Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01712:Olfr136'

104807

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr136

Ensembl Gene

ENSMUSG00000096840

Gene Name

olfactory receptor 136

Synonyms

GA_x6K02T2PSCP-2779375-2780313, MOR256-7

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL01712

Quality Score

Status

Chromosome

Chromosomal Location

38329831-38336643 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 38335957 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 267 (T267S)

Ref Sequence

ENSEMBL: ENSMUSP00000149856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077203] [ENSMUST00000208525] [ENSMUST00000208539] [ENSMUST00000214035] [ENSMUST00000216963]

Predicted Effect

probably benign
Transcript: ENSMUST00000077203
AA Change: T267S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000076443
Gene: ENSMUSG00000096840
AA Change: T267S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.6e-48	PFAM
Pfam:7tm_1	41	290	7.1e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000208525
AA Change: T267S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

Predicted Effect

probably benign
Transcript: ENSMUST00000208539
AA Change: T267S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

Predicted Effect

probably benign
Transcript: ENSMUST00000214035
AA Change: T267S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

Predicted Effect

probably benign
Transcript: ENSMUST00000216963
AA Change: T267S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb3	A	G	1: 25,826,279	V161A	probably benign	Het
Arhgdib	G	A	6: 136,924,197	T178M	probably damaging	Het
Atp11a	T	A	8: 12,851,138	I989K	probably benign	Het
Bcam	T	C	7: 19,758,767	S498G	probably damaging	Het
Bcas3	A	G	11: 85,581,048	I728V	probably damaging	Het
Cep57	G	T	9: 13,813,417	P119Q	possibly damaging	Het
Clip4	T	A	17: 71,799,041	I73N	probably damaging	Het
Cpa4	A	G	6: 30,590,816	D371G	possibly damaging	Het
Dnah7a	A	G	1: 53,423,270	S3721P	probably benign	Het
Fam166a	T	C	2: 25,218,792		probably benign	Het
Fcrla	T	C	1: 170,921,623		probably null	Het
Foxg1	T	C	12: 49,385,620	S379P	possibly damaging	Het
Gatm	T	A	2: 122,600,825	Y227F	possibly damaging	Het
Gm8298	T	A	3: 59,868,900	I164N	possibly damaging	Het
Grid2	A	T	6: 64,665,915	D887V	possibly damaging	Het
Gtpbp6	A	T	5: 110,104,379	I429N	probably benign	Het
Ighmbp2	A	G	19: 3,273,038		probably benign	Het
Irs4	T	C	X: 141,722,399	N934D	unknown	Het
Kif16b	T	A	2: 142,648,471	N1257I	probably damaging	Het
L1cam	T	C	X: 73,864,438	Y169C	probably damaging	Het
L3mbtl3	A	T	10: 26,276,235	M821K	probably damaging	Het
Lig3	A	G	11: 82,789,541		probably benign	Het
Lpin2	T	A	17: 71,215,068	D32E	probably damaging	Het
Mcoln3	T	C	3: 146,128,264		probably benign	Het
Mgst2	T	C	3: 51,664,571	V40A	probably damaging	Het
Mov10l1	T	C	15: 89,024,766	S997P	probably damaging	Het
Mycbpap	G	T	11: 94,512,655	H187Q	possibly damaging	Het
Olfr652	T	C	7: 104,565,019	V266A	probably benign	Het
Onecut2	T	A	18: 64,386,602	S478T	probably damaging	Het
Pcdhb5	A	T	18: 37,321,253	I229F	probably damaging	Het
Pfas	A	G	11: 68,991,060	V933A	probably benign	Het
Phldb2	A	T	16: 45,751,429	I1200N	probably damaging	Het
Pla2g4e	C	A	2: 120,189,403		probably null	Het
Prr36	G	A	8: 4,215,243	P169L	probably damaging	Het
Rhot2	A	G	17: 25,841,360		probably null	Het
Serpina3f	C	T	12: 104,218,398	P267L	probably damaging	Het
Sppl2a	C	T	2: 126,904,903		probably benign	Het
Tas2r122	A	T	6: 132,711,762	M56K	possibly damaging	Het
Tbxas1	A	G	6: 39,081,060	T450A	probably benign	Het
Tex16	T	C	X: 112,093,754	S87P	probably damaging	Het
Them7	T	A	2: 105,378,885	F183L	possibly damaging	Het
Tmbim7	A	G	5: 3,670,074	T116A	probably damaging	Het
Tomm40	G	T	7: 19,703,363	S224R	probably benign	Het
Top3a	A	T	11: 60,761,736	I84N	probably damaging	Het
Vmn1r28	A	G	6: 58,265,408	T79A	probably benign	Het
Vmn2r61	A	T	7: 42,260,237	Y62F	probably damaging	Het
Zbtb42	T	C	12: 112,680,284	C298R	probably benign	Het
Zfp395	G	A	14: 65,386,387	E102K	probably damaging	Het

Other mutations in Olfr136

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01787:Olfr136	APN	17	38335579	missense	probably damaging	0.98
IGL02480:Olfr136	APN	17	38335423	missense	probably benign	0.32
IGL02603:Olfr136	APN	17	38335513	missense	probably damaging	1.00
IGL03122:Olfr136	APN	17	38335301	missense	probably benign	0.01
R0295:Olfr136	UTSW	17	38335291	missense	probably damaging	1.00
R0684:Olfr136	UTSW	17	38335844	missense	probably benign	0.11
R1874:Olfr136	UTSW	17	38335969	missense	probably damaging	1.00
R3436:Olfr136	UTSW	17	38335432	missense	probably damaging	1.00
R3437:Olfr136	UTSW	17	38335432	missense	probably damaging	1.00
R4714:Olfr136	UTSW	17	38335840	missense	possibly damaging	0.65
R4715:Olfr136	UTSW	17	38335840	missense	possibly damaging	0.65
R4716:Olfr136	UTSW	17	38335840	missense	possibly damaging	0.65
R4878:Olfr136	UTSW	17	38335627	missense	probably benign
R5296:Olfr136	UTSW	17	38335456	nonsense	probably null
R5370:Olfr136	UTSW	17	38335444	nonsense	probably null
R5413:Olfr136	UTSW	17	38335624	missense	probably benign	0.03
R5988:Olfr136	UTSW	17	38336020	missense	probably damaging	1.00
R6156:Olfr136	UTSW	17	38335173	missense	probably damaging	0.99
R6550:Olfr136	UTSW	17	38336005	missense	possibly damaging	0.65
R7395:Olfr136	UTSW	17	38335864	nonsense	probably null
R7417:Olfr136	UTSW	17	38335292	missense	probably damaging	1.00
R7746:Olfr136	UTSW	17	38335394	missense	probably benign	0.16
R7747:Olfr136	UTSW	17	38335394	missense	probably benign	0.16
R7821:Olfr136	UTSW	17	38335964	missense	probably benign	0.13
V5088:Olfr136	UTSW	17	38335159	start codon destroyed	probably null	0.99
Z1176:Olfr136	UTSW	17	38335352	missense	probably damaging	1.00

Posted On

2014-01-21