Mutagenetix > Incidental Mutation

Incidental Mutation 'R5937:Vmn2r106'

462347

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r106

Ensembl Gene

ENSMUSG00000091656

Gene Name

vomeronasal 2, receptor 106

Synonyms

EG224576

MMRRC Submission

043242-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R5937 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

20487809-20505692 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 20505667 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 9 (W9*)

Ref Sequence

ENSEMBL: ENSMUSP00000126534 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167464]

AlphaFold

E9PY92

Predicted Effect

probably null
Transcript: ENSMUST00000167464
AA Change: W9*

SMART Domains

Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: W9*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	471	3.8e-37	PFAM
Pfam:NCD3G	514	567	5.7e-22	PFAM
Pfam:7tm_3	596	835	1.3e-49	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 97.3%
20x: 91.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1bg	A	T	15: 60,791,495 (GRCm39)	W314R	probably benign	Het
Adgrv1	A	T	13: 81,255,194 (GRCm39)	V6143E	probably damaging	Het
Agap3	C	T	5: 24,682,815 (GRCm39)	T261I	probably damaging	Het
Ano6	T	C	15: 95,811,838 (GRCm39)	I241T	probably damaging	Het
Arhgef28	T	C	13: 98,076,051 (GRCm39)	T1328A	probably benign	Het
Capn10	C	T	1: 92,867,105 (GRCm39)	R112W	probably damaging	Het
Car5a	A	T	8: 122,666,560 (GRCm39)	W46R	probably damaging	Het
Cntn6	C	A	6: 104,810,064 (GRCm39)	T582K	possibly damaging	Het
Ctsh	T	C	9: 89,943,509 (GRCm39)	V60A	probably benign	Het
Ctsll3	A	G	13: 60,947,410 (GRCm39)	F259L	probably damaging	Het
Dennd2b	A	T	7: 109,156,478 (GRCm39)	C91S	possibly damaging	Het
Fam228a	T	C	12: 4,787,725 (GRCm39)	E16G	probably damaging	Het
G3bp2	A	G	5: 92,203,256 (GRCm39)	I388T	probably damaging	Het
Galnt5	A	T	2: 57,928,949 (GRCm39)	K926N	probably benign	Het
Gm10097	G	A	10: 5,019,485 (GRCm39)		probably benign	Het
Gm9978	T	A	10: 78,322,675 (GRCm39)		noncoding transcript	Het
Gria1	A	G	11: 57,080,559 (GRCm39)	T112A	probably benign	Het
Hnrnpk	A	C	13: 58,543,016 (GRCm39)	V134G	probably damaging	Het
Insr	A	G	8: 3,224,808 (GRCm39)	V220A	probably benign	Het
Lhx4	A	G	1: 155,586,023 (GRCm39)	I96T	probably damaging	Het
Lrp1	T	C	10: 127,419,745 (GRCm39)	T955A	possibly damaging	Het
Lrtm1	T	C	14: 28,743,787 (GRCm39)	V85A	possibly damaging	Het
Man2a2	T	C	7: 80,013,251 (GRCm39)	Y514C	probably damaging	Het
Npas1	T	A	7: 16,197,187 (GRCm39)	D226V	probably benign	Het
Nrcam	G	A	12: 44,619,074 (GRCm39)	V858I	probably benign	Het
Or14c40	G	T	7: 86,313,684 (GRCm39)	L271F	probably benign	Het
Or5b108	T	A	19: 13,168,675 (GRCm39)	S215T	probably damaging	Het
Pde6b	G	T	5: 108,572,193 (GRCm39)	A478S	probably benign	Het
Pex1	T	A	5: 3,674,487 (GRCm39)	N789K	possibly damaging	Het
Plekha6	A	G	1: 133,187,839 (GRCm39)	D120G	possibly damaging	Het
Pomgnt1	A	G	4: 116,011,110 (GRCm39)	T220A	probably benign	Het
Sdr39u1	A	T	14: 56,135,364 (GRCm39)	I193K	probably damaging	Het
Sec61a2	C	A	2: 5,891,368 (GRCm39)	M54I	probably benign	Het
Sema5a	A	G	15: 32,574,987 (GRCm39)	Y365C	probably damaging	Het
Sra1	C	T	18: 36,804,652 (GRCm39)		probably null	Het
Taf5	C	T	19: 47,070,334 (GRCm39)	S640L	probably damaging	Het
Tas2r140	T	A	6: 133,032,236 (GRCm39)	H174L	probably benign	Het
Tmem63a	T	A	1: 180,788,716 (GRCm39)	V351D	probably damaging	Het
Ttll7	C	T	3: 146,649,847 (GRCm39)	Q626*	probably null	Het
Ubn2	T	A	6: 38,440,917 (GRCm39)	V263E	possibly damaging	Het
Xrcc3	C	G	12: 111,774,406 (GRCm39)	C141S	probably null	Het
Zfp516	T	A	18: 82,974,958 (GRCm39)	D385E	probably damaging	Het

Other mutations in Vmn2r106

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00979:Vmn2r106	APN	17	20,497,837 (GRCm39)	missense	possibly damaging	0.90
IGL01313:Vmn2r106	APN	17	20,498,651 (GRCm39)	missense	probably damaging	0.99
IGL01419:Vmn2r106	APN	17	20,499,807 (GRCm39)	missense	probably benign	0.06
IGL01574:Vmn2r106	APN	17	20,488,572 (GRCm39)	missense	possibly damaging	0.94
IGL01796:Vmn2r106	APN	17	20,488,314 (GRCm39)	missense	possibly damaging	0.79
IGL01893:Vmn2r106	APN	17	20,497,730 (GRCm39)	missense	probably benign	0.06
IGL01895:Vmn2r106	APN	17	20,499,227 (GRCm39)	missense	probably benign	0.02
IGL02378:Vmn2r106	APN	17	20,497,791 (GRCm39)	missense	probably damaging	1.00
IGL02430:Vmn2r106	APN	17	20,499,158 (GRCm39)	missense	probably benign	0.38
IGL02664:Vmn2r106	APN	17	20,488,344 (GRCm39)	missense	possibly damaging	0.88
IGL03308:Vmn2r106	APN	17	20,498,785 (GRCm39)	nonsense	probably null
IGL03384:Vmn2r106	APN	17	20,488,405 (GRCm39)	missense	probably damaging	0.99
R0401:Vmn2r106	UTSW	17	20,499,281 (GRCm39)	missense	possibly damaging	0.86
R0842:Vmn2r106	UTSW	17	20,488,465 (GRCm39)	missense	probably damaging	1.00
R0964:Vmn2r106	UTSW	17	20,487,859 (GRCm39)	missense	probably benign	0.00
R1235:Vmn2r106	UTSW	17	20,499,741 (GRCm39)	missense	probably benign	0.00
R1709:Vmn2r106	UTSW	17	20,499,373 (GRCm39)	missense	probably benign	0.12
R1712:Vmn2r106	UTSW	17	20,498,997 (GRCm39)	missense	probably benign	0.01
R1770:Vmn2r106	UTSW	17	20,488,560 (GRCm39)	missense	probably damaging	0.99
R2049:Vmn2r106	UTSW	17	20,488,566 (GRCm39)	missense	possibly damaging	0.90
R2245:Vmn2r106	UTSW	17	20,488,423 (GRCm39)	missense	probably benign	0.13
R2336:Vmn2r106	UTSW	17	20,488,470 (GRCm39)	missense	probably benign	0.18
R2910:Vmn2r106	UTSW	17	20,498,946 (GRCm39)	missense	probably damaging	1.00
R3025:Vmn2r106	UTSW	17	20,499,147 (GRCm39)	missense	probably benign	0.00
R3944:Vmn2r106	UTSW	17	20,487,913 (GRCm39)	missense	probably damaging	1.00
R4081:Vmn2r106	UTSW	17	20,487,818 (GRCm39)	nonsense	probably null
R4153:Vmn2r106	UTSW	17	20,488,080 (GRCm39)	missense	probably damaging	1.00
R4356:Vmn2r106	UTSW	17	20,499,910 (GRCm39)	missense	probably benign	0.06
R4426:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.00
R4590:Vmn2r106	UTSW	17	20,497,728 (GRCm39)	missense	probably damaging	0.99
R4661:Vmn2r106	UTSW	17	20,487,885 (GRCm39)	missense	probably benign	0.10
R5106:Vmn2r106	UTSW	17	20,499,395 (GRCm39)	critical splice acceptor site	probably null
R5341:Vmn2r106	UTSW	17	20,497,788 (GRCm39)	missense	probably benign	0.00
R5509:Vmn2r106	UTSW	17	20,498,684 (GRCm39)	missense	probably damaging	0.99
R5826:Vmn2r106	UTSW	17	20,499,133 (GRCm39)	missense	probably benign
R5859:Vmn2r106	UTSW	17	20,505,583 (GRCm39)	missense	possibly damaging	0.72
R5972:Vmn2r106	UTSW	17	20,498,738 (GRCm39)	missense	probably benign
R6056:Vmn2r106	UTSW	17	20,487,806 (GRCm39)	splice site	probably null
R6108:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6114:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6115:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6132:Vmn2r106	UTSW	17	20,488,666 (GRCm39)	missense	probably benign
R6208:Vmn2r106	UTSW	17	20,488,591 (GRCm39)	missense	probably damaging	0.99
R6217:Vmn2r106	UTSW	17	20,488,501 (GRCm39)	missense	probably benign	0.10
R6289:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6378:Vmn2r106	UTSW	17	20,498,667 (GRCm39)	missense	probably benign	0.19
R6390:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6391:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6392:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6405:Vmn2r106	UTSW	17	20,499,361 (GRCm39)	missense	probably benign	0.22
R6427:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6435:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6436:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6511:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6512:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6587:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6703:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6730:Vmn2r106	UTSW	17	20,499,096 (GRCm39)	missense	possibly damaging	0.64
R6961:Vmn2r106	UTSW	17	20,488,646 (GRCm39)	nonsense	probably null
R7054:Vmn2r106	UTSW	17	20,499,182 (GRCm39)	missense	probably damaging	0.96
R7379:Vmn2r106	UTSW	17	20,488,037 (GRCm39)	missense	possibly damaging	0.75
R7402:Vmn2r106	UTSW	17	20,487,883 (GRCm39)	missense	probably damaging	0.99
R7497:Vmn2r106	UTSW	17	20,488,201 (GRCm39)	missense	probably damaging	1.00
R7692:Vmn2r106	UTSW	17	20,505,490 (GRCm39)	missense	possibly damaging	0.96
R8539:Vmn2r106	UTSW	17	20,499,271 (GRCm39)	missense	probably benign	0.00
R8827:Vmn2r106	UTSW	17	20,487,868 (GRCm39)	missense	probably benign	0.05
R8872:Vmn2r106	UTSW	17	20,488,401 (GRCm39)	missense	probably benign	0.19
R9118:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	missense	probably benign	0.00
R9254:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9379:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- TTATTCCACCTGAGAGAGGAAAAG -3'
(R):5'- AAATTCCCAATGCCAGGGG -3'

Sequencing Primer
(F):5'- CCACCTGAGAGAGGAAAAGAAGCC -3'
(R):5'- CCAATGCCAGGGGAGGAAGTAATAG -3'

Posted On

2017-02-28