Mutagenetix > Incidental Mutation

Incidental Mutation 'R0883:Nalcn'

80910

Institutional Source

Beutler Lab

Gene Symbol

Nalcn

Ensembl Gene

ENSMUSG00000000197

Gene Name

sodium leak channel, non-selective

Synonyms

Vgcnl1, A530023G15Rik

MMRRC Submission

039050-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0883 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

123514046-123864556 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123702152 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 453 (F453S)

Ref Sequence

ENSEMBL: ENSMUSP00000000201 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000201]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000000201
AA Change: F453S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000000201
Gene: ENSMUSG00000000197
AA Change: F453S

Domain	Start	End	E-Value	Type
Pfam:Ion_trans	35	333	2.8e-37	PFAM
low complexity region	338	348	N/A	INTRINSIC
Pfam:Ion_trans	383	609	5.7e-34	PFAM
coiled coil region	796	830	N/A	INTRINSIC
Pfam:Ion_trans	885	1166	2.4e-42	PFAM
Pfam:Ion_trans	1209	1458	6.9e-30	PFAM
low complexity region	1548	1560	N/A	INTRINSIC
low complexity region	1634	1649	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227818

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228860

Meta Mutation Damage Score

0.9622

Coding Region Coverage

1x: 99.5%
3x: 99.0%
10x: 97.8%
20x: 96.1%

Validation Efficiency

98% (148/151)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal breathing at birth and die within 24 hours. Mice homozygous for a gain of function ENU mutation exhibit reduced the total amount and episode duration of REMS. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 150 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	T	C	3: 137,775,632 (GRCm39)	L1607P	probably damaging	Het
1700016H13Rik	T	C	5: 103,796,687 (GRCm39)	*118W	probably null	Het
4930595M18Rik	G	T	X: 80,464,537 (GRCm39)	T390N	possibly damaging	Het
Abca13	C	T	11: 9,241,238 (GRCm39)	Q1034*	probably null	Het
Acsbg3	A	T	17: 57,190,835 (GRCm39)	N468Y	probably benign	Het
Adgra3	T	C	5: 50,118,065 (GRCm39)	H1161R	probably damaging	Het
Aff1	T	C	5: 103,974,004 (GRCm39)		probably benign	Het
Agap2	A	G	10: 126,927,571 (GRCm39)	T1131A	possibly damaging	Het
Ankrd12	A	G	17: 66,292,127 (GRCm39)	V1102A	probably benign	Het
Ankrd54	A	T	15: 78,946,931 (GRCm39)	C23S	probably damaging	Het
Anxa10	C	T	8: 62,531,001 (GRCm39)	V70I	probably benign	Het
Asap3	T	C	4: 135,961,636 (GRCm39)		probably benign	Het
Asb13	T	C	13: 3,695,052 (GRCm39)		probably null	Het
Atp6v1a	A	T	16: 43,922,055 (GRCm39)		probably benign	Het
Atp8b1	T	G	18: 64,697,612 (GRCm39)	I411L	probably benign	Het
Baiap3	T	A	17: 25,468,075 (GRCm39)	N313I	probably damaging	Het
Bok	T	C	1: 93,614,209 (GRCm39)	I14T	probably benign	Het
Bri3bp	T	A	5: 125,518,808 (GRCm39)		probably null	Het
C2cd2l	A	G	9: 44,227,499 (GRCm39)	L186P	probably damaging	Het
Cadm2	A	T	16: 66,679,702 (GRCm39)	C44S	probably damaging	Het
Capn11	T	C	17: 45,949,807 (GRCm39)		probably benign	Het
Carm1	T	A	9: 21,480,887 (GRCm39)		probably benign	Het
Ccdc27	T	C	4: 154,120,941 (GRCm39)	E285G	unknown	Het
Cct3	T	A	3: 88,220,864 (GRCm39)	D298E	probably damaging	Het
Cd59b	T	A	2: 103,911,331 (GRCm39)		probably benign	Het
Cdh2	T	C	18: 16,762,633 (GRCm39)	N437S	probably benign	Het
Celsr3	T	A	9: 108,719,832 (GRCm39)	I2470N	probably damaging	Het
Cfap100	G	A	6: 90,392,888 (GRCm39)		probably benign	Het
Cfap119	T	C	7: 127,184,034 (GRCm39)	E261G	probably damaging	Het
Cfap45	A	T	1: 172,359,756 (GRCm39)	R98S	possibly damaging	Het
Cfap54	T	A	10: 92,706,531 (GRCm39)	H2757L	unknown	Het
Chd1	C	A	17: 15,945,693 (GRCm39)	N72K	probably benign	Het
Cntn4	A	T	6: 106,644,501 (GRCm39)		probably benign	Het
Cstf2t	A	T	19: 31,062,026 (GRCm39)	M521L	probably benign	Het
Daam2	A	T	17: 49,805,911 (GRCm39)		probably benign	Het
Ddias	A	T	7: 92,508,545 (GRCm39)	W457R	probably benign	Het
Ddr2	C	T	1: 169,822,198 (GRCm39)	V417I	probably benign	Het
Dhx57	T	C	17: 80,577,800 (GRCm39)	T570A	probably damaging	Het
Dmp1	A	G	5: 104,355,496 (GRCm39)	E32G	possibly damaging	Het
Dtymk	C	T	1: 93,729,510 (GRCm39)	V14M	possibly damaging	Het
Dync2li1	G	A	17: 84,956,699 (GRCm39)	M286I	probably benign	Het
Eea1	G	A	10: 95,857,529 (GRCm39)	D664N	possibly damaging	Het
Esp6	G	T	17: 40,876,287 (GRCm39)	V112L	probably benign	Het
Fam83h	G	T	15: 75,878,018 (GRCm39)	Q127K	probably damaging	Het
Gabbr2	G	A	4: 46,677,474 (GRCm39)	T802I	probably benign	Het
Gart	C	A	16: 91,420,291 (GRCm39)	D851Y	possibly damaging	Het
Gemin6	T	A	17: 80,535,524 (GRCm39)	H161Q	probably damaging	Het
Gm10912	T	C	2: 103,896,875 (GRCm39)	S5P	probably benign	Het
Gm5941	G	A	X: 91,533,817 (GRCm39)	A62T	possibly damaging	Het
Gng2	G	T	14: 19,941,363 (GRCm39)	D26E	probably benign	Het
Gpr33	A	G	12: 52,070,418 (GRCm39)	V207A	probably benign	Het
Gstm3	T	A	3: 107,873,586 (GRCm39)		probably benign	Het
Havcr1	T	C	11: 46,643,259 (GRCm39)	C60R	probably damaging	Het
Hspg2	T	C	4: 137,268,751 (GRCm39)	S2157P	probably benign	Het
Ift140	A	G	17: 25,309,907 (GRCm39)	T1105A	probably benign	Het
Igsf8	C	A	1: 172,143,826 (GRCm39)	A56D	possibly damaging	Het
Kat6a	G	T	8: 23,352,230 (GRCm39)	A5S	probably damaging	Het
Kctd16	A	G	18: 40,663,828 (GRCm39)	E319G	probably damaging	Het
Kmo	T	C	1: 175,474,706 (GRCm39)	V157A	possibly damaging	Het
Lrp5	T	A	19: 3,655,308 (GRCm39)	I1071F	probably damaging	Het
Lrrc17	A	G	5: 21,766,276 (GRCm39)	T253A	probably benign	Het
Mast2	T	A	4: 116,168,964 (GRCm39)	H769L	probably damaging	Het
Mast4	T	C	13: 102,990,408 (GRCm39)	K50E	probably damaging	Het
Mbd5	A	G	2: 49,146,701 (GRCm39)	T304A	possibly damaging	Het
Mbp	T	C	18: 82,590,995 (GRCm39)	S73P	probably damaging	Het
Mc5r	T	A	18: 68,472,163 (GRCm39)	V174E	probably damaging	Het
Med13	T	A	11: 86,197,864 (GRCm39)	T736S	probably benign	Het
Med13l	T	C	5: 118,809,067 (GRCm39)		probably benign	Het
Minar1	T	C	9: 89,484,470 (GRCm39)	H309R	probably benign	Het
Mlh3	C	G	12: 85,282,488 (GRCm39)	A1382P	possibly damaging	Het
Mpdz	T	C	4: 81,278,228 (GRCm39)		probably benign	Het
Muc5ac	A	G	7: 141,350,002 (GRCm39)	T582A	possibly damaging	Het
Nrap	T	A	19: 56,333,906 (GRCm39)	M902L	probably damaging	Het
Nup85	C	T	11: 115,459,196 (GRCm39)	R100*	probably null	Het
Nxf1	T	G	19: 8,741,955 (GRCm39)	N296K	probably damaging	Het
Ogg1	A	G	6: 113,305,381 (GRCm39)	T65A	probably damaging	Het
Ogt	A	G	X: 100,687,805 (GRCm39)		probably benign	Het
Or4c10	A	G	2: 89,760,545 (GRCm39)	T131A	probably benign	Het
Or4k48	C	T	2: 111,476,136 (GRCm39)	V69I	probably benign	Het
Or51e1	T	A	7: 102,359,202 (GRCm39)	H245Q	probably damaging	Het
Or56b1b	T	A	7: 108,164,483 (GRCm39)	N173I	probably benign	Het
Ovol2	T	C	2: 144,173,710 (GRCm39)	D24G	probably damaging	Het
Pabpc1	A	G	15: 36,599,298 (GRCm39)		probably benign	Het
Pak6	T	C	2: 118,524,168 (GRCm39)	L441P	probably damaging	Het
Pappa	T	A	4: 65,107,552 (GRCm39)	C654*	probably null	Het
Paqr6	T	A	3: 88,273,298 (GRCm39)	S97T	probably damaging	Het
Parp14	T	C	16: 35,678,888 (GRCm39)	N360S	probably benign	Het
Pclo	G	T	5: 14,727,873 (GRCm39)	G2244*	probably null	Het
Pdzrn3	A	T	6: 101,132,903 (GRCm39)		probably null	Het
Pes1	T	C	11: 3,925,557 (GRCm39)	M220T	probably damaging	Het
Phip	A	T	9: 82,758,274 (GRCm39)	V1473E	probably benign	Het
Pkd2l2	T	A	18: 34,563,321 (GRCm39)		probably null	Het
Plch1	T	C	3: 63,660,677 (GRCm39)	D302G	probably damaging	Het
Plekhh2	A	G	17: 84,925,459 (GRCm39)	T1419A	probably benign	Het
Ppara	A	T	15: 85,682,372 (GRCm39)	E356V	probably damaging	Het
Ppp1r37	G	A	7: 19,266,102 (GRCm39)	P555S	probably benign	Het
Ppp6r1	T	C	7: 4,642,709 (GRCm39)	E545G	possibly damaging	Het
Proser3	G	A	7: 30,240,124 (GRCm39)	H327Y	probably damaging	Het
Prss43	T	A	9: 110,658,576 (GRCm39)	I292N	probably damaging	Het
Pwwp3b	T	A	X: 138,136,444 (GRCm39)	D327E	probably damaging	Het
Pygl	G	C	12: 70,253,178 (GRCm39)	N271K	probably damaging	Het
Rassf7	T	A	7: 140,796,903 (GRCm39)		probably benign	Het
Rfx2	T	C	17: 57,110,722 (GRCm39)	Y88C	probably damaging	Het
Rpl6	T	C	5: 121,346,541 (GRCm39)	V214A	probably benign	Het
Rspo1	T	A	4: 124,885,225 (GRCm39)		probably null	Het
Sav1	A	C	12: 70,012,979 (GRCm39)	L366V	probably benign	Het
Sema3b	T	G	9: 107,481,355 (GRCm39)	T52P	possibly damaging	Het
Senp6	A	G	9: 80,023,841 (GRCm39)	D40G	probably damaging	Het
Sh3pxd2a	A	G	19: 47,256,646 (GRCm39)	S719P	probably damaging	Het
Shank1	C	T	7: 44,001,718 (GRCm39)	R1146W	unknown	Het
Slc34a3	G	T	2: 25,121,245 (GRCm39)	D307E	probably benign	Het
Slc35b3	T	C	13: 39,121,251 (GRCm39)	I330V	probably benign	Het
Slc4a10	G	A	2: 62,073,742 (GRCm39)	C268Y	probably benign	Het
Slco6d1	A	G	1: 98,349,124 (GRCm39)	E65G	probably benign	Het
Slit2	A	G	5: 48,402,915 (GRCm39)		probably benign	Het
Smcr8	T	C	11: 60,668,941 (GRCm39)	Y30H	probably damaging	Het
Snap47	A	G	11: 59,329,326 (GRCm39)		probably benign	Het
Snrnp25	G	A	11: 32,156,960 (GRCm39)	V15I	probably damaging	Het
Spns2	T	C	11: 72,345,223 (GRCm39)	Y449C	probably damaging	Het
Stab2	T	A	10: 86,760,314 (GRCm39)		probably benign	Het
Strip1	C	A	3: 107,521,929 (GRCm39)	D750Y	probably damaging	Het
Taf1c	A	T	8: 120,326,722 (GRCm39)	I438N	probably damaging	Het
Tbc1d2	T	A	4: 46,609,003 (GRCm39)	K745*	probably null	Het
Tctn1	T	C	5: 122,402,207 (GRCm39)	T76A	probably damaging	Het
Tesl1	A	T	X: 23,773,290 (GRCm39)	I264F	probably benign	Het
Tfpi	T	C	2: 84,273,664 (GRCm39)		probably benign	Het
Timm44	A	T	8: 4,316,592 (GRCm39)	H317Q	probably benign	Het
Tnfaip1	A	T	11: 78,420,840 (GRCm39)		probably benign	Het
Tnpo3	A	T	6: 29,554,992 (GRCm39)		probably benign	Het
Top3b	T	C	16: 16,697,301 (GRCm39)		probably benign	Het
Trak1	T	A	9: 121,282,351 (GRCm39)	M410K	possibly damaging	Het
Trpm3	C	A	19: 22,956,018 (GRCm39)	P1160Q	probably damaging	Het
Tyk2	T	A	9: 21,022,433 (GRCm39)	T799S	possibly damaging	Het
Ubfd1	G	A	7: 121,666,714 (GRCm39)		probably benign	Het
Unc13a	G	A	8: 72,094,817 (GRCm39)	R1272*	probably null	Het
Unc45b	T	A	11: 82,831,031 (GRCm39)	L797Q	possibly damaging	Het
Urb2	C	T	8: 124,757,709 (GRCm39)	Q1139*	probably null	Het
Vmn2r66	A	T	7: 84,657,070 (GRCm39)	S112T	probably benign	Het
Vmn2r71	A	T	7: 85,272,842 (GRCm39)	D552V	probably benign	Het
Vmn2r76	A	G	7: 85,877,904 (GRCm39)	Y498H	probably benign	Het
Vmn2r84	A	C	10: 130,226,984 (GRCm39)	W285G	probably damaging	Het
Vps72	G	T	3: 95,029,894 (GRCm39)	L304F	probably damaging	Het
Wiz	A	T	17: 32,575,415 (GRCm39)	I907N	probably damaging	Het
Yaf2	T	C	15: 93,183,417 (GRCm39)	K131R	probably damaging	Het
Zfp141	A	T	7: 42,125,480 (GRCm39)	Y331N	possibly damaging	Het
Zfp324	G	T	7: 12,704,951 (GRCm39)	C380F	probably damaging	Het
Zfp521	T	C	18: 13,978,119 (GRCm39)	T765A	probably benign	Het
Zfp616	A	T	11: 73,976,500 (GRCm39)	H923L	probably damaging	Het
Zfpm1	C	T	8: 123,062,585 (GRCm39)	T548M	probably damaging	Het
Zp2	A	T	7: 119,742,799 (GRCm39)		probably benign	Het

Other mutations in Nalcn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00952:Nalcn	APN	14	123,586,201 (GRCm39)	missense	probably benign	0.00
IGL00964:Nalcn	APN	14	123,532,796 (GRCm39)	splice site	probably benign
IGL01310:Nalcn	APN	14	123,554,661 (GRCm39)	missense	probably benign	0.00
IGL01578:Nalcn	APN	14	123,809,503 (GRCm39)	missense	probably benign	0.00
IGL01925:Nalcn	APN	14	123,529,260 (GRCm39)	missense	possibly damaging	0.88
IGL02072:Nalcn	APN	14	123,560,770 (GRCm39)	missense	probably benign	0.05
IGL02096:Nalcn	APN	14	123,831,915 (GRCm39)	missense	probably benign	0.11
IGL02212:Nalcn	APN	14	123,752,742 (GRCm39)	missense	probably damaging	0.99
IGL02306:Nalcn	APN	14	123,560,750 (GRCm39)	missense	probably benign	0.07
IGL02471:Nalcn	APN	14	123,560,726 (GRCm39)	missense	probably benign	0.02
IGL02478:Nalcn	APN	14	123,558,717 (GRCm39)	missense	probably benign	0.26
IGL02551:Nalcn	APN	14	123,560,750 (GRCm39)	missense	probably benign	0.07
IGL02630:Nalcn	APN	14	123,555,291 (GRCm39)	missense	probably benign	0.16
IGL02632:Nalcn	APN	14	123,555,265 (GRCm39)	missense	probably benign	0.11
IGL02661:Nalcn	APN	14	123,830,321 (GRCm39)	splice site	probably benign
IGL02830:Nalcn	APN	14	123,530,881 (GRCm39)	missense	probably damaging	0.98
IGL02939:Nalcn	APN	14	123,536,284 (GRCm39)	missense	probably null	1.00
IGL03035:Nalcn	APN	14	123,515,630 (GRCm39)	nonsense	probably null
IGL03226:Nalcn	APN	14	123,518,527 (GRCm39)	missense	probably benign	0.00
IGL03242:Nalcn	APN	14	123,558,899 (GRCm39)	missense	possibly damaging	0.91
Narnia	UTSW	14	123,528,459 (GRCm39)	missense	probably benign	0.11
R0019:Nalcn	UTSW	14	123,744,901 (GRCm39)	missense	probably benign	0.18
R0144:Nalcn	UTSW	14	123,647,251 (GRCm39)	splice site	probably benign
R0144:Nalcn	UTSW	14	123,608,948 (GRCm39)	missense	probably damaging	0.96
R0359:Nalcn	UTSW	14	123,536,580 (GRCm39)	missense	probably damaging	1.00
R0383:Nalcn	UTSW	14	123,744,971 (GRCm39)	missense	probably benign	0.01
R0400:Nalcn	UTSW	14	123,528,372 (GRCm39)	splice site	probably benign
R0467:Nalcn	UTSW	14	123,528,459 (GRCm39)	missense	probably benign	0.11
R0506:Nalcn	UTSW	14	123,834,026 (GRCm39)	missense	possibly damaging	0.82
R0583:Nalcn	UTSW	14	123,531,755 (GRCm39)	missense	possibly damaging	0.46
R0620:Nalcn	UTSW	14	123,536,553 (GRCm39)	splice site	probably benign
R0624:Nalcn	UTSW	14	123,607,444 (GRCm39)	missense	probably benign
R1381:Nalcn	UTSW	14	123,551,517 (GRCm39)	missense	probably damaging	1.00
R1467:Nalcn	UTSW	14	123,702,068 (GRCm39)	splice site	probably benign
R1689:Nalcn	UTSW	14	123,522,666 (GRCm39)	missense	probably damaging	1.00
R1726:Nalcn	UTSW	14	123,545,816 (GRCm39)	missense	probably damaging	1.00
R1774:Nalcn	UTSW	14	123,515,678 (GRCm39)	missense	probably benign
R1854:Nalcn	UTSW	14	123,697,824 (GRCm39)	missense	probably damaging	1.00
R1869:Nalcn	UTSW	14	123,831,965 (GRCm39)	missense	possibly damaging	0.96
R1871:Nalcn	UTSW	14	123,831,965 (GRCm39)	missense	possibly damaging	0.96
R1873:Nalcn	UTSW	14	123,521,013 (GRCm39)	missense	probably benign	0.00
R1899:Nalcn	UTSW	14	123,553,538 (GRCm39)	missense	possibly damaging	0.50
R1915:Nalcn	UTSW	14	123,540,181 (GRCm39)	missense	probably benign	0.08
R2016:Nalcn	UTSW	14	123,831,993 (GRCm39)	splice site	probably null
R2034:Nalcn	UTSW	14	123,521,015 (GRCm39)	missense	probably benign	0.01
R2087:Nalcn	UTSW	14	123,518,557 (GRCm39)	missense	probably benign
R2149:Nalcn	UTSW	14	123,607,429 (GRCm39)	missense	probably benign	0.01
R2157:Nalcn	UTSW	14	123,647,164 (GRCm39)	missense	probably benign	0.32
R2166:Nalcn	UTSW	14	123,607,363 (GRCm39)	missense	probably benign	0.00
R2932:Nalcn	UTSW	14	123,830,430 (GRCm39)	missense	probably benign	0.06
R3408:Nalcn	UTSW	14	123,834,029 (GRCm39)	missense	probably null	0.98
R3778:Nalcn	UTSW	14	123,702,128 (GRCm39)	missense	probably damaging	1.00
R3807:Nalcn	UTSW	14	123,515,599 (GRCm39)	missense	probably damaging	1.00
R3835:Nalcn	UTSW	14	123,530,834 (GRCm39)	splice site	probably benign
R3937:Nalcn	UTSW	14	123,607,357 (GRCm39)	missense	probably benign	0.00
R4001:Nalcn	UTSW	14	123,834,006 (GRCm39)	missense	probably damaging	1.00
R4015:Nalcn	UTSW	14	123,723,799 (GRCm39)	missense	probably damaging	1.00
R4033:Nalcn	UTSW	14	123,837,401 (GRCm39)	splice site	probably benign
R4231:Nalcn	UTSW	14	123,837,325 (GRCm39)	missense	probably benign	0.01
R4464:Nalcn	UTSW	14	123,560,762 (GRCm39)	missense	probably benign
R4512:Nalcn	UTSW	14	123,532,860 (GRCm39)	missense	probably damaging	1.00
R4542:Nalcn	UTSW	14	123,558,889 (GRCm39)	synonymous	silent
R4557:Nalcn	UTSW	14	123,558,647 (GRCm39)	intron	probably benign
R4869:Nalcn	UTSW	14	123,837,296 (GRCm39)	missense	probably benign	0.44
R5083:Nalcn	UTSW	14	123,560,706 (GRCm39)	splice site	probably null
R5109:Nalcn	UTSW	14	123,515,650 (GRCm39)	missense	possibly damaging	0.86
R5131:Nalcn	UTSW	14	123,753,182 (GRCm39)	missense	probably damaging	0.98
R5158:Nalcn	UTSW	14	123,753,149 (GRCm39)	missense	probably damaging	1.00
R5259:Nalcn	UTSW	14	123,753,063 (GRCm39)	missense	possibly damaging	0.94
R5422:Nalcn	UTSW	14	123,752,777 (GRCm39)	missense	probably damaging	1.00
R5514:Nalcn	UTSW	14	123,521,123 (GRCm39)	missense	probably benign	0.14
R5523:Nalcn	UTSW	14	123,647,155 (GRCm39)	missense	probably damaging	1.00
R5551:Nalcn	UTSW	14	123,515,698 (GRCm39)	missense	possibly damaging	0.57
R5667:Nalcn	UTSW	14	123,532,818 (GRCm39)	missense	probably damaging	1.00
R5671:Nalcn	UTSW	14	123,532,818 (GRCm39)	missense	probably damaging	1.00
R5750:Nalcn	UTSW	14	123,809,450 (GRCm39)	missense	probably benign
R5765:Nalcn	UTSW	14	123,702,138 (GRCm39)	missense	possibly damaging	0.46
R6324:Nalcn	UTSW	14	123,647,161 (GRCm39)	missense	possibly damaging	0.83
R6523:Nalcn	UTSW	14	123,555,255 (GRCm39)	missense	probably benign	0.00
R6558:Nalcn	UTSW	14	123,723,919 (GRCm39)	missense	probably benign
R6631:Nalcn	UTSW	14	123,697,663 (GRCm39)	missense	probably benign	0.17
R6667:Nalcn	UTSW	14	123,558,735 (GRCm39)	missense	probably damaging	1.00
R6670:Nalcn	UTSW	14	123,702,084 (GRCm39)	missense	possibly damaging	0.96
R6724:Nalcn	UTSW	14	123,535,479 (GRCm39)	missense	probably damaging	0.99
R6731:Nalcn	UTSW	14	123,837,346 (GRCm39)	missense	probably benign	0.22
R6957:Nalcn	UTSW	14	123,744,966 (GRCm39)	missense	probably damaging	0.96
R6970:Nalcn	UTSW	14	123,551,506 (GRCm39)	missense	possibly damaging	0.46
R7010:Nalcn	UTSW	14	123,530,877 (GRCm39)	missense	probably damaging	1.00
R7018:Nalcn	UTSW	14	123,647,233 (GRCm39)	missense	probably damaging	1.00
R7040:Nalcn	UTSW	14	123,525,267 (GRCm39)	missense	probably benign
R7089:Nalcn	UTSW	14	123,515,761 (GRCm39)	missense	probably benign	0.01
R7128:Nalcn	UTSW	14	123,831,914 (GRCm39)	missense	probably damaging	0.99
R7149:Nalcn	UTSW	14	123,837,277 (GRCm39)	missense	probably benign	0.02
R7361:Nalcn	UTSW	14	123,529,251 (GRCm39)	missense	probably benign	0.00
R7378:Nalcn	UTSW	14	123,540,302 (GRCm39)	missense	probably damaging	1.00
R7408:Nalcn	UTSW	14	123,529,272 (GRCm39)	missense	probably benign	0.00
R7470:Nalcn	UTSW	14	123,809,456 (GRCm39)	missense	probably benign	0.09
R7483:Nalcn	UTSW	14	123,551,499 (GRCm39)	missense	probably damaging	1.00
R7521:Nalcn	UTSW	14	123,530,870 (GRCm39)	missense	probably damaging	1.00
R7558:Nalcn	UTSW	14	123,723,797 (GRCm39)	critical splice donor site	probably null
R7585:Nalcn	UTSW	14	123,753,050 (GRCm39)	missense	probably damaging	1.00
R7591:Nalcn	UTSW	14	123,561,297 (GRCm39)	missense	probably benign	0.01
R7761:Nalcn	UTSW	14	123,531,792 (GRCm39)	missense	probably damaging	1.00
R7761:Nalcn	UTSW	14	123,531,791 (GRCm39)	missense	probably damaging	1.00
R7811:Nalcn	UTSW	14	123,536,357 (GRCm39)	missense	probably damaging	1.00
R7983:Nalcn	UTSW	14	123,830,409 (GRCm39)	missense	probably benign	0.17
R8089:Nalcn	UTSW	14	123,537,372 (GRCm39)	missense	probably damaging	1.00
R8110:Nalcn	UTSW	14	123,702,113 (GRCm39)	missense	probably benign	0.00
R8190:Nalcn	UTSW	14	123,837,351 (GRCm39)	missense	possibly damaging	0.69
R8273:Nalcn	UTSW	14	123,554,436 (GRCm39)	missense	probably damaging	1.00
R8407:Nalcn	UTSW	14	123,554,683 (GRCm39)	missense	probably damaging	1.00
R8497:Nalcn	UTSW	14	123,752,771 (GRCm39)	missense	probably damaging	1.00
R8544:Nalcn	UTSW	14	123,608,935 (GRCm39)	missense	probably benign	0.40
R8549:Nalcn	UTSW	14	123,607,448 (GRCm39)	missense	probably benign	0.01
R8731:Nalcn	UTSW	14	123,837,266 (GRCm39)	missense	probably benign	0.01
R8862:Nalcn	UTSW	14	123,647,199 (GRCm39)	missense	possibly damaging	0.96
R8919:Nalcn	UTSW	14	123,561,284 (GRCm39)	missense	probably benign	0.00
R9072:Nalcn	UTSW	14	123,532,863 (GRCm39)	missense	possibly damaging	0.66
R9073:Nalcn	UTSW	14	123,532,863 (GRCm39)	missense	possibly damaging	0.66
R9182:Nalcn	UTSW	14	123,834,016 (GRCm39)	missense	probably damaging	1.00
R9193:Nalcn	UTSW	14	123,545,792 (GRCm39)	nonsense	probably null
R9241:Nalcn	UTSW	14	123,809,429 (GRCm39)	missense	probably benign	0.00
R9267:Nalcn	UTSW	14	123,518,567 (GRCm39)	missense	probably benign	0.08
R9274:Nalcn	UTSW	14	123,753,068 (GRCm39)	missense	probably damaging	1.00
R9277:Nalcn	UTSW	14	123,518,523 (GRCm39)	missense	probably damaging	0.98
R9376:Nalcn	UTSW	14	123,515,713 (GRCm39)	missense	possibly damaging	0.74
X0060:Nalcn	UTSW	14	123,522,653 (GRCm39)	missense	probably damaging	1.00
Z1177:Nalcn	UTSW	14	123,831,980 (GRCm39)	missense	probably damaging	1.00
Z1177:Nalcn	UTSW	14	123,531,857 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGAATCTCCCTCAGAGCCATATTACCAA -3'
(R):5'- TGAAGCATCATCCTCAGAGCAGGT -3'

Sequencing Primer
(F):5'- GCAACTTCCCTTTTCCTGAGGA -3'
(R):5'- gcagacacccacactcac -3'

Posted On

2013-11-07