Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00698:Mettl25'

9240

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mettl25

Ensembl Gene

ENSMUSG00000036009

Gene Name

methyltransferase like 25

Synonyms

BC067068

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.114) question?

Stock #

IGL00698

Quality Score

Status

Chromosome

Chromosomal Location

105599050-105677241 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 105629201 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 487 (C487F)

Ref Sequence

ENSEMBL: ENSMUSP00000038665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046638] [ENSMUST00000176924]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000046638
AA Change: C487F

PolyPhen 2 Score 0.312 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000038665
Gene: ENSMUSG00000036009
AA Change: C487F

Domain	Start	End	E-Value	Type
Pfam:Methyltransf_32	149	413	1.9e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176924

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 10 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930544G11Rik	T	A	6: 65,929,879 (GRCm39)	V38E	probably damaging	Het
Bbs12	T	C	3: 37,374,943 (GRCm39)	S579P	probably benign	Het
Chd3	A	G	11: 69,240,697 (GRCm39)	S1487P	probably damaging	Het
Cobl	G	T	11: 12,203,722 (GRCm39)	N986K	probably benign	Het
Cpd	T	C	11: 76,731,270 (GRCm39)	E312G	possibly damaging	Het
Fat4	C	A	3: 39,035,294 (GRCm39)	P2982Q	probably benign	Het
Hsf3	A	G	X: 95,382,087 (GRCm39)	I23T	possibly damaging	Het
Ranbp17	T	C	11: 33,391,910 (GRCm39)	T34A	probably benign	Het
Zfc3h1	T	C	10: 115,255,737 (GRCm39)	F1463L	possibly damaging	Het
Zfp959	A	G	17: 56,204,565 (GRCm39)	T201A	possibly damaging	Het

Other mutations in Mettl25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00310:Mettl25	APN	10	105,662,295 (GRCm39)	missense	probably benign
IGL00766:Mettl25	APN	10	105,615,443 (GRCm39)	splice site	probably benign
IGL01360:Mettl25	APN	10	105,659,058 (GRCm39)	missense	probably damaging	1.00
IGL01954:Mettl25	APN	10	105,659,068 (GRCm39)	missense	probably damaging	1.00
IGL02088:Mettl25	APN	10	105,659,111 (GRCm39)	missense	probably damaging	1.00
IGL02623:Mettl25	APN	10	105,662,185 (GRCm39)	missense	probably damaging	0.96
IGL03245:Mettl25	APN	10	105,662,358 (GRCm39)	missense	possibly damaging	0.86
IGL03134:Mettl25	UTSW	10	105,661,888 (GRCm39)	nonsense	probably null
R0238:Mettl25	UTSW	10	105,662,386 (GRCm39)	missense	probably damaging	1.00
R0238:Mettl25	UTSW	10	105,662,386 (GRCm39)	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105,662,386 (GRCm39)	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105,662,386 (GRCm39)	missense	probably damaging	1.00
R1297:Mettl25	UTSW	10	105,659,126 (GRCm39)	missense	probably benign	0.11
R1482:Mettl25	UTSW	10	105,662,451 (GRCm39)	missense	possibly damaging	0.61
R1526:Mettl25	UTSW	10	105,668,844 (GRCm39)	missense	possibly damaging	0.56
R1542:Mettl25	UTSW	10	105,661,981 (GRCm39)	missense	probably benign	0.04
R1589:Mettl25	UTSW	10	105,615,493 (GRCm39)	missense	probably damaging	1.00
R1901:Mettl25	UTSW	10	105,661,948 (GRCm39)	missense	probably damaging	0.96
R1902:Mettl25	UTSW	10	105,661,948 (GRCm39)	missense	probably damaging	0.96
R2016:Mettl25	UTSW	10	105,633,167 (GRCm39)	missense	probably benign	0.00
R2355:Mettl25	UTSW	10	105,599,316 (GRCm39)	missense	probably benign	0.00
R2920:Mettl25	UTSW	10	105,601,038 (GRCm39)	splice site	probably null
R3149:Mettl25	UTSW	10	105,662,214 (GRCm39)	missense	probably benign	0.00
R4547:Mettl25	UTSW	10	105,661,878 (GRCm39)	missense	probably damaging	1.00
R4646:Mettl25	UTSW	10	105,662,416 (GRCm39)	missense	probably damaging	1.00
R4652:Mettl25	UTSW	10	105,615,509 (GRCm39)	nonsense	probably null
R5020:Mettl25	UTSW	10	105,662,068 (GRCm39)	missense	possibly damaging	0.87
R5435:Mettl25	UTSW	10	105,615,447 (GRCm39)	critical splice donor site	probably null
R6947:Mettl25	UTSW	10	105,662,053 (GRCm39)	missense	probably benign	0.00
R7075:Mettl25	UTSW	10	105,665,785 (GRCm39)	missense	possibly damaging	0.68
R7729:Mettl25	UTSW	10	105,601,871 (GRCm39)	missense	probably benign	0.03
R8074:Mettl25	UTSW	10	105,661,941 (GRCm39)	missense	probably benign	0.02
R8108:Mettl25	UTSW	10	105,659,040 (GRCm39)	missense	possibly damaging	0.53
R8415:Mettl25	UTSW	10	105,662,002 (GRCm39)	missense	probably benign	0.05
R8937:Mettl25	UTSW	10	105,601,122 (GRCm39)	missense	probably benign	0.17
R8949:Mettl25	UTSW	10	105,668,714 (GRCm39)	missense	probably benign	0.00
R9497:Mettl25	UTSW	10	105,677,090 (GRCm39)	missense	probably damaging	0.98
R9772:Mettl25	UTSW	10	105,633,127 (GRCm39)	missense	probably benign
RF009:Mettl25	UTSW	10	105,669,100 (GRCm39)	intron	probably benign
Z1176:Mettl25	UTSW	10	105,661,959 (GRCm39)	missense	possibly damaging	0.95

Posted On

2012-12-06