Incidental Mutation 'R1254:Vmn1r7'
| ID |
151384 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r7
|
| Ensembl Gene |
ENSMUSG00000093696 |
| Gene Name |
vomeronasal 1 receptor 7 |
| Synonyms |
V1rc31, Gm5568 |
| MMRRC Submission |
039321-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.121)
|
| Stock # |
R1254 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
57001323-57002258 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 57001772 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 163
(C163R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135571
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176252]
|
| AlphaFold |
E9Q8T0 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176252
AA Change: C163R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135571
Gene: ENSMUSG00000093696
AA Change: C163R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
1.1e-59 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 96.2%
- 20x: 92.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb10 |
C |
T |
8: 124,688,791 (GRCm39) |
G495D |
probably damaging |
Het |
| Ccdc39 |
T |
C |
3: 33,880,629 (GRCm39) |
K446R |
probably damaging |
Het |
| Coro2b |
A |
G |
9: 62,336,247 (GRCm39) |
L280P |
probably damaging |
Het |
| D430041D05Rik |
T |
G |
2: 104,031,648 (GRCm39) |
K1649N |
probably damaging |
Het |
| Duox2 |
T |
A |
2: 122,113,959 (GRCm39) |
H1191L |
probably damaging |
Het |
| Etl4 |
A |
G |
2: 20,812,734 (GRCm39) |
T1430A |
probably damaging |
Het |
| Hivep3 |
A |
G |
4: 119,956,490 (GRCm39) |
Y1602C |
probably damaging |
Het |
| Ints6 |
A |
G |
14: 62,953,823 (GRCm39) |
S180P |
probably benign |
Het |
| Jarid2 |
T |
A |
13: 45,059,752 (GRCm39) |
N661K |
probably damaging |
Het |
| Klhdc3 |
C |
T |
17: 46,988,993 (GRCm39) |
V66I |
probably benign |
Het |
| Or5p56 |
T |
A |
7: 107,589,647 (GRCm39) |
V25D |
probably benign |
Het |
| Pank1 |
T |
C |
19: 34,818,260 (GRCm39) |
H93R |
probably benign |
Het |
| Pcdhb16 |
T |
G |
18: 37,612,348 (GRCm39) |
V436G |
possibly damaging |
Het |
| Plekha6 |
G |
A |
1: 133,200,327 (GRCm39) |
R302H |
probably benign |
Het |
| Ptk2 |
C |
T |
15: 73,101,819 (GRCm39) |
R797Q |
probably benign |
Het |
| Rnase10 |
A |
T |
14: 51,247,083 (GRCm39) |
M117L |
probably damaging |
Het |
| Rnf151 |
A |
T |
17: 24,936,526 (GRCm39) |
C20* |
probably null |
Het |
| Robo4 |
T |
C |
9: 37,322,136 (GRCm39) |
|
probably null |
Het |
| Rps6ka5 |
G |
T |
12: 100,585,788 (GRCm39) |
H168Q |
probably damaging |
Het |
| Sstr1 |
G |
A |
12: 58,260,108 (GRCm39) |
V244M |
possibly damaging |
Het |
| Tmem147 |
A |
T |
7: 30,428,795 (GRCm39) |
Y17* |
probably null |
Het |
|
| Other mutations in Vmn1r7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Vmn1r7
|
APN |
6 |
57,001,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01528:Vmn1r7
|
APN |
6 |
57,001,532 (GRCm39) |
missense |
probably benign |
|
|
IGL02024:Vmn1r7
|
APN |
6 |
57,001,874 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02234:Vmn1r7
|
APN |
6 |
57,001,537 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02610:Vmn1r7
|
APN |
6 |
57,002,037 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02691:Vmn1r7
|
APN |
6 |
57,001,373 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0529:Vmn1r7
|
UTSW |
6 |
57,001,450 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0548:Vmn1r7
|
UTSW |
6 |
57,002,066 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1279:Vmn1r7
|
UTSW |
6 |
57,001,934 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1582:Vmn1r7
|
UTSW |
6 |
57,002,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1973:Vmn1r7
|
UTSW |
6 |
57,002,011 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1991:Vmn1r7
|
UTSW |
6 |
57,001,853 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2160:Vmn1r7
|
UTSW |
6 |
57,001,879 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3546:Vmn1r7
|
UTSW |
6 |
57,001,834 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3547:Vmn1r7
|
UTSW |
6 |
57,001,834 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5901:Vmn1r7
|
UTSW |
6 |
57,001,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6294:Vmn1r7
|
UTSW |
6 |
57,001,404 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7063:Vmn1r7
|
UTSW |
6 |
57,001,418 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7192:Vmn1r7
|
UTSW |
6 |
57,001,452 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7647:Vmn1r7
|
UTSW |
6 |
57,002,255 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7781:Vmn1r7
|
UTSW |
6 |
57,001,553 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9457:Vmn1r7
|
UTSW |
6 |
57,001,508 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTATGAAGATGCTTGCATTGCCTC -3'
(R):5'- AGACCTGATCTCCTGTCAACTGTCC -3'
Sequencing Primer
(F):5'- TGCCTCTGATGCCTGAACAAG -3'
(R):5'- CTACTTATTCAGAGTGATGAGAGGC -3'
|
| Posted On |
2014-01-29 |
Incidental Mutation