Incidental Mutation 'R1899:Tacc2'
| ID |
214092 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tacc2
|
| Ensembl Gene |
ENSMUSG00000030852 |
| Gene Name |
transforming, acidic coiled-coil containing protein 2 |
| Synonyms |
|
| MMRRC Submission |
039919-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1899 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
130179168-130366515 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 130225932 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 891
(S891R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000149733
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059145]
[ENSMUST00000084513]
[ENSMUST00000124096]
[ENSMUST00000207789]
[ENSMUST00000207918]
[ENSMUST00000208722]
[ENSMUST00000215492]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059145
|
| SMART Domains |
Protein: ENSMUSP00000061242
Gene: ENSMUSG00000030852
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
87 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
173 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
291 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
345 |
356 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
483 |
566 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
571 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
603 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
648 |
662 |
N/A |
INTRINSIC |
|
coiled coil region
|
873 |
900 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
939 |
1145 |
4e-85 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084513
AA Change: S872R
PolyPhen 2
Score 0.180 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000081561
Gene: ENSMUSG00000030852
AA Change: S872R
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
19 |
346 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
398 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
413 |
431 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
778 |
1068 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
1397 |
1415 |
N/A |
INTRINSIC |
|
low complexity region
|
1723 |
1739 |
N/A |
INTRINSIC |
|
low complexity region
|
1794 |
1809 |
N/A |
INTRINSIC |
|
low complexity region
|
1854 |
1880 |
N/A |
INTRINSIC |
|
low complexity region
|
2052 |
2063 |
N/A |
INTRINSIC |
|
low complexity region
|
2278 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2310 |
2321 |
N/A |
INTRINSIC |
|
low complexity region
|
2355 |
2369 |
N/A |
INTRINSIC |
|
coiled coil region
|
2606 |
2633 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
2673 |
2873 |
6.1e-87 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
| SMART Domains |
Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
|
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207789
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000207918
AA Change: S872R
PolyPhen 2
Score 0.617 (Sensitivity: 0.87; Specificity: 0.91)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207999
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000208722
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000215492
AA Change: S891R
PolyPhen 2
Score 0.808 (Sensitivity: 0.84; Specificity: 0.93)
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.4%
|
| Validation Efficiency |
94% (94/100) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any increase in tumorigenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
T |
A |
5: 109,884,664 (GRCm39) |
Q398L |
probably benign |
Het |
| 4930596D02Rik |
T |
G |
14: 35,532,089 (GRCm39) |
K162T |
probably damaging |
Het |
| Abca8b |
G |
T |
11: 109,828,744 (GRCm39) |
T1353K |
possibly damaging |
Het |
| Abcg3 |
A |
C |
5: 105,086,065 (GRCm39) |
C565G |
probably damaging |
Het |
| Actr3b |
G |
A |
5: 26,034,536 (GRCm39) |
V185I |
possibly damaging |
Het |
| Akap6 |
A |
T |
12: 53,188,635 (GRCm39) |
E2016D |
possibly damaging |
Het |
| Aldh3b2 |
T |
C |
19: 4,028,662 (GRCm39) |
V148A |
possibly damaging |
Het |
| Ankfy1 |
C |
T |
11: 72,645,233 (GRCm39) |
Q771* |
probably null |
Het |
| Anks1b |
A |
G |
10: 90,096,618 (GRCm39) |
D425G |
probably damaging |
Het |
| Arrb1 |
T |
C |
7: 99,231,504 (GRCm39) |
|
probably benign |
Het |
| Atg2a |
C |
A |
19: 6,295,097 (GRCm39) |
T170N |
probably damaging |
Het |
| Atp8b5 |
C |
T |
4: 43,361,804 (GRCm39) |
R617C |
possibly damaging |
Het |
| Bicra |
T |
C |
7: 15,721,676 (GRCm39) |
T614A |
possibly damaging |
Het |
| Cacna1i |
A |
G |
15: 80,275,843 (GRCm39) |
D167G |
possibly damaging |
Het |
| Calr4 |
T |
G |
4: 109,103,490 (GRCm39) |
|
probably null |
Het |
| Camsap3 |
G |
T |
8: 3,653,922 (GRCm39) |
E515* |
probably null |
Het |
| Casp8ap2 |
T |
C |
4: 32,643,647 (GRCm39) |
S907P |
probably damaging |
Het |
| Cdk19 |
T |
A |
10: 40,355,776 (GRCm39) |
|
probably benign |
Het |
| Chst14 |
A |
G |
2: 118,757,496 (GRCm39) |
M122V |
possibly damaging |
Het |
| Cntn4 |
A |
G |
6: 106,652,774 (GRCm39) |
M748V |
probably benign |
Het |
| Col7a1 |
A |
G |
9: 108,807,956 (GRCm39) |
D2552G |
unknown |
Het |
| Cpeb2 |
C |
A |
5: 43,434,930 (GRCm39) |
P600Q |
probably damaging |
Het |
| Cyp2a5 |
C |
T |
7: 26,538,458 (GRCm39) |
R274* |
probably null |
Het |
| Dele1 |
T |
C |
18: 38,391,395 (GRCm39) |
W378R |
probably benign |
Het |
| Dexi |
A |
G |
16: 10,360,382 (GRCm39) |
F58S |
probably damaging |
Het |
| Dlg5 |
C |
A |
14: 24,198,368 (GRCm39) |
G1522W |
probably damaging |
Het |
| Dock2 |
T |
C |
11: 34,244,286 (GRCm39) |
H1048R |
probably benign |
Het |
| Dpp4 |
T |
C |
2: 62,175,394 (GRCm39) |
|
probably benign |
Het |
| Dusp10 |
A |
T |
1: 183,801,377 (GRCm39) |
K381N |
possibly damaging |
Het |
| Ercc4 |
A |
G |
16: 12,965,651 (GRCm39) |
E761G |
probably damaging |
Het |
| Ern2 |
T |
C |
7: 121,783,065 (GRCm39) |
|
probably benign |
Het |
| Fam83f |
A |
T |
15: 80,576,281 (GRCm39) |
T311S |
probably damaging |
Het |
| Fat2 |
T |
C |
11: 55,153,004 (GRCm39) |
D3736G |
probably benign |
Het |
| Fgf11 |
G |
T |
11: 69,692,279 (GRCm39) |
T58K |
probably benign |
Het |
| Galntl5 |
C |
G |
5: 25,403,530 (GRCm39) |
S167* |
probably null |
Het |
| Glg1 |
T |
G |
8: 111,892,306 (GRCm39) |
E846D |
probably benign |
Het |
| Grm8 |
C |
A |
6: 28,125,894 (GRCm39) |
E77D |
probably damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,533,202 (GRCm39) |
D3028E |
probably damaging |
Het |
| Htt |
A |
G |
5: 35,064,429 (GRCm39) |
I2943V |
probably benign |
Het |
| Ift80 |
T |
C |
3: 68,825,846 (GRCm39) |
K498R |
probably benign |
Het |
| Ipo9 |
A |
T |
1: 135,327,884 (GRCm39) |
M509K |
probably damaging |
Het |
| Kcnj3 |
T |
C |
2: 55,327,256 (GRCm39) |
V15A |
probably damaging |
Het |
| Kcnn3 |
A |
T |
3: 89,427,762 (GRCm39) |
|
probably benign |
Het |
| Larp1b |
T |
A |
3: 40,918,519 (GRCm39) |
D53E |
probably benign |
Het |
| Ltf |
T |
C |
9: 110,851,913 (GRCm39) |
F117L |
possibly damaging |
Het |
| Maml1 |
A |
G |
11: 50,156,957 (GRCm39) |
L406P |
probably damaging |
Het |
| Mnx1 |
G |
A |
5: 29,678,955 (GRCm39) |
A376V |
unknown |
Het |
| Mroh2a |
G |
A |
1: 88,163,098 (GRCm39) |
R376H |
probably benign |
Het |
| Mrpl4 |
A |
G |
9: 20,918,127 (GRCm39) |
Y111C |
probably damaging |
Het |
| Mto1 |
T |
C |
9: 78,368,799 (GRCm39) |
|
probably benign |
Het |
| Nalcn |
A |
T |
14: 123,553,538 (GRCm39) |
M972K |
possibly damaging |
Het |
| Nemf |
T |
C |
12: 69,393,152 (GRCm39) |
I225V |
probably null |
Het |
| Nipal4 |
T |
G |
11: 46,041,058 (GRCm39) |
D379A |
probably damaging |
Het |
| Nktr |
A |
G |
9: 121,577,932 (GRCm39) |
|
probably benign |
Het |
| Nlrp5 |
A |
G |
7: 23,104,222 (GRCm39) |
T28A |
probably benign |
Het |
| Nxph1 |
T |
A |
6: 9,247,622 (GRCm39) |
Y198N |
probably damaging |
Het |
| Or4c123 |
T |
C |
2: 89,127,014 (GRCm39) |
N200S |
probably damaging |
Het |
| Or5an10 |
T |
C |
19: 12,275,707 (GRCm39) |
Y263C |
probably damaging |
Het |
| Or8u10 |
A |
T |
2: 85,916,064 (GRCm39) |
V19D |
probably benign |
Het |
| P2rx7 |
A |
G |
5: 122,811,799 (GRCm39) |
Y370C |
probably benign |
Het |
| Piezo1 |
T |
C |
8: 123,209,384 (GRCm39) |
|
probably benign |
Het |
| Piezo1 |
T |
C |
8: 123,216,305 (GRCm39) |
D1401G |
probably damaging |
Het |
| Plxnd1 |
A |
G |
6: 115,946,324 (GRCm39) |
L879P |
probably benign |
Het |
| Polr2a |
A |
T |
11: 69,634,772 (GRCm39) |
I636N |
probably damaging |
Het |
| Prex2 |
G |
T |
1: 11,232,590 (GRCm39) |
E886* |
probably null |
Het |
| Proca1 |
A |
T |
11: 78,095,847 (GRCm39) |
I73F |
probably damaging |
Het |
| Prss55 |
A |
T |
14: 64,316,839 (GRCm39) |
V101E |
probably benign |
Het |
| Psg26 |
T |
A |
7: 18,212,350 (GRCm39) |
H335L |
probably benign |
Het |
| Rai1 |
A |
G |
11: 60,076,746 (GRCm39) |
E270G |
probably benign |
Het |
| Reep1 |
A |
G |
6: 71,757,781 (GRCm39) |
N127D |
probably benign |
Het |
| Rims1 |
G |
T |
1: 22,498,725 (GRCm39) |
P769Q |
probably damaging |
Het |
| Robo4 |
A |
T |
9: 37,315,366 (GRCm39) |
|
probably benign |
Het |
| Ryr2 |
A |
T |
13: 11,606,222 (GRCm39) |
D888E |
probably benign |
Het |
| Scamp3 |
A |
G |
3: 89,087,567 (GRCm39) |
N135D |
probably damaging |
Het |
| Sdk2 |
C |
T |
11: 113,729,472 (GRCm39) |
|
silent |
Het |
| Sema4f |
A |
G |
6: 82,895,010 (GRCm39) |
M395T |
probably benign |
Het |
| Sgip1 |
T |
C |
4: 102,825,534 (GRCm39) |
|
probably null |
Het |
| Sik2 |
A |
T |
9: 50,906,974 (GRCm39) |
|
probably benign |
Het |
| Smtn |
G |
T |
11: 3,481,326 (GRCm39) |
A223D |
possibly damaging |
Het |
| Spen |
T |
C |
4: 141,197,654 (GRCm39) |
T3405A |
probably benign |
Het |
| Srebf1 |
A |
G |
11: 60,094,312 (GRCm39) |
L601P |
probably damaging |
Het |
| Srsf11 |
A |
T |
3: 157,737,217 (GRCm39) |
|
probably benign |
Het |
| Tbc1d17 |
T |
A |
7: 44,491,057 (GRCm39) |
|
probably benign |
Het |
| Tgfbr3l |
C |
A |
8: 4,299,600 (GRCm39) |
R128S |
probably damaging |
Het |
| Thsd1 |
G |
A |
8: 22,742,334 (GRCm39) |
|
probably benign |
Het |
| Tlx3 |
T |
C |
11: 33,153,072 (GRCm39) |
S130G |
probably benign |
Het |
| Tmem25 |
A |
T |
9: 44,709,513 (GRCm39) |
|
probably null |
Het |
| Trak2 |
A |
T |
1: 58,985,495 (GRCm39) |
M1K |
probably null |
Het |
| Trappc12 |
C |
T |
12: 28,796,984 (GRCm39) |
E183K |
probably damaging |
Het |
| Ubl3 |
A |
G |
5: 148,446,090 (GRCm39) |
V71A |
possibly damaging |
Het |
| Unc50 |
A |
G |
1: 37,477,880 (GRCm39) |
Y254C |
probably damaging |
Het |
| Unkl |
T |
C |
17: 25,448,434 (GRCm39) |
|
probably null |
Het |
| Uso1 |
T |
A |
5: 92,349,051 (GRCm39) |
S819T |
probably benign |
Het |
| Yes1 |
A |
T |
5: 32,802,395 (GRCm39) |
R103S |
probably damaging |
Het |
| Zfp131 |
A |
G |
13: 120,228,561 (GRCm39) |
V396A |
probably damaging |
Het |
| Zfp553 |
T |
C |
7: 126,834,826 (GRCm39) |
I127T |
possibly damaging |
Het |
| Zfp599 |
A |
T |
9: 22,162,845 (GRCm39) |
N102K |
probably benign |
Het |
| Zmynd10 |
A |
T |
9: 107,427,236 (GRCm39) |
Q288L |
probably benign |
Het |
|
| Other mutations in Tacc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00836:Tacc2
|
APN |
7 |
130,360,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01396:Tacc2
|
APN |
7 |
130,360,919 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01621:Tacc2
|
APN |
7 |
130,331,498 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02000:Tacc2
|
APN |
7 |
130,330,898 (GRCm39) |
splice site |
probably null |
|
|
IGL02075:Tacc2
|
APN |
7 |
130,330,582 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02201:Tacc2
|
APN |
7 |
130,227,942 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02205:Tacc2
|
APN |
7 |
130,228,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Tacc2
|
APN |
7 |
130,225,129 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02456:Tacc2
|
APN |
7 |
130,227,991 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL02559:Tacc2
|
APN |
7 |
130,360,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02734:Tacc2
|
APN |
7 |
130,227,829 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02800:Tacc2
|
APN |
7 |
130,225,809 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02938:Tacc2
|
APN |
7 |
130,330,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03031:Tacc2
|
APN |
7 |
130,225,585 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03278:Tacc2
|
APN |
7 |
130,335,298 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03283:Tacc2
|
APN |
7 |
130,343,996 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL03371:Tacc2
|
APN |
7 |
130,227,791 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
aces
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Jacks
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
kings
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0002:Tacc2
|
UTSW |
7 |
130,223,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0119:Tacc2
|
UTSW |
7 |
130,223,605 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0244:Tacc2
|
UTSW |
7 |
130,353,555 (GRCm39) |
splice site |
probably benign |
|
|
R0619:Tacc2
|
UTSW |
7 |
130,318,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Tacc2
|
UTSW |
7 |
130,179,239 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0632:Tacc2
|
UTSW |
7 |
130,227,325 (GRCm39) |
nonsense |
probably null |
|
|
R1015:Tacc2
|
UTSW |
7 |
130,225,795 (GRCm39) |
missense |
probably benign |
|
|
R1081:Tacc2
|
UTSW |
7 |
130,330,304 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1086:Tacc2
|
UTSW |
7 |
130,228,227 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1351:Tacc2
|
UTSW |
7 |
130,264,733 (GRCm39) |
intron |
probably benign |
|
|
R1538:Tacc2
|
UTSW |
7 |
130,227,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1743:Tacc2
|
UTSW |
7 |
130,228,328 (GRCm39) |
nonsense |
probably null |
|
|
R1771:Tacc2
|
UTSW |
7 |
130,343,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1876:Tacc2
|
UTSW |
7 |
130,225,475 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1893:Tacc2
|
UTSW |
7 |
130,227,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2005:Tacc2
|
UTSW |
7 |
130,333,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Tacc2
|
UTSW |
7 |
130,223,587 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2338:Tacc2
|
UTSW |
7 |
130,335,299 (GRCm39) |
splice site |
probably null |
|
|
R2407:Tacc2
|
UTSW |
7 |
130,223,770 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R3051:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3052:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3053:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3116:Tacc2
|
UTSW |
7 |
130,360,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Tacc2
|
UTSW |
7 |
130,336,724 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3683:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3685:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3872:Tacc2
|
UTSW |
7 |
130,224,152 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4063:Tacc2
|
UTSW |
7 |
130,330,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4410:Tacc2
|
UTSW |
7 |
130,343,941 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4434:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4438:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4618:Tacc2
|
UTSW |
7 |
130,227,946 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4674:Tacc2
|
UTSW |
7 |
130,226,591 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4742:Tacc2
|
UTSW |
7 |
130,227,697 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4934:Tacc2
|
UTSW |
7 |
130,330,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4947:Tacc2
|
UTSW |
7 |
130,227,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4964:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4966:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4967:Tacc2
|
UTSW |
7 |
130,225,678 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5052:Tacc2
|
UTSW |
7 |
130,336,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5276:Tacc2
|
UTSW |
7 |
130,331,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Tacc2
|
UTSW |
7 |
130,224,990 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5556:Tacc2
|
UTSW |
7 |
130,276,336 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5645:Tacc2
|
UTSW |
7 |
130,225,781 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5886:Tacc2
|
UTSW |
7 |
130,330,850 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5996:Tacc2
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6074:Tacc2
|
UTSW |
7 |
130,227,165 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6127:Tacc2
|
UTSW |
7 |
130,227,845 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6156:Tacc2
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6298:Tacc2
|
UTSW |
7 |
130,228,255 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6444:Tacc2
|
UTSW |
7 |
130,225,142 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6533:Tacc2
|
UTSW |
7 |
130,224,567 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6724:Tacc2
|
UTSW |
7 |
130,330,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Tacc2
|
UTSW |
7 |
130,330,618 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7150:Tacc2
|
UTSW |
7 |
130,330,807 (GRCm39) |
missense |
probably benign |
|
|
R7290:Tacc2
|
UTSW |
7 |
130,331,103 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7404:Tacc2
|
UTSW |
7 |
130,225,066 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7460:Tacc2
|
UTSW |
7 |
130,226,363 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7651:Tacc2
|
UTSW |
7 |
130,224,884 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7666:Tacc2
|
UTSW |
7 |
130,318,544 (GRCm39) |
start gained |
probably benign |
|
|
R7695:Tacc2
|
UTSW |
7 |
130,330,633 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7766:Tacc2
|
UTSW |
7 |
130,345,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7793:Tacc2
|
UTSW |
7 |
130,224,843 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7861:Tacc2
|
UTSW |
7 |
130,227,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8204:Tacc2
|
UTSW |
7 |
130,226,159 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8244:Tacc2
|
UTSW |
7 |
130,330,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tacc2
|
UTSW |
7 |
130,331,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Tacc2
|
UTSW |
7 |
130,227,034 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8348:Tacc2
|
UTSW |
7 |
130,225,019 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8369:Tacc2
|
UTSW |
7 |
130,223,888 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8381:Tacc2
|
UTSW |
7 |
130,225,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8804:Tacc2
|
UTSW |
7 |
130,294,693 (GRCm39) |
missense |
probably benign |
|
|
R8809:Tacc2
|
UTSW |
7 |
130,276,421 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8835:Tacc2
|
UTSW |
7 |
130,228,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8880:Tacc2
|
UTSW |
7 |
130,318,564 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8918:Tacc2
|
UTSW |
7 |
130,227,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8936:Tacc2
|
UTSW |
7 |
130,228,367 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8953:Tacc2
|
UTSW |
7 |
130,227,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9026:Tacc2
|
UTSW |
7 |
130,225,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Tacc2
|
UTSW |
7 |
130,228,304 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,058 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9222:Tacc2
|
UTSW |
7 |
130,227,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9264:Tacc2
|
UTSW |
7 |
130,228,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Tacc2
|
UTSW |
7 |
130,223,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9380:Tacc2
|
UTSW |
7 |
130,226,771 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9515:Tacc2
|
UTSW |
7 |
130,366,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9705:Tacc2
|
UTSW |
7 |
130,361,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Tacc2
|
UTSW |
7 |
130,336,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,346,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,226,000 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,225,100 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,336,679 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,227,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,226,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAAAGGCTTGTCAAAGTGACCC -3'
(R):5'- TCCTGTTGGGACTTGCTCAG -3'
Sequencing Primer
(F):5'- TTGTCAAAGTGACCCAGGTC -3'
(R):5'- CACCCAAGTTTTCTGTAAGAGCGG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation