Incidental Mutation 'IGL00229:Nmur2'
ID 2224
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nmur2
Ensembl Gene ENSMUSG00000037393
Gene Name neuromedin U receptor 2
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.193) question?
Stock # IGL00229
Quality Score
Status
Chromosome 11
Chromosomal Location 56024987-56041010 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 56040777 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 36 (L36P)
Ref Sequence ENSEMBL: ENSMUSP00000044718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037682]
AlphaFold Q8BZ39
Predicted Effect probably damaging
Transcript: ENSMUST00000037682
AA Change: L36P

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000044718
Gene: ENSMUSG00000037393
AA Change: L36P

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srw 42 337 4.7e-7 PFAM
Pfam:7TM_GPCR_Srsx 48 334 1.8e-13 PFAM
Pfam:7tm_1 54 319 5.7e-51 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134285
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for one knock-out allele exhibit increased chemical and thermal nociception thresholds, insensitivity to treatment with Nmu or Nms, and altered weight gain following a fast or when fed a high-fat diet that can be sex-dependent. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624J02Rik T A 7: 118,804,191 (GRCm38) probably benign Het
Abca4 A G 3: 122,170,954 (GRCm38) T929A probably damaging Het
Adam6b G A 12: 113,491,393 (GRCm38) R610H probably damaging Het
Adamts12 T A 15: 11,311,599 (GRCm38) M1314K probably benign Het
Alg6 T A 4: 99,753,054 (GRCm38) F152I probably damaging Het
Aopep A G 13: 63,199,500 (GRCm38) probably benign Het
Arid5b A G 10: 68,128,975 (GRCm38) S289P probably damaging Het
Axin1 T C 17: 26,194,072 (GRCm38) F780L probably damaging Het
C9 C T 15: 6,483,231 (GRCm38) S278L possibly damaging Het
Calr4 A T 4: 109,244,115 (GRCm38) I65F probably damaging Het
Cdh23 A G 10: 60,523,548 (GRCm38) V260A probably benign Het
Ddx25 T C 9: 35,543,595 (GRCm38) probably benign Het
Dppa4 A G 16: 48,291,083 (GRCm38) T92A possibly damaging Het
Ercc5 T C 1: 44,163,898 (GRCm38) Y232H probably damaging Het
Exoc4 A G 6: 33,918,399 (GRCm38) probably null Het
Fam149a A G 8: 45,351,786 (GRCm38) V253A probably damaging Het
Fam209 C T 2: 172,474,182 (GRCm38) T159I probably damaging Het
Gcfc2 A T 6: 81,936,015 (GRCm38) N265I probably damaging Het
Glud1 T C 14: 34,336,130 (GRCm38) V366A probably benign Het
Hdac10 T C 15: 89,128,442 (GRCm38) T3A probably damaging Het
Ifnar1 T C 16: 91,489,782 (GRCm38) S54P probably damaging Het
Itpr2 T C 6: 146,144,185 (GRCm38) Y2561C probably damaging Het
Klhl30 A G 1: 91,354,157 (GRCm38) E160G possibly damaging Het
Kmt2d A T 15: 98,862,333 (GRCm38) S1015T unknown Het
Lactb2 A G 1: 13,660,374 (GRCm38) M26T probably damaging Het
Lactbl1 A T 4: 136,631,051 (GRCm38) D111V probably damaging Het
Lig4 T C 8: 9,972,775 (GRCm38) Y335C probably damaging Het
Lrrc8e T A 8: 4,235,921 (GRCm38) D715E probably benign Het
Med6 A T 12: 81,579,574 (GRCm38) V142D possibly damaging Het
Men1 G A 19: 6,337,207 (GRCm38) probably null Het
Mettl13 A G 1: 162,535,865 (GRCm38) V600A possibly damaging Het
Mpdz A T 4: 81,310,224 (GRCm38) C1314* probably null Het
Nbeal2 A G 9: 110,635,869 (GRCm38) V1009A probably damaging Het
Nudt2 T A 4: 41,480,474 (GRCm38) L119Q probably damaging Het
Or5b117 T C 19: 13,453,840 (GRCm38) M226V possibly damaging Het
Osbpl3 C T 6: 50,323,068 (GRCm38) E519K probably damaging Het
Pak6 A T 2: 118,689,845 (GRCm38) T106S possibly damaging Het
Pggt1b T G 18: 46,280,719 (GRCm38) Q34P probably benign Het
Phactr4 T C 4: 132,370,992 (GRCm38) T322A possibly damaging Het
Plekhj1 T C 10: 80,796,602 (GRCm38) probably null Het
Pnpt1 T C 11: 29,154,217 (GRCm38) probably null Het
Pramel32 A G 4: 88,629,053 (GRCm38) I214T probably damaging Het
Prr14l T C 5: 32,830,676 (GRCm38) I492V probably benign Het
Ranbp2 C A 10: 58,477,256 (GRCm38) A1266E probably damaging Het
Riok3 G A 18: 12,137,020 (GRCm38) D140N probably damaging Het
Rsph4a G A 10: 33,914,343 (GRCm38) E643K probably damaging Het
Scara3 T G 14: 65,933,121 (GRCm38) E103A probably benign Het
Sgk3 T C 1: 9,868,384 (GRCm38) V33A probably damaging Het
Slc38a4 A G 15: 96,999,494 (GRCm38) F480S probably damaging Het
Slc44a1 G A 4: 53,543,571 (GRCm38) V372M probably damaging Het
Slc9a2 A G 1: 40,767,737 (GRCm38) Y728C probably benign Het
Sox4 C A 13: 28,952,973 (GRCm38) G17W probably damaging Het
Spidr A T 16: 15,895,578 (GRCm38) L847Q probably damaging Het
Sptb A G 12: 76,620,753 (GRCm38) S857P probably benign Het
Syde1 A G 10: 78,585,809 (GRCm38) V636A probably damaging Het
Syna A G 5: 134,559,717 (GRCm38) L126P possibly damaging Het
Taar2 A G 10: 23,941,368 (GRCm38) T269A possibly damaging Het
Tapbp C T 17: 33,925,704 (GRCm38) T258I probably damaging Het
Tcf20 T A 15: 82,857,142 (GRCm38) Q36L possibly damaging Het
Tmem131l A T 3: 83,942,500 (GRCm38) M260K probably damaging Het
Tnc T A 4: 64,016,824 (GRCm38) probably benign Het
Ugp2 T A 11: 21,354,345 (GRCm38) E27D probably benign Het
Wdr27 A T 17: 14,928,310 (GRCm38) C140* probably null Het
Wnt2b T C 3: 104,953,133 (GRCm38) T153A possibly damaging Het
Xirp2 A T 2: 67,513,375 (GRCm38) T1987S probably benign Het
Zfp36l1 C A 12: 80,110,464 (GRCm38) G48C probably damaging Het
Zfp474 A T 18: 52,638,493 (GRCm38) I73F possibly damaging Het
Zfp790 T A 7: 29,828,563 (GRCm38) F224L probably benign Het
Other mutations in Nmur2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01591:Nmur2 APN 11 56,026,999 (GRCm38) missense probably benign
IGL01960:Nmur2 APN 11 56,040,511 (GRCm38) missense probably damaging 0.99
IGL02108:Nmur2 APN 11 56,040,364 (GRCm38) missense probably benign 0.33
IGL02602:Nmur2 APN 11 56,027,063 (GRCm38) missense probably benign 0.19
PIT4677001:Nmur2 UTSW 11 56,033,009 (GRCm38) missense probably benign 0.00
R0324:Nmur2 UTSW 11 56,040,520 (GRCm38) missense probably damaging 1.00
R0458:Nmur2 UTSW 11 56,040,568 (GRCm38) missense possibly damaging 0.93
R0718:Nmur2 UTSW 11 56,029,498 (GRCm38) splice site probably benign
R1799:Nmur2 UTSW 11 56,029,621 (GRCm38) missense probably damaging 1.00
R2099:Nmur2 UTSW 11 56,040,763 (GRCm38) missense probably benign 0.00
R2263:Nmur2 UTSW 11 56,029,561 (GRCm38) missense probably damaging 0.97
R3701:Nmur2 UTSW 11 56,040,777 (GRCm38) missense probably damaging 0.99
R3705:Nmur2 UTSW 11 56,040,474 (GRCm38) missense probably damaging 1.00
R3951:Nmur2 UTSW 11 56,040,225 (GRCm38) missense probably damaging 1.00
R4083:Nmur2 UTSW 11 56,040,225 (GRCm38) missense probably damaging 1.00
R4744:Nmur2 UTSW 11 56,040,835 (GRCm38) missense probably benign 0.01
R4747:Nmur2 UTSW 11 56,040,279 (GRCm38) missense probably benign 0.05
R5288:Nmur2 UTSW 11 56,040,214 (GRCm38) missense probably damaging 1.00
R5384:Nmur2 UTSW 11 56,040,214 (GRCm38) missense probably damaging 1.00
R5579:Nmur2 UTSW 11 56,033,009 (GRCm38) missense probably benign 0.00
R6329:Nmur2 UTSW 11 56,029,585 (GRCm38) missense probably benign 0.30
R6477:Nmur2 UTSW 11 56,029,591 (GRCm38) missense probably damaging 1.00
R7445:Nmur2 UTSW 11 56,032,940 (GRCm38) missense probably damaging 0.97
R7580:Nmur2 UTSW 11 56,026,982 (GRCm38) missense probably benign 0.03
R7899:Nmur2 UTSW 11 56,040,335 (GRCm38) missense probably benign
R8688:Nmur2 UTSW 11 56,040,828 (GRCm38) missense probably damaging 1.00
R9090:Nmur2 UTSW 11 56,040,482 (GRCm38) missense probably benign 0.44
R9098:Nmur2 UTSW 11 56,029,582 (GRCm38) missense possibly damaging 0.93
R9271:Nmur2 UTSW 11 56,040,482 (GRCm38) missense probably benign 0.44
R9542:Nmur2 UTSW 11 56,040,823 (GRCm38) missense probably damaging 0.98
X0062:Nmur2 UTSW 11 56,040,849 (GRCm38) missense probably benign 0.01
Z1176:Nmur2 UTSW 11 56,027,101 (GRCm38) missense probably benign 0.12
Z1186:Nmur2 UTSW 11 56,040,278 (GRCm38) missense probably benign
Z1187:Nmur2 UTSW 11 56,040,278 (GRCm38) missense probably benign
Z1188:Nmur2 UTSW 11 56,040,278 (GRCm38) missense probably benign
Z1189:Nmur2 UTSW 11 56,040,278 (GRCm38) missense probably benign
Z1190:Nmur2 UTSW 11 56,040,278 (GRCm38) missense probably benign
Z1191:Nmur2 UTSW 11 56,040,278 (GRCm38) missense probably benign
Z1192:Nmur2 UTSW 11 56,040,278 (GRCm38) missense probably benign
Posted On 2011-12-09