Mutagenetix > Incidental Mutation

Incidental Mutation 'R4754:Dnah5'

357848

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

Dnahc5, b2b3491Clo, b2b1154Clo, b2b1134Clo, b2b1565Clo, b2b1537Clo, Mdnah5

Accession Numbers

Essential gene?

Probably essential (E-score: 0.791) question?

Stock #

R4754 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

28203898-28472198 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 28421101 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000067048

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.7%

Validation Efficiency

98% (107/109)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A130010J15Rik	A	G	1: 192,856,837 (GRCm39)	Y63C	probably damaging	Het
Abcb4	C	A	5: 8,960,717 (GRCm39)	F266L	probably damaging	Het
Adam8	A	T	7: 139,564,693 (GRCm39)	I681N	possibly damaging	Het
Adgrf3	T	A	5: 30,402,615 (GRCm39)		probably null	Het
Ang2	A	G	14: 51,432,974 (GRCm39)	V136A	probably damaging	Het
Ankar	C	T	1: 72,737,853 (GRCm39)	G110R	probably damaging	Het
Ap3b1	T	C	13: 94,540,468 (GRCm39)	L130P	probably damaging	Het
Apc2	T	G	10: 80,150,192 (GRCm39)	W1749G	probably benign	Het
Asb2	T	C	12: 103,290,096 (GRCm39)	N565S	possibly damaging	Het
B3gnt7	C	A	1: 86,233,279 (GRCm39)	T58K	probably benign	Het
Bltp1	C	T	3: 37,076,615 (GRCm39)	Q3663*	probably null	Het
Brpf1	T	A	6: 113,297,408 (GRCm39)	N876K	possibly damaging	Het
Ccdc157	T	C	11: 4,098,994 (GRCm39)	I69V	possibly damaging	Het
Cd109	CATTTATTTATTTATTTATTTATTTATTTATTTAT	CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT	9: 78,619,782 (GRCm39)		probably benign	Het
Cdh20	A	T	1: 104,912,410 (GRCm39)	I555F	probably damaging	Het
Cfap73	T	C	5: 120,767,729 (GRCm39)	D274G	probably damaging	Het
Chd5	T	A	4: 152,462,203 (GRCm39)	I1310N	probably damaging	Het
Ckap2	T	A	8: 22,658,911 (GRCm39)	I611F	possibly damaging	Het
Cpeb2	A	G	5: 43,443,200 (GRCm39)	I964V	possibly damaging	Het
Ctbp2	C	A	7: 132,625,287 (GRCm39)		probably null	Het
Dhrs2	A	T	14: 55,476,205 (GRCm39)	I142F	probably damaging	Het
Dst	T	C	1: 34,251,390 (GRCm39)	S1822P	probably damaging	Het
Ect2	T	C	3: 27,181,112 (GRCm39)	K581E	probably damaging	Het
Edem1	C	T	6: 108,818,658 (GRCm39)	T222M	probably damaging	Het
Eif2ak1	A	G	5: 143,838,621 (GRCm39)	M592V	probably damaging	Het
Endou	T	G	15: 97,624,420 (GRCm39)	D49A	probably damaging	Het
Ensa	A	G	3: 95,529,865 (GRCm39)		probably benign	Het
Evc2	G	T	5: 37,544,375 (GRCm39)	R708L	probably damaging	Het
Fam120b	T	A	17: 15,643,224 (GRCm39)	C668S	probably damaging	Het
Fam135a	A	T	1: 24,067,835 (GRCm39)	C798*	probably null	Het
Fam135b	T	C	15: 71,334,800 (GRCm39)	D798G	probably benign	Het
Fshb	A	C	2: 106,887,627 (GRCm39)	*131E	probably null	Het
G3bp2	C	T	5: 92,202,768 (GRCm39)	V441M	possibly damaging	Het
Galnt6	A	T	15: 100,597,105 (GRCm39)	F354I	probably damaging	Het
Gm1123	C	A	9: 98,905,293 (GRCm39)		probably null	Het
Gm1123	A	T	9: 98,905,294 (GRCm39)		probably null	Het
Gm15130	T	C	2: 110,973,207 (GRCm39)	N115S	unknown	Het
Gm7104	A	G	12: 88,252,765 (GRCm39)		noncoding transcript	Het
Gm9762	A	T	3: 78,873,728 (GRCm39)		noncoding transcript	Het
Grip2	T	C	6: 91,756,173 (GRCm39)	T505A	probably damaging	Het
Grip2	A	G	6: 91,756,163 (GRCm39)	V508A	probably damaging	Het
Haus4	A	G	14: 54,787,349 (GRCm39)		probably null	Het
Herc1	T	A	9: 66,408,488 (GRCm39)	D4571E	probably benign	Het
Hnrnpk	T	A	13: 58,546,950 (GRCm39)		probably benign	Het
Ica1l	T	C	1: 60,067,321 (GRCm39)	Y23C	probably damaging	Het
Kansl2-ps	A	G	7: 72,322,881 (GRCm39)		noncoding transcript	Het
Kcnma1	T	C	14: 23,413,904 (GRCm39)	D833G	probably damaging	Het
Kmt2e	A	T	5: 23,687,439 (GRCm39)	I430F	possibly damaging	Het
Lama2	C	A	10: 26,994,527 (GRCm39)	R1794L	possibly damaging	Het
Mcpt1	T	A	14: 56,256,137 (GRCm39)	F59I	probably damaging	Het
Mib2	G	T	4: 155,739,822 (GRCm39)	T783K	possibly damaging	Het
Nlrp4g	T	C	9: 124,349,788 (GRCm38)		noncoding transcript	Het
Nudt16l2	A	T	9: 105,021,592 (GRCm39)	F151L	probably benign	Het
Obscn	T	C	11: 58,926,869 (GRCm39)	I6352V	possibly damaging	Het
Or2j6	C	T	7: 139,980,072 (GRCm39)	A296T	probably damaging	Het
Or4a72	A	T	2: 89,405,391 (GRCm39)	H226Q	probably benign	Het
Or4k1	T	A	14: 50,377,490 (GRCm39)	N202I	possibly damaging	Het
Or4k1	T	G	14: 50,377,491 (GRCm39)	N202H	probably benign	Het
Or52a5	T	C	7: 103,426,875 (GRCm39)	I226V	probably benign	Het
Or5b125-ps1	T	A	19: 13,056,225 (GRCm39)		noncoding transcript	Het
Pcdh10	G	A	3: 45,335,072 (GRCm39)	R462H	probably damaging	Het
Pcdhga12	C	A	18: 37,899,604 (GRCm39)	N145K	probably damaging	Het
Pik3r6	T	A	11: 68,435,601 (GRCm39)	L613Q	probably damaging	Het
Pknox2	T	C	9: 36,821,016 (GRCm39)	D282G	probably damaging	Het
Plod2	T	G	9: 92,488,584 (GRCm39)	Y624*	probably null	Het
Prkd3	C	A	17: 79,264,043 (GRCm39)	V684F	probably damaging	Het
Ptpn1	T	A	2: 167,816,080 (GRCm39)	V198D	probably damaging	Het
Ptpn12	G	T	5: 21,203,587 (GRCm39)	P397Q	probably benign	Het
Rad1	C	A	15: 10,493,212 (GRCm39)		probably benign	Het
Rasl11a	A	G	5: 146,783,825 (GRCm39)	D90G	probably benign	Het
Rnf181	A	G	6: 72,337,543 (GRCm39)		probably benign	Het
Ryr3	T	C	2: 112,587,984 (GRCm39)	I2652M	possibly damaging	Het
Siglecg	C	T	7: 43,061,295 (GRCm39)		probably benign	Het
Slc22a3	T	C	17: 12,726,082 (GRCm39)	S44G	probably benign	Het
Slc38a1	A	T	15: 96,474,663 (GRCm39)	F463I	probably damaging	Het
Smg1	A	T	7: 117,755,954 (GRCm39)		probably benign	Het
Syk	T	C	13: 52,766,295 (GRCm39)		probably benign	Het
Tasor	A	T	14: 27,183,052 (GRCm39)	I504L	probably benign	Het
Tbc1d5	T	C	17: 51,107,193 (GRCm39)	I454M	probably benign	Het
Tmed6	C	A	8: 107,790,362 (GRCm39)	D146Y	probably damaging	Het
Tmem132e	A	T	11: 82,335,677 (GRCm39)	K828*	probably null	Het
Tmprss15	A	T	16: 78,851,012 (GRCm39)	S294T	probably damaging	Het
Trp53bp1	A	G	2: 121,038,360 (GRCm39)	S1493P	probably damaging	Het
Tshb	A	T	3: 102,685,491 (GRCm39)	I46N	probably damaging	Het
Tspan11	T	C	6: 127,915,183 (GRCm39)	V99A	probably benign	Het
Ttn	T	C	2: 76,545,905 (GRCm39)	T24176A	probably benign	Het
Vmn1r8	T	C	6: 57,012,952 (GRCm39)	M1T	probably null	Het
Vmn2r104	A	T	17: 20,261,030 (GRCm39)	Y464*	probably null	Het
Vmn2r110	T	C	17: 20,816,458 (GRCm39)	T22A	probably benign	Het
Vmn2r17	T	A	5: 109,600,715 (GRCm39)	I671K	probably damaging	Het
Zbtb21	T	C	16: 97,752,466 (GRCm39)	N606D	probably damaging	Het
Zfy2	A	T	Y: 2,121,477 (GRCm39)	S139T	probably benign	Het
Zkscan17	G	A	11: 59,393,851 (GRCm39)	R156*	probably null	Het
Zp2	A	G	7: 119,737,541 (GRCm39)	V248A	probably benign	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,488 (GRCm39)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,766 (GRCm39)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,364 (GRCm39)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,848 (GRCm39)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,149 (GRCm39)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,545 (GRCm39)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,802 (GRCm39)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,295,059 (GRCm39)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,418 (GRCm39)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,636 (GRCm39)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,686 (GRCm39)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,815 (GRCm39)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,872 (GRCm39)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,872 (GRCm39)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,798 (GRCm39)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,783 (GRCm39)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,480 (GRCm39)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,928 (GRCm39)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,315 (GRCm39)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,510 (GRCm39)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,899 (GRCm39)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,435 (GRCm39)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,682 (GRCm39)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,698 (GRCm39)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,264 (GRCm39)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,187 (GRCm39)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,270 (GRCm39)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,248,031 (GRCm39)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,386 (GRCm39)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,527 (GRCm39)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,296 (GRCm39)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,422 (GRCm39)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,193 (GRCm39)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,768 (GRCm39)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,333 (GRCm39)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,442 (GRCm39)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,289 (GRCm39)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,389 (GRCm39)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,358 (GRCm39)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,771 (GRCm39)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,572 (GRCm39)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,331 (GRCm39)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,607 (GRCm39)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,471 (GRCm39)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,545 (GRCm39)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,309 (GRCm39)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,300 (GRCm39)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,294 (GRCm39)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,795 (GRCm39)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,441 (GRCm39)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,420,086 (GRCm39)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,287 (GRCm39)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,473 (GRCm39)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,513 (GRCm39)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,279 (GRCm39)	splice site	probably null
notherone	UTSW	15	28,340,552 (GRCm39)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,237 (GRCm39)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,546 (GRCm39)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,533 (GRCm39)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,619 (GRCm39)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,723 (GRCm39)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,663 (GRCm39)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,759 (GRCm39)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,240,080 (GRCm39)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,897 (GRCm39)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,897 (GRCm39)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,499 (GRCm39)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,825 (GRCm39)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,509 (GRCm39)	missense	probably damaging	1.00
R0126:Dnah5	UTSW	15	28,246,465 (GRCm39)	missense	probably benign	0.00
R0127:Dnah5	UTSW	15	28,295,071 (GRCm39)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,216 (GRCm39)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,256 (GRCm39)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,727 (GRCm39)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,687 (GRCm39)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,745 (GRCm39)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,467 (GRCm39)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,925 (GRCm39)	missense	probably benign
R0720:Dnah5	UTSW	15	28,314,007 (GRCm39)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,289 (GRCm39)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,333 (GRCm39)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,332 (GRCm39)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,633 (GRCm39)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,745 (GRCm39)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,617 (GRCm39)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,598 (GRCm39)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,836 (GRCm39)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,836 (GRCm39)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,403 (GRCm39)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,877 (GRCm39)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,877 (GRCm39)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,657 (GRCm39)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,314,064 (GRCm39)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,402,059 (GRCm39)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,555 (GRCm39)	missense	probably benign
R1430:Dnah5	UTSW	15	28,346,003 (GRCm39)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,688 (GRCm39)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,609 (GRCm39)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,609 (GRCm39)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,149 (GRCm39)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,323 (GRCm39)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,569 (GRCm39)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,569 (GRCm39)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,326 (GRCm39)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,295,131 (GRCm39)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,294 (GRCm39)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,782 (GRCm39)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,932 (GRCm39)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,932 (GRCm39)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,572 (GRCm39)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,546 (GRCm39)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,546 (GRCm39)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,270 (GRCm39)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,815 (GRCm39)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,859 (GRCm39)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,859 (GRCm39)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,416 (GRCm39)	missense	probably damaging	1.00
R2069:Dnah5	UTSW	15	28,312,534 (GRCm39)	splice site	probably null
R2121:Dnah5	UTSW	15	28,297,151 (GRCm39)	splice site	probably benign
R2128:Dnah5	UTSW	15	28,408,467 (GRCm39)	missense	probably benign	0.00
R2129:Dnah5	UTSW	15	28,408,467 (GRCm39)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,237 (GRCm39)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,691 (GRCm39)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,817 (GRCm39)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,563 (GRCm39)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,563 (GRCm39)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,448 (GRCm39)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,913 (GRCm39)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,314,028 (GRCm39)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,537 (GRCm39)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,722 (GRCm39)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,237 (GRCm39)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,413 (GRCm39)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,937 (GRCm39)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,566 (GRCm39)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,268 (GRCm39)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,656 (GRCm39)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,421,144 (GRCm39)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,444 (GRCm39)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,937 (GRCm39)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,335 (GRCm39)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,248 (GRCm39)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,248 (GRCm39)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,375 (GRCm39)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,300 (GRCm39)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,909 (GRCm39)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,396 (GRCm39)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,745 (GRCm39)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,420,140 (GRCm39)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,402,099 (GRCm39)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,406 (GRCm39)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,521 (GRCm39)	missense	probably damaging	0.97
R4767:Dnah5	UTSW	15	28,270,620 (GRCm39)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,953 (GRCm39)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,784 (GRCm39)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,938 (GRCm39)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,388,050 (GRCm39)	missense	probably damaging	1.00
R4946:Dnah5	UTSW	15	28,326,703 (GRCm39)	missense	probably damaging	0.96
R4947:Dnah5	UTSW	15	28,272,518 (GRCm39)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,824 (GRCm39)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,438 (GRCm39)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,550 (GRCm39)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,424 (GRCm39)	missense	probably damaging	0.99
R5187:Dnah5	UTSW	15	28,272,318 (GRCm39)	missense	probably benign	0.41
R5272:Dnah5	UTSW	15	28,350,811 (GRCm39)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,797 (GRCm39)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,474 (GRCm39)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,390 (GRCm39)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,872 (GRCm39)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,754 (GRCm39)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,420,078 (GRCm39)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,581 (GRCm39)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,210 (GRCm39)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,513 (GRCm39)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,402,014 (GRCm39)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,298 (GRCm39)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,967 (GRCm39)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,738 (GRCm39)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,341 (GRCm39)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,159 (GRCm39)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,599 (GRCm39)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,206 (GRCm39)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,513 (GRCm39)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,979 (GRCm39)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,473 (GRCm39)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,864 (GRCm39)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,354 (GRCm39)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,353 (GRCm39)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,425 (GRCm39)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,730 (GRCm39)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,428 (GRCm39)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,372 (GRCm39)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,328,030 (GRCm39)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,979 (GRCm39)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,614 (GRCm39)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,566 (GRCm39)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,377 (GRCm39)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,331 (GRCm39)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,177 (GRCm39)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,489 (GRCm39)	missense	probably benign	0.08
R6266:Dnah5	UTSW	15	28,335,773 (GRCm39)	missense	possibly damaging	0.67
R6321:Dnah5	UTSW	15	28,372,557 (GRCm39)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,657 (GRCm39)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,970 (GRCm39)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,329 (GRCm39)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,891 (GRCm39)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,346 (GRCm39)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,266 (GRCm39)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,933 (GRCm39)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,633 (GRCm39)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,302 (GRCm39)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,384 (GRCm39)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,609 (GRCm39)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,661 (GRCm39)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,770 (GRCm39)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,786 (GRCm39)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,414 (GRCm39)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,866 (GRCm39)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,208 (GRCm39)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,738 (GRCm39)	missense	probably benign
R7032:Dnah5	UTSW	15	28,326,796 (GRCm39)	missense	probably damaging	1.00
R7063:Dnah5	UTSW	15	28,233,394 (GRCm39)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,482 (GRCm39)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,410 (GRCm39)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,983 (GRCm39)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,668 (GRCm39)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,371 (GRCm39)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,984 (GRCm39)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,616 (GRCm39)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,965 (GRCm39)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,524 (GRCm39)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,347,098 (GRCm39)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,596 (GRCm39)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,561 (GRCm39)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,629 (GRCm39)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,212 (GRCm39)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,389 (GRCm39)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,347,098 (GRCm39)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,402,014 (GRCm39)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,248,125 (GRCm39)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,378 (GRCm39)	splice site	probably null
R7763:Dnah5	UTSW	15	28,314,001 (GRCm39)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,678 (GRCm39)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,958 (GRCm39)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,830 (GRCm39)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,560 (GRCm39)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,742 (GRCm39)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,368 (GRCm39)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,983 (GRCm39)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,323 (GRCm39)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,729 (GRCm39)	missense	probably benign
R8084:Dnah5	UTSW	15	28,388,099 (GRCm39)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,548 (GRCm39)	missense	probably benign
R8114:Dnah5	UTSW	15	28,240,122 (GRCm39)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,519 (GRCm39)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,576 (GRCm39)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,850 (GRCm39)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,279 (GRCm39)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,355 (GRCm39)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,414 (GRCm39)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,538 (GRCm39)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,743 (GRCm39)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,347,011 (GRCm39)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,812 (GRCm39)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,313 (GRCm39)	missense	probably benign	0.03
R8356:Dnah5	UTSW	15	28,444,469 (GRCm39)	missense	probably null	0.02
R8361:Dnah5	UTSW	15	28,331,956 (GRCm39)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,489 (GRCm39)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,978 (GRCm39)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,941 (GRCm39)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,977 (GRCm39)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,414 (GRCm39)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,245 (GRCm39)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,367 (GRCm39)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,346,006 (GRCm39)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,365 (GRCm39)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,388,097 (GRCm39)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,719 (GRCm39)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,502 (GRCm39)	splice site	probably benign
R8873:Dnah5	UTSW	15	28,219,334 (GRCm39)	missense	probably benign
R8885:Dnah5	UTSW	15	28,327,886 (GRCm39)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,715 (GRCm39)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,412 (GRCm39)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,248,104 (GRCm39)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,391,014 (GRCm39)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,812 (GRCm39)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,936 (GRCm39)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,420,107 (GRCm39)	missense
R9118:Dnah5	UTSW	15	28,401,994 (GRCm39)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,914 (GRCm39)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,552 (GRCm39)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,480 (GRCm39)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,204,054 (GRCm39)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,240,032 (GRCm39)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,579 (GRCm39)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,204,054 (GRCm39)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,306 (GRCm39)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,286 (GRCm39)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,293 (GRCm39)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,146 (GRCm39)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,328,025 (GRCm39)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,422 (GRCm39)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,286 (GRCm39)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,774 (GRCm39)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,650 (GRCm39)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,900 (GRCm39)	missense	probably benign
R9657:Dnah5	UTSW	15	28,410,089 (GRCm39)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,965 (GRCm39)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,316 (GRCm39)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,165 (GRCm39)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,527 (GRCm39)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,500 (GRCm39)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,557 (GRCm39)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,454 (GRCm39)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,623 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,503 (GRCm39)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,376 (GRCm39)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,457 (GRCm39)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,549 (GRCm39)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,500 (GRCm39)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,909 (GRCm39)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- TGTGACCAACTGCATCCTTTG -3'
(R):5'- GTCCTCATTCACAGATAAAGAATCC -3'

Sequencing Primer
(F):5'- TGCTGAGTGTTAAATGTACAACC -3'
(R):5'- TCCAGCTCAACTTCCCAGGG -3'

Posted On

2015-11-11