Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01762:Vmn2r124'

153262

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r124

Ensembl Gene

ENSMUSG00000094396

Gene Name

vomeronasal 2, receptor 124

Synonyms

Vmn2r-ps113, Gm7196

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.270) question?

Stock #

IGL01762

Quality Score

Status

Chromosome

Chromosomal Location

18269746-18294482 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18283434 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 376 (Q376R)

Ref Sequence

ENSEMBL: ENSMUSP00000135613 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176802] [ENSMUST00000231546]

AlphaFold

K7N789

Predicted Effect

possibly damaging
Transcript: ENSMUST00000176802
AA Change: Q376R

PolyPhen 2 Score 0.506 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000135613
Gene: ENSMUSG00000094396
AA Change: Q376R

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	84	449	2.2e-37	PFAM
Pfam:NCD3G	510	563	9.3e-21	PFAM
Pfam:7tm_3	596	831	1.6e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231546

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030612E09Rik	T	A	10: 43,050,847 (GRCm39)	L47*	probably null	Het
Abca13	A	T	11: 9,265,423 (GRCm39)	T3033S	probably benign	Het
Atp1a2	C	A	1: 172,112,480 (GRCm39)	V503L	possibly damaging	Het
Cacna1e	T	A	1: 154,347,119 (GRCm39)	D770V	possibly damaging	Het
Camkk1	A	G	11: 72,921,627 (GRCm39)		probably null	Het
Cd34	T	A	1: 194,621,341 (GRCm39)	M23K	probably benign	Het
Cndp1	T	A	18: 84,640,411 (GRCm39)	I265F	probably damaging	Het
Cux2	A	G	5: 122,011,208 (GRCm39)	I574T	probably damaging	Het
Fhdc1	G	A	3: 84,352,042 (GRCm39)	A1061V	possibly damaging	Het
Galk1	A	G	11: 115,900,834 (GRCm39)	Y236H	probably damaging	Het
Gbp11	T	C	5: 105,475,473 (GRCm39)	I292V	probably benign	Het
Gprc5c	A	G	11: 114,754,850 (GRCm39)	I176V	probably benign	Het
Hrob	T	C	11: 102,146,422 (GRCm39)	C233R	probably benign	Het
Myh6	T	C	14: 55,199,538 (GRCm39)	K258E	probably benign	Het
Niban1	T	C	1: 151,512,242 (GRCm39)	V48A	probably damaging	Het
Nlrp9c	T	A	7: 26,084,850 (GRCm39)	D243V	probably damaging	Het
Nobox	T	G	6: 43,280,927 (GRCm39)	K516Q	probably damaging	Het
Nudcd3	A	G	11: 6,100,560 (GRCm39)	S195P	probably damaging	Het
Pde10a	T	C	17: 9,161,750 (GRCm39)	I477T	possibly damaging	Het
Pgbd5	C	T	8: 125,097,349 (GRCm39)	A394T	probably damaging	Het
Piezo1	G	A	8: 123,214,668 (GRCm39)	R1553*	probably null	Het
Prkd1	T	C	12: 50,434,013 (GRCm39)	I577V	probably benign	Het
Prss34	T	C	17: 25,518,786 (GRCm39)	I256T	probably benign	Het
Ptprg	A	G	14: 12,037,386 (GRCm38)	T189A	probably benign	Het
Ptprr	C	T	10: 116,072,638 (GRCm39)	T200I	probably damaging	Het
Samd8	C	T	14: 21,830,168 (GRCm39)	P198L	probably damaging	Het
Sema3c	T	C	5: 17,899,849 (GRCm39)	L447P	possibly damaging	Het
Slc22a23	A	T	13: 34,387,984 (GRCm39)	F371I	possibly damaging	Het
Slc2a2	A	G	3: 28,771,621 (GRCm39)	R184G	probably damaging	Het
Slitrk6	T	A	14: 110,989,056 (GRCm39)	D217V	probably damaging	Het
Tlr2	A	G	3: 83,744,301 (GRCm39)	V594A	probably benign	Het
Vmn2r109	A	G	17: 20,774,654 (GRCm39)	F234L	probably benign	Het
Vmn2r12	A	C	5: 109,234,430 (GRCm39)	L594R	probably damaging	Het
Vmn2r7	T	C	3: 64,598,856 (GRCm39)	D567G	probably benign	Het

Other mutations in Vmn2r124

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00988:Vmn2r124	APN	17	18,282,932 (GRCm39)	missense	probably benign	0.04
IGL01356:Vmn2r124	APN	17	18,293,733 (GRCm39)	missense	probably benign	0.08
IGL01387:Vmn2r124	APN	17	18,283,188 (GRCm39)	missense	probably damaging	0.98
IGL01413:Vmn2r124	APN	17	18,282,827 (GRCm39)	missense	probably benign	0.41
IGL01550:Vmn2r124	APN	17	18,283,617 (GRCm39)	critical splice donor site	probably null
IGL01759:Vmn2r124	APN	17	18,284,330 (GRCm39)	missense	probably benign	0.00
IGL02132:Vmn2r124	APN	17	18,284,491 (GRCm39)	splice site	probably benign
IGL02290:Vmn2r124	APN	17	18,293,597 (GRCm39)	missense	probably benign	0.09
IGL02370:Vmn2r124	APN	17	18,284,453 (GRCm39)	missense	probably benign	0.14
IGL02527:Vmn2r124	APN	17	18,286,764 (GRCm39)	critical splice acceptor site	probably null
PIT4280001:Vmn2r124	UTSW	17	18,283,487 (GRCm39)	missense	probably benign	0.22
PIT4514001:Vmn2r124	UTSW	17	18,293,974 (GRCm39)	missense	probably benign	0.01
R0362:Vmn2r124	UTSW	17	18,284,486 (GRCm39)	critical splice donor site	probably null
R0401:Vmn2r124	UTSW	17	18,284,407 (GRCm39)	missense	probably damaging	0.99
R0513:Vmn2r124	UTSW	17	18,293,991 (GRCm39)	missense	possibly damaging	0.89
R1139:Vmn2r124	UTSW	17	18,294,052 (GRCm39)	missense	possibly damaging	0.56
R1513:Vmn2r124	UTSW	17	18,283,535 (GRCm39)	missense	probably damaging	1.00
R1669:Vmn2r124	UTSW	17	18,283,206 (GRCm39)	missense	possibly damaging	0.94
R1710:Vmn2r124	UTSW	17	18,282,187 (GRCm39)	splice site	probably benign
R1852:Vmn2r124	UTSW	17	18,283,436 (GRCm39)	missense	probably benign
R1860:Vmn2r124	UTSW	17	18,269,759 (GRCm39)	missense	probably benign	0.11
R1953:Vmn2r124	UTSW	17	18,283,122 (GRCm39)	missense	probably benign	0.08
R2233:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2234:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2235:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2397:Vmn2r124	UTSW	17	18,269,859 (GRCm39)	missense	possibly damaging	0.95
R2519:Vmn2r124	UTSW	17	18,294,280 (GRCm39)	missense	probably damaging	1.00
R3845:Vmn2r124	UTSW	17	18,293,953 (GRCm39)	missense	possibly damaging	0.90
R3846:Vmn2r124	UTSW	17	18,293,953 (GRCm39)	missense	possibly damaging	0.90
R4594:Vmn2r124	UTSW	17	18,294,231 (GRCm39)	missense	probably damaging	1.00
R4612:Vmn2r124	UTSW	17	18,283,284 (GRCm39)	missense	probably benign	0.12
R4790:Vmn2r124	UTSW	17	18,269,855 (GRCm39)	missense	probably damaging	1.00
R4809:Vmn2r124	UTSW	17	18,294,007 (GRCm39)	missense	probably benign	0.00
R5227:Vmn2r124	UTSW	17	18,269,819 (GRCm39)	missense	possibly damaging	0.95
R5254:Vmn2r124	UTSW	17	18,283,339 (GRCm39)	missense	probably benign	0.00
R5609:Vmn2r124	UTSW	17	18,294,102 (GRCm39)	missense	probably benign
R6145:Vmn2r124	UTSW	17	18,283,113 (GRCm39)	missense	probably benign	0.05
R6181:Vmn2r124	UTSW	17	18,294,019 (GRCm39)	missense	possibly damaging	0.93
R6271:Vmn2r124	UTSW	17	18,283,145 (GRCm39)	missense	probably benign	0.01
R7297:Vmn2r124	UTSW	17	18,293,835 (GRCm39)	missense	probably damaging	1.00
R7397:Vmn2r124	UTSW	17	18,282,947 (GRCm39)	missense	probably damaging	1.00
R7406:Vmn2r124	UTSW	17	18,282,306 (GRCm39)	missense	unknown
R7699:Vmn2r124	UTSW	17	18,293,985 (GRCm39)	missense	probably benign	0.00
R7859:Vmn2r124	UTSW	17	18,282,212 (GRCm39)	missense	probably damaging	1.00
R8121:Vmn2r124	UTSW	17	18,282,433 (GRCm39)	missense	probably benign
R8138:Vmn2r124	UTSW	17	18,283,610 (GRCm39)	missense	probably damaging	0.99
R8756:Vmn2r124	UTSW	17	18,294,094 (GRCm39)	missense	probably benign	0.08
R8796:Vmn2r124	UTSW	17	18,282,933 (GRCm39)	missense	possibly damaging	0.95
R8841:Vmn2r124	UTSW	17	18,283,299 (GRCm39)	missense
R8960:Vmn2r124	UTSW	17	18,283,291 (GRCm39)	nonsense	probably null
R8970:Vmn2r124	UTSW	17	18,294,439 (GRCm39)	missense	probably benign
R9128:Vmn2r124	UTSW	17	18,294,439 (GRCm39)	missense	probably benign
R9566:Vmn2r124	UTSW	17	18,293,581 (GRCm39)	missense	probably benign	0.14
R9680:Vmn2r124	UTSW	17	18,293,758 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-02-04