Incidental Mutation 'R0991:Vmn1r65'
ID |
97702 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r65
|
Ensembl Gene |
ENSMUSG00000066850 |
Gene Name |
vomeronasal 1 receptor 65 |
Synonyms |
V1rd6, V3R6 |
MMRRC Submission |
039111-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.056)
|
Stock # |
R0991 (G1)
|
Quality Score |
107 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
6010749-6014009 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 6012076 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Proline to Serine
at position 53
(P53S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000083520
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086338]
|
AlphaFold |
Q9EPS7 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000086338
AA Change: P53S
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000083520 Gene: ENSMUSG00000066850 AA Change: P53S
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
20 |
308 |
7.3e-14 |
PFAM |
Pfam:7tm_1
|
42 |
301 |
1.6e-6 |
PFAM |
Pfam:V1R
|
53 |
308 |
5.6e-15 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227656
|
Coding Region Coverage |
- 1x: 99.0%
- 3x: 97.4%
- 10x: 91.6%
- 20x: 77.4%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 13 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Apc |
T |
A |
18: 34,449,160 (GRCm39) |
C1985S |
probably damaging |
Het |
Atp8a2 |
T |
C |
14: 60,031,378 (GRCm39) |
S899G |
probably benign |
Het |
Dna2 |
C |
T |
10: 62,784,966 (GRCm39) |
R28W |
probably benign |
Het |
Dtwd1 |
G |
A |
2: 126,001,940 (GRCm39) |
R220Q |
probably damaging |
Het |
Edil3 |
A |
T |
13: 89,437,625 (GRCm39) |
K409* |
probably null |
Het |
Ltbp1 |
A |
G |
17: 75,532,280 (GRCm39) |
Q118R |
possibly damaging |
Het |
Mia |
G |
A |
7: 26,880,145 (GRCm39) |
R81C |
probably damaging |
Het |
Pik3c2a |
A |
G |
7: 115,961,280 (GRCm39) |
|
probably null |
Het |
Prl2c2 |
G |
C |
13: 13,176,786 (GRCm39) |
T47R |
probably damaging |
Het |
Rd3 |
A |
G |
1: 191,717,199 (GRCm39) |
E223G |
probably damaging |
Het |
Sf3b1 |
C |
G |
1: 55,058,554 (GRCm39) |
E12Q |
possibly damaging |
Het |
Tenm2 |
C |
T |
11: 35,954,004 (GRCm39) |
G1236R |
possibly damaging |
Het |
Xrn2 |
A |
G |
2: 146,884,002 (GRCm39) |
K587R |
probably benign |
Het |
|
Other mutations in Vmn1r65 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01636:Vmn1r65
|
APN |
7 |
6,011,720 (GRCm39) |
missense |
probably benign |
0.12 |
IGL02821:Vmn1r65
|
APN |
7 |
6,011,893 (GRCm39) |
missense |
possibly damaging |
0.62 |
R1457:Vmn1r65
|
UTSW |
7 |
6,012,156 (GRCm39) |
missense |
probably benign |
0.10 |
R1507:Vmn1r65
|
UTSW |
7 |
6,012,108 (GRCm39) |
missense |
probably benign |
0.13 |
R1856:Vmn1r65
|
UTSW |
7 |
6,011,265 (GRCm39) |
missense |
possibly damaging |
0.93 |
R2914:Vmn1r65
|
UTSW |
7 |
6,012,040 (GRCm39) |
missense |
possibly damaging |
0.69 |
R5147:Vmn1r65
|
UTSW |
7 |
6,011,818 (GRCm39) |
missense |
probably benign |
0.01 |
R5279:Vmn1r65
|
UTSW |
7 |
6,011,754 (GRCm39) |
missense |
probably damaging |
1.00 |
R5399:Vmn1r65
|
UTSW |
7 |
6,011,809 (GRCm39) |
nonsense |
probably null |
|
R5409:Vmn1r65
|
UTSW |
7 |
6,012,012 (GRCm39) |
missense |
possibly damaging |
0.77 |
R5646:Vmn1r65
|
UTSW |
7 |
6,012,223 (GRCm39) |
missense |
probably benign |
0.01 |
R5963:Vmn1r65
|
UTSW |
7 |
6,011,608 (GRCm39) |
missense |
probably damaging |
1.00 |
R6034:Vmn1r65
|
UTSW |
7 |
6,011,868 (GRCm39) |
missense |
probably damaging |
1.00 |
R6034:Vmn1r65
|
UTSW |
7 |
6,011,868 (GRCm39) |
missense |
probably damaging |
1.00 |
R6327:Vmn1r65
|
UTSW |
7 |
6,011,651 (GRCm39) |
missense |
possibly damaging |
0.48 |
R7958:Vmn1r65
|
UTSW |
7 |
6,011,254 (GRCm39) |
missense |
probably benign |
0.01 |
R8121:Vmn1r65
|
UTSW |
7 |
6,011,464 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8345:Vmn1r65
|
UTSW |
7 |
6,011,256 (GRCm39) |
missense |
probably benign |
|
R8725:Vmn1r65
|
UTSW |
7 |
6,011,503 (GRCm39) |
missense |
probably damaging |
1.00 |
R8727:Vmn1r65
|
UTSW |
7 |
6,011,503 (GRCm39) |
missense |
probably damaging |
1.00 |
R9246:Vmn1r65
|
UTSW |
7 |
6,011,769 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9279:Vmn1r65
|
UTSW |
7 |
6,011,988 (GRCm39) |
missense |
probably benign |
0.06 |
R9778:Vmn1r65
|
UTSW |
7 |
6,011,387 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- CAGAAGTTGAGCAGACCCACTTACC -3'
(R):5'- AGACTCTGCAAGACAGCAGTGTCC -3'
Sequencing Primer
(F):5'- TGAGGACCACTAACATTCATTGGG -3'
(R):5'- ACAGCAGTGTCCTACATGGTC -3'
|
Posted On |
2014-01-05 |