Incidental Mutation 'R5345:Or10g3'
ID 422580
Institutional Source Beutler Lab
Gene Symbol Or10g3
Ensembl Gene ENSMUSG00000094140
Gene Name olfactory receptor family 10 subfamily G member 3
Synonyms GA_x6K02T2RJGY-622120-623061, MOR223-5, Olfr1512
MMRRC Submission 042924-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # R5345 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 52609567-52610508 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 52609725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 262 (R262*)
Ref Sequence ENSEMBL: ENSMUSP00000149717 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071221] [ENSMUST00000214980]
AlphaFold Q8VF72
Predicted Effect probably null
Transcript: ENSMUST00000071221
AA Change: R262*
SMART Domains Protein: ENSMUSP00000071208
Gene: ENSMUSG00000094140
AA Change: R262*

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.1e-48 PFAM
Pfam:7tm_1 41 290 2.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192537
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200261
Predicted Effect probably null
Transcript: ENSMUST00000214980
AA Change: R262*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 96.0%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 T A 2: 31,687,059 (GRCm39) S519T probably damaging Het
Acap2 A G 16: 30,926,944 (GRCm39) S524P probably benign Het
Acot1 T A 12: 84,063,942 (GRCm39) I350N probably damaging Het
Adam8 A G 7: 139,567,552 (GRCm39) V397A probably benign Het
Ankar A G 1: 72,709,310 (GRCm39) M735T possibly damaging Het
Cacna1c A G 6: 118,633,497 (GRCm39) probably null Het
Cdc25b A G 2: 131,034,516 (GRCm39) S222G probably benign Het
Celsr3 T C 9: 108,709,323 (GRCm39) S1390P probably damaging Het
Clca4a T G 3: 144,676,222 (GRCm39) D104A probably damaging Het
Clcn6 A T 4: 148,123,206 (GRCm39) probably benign Het
Coq8b A G 7: 26,949,773 (GRCm39) T320A probably benign Het
Cspg5 A T 9: 110,075,698 (GRCm39) M145L probably benign Het
Cyp2c67 T A 19: 39,614,676 (GRCm39) I284F probably benign Het
Eya4 T C 10: 22,985,947 (GRCm39) I565V probably benign Het
Fbxw11 A G 11: 32,688,471 (GRCm39) N410S probably damaging Het
Gabrb2 C T 11: 42,517,636 (GRCm39) A448V possibly damaging Het
Hectd4 A G 5: 121,402,037 (GRCm39) D375G possibly damaging Het
Itsn2 T C 12: 4,722,783 (GRCm39) V1073A probably damaging Het
Kif5c A G 2: 49,613,078 (GRCm39) T139A probably benign Het
L1td1 G A 4: 98,624,684 (GRCm39) G293D probably damaging Het
Lama1 A G 17: 68,124,558 (GRCm39) M2873V probably benign Het
Msantd5f6 A T 4: 73,319,514 (GRCm39) W77R probably damaging Het
Myo15a A G 11: 60,388,364 (GRCm39) R1960G probably damaging Het
Nbeal1 T C 1: 60,367,369 (GRCm39) probably null Het
Ndufb4 A G 16: 37,474,540 (GRCm39) probably null Het
Nup153 A T 13: 46,840,341 (GRCm39) L1089* probably null Het
Or2l13b T A 16: 19,349,527 (GRCm39) I48F probably damaging Het
Or5aq1b A G 2: 86,901,836 (GRCm39) V214A possibly damaging Het
P2rx1 A G 11: 72,900,056 (GRCm39) T158A probably damaging Het
Park7 A G 4: 150,992,880 (GRCm39) probably benign Het
Parl A T 16: 20,116,892 (GRCm39) F102I probably damaging Het
Plxnc1 T A 10: 94,685,831 (GRCm39) H720L probably benign Het
Ptpn4 A G 1: 119,693,207 (GRCm39) S140P probably benign Het
Rel A G 11: 23,692,462 (GRCm39) S524P probably benign Het
Ripply2 A G 9: 86,901,779 (GRCm39) probably null Het
Rmc1 C T 18: 12,312,234 (GRCm39) T158M probably benign Het
Rps4l-ps T C 7: 114,526,433 (GRCm39) noncoding transcript Het
Rtn4ip1 T C 10: 43,808,466 (GRCm39) L81P probably damaging Het
Sap130 T C 18: 31,781,251 (GRCm39) L138P probably benign Het
Scp2 A T 4: 107,912,776 (GRCm39) probably null Het
Sec24c T A 14: 20,743,288 (GRCm39) M970K probably benign Het
Setd5 C T 6: 113,092,968 (GRCm39) P340L probably damaging Het
Sgcg A T 14: 61,483,218 (GRCm39) M61K probably damaging Het
Slc22a27 C G 19: 7,843,303 (GRCm39) A359P probably damaging Het
Slc34a1 A G 13: 55,548,331 (GRCm39) R21G probably benign Het
Slc7a14 A C 3: 31,278,006 (GRCm39) L533W probably damaging Het
Srsf9 A G 5: 115,468,595 (GRCm39) D77G probably benign Het
Tab1 A T 15: 80,034,014 (GRCm39) E119V possibly damaging Het
Tcstv5 A T 13: 120,411,384 (GRCm39) V74E probably damaging Het
Tnrc6c C T 11: 117,614,113 (GRCm39) A757V possibly damaging Het
Tradd A T 8: 105,986,556 (GRCm39) I72N probably damaging Het
Trbv12-1 C T 6: 41,090,781 (GRCm39) T51M probably benign Het
Tsga10 T C 1: 37,802,392 (GRCm39) K605E probably damaging Het
Vwc2l A G 1: 70,768,077 (GRCm39) D47G probably damaging Het
Zfp647 T A 15: 76,795,695 (GRCm39) T322S possibly damaging Het
Zscan20 A C 4: 128,481,914 (GRCm39) S583A probably benign Het
Other mutations in Or10g3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01328:Or10g3 APN 14 52,609,967 (GRCm39) missense probably damaging 1.00
IGL01375:Or10g3 APN 14 52,609,865 (GRCm39) missense probably damaging 0.99
IGL02343:Or10g3 APN 14 52,609,934 (GRCm39) missense probably damaging 1.00
R1443:Or10g3 UTSW 14 52,610,408 (GRCm39) missense probably damaging 1.00
R1902:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R1903:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R3115:Or10g3 UTSW 14 52,610,397 (GRCm39) missense probably damaging 1.00
R4752:Or10g3 UTSW 14 52,609,764 (GRCm39) missense probably damaging 1.00
R5689:Or10g3 UTSW 14 52,610,214 (GRCm39) missense possibly damaging 0.83
R6185:Or10g3 UTSW 14 52,610,019 (GRCm39) missense possibly damaging 0.91
R6287:Or10g3 UTSW 14 52,609,748 (GRCm39) missense probably damaging 1.00
R6757:Or10g3 UTSW 14 52,610,172 (GRCm39) missense probably damaging 1.00
R8751:Or10g3 UTSW 14 52,610,420 (GRCm39) missense probably benign 0.03
R8855:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R8866:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R9038:Or10g3 UTSW 14 52,609,716 (GRCm39) missense probably damaging 0.99
R9450:Or10g3 UTSW 14 52,610,110 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAACCTGGGTGTCTCCTCAG -3'
(R):5'- ACCACAGTCAATGAGTTGGTGAC -3'

Sequencing Primer
(F):5'- ACCTGGGTGTCTCCTCAGAAGAG -3'
(R):5'- CACAGTCAATGAGTTGGTGACCTTTG -3'
Posted On 2016-08-04