Incidental Mutation 'R0304:Arhgap21'
| ID |
37719 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgap21
|
| Ensembl Gene |
ENSMUSG00000036591 |
| Gene Name |
Rho GTPase activating protein 21 |
| Synonyms |
ARHGAP10, 5530401C11Rik |
| MMRRC Submission |
038515-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.570)
|
| Stock # |
R0304 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
20852730-20973692 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to T
at 20864612 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133347
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114594]
[ENSMUST00000141298]
[ENSMUST00000154230]
[ENSMUST00000173194]
[ENSMUST00000174584]
[ENSMUST00000173784]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114594
|
| SMART Domains |
Protein: ENSMUSP00000110241
Gene: ENSMUSG00000036591
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
58 |
159 |
1.03e-16 |
SMART |
|
low complexity region
|
351 |
362 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
625 |
635 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
925 |
N/A |
INTRINSIC |
|
PH
|
930 |
1040 |
2.09e-16 |
SMART |
|
RhoGAP
|
1157 |
1334 |
3.26e-62 |
SMART |
|
low complexity region
|
1381 |
1399 |
N/A |
INTRINSIC |
|
low complexity region
|
1448 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1533 |
1565 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1593 |
N/A |
INTRINSIC |
|
low complexity region
|
1891 |
1900 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127512
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136241
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141298
|
| SMART Domains |
Protein: ENSMUSP00000120357
Gene: ENSMUSG00000036591
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154230
|
| SMART Domains |
Protein: ENSMUSP00000122497
Gene: ENSMUSG00000036591
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154657
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173194
|
| SMART Domains |
Protein: ENSMUSP00000133851
Gene: ENSMUSG00000036591
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
347 |
358 |
N/A |
INTRINSIC |
|
low complexity region
|
441 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
907 |
921 |
N/A |
INTRINSIC |
|
PH
|
926 |
1036 |
2.09e-16 |
SMART |
|
RhoGAP
|
1153 |
1330 |
3.26e-62 |
SMART |
|
low complexity region
|
1377 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1561 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
1887 |
1896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174584
|
| SMART Domains |
Protein: ENSMUSP00000133347
Gene: ENSMUSG00000036591
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
186 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
294 |
N/A |
INTRINSIC |
|
low complexity region
|
460 |
470 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
760 |
N/A |
INTRINSIC |
|
PH
|
765 |
875 |
2.09e-16 |
SMART |
|
RhoGAP
|
992 |
1169 |
3.26e-62 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000174825
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173784
|
| SMART Domains |
Protein: ENSMUSP00000133539
Gene: ENSMUSG00000036591
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
35 |
N/A |
INTRINSIC |
|
PH
|
40 |
150 |
2.09e-16 |
SMART |
|
RhoGAP
|
268 |
395 |
1.55e-22 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl4fm1 |
C |
T |
4: 144,246,619 (GRCm39) |
T55I |
probably benign |
Het |
| Acod1 |
T |
A |
14: 103,292,418 (GRCm39) |
I314N |
probably damaging |
Het |
| Actl11 |
T |
A |
9: 107,806,967 (GRCm39) |
V430E |
probably damaging |
Het |
| Adam19 |
A |
C |
11: 46,018,219 (GRCm39) |
D427A |
possibly damaging |
Het |
| Adarb2 |
C |
T |
13: 8,802,606 (GRCm39) |
|
probably benign |
Het |
| Akap7 |
A |
T |
10: 25,147,450 (GRCm39) |
H93Q |
probably damaging |
Het |
| Ankrd36 |
C |
A |
11: 5,578,981 (GRCm39) |
R82S |
possibly damaging |
Het |
| Atm |
T |
A |
9: 53,427,644 (GRCm39) |
I489F |
probably benign |
Het |
| Carmil1 |
T |
C |
13: 24,323,324 (GRCm39) |
S243G |
probably damaging |
Het |
| Cdc42bpg |
T |
C |
19: 6,367,278 (GRCm39) |
V939A |
probably damaging |
Het |
| Cel |
A |
C |
2: 28,447,783 (GRCm39) |
L377R |
probably benign |
Het |
| Clock |
A |
G |
5: 76,374,832 (GRCm39) |
V779A |
unknown |
Het |
| Cluap1 |
G |
A |
16: 3,747,782 (GRCm39) |
|
probably benign |
Het |
| Ctif |
A |
T |
18: 75,654,889 (GRCm39) |
H212Q |
probably benign |
Het |
| Cyp4a29 |
T |
A |
4: 115,110,129 (GRCm39) |
|
probably benign |
Het |
| Cytip |
T |
C |
2: 58,038,258 (GRCm39) |
N101S |
possibly damaging |
Het |
| D130043K22Rik |
T |
C |
13: 25,048,798 (GRCm39) |
M434T |
probably benign |
Het |
| Ddx47 |
A |
G |
6: 134,994,183 (GRCm39) |
I154V |
possibly damaging |
Het |
| Dnah6 |
C |
T |
6: 73,136,098 (GRCm39) |
E1014K |
probably damaging |
Het |
| Dnajc27 |
T |
G |
12: 4,156,793 (GRCm39) |
|
probably benign |
Het |
| Drc7 |
A |
T |
8: 95,785,756 (GRCm39) |
D204V |
probably damaging |
Het |
| Dsc3 |
A |
G |
18: 20,114,298 (GRCm39) |
Y319H |
probably damaging |
Het |
| Eml6 |
T |
C |
11: 29,727,441 (GRCm39) |
Q1227R |
probably benign |
Het |
| Enpp2 |
A |
T |
15: 54,741,202 (GRCm39) |
D365E |
probably benign |
Het |
| Ercc2 |
T |
C |
7: 19,120,633 (GRCm39) |
I199T |
possibly damaging |
Het |
| Exd2 |
G |
A |
12: 80,538,014 (GRCm39) |
|
probably benign |
Het |
| F2 |
A |
T |
2: 91,463,578 (GRCm39) |
I128N |
probably damaging |
Het |
| Fam219b |
T |
C |
9: 57,446,159 (GRCm39) |
L123P |
probably damaging |
Het |
| Fasn |
A |
G |
11: 120,710,762 (GRCm39) |
V299A |
possibly damaging |
Het |
| Fastkd2 |
T |
C |
1: 63,791,559 (GRCm39) |
V689A |
possibly damaging |
Het |
| Fbxw13 |
C |
T |
9: 109,023,789 (GRCm39) |
R85Q |
probably benign |
Het |
| Fer1l6 |
A |
G |
15: 58,462,411 (GRCm39) |
Y822C |
probably benign |
Het |
| Fhl5 |
T |
C |
4: 25,207,241 (GRCm39) |
T176A |
probably benign |
Het |
| Gm20530 |
T |
G |
17: 36,405,118 (GRCm39) |
|
noncoding transcript |
Het |
| Gm4787 |
A |
T |
12: 81,425,708 (GRCm39) |
I150N |
probably damaging |
Het |
| Grip1 |
G |
A |
10: 119,911,376 (GRCm39) |
S618N |
probably benign |
Het |
| Hdac9 |
T |
C |
12: 34,424,110 (GRCm39) |
K454E |
probably damaging |
Het |
| Iars2 |
T |
A |
1: 185,019,353 (GRCm39) |
I978F |
possibly damaging |
Het |
| Icosl |
A |
G |
10: 77,911,156 (GRCm39) |
Y299C |
probably benign |
Het |
| Idi1 |
T |
C |
13: 8,940,393 (GRCm39) |
Y192H |
probably damaging |
Het |
| Iqub |
T |
G |
6: 24,454,290 (GRCm39) |
Q531P |
probably damaging |
Het |
| Itih4 |
T |
A |
14: 30,612,051 (GRCm39) |
|
probably null |
Het |
| Izumo4 |
A |
T |
10: 80,538,770 (GRCm39) |
H71L |
probably damaging |
Het |
| Jcad |
A |
T |
18: 4,673,325 (GRCm39) |
E362D |
possibly damaging |
Het |
| Kif21a |
G |
T |
15: 90,860,724 (GRCm39) |
|
probably null |
Het |
| Kynu |
A |
T |
2: 43,569,893 (GRCm39) |
I392F |
probably damaging |
Het |
| Luc7l2 |
A |
G |
6: 38,569,711 (GRCm39) |
E223G |
probably damaging |
Het |
| Map3k8 |
A |
C |
18: 4,339,552 (GRCm39) |
L273R |
probably damaging |
Het |
| Max |
A |
G |
12: 76,985,361 (GRCm39) |
L119P |
probably benign |
Het |
| Mphosph9 |
T |
C |
5: 124,436,892 (GRCm39) |
N484S |
probably benign |
Het |
| Mrgprg |
A |
G |
7: 143,318,792 (GRCm39) |
Y107H |
probably damaging |
Het |
| Mrps31 |
A |
T |
8: 22,911,354 (GRCm39) |
I199F |
probably benign |
Het |
| Mtr |
C |
G |
13: 12,237,040 (GRCm39) |
|
probably null |
Het |
| Muc6 |
G |
A |
7: 141,218,313 (GRCm39) |
S2120F |
possibly damaging |
Het |
| Nkapd1 |
T |
C |
9: 50,519,222 (GRCm39) |
D130G |
probably damaging |
Het |
| Nptx2 |
A |
G |
5: 144,490,460 (GRCm39) |
|
probably benign |
Het |
| Nrip1 |
T |
C |
16: 76,089,595 (GRCm39) |
Q654R |
possibly damaging |
Het |
| Ocm |
A |
G |
5: 143,961,352 (GRCm39) |
F30L |
probably damaging |
Het |
| Oosp1 |
T |
C |
19: 11,668,333 (GRCm39) |
M17V |
probably benign |
Het |
| Or14c45 |
C |
T |
7: 86,176,195 (GRCm39) |
P77S |
probably damaging |
Het |
| Or4c111 |
G |
A |
2: 88,843,632 (GRCm39) |
R259W |
probably damaging |
Het |
| Or4c118 |
A |
C |
2: 88,975,108 (GRCm39) |
Y86* |
probably null |
Het |
| Or52ad1 |
G |
T |
7: 102,995,918 (GRCm39) |
D72E |
probably damaging |
Het |
| Pax1 |
A |
T |
2: 147,208,067 (GRCm39) |
Y225F |
probably benign |
Het |
| Pde4dip |
T |
A |
3: 97,751,028 (GRCm39) |
H62L |
probably benign |
Het |
| Pkd1 |
C |
A |
17: 24,804,920 (GRCm39) |
Q3190K |
probably damaging |
Het |
| Pkn1 |
A |
C |
8: 84,410,236 (GRCm39) |
|
probably benign |
Het |
| Plin5 |
T |
C |
17: 56,422,597 (GRCm39) |
D113G |
probably damaging |
Het |
| Ppfia1 |
A |
G |
7: 144,036,082 (GRCm39) |
V1141A |
probably damaging |
Het |
| Ppp4r1 |
T |
A |
17: 66,123,001 (GRCm39) |
D334E |
probably benign |
Het |
| Ptov1 |
A |
T |
7: 44,512,873 (GRCm39) |
|
probably null |
Het |
| Rab22a |
G |
A |
2: 173,503,252 (GRCm39) |
V22M |
probably damaging |
Het |
| Rictor |
T |
A |
15: 6,815,852 (GRCm39) |
|
probably null |
Het |
| Sart1 |
G |
T |
19: 5,430,559 (GRCm39) |
|
probably benign |
Het |
| Scn11a |
G |
A |
9: 119,648,928 (GRCm39) |
A45V |
probably benign |
Het |
| Serpina5 |
A |
G |
12: 104,069,459 (GRCm39) |
T224A |
possibly damaging |
Het |
| Siglecf |
G |
T |
7: 43,001,825 (GRCm39) |
G212C |
probably damaging |
Het |
| Slc38a4 |
A |
T |
15: 96,906,335 (GRCm39) |
M378K |
probably damaging |
Het |
| Spata22 |
T |
A |
11: 73,231,275 (GRCm39) |
C176* |
probably null |
Het |
| Tmc3 |
G |
A |
7: 83,245,347 (GRCm39) |
E131K |
probably damaging |
Het |
| Trappc10 |
A |
T |
10: 78,046,594 (GRCm39) |
|
probably benign |
Het |
| Uvrag |
A |
G |
7: 98,537,180 (GRCm39) |
F672L |
probably benign |
Het |
| Vmn1r121 |
A |
G |
7: 20,832,332 (GRCm39) |
V36A |
possibly damaging |
Het |
| Vmn1r13 |
A |
T |
6: 57,187,611 (GRCm39) |
M257L |
probably benign |
Het |
| Vmn1r58 |
C |
T |
7: 5,413,495 (GRCm39) |
C245Y |
probably damaging |
Het |
| Vmn1r86 |
C |
A |
7: 12,836,707 (GRCm39) |
M56I |
probably benign |
Het |
| Wdr62 |
T |
C |
7: 29,942,299 (GRCm39) |
Y1051C |
probably benign |
Het |
| Xpnpep3 |
A |
G |
15: 81,314,915 (GRCm39) |
D205G |
probably damaging |
Het |
| Zdhhc14 |
T |
C |
17: 5,775,611 (GRCm39) |
|
probably benign |
Het |
| Zfp607a |
A |
T |
7: 27,578,637 (GRCm39) |
D569V |
possibly damaging |
Het |
| Zfp609 |
C |
T |
9: 65,608,470 (GRCm39) |
E1137K |
possibly damaging |
Het |
| Zfp871 |
T |
C |
17: 32,993,408 (GRCm39) |
Y589C |
probably damaging |
Het |
| Zzef1 |
A |
T |
11: 72,771,450 (GRCm39) |
D1644V |
probably benign |
Het |
|
| Other mutations in Arhgap21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Arhgap21
|
APN |
2 |
20,860,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01472:Arhgap21
|
APN |
2 |
20,854,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01634:Arhgap21
|
APN |
2 |
20,919,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01766:Arhgap21
|
APN |
2 |
20,854,448 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02097:Arhgap21
|
APN |
2 |
20,884,813 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02197:Arhgap21
|
APN |
2 |
20,885,117 (GRCm39) |
missense |
probably benign |
|
|
IGL02264:Arhgap21
|
APN |
2 |
20,864,850 (GRCm39) |
splice site |
probably null |
|
|
IGL02346:Arhgap21
|
APN |
2 |
20,884,762 (GRCm39) |
splice site |
probably benign |
|
|
IGL02418:Arhgap21
|
APN |
2 |
20,885,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02605:Arhgap21
|
APN |
2 |
20,860,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02701:Arhgap21
|
APN |
2 |
20,896,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03019:Arhgap21
|
APN |
2 |
20,865,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Arhgap21
|
APN |
2 |
20,919,532 (GRCm39) |
missense |
probably benign |
|
|
IGL03265:Arhgap21
|
APN |
2 |
20,854,439 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03379:Arhgap21
|
APN |
2 |
20,885,500 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0363:Arhgap21
|
UTSW |
2 |
20,885,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0498:Arhgap21
|
UTSW |
2 |
20,867,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Arhgap21
|
UTSW |
2 |
20,919,610 (GRCm39) |
nonsense |
probably null |
|
|
R0633:Arhgap21
|
UTSW |
2 |
20,860,198 (GRCm39) |
nonsense |
probably null |
|
|
R0905:Arhgap21
|
UTSW |
2 |
20,854,745 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1550:Arhgap21
|
UTSW |
2 |
20,886,576 (GRCm39) |
nonsense |
probably null |
|
|
R1570:Arhgap21
|
UTSW |
2 |
20,885,651 (GRCm39) |
missense |
probably benign |
|
|
R1686:Arhgap21
|
UTSW |
2 |
20,886,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1746:Arhgap21
|
UTSW |
2 |
20,865,910 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1864:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2209:Arhgap21
|
UTSW |
2 |
20,854,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2211:Arhgap21
|
UTSW |
2 |
20,886,451 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2276:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2279:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2336:Arhgap21
|
UTSW |
2 |
20,884,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2516:Arhgap21
|
UTSW |
2 |
20,859,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Arhgap21
|
UTSW |
2 |
20,855,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3877:Arhgap21
|
UTSW |
2 |
20,864,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4017:Arhgap21
|
UTSW |
2 |
20,896,915 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4232:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4233:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4234:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4236:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4434:Arhgap21
|
UTSW |
2 |
20,972,146 (GRCm39) |
missense |
probably benign |
|
|
R4686:Arhgap21
|
UTSW |
2 |
20,868,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4817:Arhgap21
|
UTSW |
2 |
20,854,967 (GRCm39) |
missense |
probably benign |
|
|
R4834:Arhgap21
|
UTSW |
2 |
20,870,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Arhgap21
|
UTSW |
2 |
20,885,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4889:Arhgap21
|
UTSW |
2 |
20,885,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4904:Arhgap21
|
UTSW |
2 |
20,854,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4911:Arhgap21
|
UTSW |
2 |
20,863,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4994:Arhgap21
|
UTSW |
2 |
20,854,701 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5067:Arhgap21
|
UTSW |
2 |
20,884,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5086:Arhgap21
|
UTSW |
2 |
20,853,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5281:Arhgap21
|
UTSW |
2 |
20,854,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5364:Arhgap21
|
UTSW |
2 |
20,854,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5420:Arhgap21
|
UTSW |
2 |
20,885,897 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5476:Arhgap21
|
UTSW |
2 |
20,885,497 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5831:Arhgap21
|
UTSW |
2 |
20,868,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5949:Arhgap21
|
UTSW |
2 |
20,853,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5994:Arhgap21
|
UTSW |
2 |
20,886,187 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6014:Arhgap21
|
UTSW |
2 |
20,886,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Arhgap21
|
UTSW |
2 |
20,885,543 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6817:Arhgap21
|
UTSW |
2 |
20,885,107 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6821:Arhgap21
|
UTSW |
2 |
20,853,659 (GRCm39) |
missense |
probably benign |
|
|
R6844:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6870:Arhgap21
|
UTSW |
2 |
20,885,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Arhgap21
|
UTSW |
2 |
20,855,142 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7011:Arhgap21
|
UTSW |
2 |
20,853,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7144:Arhgap21
|
UTSW |
2 |
20,870,198 (GRCm39) |
missense |
probably benign |
|
|
R7237:Arhgap21
|
UTSW |
2 |
20,854,783 (GRCm39) |
nonsense |
probably null |
|
|
R7261:Arhgap21
|
UTSW |
2 |
20,885,177 (GRCm39) |
missense |
probably benign |
|
|
R7558:Arhgap21
|
UTSW |
2 |
20,860,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7566:Arhgap21
|
UTSW |
2 |
20,917,102 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,855,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,854,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Arhgap21
|
UTSW |
2 |
20,867,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7822:Arhgap21
|
UTSW |
2 |
20,885,524 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7965:Arhgap21
|
UTSW |
2 |
20,854,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7986:Arhgap21
|
UTSW |
2 |
20,867,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Arhgap21
|
UTSW |
2 |
20,885,216 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8209:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Arhgap21
|
UTSW |
2 |
20,854,221 (GRCm39) |
missense |
probably benign |
|
|
R8486:Arhgap21
|
UTSW |
2 |
20,865,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8508:Arhgap21
|
UTSW |
2 |
20,858,991 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8835:Arhgap21
|
UTSW |
2 |
20,972,144 (GRCm39) |
nonsense |
probably null |
|
|
R9140:Arhgap21
|
UTSW |
2 |
20,886,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Arhgap21
|
UTSW |
2 |
20,858,983 (GRCm39) |
missense |
probably null |
0.04 |
|
R9204:Arhgap21
|
UTSW |
2 |
20,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9227:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9230:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9308:Arhgap21
|
UTSW |
2 |
20,854,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9374:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9449:Arhgap21
|
UTSW |
2 |
20,885,464 (GRCm39) |
missense |
probably benign |
|
|
R9454:Arhgap21
|
UTSW |
2 |
20,870,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9499:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9544:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9552:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Arhgap21
|
UTSW |
2 |
20,896,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9588:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9749:Arhgap21
|
UTSW |
2 |
20,854,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1191:Arhgap21
|
UTSW |
2 |
20,886,283 (GRCm39) |
missense |
probably benign |
0.30 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTCCGCTATGCTTCATGTCCAGAG -3'
(R):5'- TTACCGAGTTCCCGGCAACAAC -3'
Sequencing Primer
(F):5'- GAGCCAAGATAACTGCTGTTTCC -3'
(R):5'- AACGCAGCCATTTCAAGC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation