Incidental Mutation 'R4807:Apc2'
| ID |
370771 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Apc2
|
| Ensembl Gene |
ENSMUSG00000020135 |
| Gene Name |
APC regulator of WNT signaling pathway 2 |
| Synonyms |
APCL |
| MMRRC Submission |
042426-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R4807 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
80131811-80154097 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 80150196 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Leucine
at position 1721
(R1721L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000020349
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020341]
[ENSMUST00000020349]
[ENSMUST00000105359]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020341
|
| SMART Domains |
Protein: ENSMUSP00000020341
Gene: ENSMUSG00000020133
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:UPF0449
|
6 |
103 |
7.5e-40 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020349
AA Change: R1721L
PolyPhen 2
Score 0.128 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000020349
Gene: ENSMUSG00000020135
AA Change: R1721L
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
4 |
57 |
9e-17 |
PDB |
|
Pfam:Suppressor_APC
|
123 |
205 |
1.3e-28 |
PFAM |
|
coiled coil region
|
214 |
236 |
N/A |
INTRINSIC |
|
low complexity region
|
242 |
261 |
N/A |
INTRINSIC |
|
ARM
|
300 |
355 |
2.95e0 |
SMART |
|
ARM
|
417 |
468 |
2.22e-2 |
SMART |
|
ARM
|
470 |
511 |
3.22e0 |
SMART |
|
ARM
|
513 |
555 |
3.56e-1 |
SMART |
|
ARM
|
557 |
602 |
2.1e1 |
SMART |
|
ARM
|
607 |
647 |
1.82e-7 |
SMART |
|
Blast:ARM
|
649 |
689 |
6e-18 |
BLAST |
|
low complexity region
|
772 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
971 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1103 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1134 |
1159 |
4.4e-9 |
PFAM |
|
low complexity region
|
1197 |
1208 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1244 |
1269 |
4.1e-8 |
PFAM |
|
Pfam:SAMP
|
1323 |
1343 |
2.1e-10 |
PFAM |
|
Pfam:APC_crr
|
1369 |
1394 |
5.8e-8 |
PFAM |
|
low complexity region
|
1500 |
1516 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1540 |
1565 |
5.7e-8 |
PFAM |
|
Pfam:SAMP
|
1594 |
1613 |
8.8e-11 |
PFAM |
|
low complexity region
|
1673 |
1699 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1757 |
2093 |
1.1e-142 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105359
AA Change: R1750L
PolyPhen 2
Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000100996
Gene: ENSMUSG00000020135
AA Change: R1750L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:APC_N_CC
|
30 |
81 |
2.7e-34 |
PFAM |
|
Pfam:Suppressor_APC
|
148 |
228 |
1.4e-27 |
PFAM |
|
coiled coil region
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
285 |
N/A |
INTRINSIC |
|
ARM
|
324 |
379 |
2.95e0 |
SMART |
|
ARM
|
446 |
497 |
2.22e-2 |
SMART |
|
ARM
|
499 |
540 |
3.22e0 |
SMART |
|
ARM
|
542 |
584 |
3.56e-1 |
SMART |
|
ARM
|
586 |
631 |
2.1e1 |
SMART |
|
ARM
|
636 |
676 |
1.82e-7 |
SMART |
|
Blast:ARM
|
678 |
718 |
6e-18 |
BLAST |
|
Pfam:Arm_APC_u3
|
719 |
977 |
1.1e-26 |
PFAM |
|
low complexity region
|
1000 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1086 |
1098 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1164 |
1187 |
9.3e-8 |
PFAM |
|
low complexity region
|
1226 |
1237 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1274 |
1297 |
7.9e-10 |
PFAM |
|
Pfam:APC_crr
|
1399 |
1423 |
1.3e-9 |
PFAM |
|
low complexity region
|
1529 |
1545 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1603 |
N/A |
INTRINSIC |
|
Pfam:SAMP
|
1624 |
1642 |
1.3e-11 |
PFAM |
|
low complexity region
|
1702 |
1728 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1786 |
2122 |
1.3e-122 |
PFAM |
|
| Meta Mutation Damage Score |
0.0719 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.2%
|
| Validation Efficiency |
98% (86/88) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
C |
T |
7: 120,139,832 (GRCm39) |
A1499V |
probably damaging |
Het |
| Agap3 |
T |
A |
5: 24,682,114 (GRCm39) |
D386E |
probably damaging |
Het |
| Ahdc1 |
C |
A |
4: 132,791,624 (GRCm39) |
T955K |
possibly damaging |
Het |
| Ankrd9 |
A |
G |
12: 110,943,669 (GRCm39) |
Y122H |
probably benign |
Het |
| Arfgef3 |
A |
G |
10: 18,522,385 (GRCm39) |
V547A |
probably benign |
Het |
| Arhgap42 |
T |
C |
9: 9,046,629 (GRCm39) |
N203D |
possibly damaging |
Het |
| Arl6ip1 |
AAAATAAATAAATAAATAAATAAATA |
AAAATAAATAAATAAATAAATAAATAAATA |
7: 117,721,122 (GRCm39) |
|
probably benign |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Aspm |
T |
A |
1: 139,405,657 (GRCm39) |
F1515I |
probably damaging |
Het |
| Baz1a |
T |
C |
12: 54,945,267 (GRCm39) |
T1363A |
probably benign |
Het |
| Cacng3 |
C |
T |
7: 122,353,732 (GRCm39) |
A72V |
probably benign |
Het |
| Casp8ap2 |
T |
C |
4: 32,644,505 (GRCm39) |
C1193R |
possibly damaging |
Het |
| Ccr3 |
A |
G |
9: 123,829,334 (GRCm39) |
Y223C |
probably damaging |
Het |
| Clcn3 |
C |
A |
8: 61,387,564 (GRCm39) |
L201F |
probably damaging |
Het |
| Cltc |
A |
C |
11: 86,591,902 (GRCm39) |
|
probably benign |
Het |
| Cyp19a1 |
G |
T |
9: 54,083,930 (GRCm39) |
T86K |
possibly damaging |
Het |
| Ddx24 |
A |
T |
12: 103,385,720 (GRCm39) |
F248L |
probably damaging |
Het |
| Ddx60 |
G |
A |
8: 62,432,372 (GRCm39) |
V885I |
probably damaging |
Het |
| Dync2h1 |
T |
C |
9: 7,139,422 (GRCm39) |
I1404M |
probably benign |
Het |
| Emilin2 |
A |
T |
17: 71,580,443 (GRCm39) |
V761E |
probably damaging |
Het |
| Endou |
C |
T |
15: 97,629,113 (GRCm39) |
C13Y |
probably benign |
Het |
| Ep400 |
C |
A |
5: 110,843,444 (GRCm39) |
|
probably null |
Het |
| Fbxo33 |
C |
A |
12: 59,265,998 (GRCm39) |
D90Y |
probably damaging |
Het |
| Fryl |
A |
G |
5: 73,198,705 (GRCm39) |
F2641L |
probably benign |
Het |
| Gbp2b |
A |
G |
3: 142,304,006 (GRCm39) |
I34V |
probably benign |
Het |
| Ghdc |
T |
C |
11: 100,661,051 (GRCm39) |
H38R |
probably damaging |
Het |
| Gm10722 |
T |
C |
9: 3,000,937 (GRCm39) |
C6R |
probably benign |
Het |
| Gpr63 |
A |
C |
4: 25,007,446 (GRCm39) |
M57L |
probably benign |
Het |
| Gprc5c |
A |
G |
11: 114,755,324 (GRCm39) |
S3G |
probably damaging |
Het |
| Grk4 |
A |
T |
5: 34,909,552 (GRCm39) |
M539L |
probably benign |
Het |
| Gulo |
C |
T |
14: 66,227,833 (GRCm39) |
M366I |
probably benign |
Het |
| Heatr5a |
T |
C |
12: 51,924,303 (GRCm39) |
H1970R |
probably damaging |
Het |
| Hmbox1 |
T |
C |
14: 65,062,998 (GRCm39) |
|
probably benign |
Het |
| Ighg2b |
T |
C |
12: 113,267,965 (GRCm39) |
|
probably benign |
Het |
| Il1b |
A |
T |
2: 129,212,226 (GRCm39) |
C9S |
probably benign |
Het |
| Itpkb |
A |
T |
1: 180,162,440 (GRCm39) |
|
probably benign |
Het |
| Kcnn1 |
T |
A |
8: 71,300,822 (GRCm39) |
H473L |
probably damaging |
Het |
| Kidins220 |
C |
T |
12: 25,107,284 (GRCm39) |
S1579L |
probably damaging |
Het |
| Kif1b |
A |
T |
4: 149,332,378 (GRCm39) |
|
probably benign |
Het |
| Lyg2 |
A |
T |
1: 37,950,148 (GRCm39) |
M60K |
possibly damaging |
Het |
| Mak16 |
G |
T |
8: 31,656,161 (GRCm39) |
H107Q |
probably benign |
Het |
| Mapkap1 |
G |
A |
2: 34,487,434 (GRCm39) |
|
probably null |
Het |
| Mastl |
A |
G |
2: 23,022,855 (GRCm39) |
S623P |
probably benign |
Het |
| Mccc1 |
T |
C |
3: 36,039,195 (GRCm39) |
Y46C |
probably damaging |
Het |
| Mdn1 |
T |
G |
4: 32,685,651 (GRCm39) |
|
probably null |
Het |
| Med25 |
T |
A |
7: 44,534,043 (GRCm39) |
T31S |
probably benign |
Het |
| Mprip |
G |
A |
11: 59,648,846 (GRCm39) |
G850D |
probably benign |
Het |
| Mrpl10 |
T |
C |
11: 96,932,449 (GRCm39) |
I8T |
probably benign |
Het |
| Msr1 |
T |
C |
8: 40,095,668 (GRCm39) |
|
probably benign |
Het |
| Myo3b |
T |
A |
2: 69,936,056 (GRCm39) |
I99N |
probably damaging |
Het |
| Neurod6 |
A |
T |
6: 55,655,640 (GRCm39) |
N332K |
probably damaging |
Het |
| Npc1l1 |
T |
C |
11: 6,168,723 (GRCm39) |
Y886C |
probably damaging |
Het |
| Nsmaf |
T |
C |
4: 6,398,542 (GRCm39) |
|
probably null |
Het |
| Ntn4 |
C |
T |
10: 93,480,362 (GRCm39) |
R29C |
probably damaging |
Het |
| Or5d47 |
T |
A |
2: 87,804,095 (GRCm39) |
I305L |
probably benign |
Het |
| Plppr2 |
A |
G |
9: 21,855,810 (GRCm39) |
N261S |
probably damaging |
Het |
| Prkar2a |
T |
A |
9: 108,617,584 (GRCm39) |
|
probably benign |
Het |
| Pxk |
G |
A |
14: 8,144,133 (GRCm38) |
V294M |
probably damaging |
Het |
| Rars1 |
A |
G |
11: 35,699,973 (GRCm39) |
F608L |
possibly damaging |
Het |
| Rasa3 |
A |
G |
8: 13,664,633 (GRCm39) |
F60L |
probably damaging |
Het |
| Rbm47 |
C |
T |
5: 66,176,647 (GRCm39) |
A490T |
possibly damaging |
Het |
| Sardh |
T |
C |
2: 27,079,539 (GRCm39) |
I918V |
probably benign |
Het |
| Saxo5 |
A |
G |
8: 3,529,004 (GRCm39) |
K193R |
possibly damaging |
Het |
| Sdhc |
T |
C |
1: 170,963,626 (GRCm39) |
Y80C |
probably damaging |
Het |
| Selp |
T |
A |
1: 163,971,505 (GRCm39) |
M653K |
probably damaging |
Het |
| Slc6a17 |
T |
C |
3: 107,407,803 (GRCm39) |
D56G |
possibly damaging |
Het |
| Slco1b2 |
T |
C |
6: 141,615,195 (GRCm39) |
S367P |
probably damaging |
Het |
| Spry4 |
TTGAGGTCC |
T |
18: 38,723,328 (GRCm39) |
|
probably null |
Het |
| Strip2 |
T |
A |
6: 29,925,092 (GRCm39) |
Y143* |
probably null |
Het |
| Sycp2 |
T |
C |
2: 178,035,754 (GRCm39) |
|
probably benign |
Het |
| Tex30 |
C |
A |
1: 44,126,118 (GRCm39) |
V204L |
possibly damaging |
Het |
| Tln2 |
G |
T |
9: 67,239,015 (GRCm39) |
T1087K |
probably benign |
Het |
| Tmeff2 |
A |
C |
1: 51,018,546 (GRCm39) |
N176T |
probably benign |
Het |
| Togaram2 |
C |
G |
17: 72,004,918 (GRCm39) |
T324R |
probably damaging |
Het |
| Trpc3 |
C |
T |
3: 36,688,531 (GRCm39) |
R836Q |
probably benign |
Het |
| Trpm7 |
A |
C |
2: 126,673,149 (GRCm39) |
L535V |
probably benign |
Het |
| Vmn1r213 |
G |
A |
13: 23,195,775 (GRCm39) |
W119* |
probably null |
Het |
| Vps29 |
T |
G |
5: 122,500,951 (GRCm39) |
V176G |
probably damaging |
Het |
| Vsig10l |
A |
G |
7: 43,113,173 (GRCm39) |
T144A |
possibly damaging |
Het |
| Wdr11 |
T |
C |
7: 129,229,746 (GRCm39) |
Y844H |
probably benign |
Het |
| Zbp1 |
A |
T |
2: 173,053,999 (GRCm39) |
M174K |
probably damaging |
Het |
| Zfp341 |
G |
A |
2: 154,487,786 (GRCm39) |
|
probably benign |
Het |
| Zfp638 |
G |
A |
6: 83,920,040 (GRCm39) |
R546H |
probably damaging |
Het |
| Zfp820 |
A |
T |
17: 22,042,853 (GRCm39) |
M1K |
probably null |
Het |
|
| Other mutations in Apc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01069:Apc2
|
APN |
10 |
80,147,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01154:Apc2
|
APN |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01411:Apc2
|
APN |
10 |
80,150,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01598:Apc2
|
APN |
10 |
80,148,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01621:Apc2
|
APN |
10 |
80,142,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01720:Apc2
|
APN |
10 |
80,150,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Apc2
|
APN |
10 |
80,150,492 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01933:Apc2
|
APN |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02243:Apc2
|
APN |
10 |
80,138,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02292:Apc2
|
APN |
10 |
80,138,258 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02956:Apc2
|
APN |
10 |
80,142,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03081:Apc2
|
APN |
10 |
80,148,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Apc2
|
APN |
10 |
80,149,220 (GRCm39) |
missense |
probably damaging |
0.98 |
|
LCD18:Apc2
|
UTSW |
10 |
80,135,808 (GRCm39) |
intron |
probably benign |
|
|
R0278:Apc2
|
UTSW |
10 |
80,148,647 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0501:Apc2
|
UTSW |
10 |
80,150,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Apc2
|
UTSW |
10 |
80,142,090 (GRCm39) |
nonsense |
probably null |
|
|
R0607:Apc2
|
UTSW |
10 |
80,149,935 (GRCm39) |
missense |
probably benign |
|
|
R0624:Apc2
|
UTSW |
10 |
80,150,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0633:Apc2
|
UTSW |
10 |
80,143,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0638:Apc2
|
UTSW |
10 |
80,140,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0647:Apc2
|
UTSW |
10 |
80,140,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0830:Apc2
|
UTSW |
10 |
80,151,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Apc2
|
UTSW |
10 |
80,147,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1221:Apc2
|
UTSW |
10 |
80,142,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Apc2
|
UTSW |
10 |
80,148,183 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1579:Apc2
|
UTSW |
10 |
80,147,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Apc2
|
UTSW |
10 |
80,137,676 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1700:Apc2
|
UTSW |
10 |
80,148,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Apc2
|
UTSW |
10 |
80,144,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Apc2
|
UTSW |
10 |
80,149,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Apc2
|
UTSW |
10 |
80,150,678 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1915:Apc2
|
UTSW |
10 |
80,151,701 (GRCm39) |
missense |
probably benign |
|
|
R1999:Apc2
|
UTSW |
10 |
80,144,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Apc2
|
UTSW |
10 |
80,143,443 (GRCm39) |
splice site |
probably null |
|
|
R2219:Apc2
|
UTSW |
10 |
80,144,943 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2393:Apc2
|
UTSW |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3862:Apc2
|
UTSW |
10 |
80,143,393 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3900:Apc2
|
UTSW |
10 |
80,131,806 (GRCm39) |
splice site |
probably null |
|
|
R3901:Apc2
|
UTSW |
10 |
80,150,922 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3952:Apc2
|
UTSW |
10 |
80,150,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Apc2
|
UTSW |
10 |
80,149,426 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4090:Apc2
|
UTSW |
10 |
80,141,378 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4695:Apc2
|
UTSW |
10 |
80,146,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Apc2
|
UTSW |
10 |
80,150,192 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4886:Apc2
|
UTSW |
10 |
80,150,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Apc2
|
UTSW |
10 |
80,149,841 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5056:Apc2
|
UTSW |
10 |
80,137,148 (GRCm39) |
missense |
probably benign |
|
|
R5057:Apc2
|
UTSW |
10 |
80,144,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Apc2
|
UTSW |
10 |
80,151,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5241:Apc2
|
UTSW |
10 |
80,148,068 (GRCm39) |
missense |
probably benign |
|
|
R5649:Apc2
|
UTSW |
10 |
80,149,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Apc2
|
UTSW |
10 |
80,147,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6124:Apc2
|
UTSW |
10 |
80,142,185 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6218:Apc2
|
UTSW |
10 |
80,142,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6376:Apc2
|
UTSW |
10 |
80,148,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Apc2
|
UTSW |
10 |
80,149,757 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6572:Apc2
|
UTSW |
10 |
80,147,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Apc2
|
UTSW |
10 |
80,149,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7171:Apc2
|
UTSW |
10 |
80,151,170 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7180:Apc2
|
UTSW |
10 |
80,146,990 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7326:Apc2
|
UTSW |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Apc2
|
UTSW |
10 |
80,149,316 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7378:Apc2
|
UTSW |
10 |
80,147,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7384:Apc2
|
UTSW |
10 |
80,148,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Apc2
|
UTSW |
10 |
80,138,017 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7543:Apc2
|
UTSW |
10 |
80,150,720 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7743:Apc2
|
UTSW |
10 |
80,140,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7759:Apc2
|
UTSW |
10 |
80,147,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Apc2
|
UTSW |
10 |
80,151,166 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8327:Apc2
|
UTSW |
10 |
80,137,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8489:Apc2
|
UTSW |
10 |
80,143,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8494:Apc2
|
UTSW |
10 |
80,150,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Apc2
|
UTSW |
10 |
80,149,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8773:Apc2
|
UTSW |
10 |
80,142,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8920:Apc2
|
UTSW |
10 |
80,149,934 (GRCm39) |
missense |
probably benign |
|
|
R9178:Apc2
|
UTSW |
10 |
80,150,235 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9224:Apc2
|
UTSW |
10 |
80,150,111 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9357:Apc2
|
UTSW |
10 |
80,146,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9394:Apc2
|
UTSW |
10 |
80,145,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Apc2
|
UTSW |
10 |
80,147,183 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9689:Apc2
|
UTSW |
10 |
80,150,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Apc2
|
UTSW |
10 |
80,148,098 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Apc2
|
UTSW |
10 |
80,147,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGCAAACTCCATTGTCACATG -3'
(R):5'- AGTGGTACCAGATGTCCCTG -3'
Sequencing Primer
(F):5'- CATTGTCACATGGCTGCATCAGG -3'
(R):5'- GGTCCAGAAATACCTTTGGACTG -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation