|Institutional Source||Beutler Lab|
|Gene Name||a disintegrin and metallopeptidase domain 18|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1568 (G1)|
|Chromosomal Location||24602246-24674755 bp(-) (GRCm38)|
|Type of Mutation||splice site (3 bp from exon)|
|DNA Base Change (assembly)||T to G at 24647783 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000033957 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000033957] [ENSMUST00000173833]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during early stages of spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
PHENOTYPE: Homozygous mutant mice exhibit enhanced motor coordination during inverted screen testing when compared with that of controls. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Adam18||
(F):5'- AGGCAACAAAGTAGCAACAGTATCATGT -3'
(R):5'- CCTACCTGTTCTGGCTTTAACCTTCAAA -3'
(F):5'- ctgagttttatacccagcattcc -3'
(R):5'- GCAAAGATGTTCATCATTTGCC -3'