Incidental Mutation 'IGL01618:Olfr395'
ID 92449
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr395
Ensembl Gene ENSMUSG00000062186
Gene Name olfactory receptor 395
Synonyms GA_x6K02T2P1NL-4062605-4061667, MOR135-10
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # IGL01618
Quality Score
Status
Chromosome 11
Chromosomal Location 73903318-73909299 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73907477 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 5 (N5S)
Ref Sequence ENSEMBL: ENSMUSP00000149064 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072991] [ENSMUST00000215690]
AlphaFold Q8VGR3
Predicted Effect probably damaging
Transcript: ENSMUST00000072991
AA Change: N5S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072756
Gene: ENSMUSG00000062186
AA Change: N5S

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
Pfam:7tm_4 31 309 6.2e-56 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.8e-8 PFAM
Pfam:7tm_1 41 290 3.7e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215690
AA Change: N5S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 C T 19: 55,272,833 A74V probably benign Het
Adh4 C T 3: 138,429,027 probably benign Het
Aldh1a3 G A 7: 66,409,230 T239I probably damaging Het
Anxa9 A G 3: 95,300,536 probably null Het
Atp5k C A 5: 108,434,033 K28N probably damaging Het
C9 T G 15: 6,459,668 Y169D probably benign Het
Cbwd1 T C 19: 24,940,776 E210G possibly damaging Het
Chat T A 14: 32,446,892 probably null Het
Csmd3 C T 15: 48,011,083 E706K probably benign Het
Ctbs A G 3: 146,455,112 K145E probably benign Het
Dennd5a A G 7: 109,934,095 M156T probably damaging Het
Dhx29 A G 13: 112,965,222 Y1275C probably damaging Het
Dpp10 A T 1: 123,367,867 F517Y probably benign Het
Dst G A 1: 34,188,909 W1536* probably null Het
Galc T C 12: 98,252,081 T171A possibly damaging Het
Gsap T C 5: 21,226,248 I190T probably damaging Het
Hars2 A T 18: 36,789,577 R388* probably null Het
Igsf21 C T 4: 140,107,364 G66S possibly damaging Het
Itgbl1 T A 14: 123,827,799 S122T possibly damaging Het
Jhy G T 9: 40,960,964 T83K possibly damaging Het
Kcne4 A T 1: 78,817,808 M58L possibly damaging Het
Lamc3 T A 2: 31,912,107 I509N probably damaging Het
Lpar6 T C 14: 73,239,066 S156P probably damaging Het
Man2c1 T C 9: 57,141,556 probably benign Het
March11 T C 15: 26,409,199 I328T possibly damaging Het
Mc3r T A 2: 172,249,370 C171S probably benign Het
Muc4 A T 16: 32,756,627 Q2167L unknown Het
Myom1 T C 17: 71,099,993 V1135A possibly damaging Het
Nectin1 C T 9: 43,791,258 R101* probably null Het
Nxpe4 T C 9: 48,394,140 S277P possibly damaging Het
Olfr1152 A C 2: 87,868,144 D51A probably damaging Het
Olfr1459 T A 19: 13,146,250 K136N probably benign Het
Olfr437 T A 6: 43,167,703 V215E probably damaging Het
Olfr584 G A 7: 103,086,375 V281I probably benign Het
Pappa2 G T 1: 158,857,378 N730K probably damaging Het
Prepl A G 17: 85,066,281 V586A probably damaging Het
Prrc2a T C 17: 35,149,553 Y2098C probably damaging Het
Rdh16 G A 10: 127,801,307 C37Y probably damaging Het
Rnd1 A T 15: 98,673,865 M100K probably benign Het
Sema3c A G 5: 17,672,506 N204D probably damaging Het
Susd4 A G 1: 182,858,461 probably null Het
Taar7f G T 10: 24,050,341 A278S possibly damaging Het
Tle4 T A 19: 14,544,814 M122L probably benign Het
Trim9 C T 12: 70,248,351 V662I probably benign Het
Vmn2r10 C A 5: 109,002,479 C233F probably damaging Het
Vmn2r98 A C 17: 19,065,259 T114P possibly damaging Het
Zfyve21 C T 12: 111,827,813 probably benign Het
Other mutations in Olfr395
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Olfr395 APN 11 73907313 missense probably damaging 1.00
IGL01995:Olfr395 APN 11 73907435 missense possibly damaging 0.52
IGL02494:Olfr395 APN 11 73906724 missense possibly damaging 0.55
IGL02995:Olfr395 APN 11 73907219 missense possibly damaging 0.90
IGL03256:Olfr395 APN 11 73906696 missense probably benign 0.07
R0018:Olfr395 UTSW 11 73906626 missense probably damaging 1.00
R0701:Olfr395 UTSW 11 73906829 missense probably damaging 1.00
R0839:Olfr395 UTSW 11 73907312 missense probably damaging 0.99
R1222:Olfr395 UTSW 11 73907414 missense probably damaging 1.00
R1737:Olfr395 UTSW 11 73907085 missense possibly damaging 0.69
R1819:Olfr395 UTSW 11 73906679 missense probably benign 0.02
R2994:Olfr395 UTSW 11 73906715 missense probably damaging 1.00
R3195:Olfr395 UTSW 11 73906658 missense possibly damaging 0.91
R4622:Olfr395 UTSW 11 73906911 missense possibly damaging 0.55
R4753:Olfr395 UTSW 11 73906851 missense probably damaging 1.00
R5137:Olfr395 UTSW 11 73906626 missense probably damaging 1.00
R5448:Olfr395 UTSW 11 73906611 missense probably damaging 1.00
R5604:Olfr395 UTSW 11 73907027 missense probably benign 0.02
R5748:Olfr395 UTSW 11 73906895 missense probably damaging 0.98
R5899:Olfr395 UTSW 11 73906929 missense probably damaging 1.00
R6156:Olfr395 UTSW 11 73906621 nonsense probably null
R6388:Olfr395 UTSW 11 73907292 missense probably damaging 1.00
R6572:Olfr395 UTSW 11 73906803 missense possibly damaging 0.91
R7241:Olfr395 UTSW 11 73907232 missense probably benign 0.05
R8870:Olfr395 UTSW 11 73906899 missense probably benign 0.03
R9358:Olfr395 UTSW 11 73906625 missense probably damaging 1.00
R9544:Olfr395 UTSW 11 73906811 missense probably benign 0.14
R9645:Olfr395 UTSW 11 73906887 missense probably benign
R9667:Olfr395 UTSW 11 73907271 missense possibly damaging 0.83
R9707:Olfr395 UTSW 11 73907264 missense possibly damaging 0.79
Z1177:Olfr395 UTSW 11 73906613 missense probably damaging 1.00
Posted On 2013-12-09