Incidental Mutation 'R0673:Lingo3'
| ID |
61527 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lingo3
|
| Ensembl Gene |
ENSMUSG00000051067 |
| Gene Name |
leucine rich repeat and Ig domain containing 3 |
| Synonyms |
LERN2 |
| MMRRC Submission |
038858-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.072)
|
| Stock # |
R0673 (G1)
|
| Quality Score |
94 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
80668635-80679873 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 80671618 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Leucine
at position 104
(R104L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000054960
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053986]
[ENSMUST00000219924]
|
| AlphaFold |
Q6GQU6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053986
AA Change: R104L
PolyPhen 2
Score 0.110 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000054960
Gene: ENSMUSG00000051067
AA Change: R104L
| Domain | Start | End | E-Value | Type |
|---|
|
LRRNT
|
23 |
57 |
1.54e-5 |
SMART |
|
LRR_TYP
|
76 |
99 |
1.38e-3 |
SMART |
|
LRR_TYP
|
100 |
123 |
4.94e-5 |
SMART |
|
LRR
|
124 |
147 |
3.86e0 |
SMART |
|
LRR
|
148 |
171 |
4.98e-1 |
SMART |
|
LRR
|
172 |
195 |
1.62e1 |
SMART |
|
LRR
|
246 |
267 |
3.46e2 |
SMART |
|
LRR
|
269 |
291 |
3.86e0 |
SMART |
|
LRR
|
292 |
315 |
3.24e0 |
SMART |
|
LRR
|
316 |
339 |
4.34e-1 |
SMART |
|
LRRCT
|
351 |
404 |
7.18e-3 |
SMART |
|
IGc2
|
419 |
486 |
3.12e-14 |
SMART |
|
transmembrane domain
|
526 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
581 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000219924
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.4%
- 20x: 95.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600014C23Rik |
C |
T |
17: 46,043,999 (GRCm39) |
W86* |
probably null |
Het |
| 2700049A03Rik |
C |
T |
12: 71,224,642 (GRCm39) |
P894S |
probably damaging |
Het |
| Adgrg7 |
A |
T |
16: 56,593,849 (GRCm39) |
N122K |
possibly damaging |
Het |
| Ankrd13d |
A |
T |
19: 4,323,047 (GRCm39) |
|
probably null |
Het |
| Blm |
A |
T |
7: 80,149,499 (GRCm39) |
|
probably null |
Het |
| Caml |
C |
T |
13: 55,779,641 (GRCm39) |
T238M |
probably damaging |
Het |
| Casd1 |
T |
A |
6: 4,624,440 (GRCm39) |
V411D |
possibly damaging |
Het |
| Cdc25b |
A |
G |
2: 131,039,182 (GRCm39) |
N516D |
probably benign |
Het |
| Cmya5 |
A |
G |
13: 93,226,505 (GRCm39) |
I2861T |
probably damaging |
Het |
| Csmd3 |
A |
G |
15: 47,777,336 (GRCm39) |
L1294P |
probably damaging |
Het |
| Cxxc1 |
A |
G |
18: 74,351,984 (GRCm39) |
D287G |
possibly damaging |
Het |
| Dgkq |
T |
C |
5: 108,803,455 (GRCm39) |
H217R |
probably damaging |
Het |
| Disp2 |
A |
T |
2: 118,621,325 (GRCm39) |
I686F |
possibly damaging |
Het |
| Dnah6 |
T |
A |
6: 73,100,794 (GRCm39) |
N2003I |
probably benign |
Het |
| Dsc3 |
T |
A |
18: 20,122,647 (GRCm39) |
R92S |
probably damaging |
Het |
| Ei24 |
T |
G |
9: 36,699,551 (GRCm39) |
|
probably null |
Het |
| Fgl1 |
G |
T |
8: 41,644,661 (GRCm39) |
T281K |
probably benign |
Het |
| Gbp3 |
A |
G |
3: 142,271,015 (GRCm39) |
T140A |
probably benign |
Het |
| Gtpbp3 |
A |
T |
8: 71,945,379 (GRCm39) |
I485F |
probably damaging |
Het |
| Harbi1 |
C |
T |
2: 91,542,880 (GRCm39) |
R114W |
probably damaging |
Het |
| Inmt |
A |
C |
6: 55,148,212 (GRCm39) |
V139G |
probably damaging |
Het |
| Inpp5j |
T |
A |
11: 3,451,147 (GRCm39) |
M501L |
probably benign |
Het |
| Jmjd1c |
A |
G |
10: 67,062,588 (GRCm39) |
N1647S |
probably damaging |
Het |
| Lgals9 |
A |
G |
11: 78,856,679 (GRCm39) |
F252L |
probably damaging |
Het |
| Lrrc8c |
G |
A |
5: 105,755,544 (GRCm39) |
V440M |
probably damaging |
Het |
| Mybpc3 |
G |
A |
2: 90,950,772 (GRCm39) |
G36D |
probably damaging |
Het |
| Ncapd3 |
T |
A |
9: 26,998,773 (GRCm39) |
N1254K |
probably benign |
Het |
| Neb |
A |
G |
2: 52,146,136 (GRCm39) |
V2947A |
possibly damaging |
Het |
| Nudt12 |
A |
T |
17: 59,314,617 (GRCm39) |
|
probably null |
Het |
| Or2l5 |
A |
G |
16: 19,334,146 (GRCm39) |
M80T |
probably damaging |
Het |
| Or4c3d |
A |
C |
2: 89,882,596 (GRCm39) |
M24R |
probably benign |
Het |
| Otop1 |
T |
C |
5: 38,445,292 (GRCm39) |
V150A |
possibly damaging |
Het |
| Prr14l |
C |
T |
5: 32,986,259 (GRCm39) |
D1079N |
probably benign |
Het |
| Rasal1 |
A |
G |
5: 120,808,449 (GRCm39) |
T494A |
probably benign |
Het |
| Sacs |
A |
G |
14: 61,447,664 (GRCm39) |
K3237E |
possibly damaging |
Het |
| Sh3d19 |
T |
C |
3: 86,014,280 (GRCm39) |
S415P |
probably benign |
Het |
| Sypl1 |
A |
T |
12: 33,015,420 (GRCm39) |
T40S |
probably damaging |
Het |
| Tg |
A |
T |
15: 66,613,333 (GRCm39) |
|
probably null |
Het |
| Tmed8 |
A |
G |
12: 87,220,878 (GRCm39) |
V236A |
probably damaging |
Het |
| Vmn1r33 |
T |
C |
6: 66,588,783 (GRCm39) |
Y257C |
probably damaging |
Het |
| Yme1l1 |
T |
C |
2: 23,058,300 (GRCm39) |
F144S |
probably benign |
Het |
|
| Other mutations in Lingo3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01141:Lingo3
|
APN |
10 |
80,671,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02120:Lingo3
|
APN |
10 |
80,671,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02755:Lingo3
|
APN |
10 |
80,671,843 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02938:Lingo3
|
APN |
10 |
80,670,988 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02945:Lingo3
|
APN |
10 |
80,670,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03167:Lingo3
|
APN |
10 |
80,671,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Lingo3
|
UTSW |
10 |
80,671,618 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0645:Lingo3
|
UTSW |
10 |
80,671,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1250:Lingo3
|
UTSW |
10 |
80,670,605 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1521:Lingo3
|
UTSW |
10 |
80,671,555 (GRCm39) |
missense |
probably benign |
|
|
R1794:Lingo3
|
UTSW |
10 |
80,671,432 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4665:Lingo3
|
UTSW |
10 |
80,671,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5587:Lingo3
|
UTSW |
10 |
80,671,364 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6458:Lingo3
|
UTSW |
10 |
80,671,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7082:Lingo3
|
UTSW |
10 |
80,671,625 (GRCm39) |
missense |
probably benign |
|
|
R7231:Lingo3
|
UTSW |
10 |
80,670,938 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7314:Lingo3
|
UTSW |
10 |
80,670,707 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7390:Lingo3
|
UTSW |
10 |
80,670,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Lingo3
|
UTSW |
10 |
80,670,671 (GRCm39) |
nonsense |
probably null |
|
|
R7650:Lingo3
|
UTSW |
10 |
80,671,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7894:Lingo3
|
UTSW |
10 |
80,670,610 (GRCm39) |
nonsense |
probably null |
|
|
R7920:Lingo3
|
UTSW |
10 |
80,670,382 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8070:Lingo3
|
UTSW |
10 |
80,671,955 (GRCm39) |
start gained |
probably benign |
|
|
R8095:Lingo3
|
UTSW |
10 |
80,671,255 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8171:Lingo3
|
UTSW |
10 |
80,670,595 (GRCm39) |
missense |
probably benign |
|
|
R8178:Lingo3
|
UTSW |
10 |
80,670,464 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8425:Lingo3
|
UTSW |
10 |
80,670,816 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9053:Lingo3
|
UTSW |
10 |
80,670,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9059:Lingo3
|
UTSW |
10 |
80,670,523 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9706:Lingo3
|
UTSW |
10 |
80,670,288 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9794:Lingo3
|
UTSW |
10 |
80,670,707 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Z1176:Lingo3
|
UTSW |
10 |
80,670,689 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGATGAACACCAGGTCATTGTCGC -3'
(R):5'- TGGGTCAACGTCCTTGTGTCTAGC -3'
Sequencing Primer
(F):5'- AGGTCATTGTCGCCCACC -3'
(R):5'- CGTGGATACTGATAAAGTCTATCCCC -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation