Incidental Mutation 'R7054:Vmn2r106'
| ID |
547807 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r106
|
| Ensembl Gene |
ENSMUSG00000091656 |
| Gene Name |
vomeronasal 2, receptor 106 |
| Synonyms |
EG224576 |
| MMRRC Submission |
045151-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
R7054 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20487809-20505692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20499182 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 243
(V243A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126534
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167464]
|
| AlphaFold |
E9PY92 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167464
AA Change: V243A
PolyPhen 2
Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: V243A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
471 |
3.8e-37 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.7e-22 |
PFAM |
|
Pfam:7tm_3
|
596 |
835 |
1.3e-49 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
94% (67/71) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930553M12Rik |
T |
A |
4: 88,786,486 (GRCm39) |
H44L |
unknown |
Het |
| Abcc3 |
T |
C |
11: 94,256,051 (GRCm39) |
K478R |
probably benign |
Het |
| Ank2 |
A |
T |
3: 126,736,952 (GRCm39) |
|
probably benign |
Het |
| Apod |
A |
G |
16: 31,129,950 (GRCm39) |
V2A |
probably benign |
Het |
| Armh4 |
C |
A |
14: 50,011,155 (GRCm39) |
S184I |
probably damaging |
Het |
| Aspg |
T |
A |
12: 112,092,824 (GRCm39) |
D530E |
probably damaging |
Het |
| Atxn7 |
A |
T |
14: 14,100,878 (GRCm38) |
T855S |
probably benign |
Het |
| Blmh |
G |
C |
11: 76,859,451 (GRCm39) |
G351R |
probably damaging |
Het |
| Cc2d2a |
C |
T |
5: 43,857,321 (GRCm39) |
R454* |
probably null |
Het |
| Cenpp |
T |
C |
13: 49,619,233 (GRCm39) |
E188G |
probably damaging |
Het |
| Cimip3 |
A |
G |
17: 47,748,114 (GRCm39) |
|
probably null |
Het |
| Creg2 |
T |
C |
1: 39,662,376 (GRCm39) |
E252G |
probably benign |
Het |
| Dot1l |
A |
G |
10: 80,622,857 (GRCm39) |
Y636C |
probably damaging |
Het |
| Dpy30 |
A |
G |
17: 74,614,835 (GRCm39) |
I36T |
probably benign |
Het |
| Eed |
A |
G |
7: 89,613,935 (GRCm39) |
|
probably null |
Het |
| Fmn1 |
A |
G |
2: 113,195,353 (GRCm39) |
D351G |
unknown |
Het |
| Fra10ac1 |
C |
T |
19: 38,212,567 (GRCm39) |
|
probably benign |
Het |
| Gdpd4 |
T |
A |
7: 97,623,136 (GRCm39) |
I249N |
probably damaging |
Het |
| Glb1l2 |
A |
T |
9: 26,676,423 (GRCm39) |
V600D |
probably null |
Het |
| Gm13889 |
A |
T |
2: 93,787,459 (GRCm39) |
|
probably benign |
Het |
| Gm17654 |
T |
A |
14: 43,813,327 (GRCm39) |
N188Y |
|
Het |
| Gm3327 |
T |
C |
14: 44,363,732 (GRCm39) |
F112S |
|
Het |
| H2-Ab1 |
T |
C |
17: 34,482,316 (GRCm39) |
S11P |
probably benign |
Het |
| Hcn4 |
T |
C |
9: 58,763,000 (GRCm39) |
S522P |
unknown |
Het |
| Hfm1 |
T |
C |
5: 107,043,909 (GRCm39) |
T576A |
probably benign |
Het |
| Hoxa1 |
A |
G |
6: 52,135,180 (GRCm39) |
S8P |
probably damaging |
Het |
| Hoxd13 |
A |
G |
2: 74,499,369 (GRCm39) |
Y239C |
probably damaging |
Het |
| Ifih1 |
T |
A |
2: 62,440,859 (GRCm39) |
I485L |
probably benign |
Het |
| Ift52 |
G |
A |
2: 162,871,716 (GRCm39) |
V183M |
probably damaging |
Het |
| Ikbkb |
A |
G |
8: 23,161,658 (GRCm39) |
V410A |
possibly damaging |
Het |
| Il22ra1 |
G |
A |
4: 135,478,473 (GRCm39) |
V515I |
probably benign |
Het |
| Klk1b3 |
A |
T |
7: 43,850,863 (GRCm39) |
I132F |
probably damaging |
Het |
| Limk2 |
T |
C |
11: 3,305,448 (GRCm39) |
T206A |
possibly damaging |
Het |
| Llph |
A |
T |
10: 120,067,240 (GRCm39) |
|
probably benign |
Het |
| Lrrc26 |
T |
A |
2: 25,180,087 (GRCm39) |
D29E |
probably benign |
Het |
| Ltbp4 |
A |
G |
7: 27,007,191 (GRCm39) |
|
probably null |
Het |
| Mageb3 |
A |
T |
2: 121,784,973 (GRCm39) |
V243E |
probably damaging |
Het |
| Mfhas1 |
T |
C |
8: 36,055,792 (GRCm39) |
V89A |
probably benign |
Het |
| Mycbp2 |
G |
A |
14: 103,393,534 (GRCm39) |
T2899I |
possibly damaging |
Het |
| Nckap5 |
A |
T |
1: 126,186,449 (GRCm39) |
|
probably null |
Het |
| Ncor1 |
T |
C |
11: 62,275,619 (GRCm39) |
D530G |
probably null |
Het |
| Or10ag55-ps1 |
T |
A |
2: 87,114,775 (GRCm39) |
M47K |
probably benign |
Het |
| Or56a3b |
C |
T |
7: 104,771,170 (GRCm39) |
R169* |
probably null |
Het |
| Pax4 |
A |
G |
6: 28,446,322 (GRCm39) |
I57T |
probably damaging |
Het |
| Peg12 |
T |
C |
7: 62,113,711 (GRCm39) |
I129V |
possibly damaging |
Het |
| Pex6 |
G |
A |
17: 47,031,447 (GRCm39) |
A416T |
probably benign |
Het |
| Pgghg |
G |
A |
7: 140,524,631 (GRCm39) |
R326H |
probably benign |
Het |
| Pgk2 |
T |
A |
17: 40,519,366 (GRCm39) |
M21L |
probably benign |
Het |
| Polh |
A |
T |
17: 46,509,642 (GRCm39) |
W64R |
probably benign |
Het |
| Rassf7 |
T |
A |
7: 140,797,556 (GRCm39) |
H256Q |
probably benign |
Het |
| Rc3h2 |
A |
G |
2: 37,265,258 (GRCm39) |
M1184T |
probably benign |
Het |
| Ror1 |
A |
T |
4: 100,299,436 (GRCm39) |
E936D |
probably benign |
Het |
| Skic3 |
G |
A |
13: 76,283,079 (GRCm39) |
A769T |
probably damaging |
Het |
| Slco1b2 |
A |
T |
6: 141,617,974 (GRCm39) |
T440S |
probably damaging |
Het |
| Specc1 |
T |
A |
11: 62,008,604 (GRCm39) |
V40E |
probably damaging |
Het |
| Tarbp1 |
T |
A |
8: 127,201,234 (GRCm39) |
S191C |
possibly damaging |
Het |
| Timm22 |
A |
G |
11: 76,298,071 (GRCm39) |
E14G |
possibly damaging |
Het |
| Tpp2 |
T |
A |
1: 44,022,318 (GRCm39) |
D905E |
probably damaging |
Het |
| Trav7-5 |
T |
C |
14: 53,768,756 (GRCm39) |
L108P |
probably damaging |
Het |
| Ttc9b |
A |
G |
7: 27,353,667 (GRCm39) |
T106A |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,545,012 (GRCm39) |
S32697G |
probably damaging |
Het |
| Usp17la |
T |
G |
7: 104,510,514 (GRCm39) |
L373R |
probably benign |
Het |
| Vmn1r113 |
A |
G |
7: 20,521,427 (GRCm39) |
N73S |
probably benign |
Het |
| Vmn1r42 |
T |
C |
6: 89,822,051 (GRCm39) |
T173A |
possibly damaging |
Het |
| Vmn2r111 |
T |
C |
17: 22,778,032 (GRCm39) |
N549S |
possibly damaging |
Het |
| Vmn2r25 |
T |
A |
6: 123,800,569 (GRCm39) |
D591V |
probably damaging |
Het |
| Zc3h13 |
T |
C |
14: 75,559,227 (GRCm39) |
S379P |
probably benign |
Het |
| Zfp870 |
T |
C |
17: 33,102,456 (GRCm39) |
Y292C |
probably damaging |
Het |
| Zfp977 |
A |
T |
7: 42,229,786 (GRCm39) |
N246K |
possibly damaging |
Het |
| Zp1 |
G |
A |
19: 10,896,104 (GRCm39) |
T207M |
probably damaging |
Het |
|
| Other mutations in Vmn2r106 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00979:Vmn2r106
|
APN |
17 |
20,497,837 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01313:Vmn2r106
|
APN |
17 |
20,498,651 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01419:Vmn2r106
|
APN |
17 |
20,499,807 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01574:Vmn2r106
|
APN |
17 |
20,488,572 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01796:Vmn2r106
|
APN |
17 |
20,488,314 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01893:Vmn2r106
|
APN |
17 |
20,497,730 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01895:Vmn2r106
|
APN |
17 |
20,499,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02378:Vmn2r106
|
APN |
17 |
20,497,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02430:Vmn2r106
|
APN |
17 |
20,499,158 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02664:Vmn2r106
|
APN |
17 |
20,488,344 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03308:Vmn2r106
|
APN |
17 |
20,498,785 (GRCm39) |
nonsense |
probably null |
|
|
IGL03384:Vmn2r106
|
APN |
17 |
20,488,405 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0401:Vmn2r106
|
UTSW |
17 |
20,499,281 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0842:Vmn2r106
|
UTSW |
17 |
20,488,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0964:Vmn2r106
|
UTSW |
17 |
20,487,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1235:Vmn2r106
|
UTSW |
17 |
20,499,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1709:Vmn2r106
|
UTSW |
17 |
20,499,373 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1712:Vmn2r106
|
UTSW |
17 |
20,498,997 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1770:Vmn2r106
|
UTSW |
17 |
20,488,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2049:Vmn2r106
|
UTSW |
17 |
20,488,566 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2245:Vmn2r106
|
UTSW |
17 |
20,488,423 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2336:Vmn2r106
|
UTSW |
17 |
20,488,470 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2910:Vmn2r106
|
UTSW |
17 |
20,498,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3025:Vmn2r106
|
UTSW |
17 |
20,499,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3944:Vmn2r106
|
UTSW |
17 |
20,487,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4081:Vmn2r106
|
UTSW |
17 |
20,487,818 (GRCm39) |
nonsense |
probably null |
|
|
R4153:Vmn2r106
|
UTSW |
17 |
20,488,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4356:Vmn2r106
|
UTSW |
17 |
20,499,910 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4426:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4590:Vmn2r106
|
UTSW |
17 |
20,497,728 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4661:Vmn2r106
|
UTSW |
17 |
20,487,885 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5106:Vmn2r106
|
UTSW |
17 |
20,499,395 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5341:Vmn2r106
|
UTSW |
17 |
20,497,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5509:Vmn2r106
|
UTSW |
17 |
20,498,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5826:Vmn2r106
|
UTSW |
17 |
20,499,133 (GRCm39) |
missense |
probably benign |
|
|
R5859:Vmn2r106
|
UTSW |
17 |
20,505,583 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5937:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
nonsense |
probably null |
|
|
R5972:Vmn2r106
|
UTSW |
17 |
20,498,738 (GRCm39) |
missense |
probably benign |
|
|
R6056:Vmn2r106
|
UTSW |
17 |
20,487,806 (GRCm39) |
splice site |
probably null |
|
|
R6108:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6114:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6115:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6132:Vmn2r106
|
UTSW |
17 |
20,488,666 (GRCm39) |
missense |
probably benign |
|
|
R6208:Vmn2r106
|
UTSW |
17 |
20,488,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6217:Vmn2r106
|
UTSW |
17 |
20,488,501 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6289:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Vmn2r106
|
UTSW |
17 |
20,498,667 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6390:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6391:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6392:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6405:Vmn2r106
|
UTSW |
17 |
20,499,361 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6427:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6435:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6436:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6437:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6511:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6512:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6587:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6703:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6730:Vmn2r106
|
UTSW |
17 |
20,499,096 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6961:Vmn2r106
|
UTSW |
17 |
20,488,646 (GRCm39) |
nonsense |
probably null |
|
|
R7379:Vmn2r106
|
UTSW |
17 |
20,488,037 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7402:Vmn2r106
|
UTSW |
17 |
20,487,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7497:Vmn2r106
|
UTSW |
17 |
20,488,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7692:Vmn2r106
|
UTSW |
17 |
20,505,490 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8539:Vmn2r106
|
UTSW |
17 |
20,499,271 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8827:Vmn2r106
|
UTSW |
17 |
20,487,868 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8872:Vmn2r106
|
UTSW |
17 |
20,488,401 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9118:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9254:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9379:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAGCATAGTCAGTAACATGTGG -3'
(R):5'- ATGATCCCATCTTGAGTGACCG -3'
Sequencing Primer
(F):5'- GTGGTTCAATGTTCAAGACCCAGAC -3'
(R):5'- GATCCCATCTTGAGTGACCGAAGTC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation