
Transcript: ENSMUST00000225141
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225222
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225796
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225917
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226017
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 93.2%
Validation Efficiency 96% (45/47)
MGI Phenotype FUNCTION: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. Expression of the encoded protein is upregulated following lymphocyte activation. Data from a human cell line suggests that the encoded enzyme may be important for viral entry into host cells. [provided by RefSeq, Aug 2015]
PHENOTYPE: Homozygous null mutants are fertile and healthy with normal cytotoxic lymphocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn4 G T 7: 28,612,855 (GRCm39) A116E probably damaging Het
Adamtsl3 A G 7: 82,225,204 (GRCm39) I338V probably damaging Het
Akap13 T G 7: 75,375,128 (GRCm39) V1920G probably damaging Het
Atp6v0d2 C T 4: 19,880,055 (GRCm39) V281I probably benign Het
AW209491 T G 13: 14,811,607 (GRCm39) S153R probably damaging Het
Brd7 A T 8: 89,069,395 (GRCm39) Y433* probably null Het
Bub1b A G 2: 118,440,457 (GRCm39) H187R probably damaging Het
Clstn2 T A 9: 97,452,681 (GRCm39) Q242L probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Comt T C 16: 18,226,711 (GRCm39) Y225C probably damaging Het
Ctbs T A 3: 146,160,862 (GRCm39) L143Q probably damaging Het
Dhx16 T C 17: 36,194,194 (GRCm39) I435T probably damaging Het
Dmxl1 T C 18: 50,026,469 (GRCm39) F1859S probably damaging Het
Glud1 A G 14: 34,051,351 (GRCm39) probably benign Het
Gm8220 A G 14: 44,524,248 (GRCm39) H71R probably damaging Het
Gnb1l A G 16: 18,371,223 (GRCm39) E238G probably benign Het
H2-T23 T C 17: 36,341,475 (GRCm39) H332R probably benign Het
Itga5 T A 15: 103,259,196 (GRCm39) T744S probably benign Het
Larp1 A G 11: 57,938,576 (GRCm39) E453G probably benign Het
Lrrk2 C A 15: 91,640,165 (GRCm39) P1570Q probably benign Het
Lrsam1 C T 2: 32,843,455 (GRCm39) R150Q possibly damaging Het
Mroh2a A G 1: 88,186,386 (GRCm39) S64G probably benign Het
Msln T C 17: 25,969,770 (GRCm39) Y320C probably damaging Het
Mtbp T C 15: 55,426,486 (GRCm39) probably null Het
Muc5b A G 7: 141,404,183 (GRCm39) probably null Het
Mup21 A G 4: 62,068,547 (GRCm39) S40P probably damaging Het
Myh8 T C 11: 67,177,090 (GRCm39) V414A probably damaging Het
P2rx5 T C 11: 73,056,400 (GRCm39) I108T probably damaging Het
Paqr9 T C 9: 95,442,793 (GRCm39) L261P probably damaging Het
Pde5a A G 3: 122,522,980 (GRCm39) D29G probably benign Het
Phf11d A T 14: 59,590,793 (GRCm39) M188K possibly damaging Het
Pih1d1 A G 7: 44,809,106 (GRCm39) D230G probably benign Het
Pik3r1 G T 13: 101,822,772 (GRCm39) D643E probably benign Het
Rnf207 A G 4: 152,396,521 (GRCm39) probably benign Het
Septin9 T C 11: 117,247,151 (GRCm39) probably benign Het
Serinc1 A T 10: 57,401,479 (GRCm39) S105T probably benign Het
Slc8a1 A G 17: 81,745,177 (GRCm39) S676P probably benign Het
Srrm4 C T 5: 116,582,944 (GRCm39) probably null Het
Tcn2 T A 11: 3,869,349 (GRCm39) D391V probably benign Het
Tmem131 T C 1: 36,855,303 (GRCm39) T808A probably damaging Het
Ubqln3 G T 7: 103,791,275 (GRCm39) Q272K probably damaging Het
Unc79 T C 12: 103,139,703 (GRCm39) probably benign Het
Xpo6 G A 7: 125,728,715 (GRCm39) probably benign Het
Zfp667 A T 7: 6,309,091 (GRCm39) K586N possibly damaging Het
Other mutations in Ctsw
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1566:Ctsw UTSW 19 5,515,445 (GRCm39) missense probably damaging 1.00
R2306:Ctsw UTSW 19 5,517,010 (GRCm39) splice site probably null
R5023:Ctsw UTSW 19 5,516,077 (GRCm39) missense probably damaging 1.00
R5076:Ctsw UTSW 19 5,518,486 (GRCm39) missense probably benign
R5101:Ctsw UTSW 19 5,515,703 (GRCm39) missense probably benign 0.20
R5112:Ctsw UTSW 19 5,516,285 (GRCm39) missense probably damaging 0.98
R5188:Ctsw UTSW 19 5,517,120 (GRCm39) missense probably damaging 1.00
R6109:Ctsw UTSW 19 5,517,147 (GRCm39) missense probably benign
R6436:Ctsw UTSW 19 5,516,322 (GRCm39) missense possibly damaging 0.91
R6984:Ctsw UTSW 19 5,516,646 (GRCm39) missense probably damaging 1.00
R6993:Ctsw UTSW 19 5,515,865 (GRCm39) missense probably damaging 1.00
R7720:Ctsw UTSW 19 5,517,072 (GRCm39) missense probably damaging 0.99
R9077:Ctsw UTSW 19 5,516,431 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGTGCTCAAGTGCTGTGCCATC -3'
(R):5'- TCCCATTCTCGAAAACGTCGCC -3'

Sequencing Primer
(F):5'- ACCATGACACATTCGGGGTC -3'
(R):5'- GAAAACGTCGCCACTCCTC -3'
Posted On 2013-10-16