Incidental Mutation 'R2341:Sun5'
ID246740
Institutional Source Beutler Lab
Gene Symbol Sun5
Ensembl Gene ENSMUSG00000027480
Gene NameSad1 and UNC84 domain containing 5
SynonymsSpag4l, 1700021O15Rik
MMRRC Submission 040327-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R2341 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location153856188-153871084 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 153867502 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000028982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028982]
Predicted Effect probably benign
Transcript: ENSMUST00000028982
SMART Domains Protein: ENSMUSP00000028982
Gene: ENSMUSG00000027480

DomainStartEndE-ValueType
Pfam:Sad1_UNC 204 336 8.9e-43 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124414
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129011
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 97% (36/37)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017D01Rik T A 19: 11,105,793 M88L probably benign Het
4933412E24Rik A G 15: 60,016,363 V76A possibly damaging Het
Aif1 G A 17: 35,172,151 P44L probably benign Het
Anapc4 T C 5: 52,841,937 probably benign Het
Anxa4 A G 6: 86,743,153 S144P probably benign Het
Bcr A G 10: 75,131,112 E517G probably damaging Het
Ccdc57 T C 11: 120,860,523 E907G probably benign Het
Chd6 TG T 2: 160,965,759 probably null Het
Dock6 A G 9: 21,839,486 probably benign Het
Dock8 A G 19: 25,200,393 K2031E probably damaging Het
Gm5444 T C 13: 4,834,345 noncoding transcript Het
Hlx G T 1: 184,731,987 A52D probably damaging Het
Ifna16 A G 4: 88,676,328 S177P probably damaging Het
Ino80d T C 1: 63,065,826 N364D possibly damaging Het
Ltbp2 T C 12: 84,809,163 T769A probably benign Het
Mug1 T C 6: 121,884,629 V1350A probably benign Het
Nedd9 A G 13: 41,316,511 S389P probably damaging Het
Olfr1098 T C 2: 86,922,638 K298R possibly damaging Het
Olfr1122 A T 2: 87,387,740 I12F probably benign Het
Olfr1201 A G 2: 88,794,645 N88D probably benign Het
Pole A T 5: 110,330,963 I28F possibly damaging Het
Prkce C A 17: 86,474,442 P180T probably damaging Het
Ralgapa1 T C 12: 55,677,124 H1995R possibly damaging Het
Rnf144b A G 13: 47,220,500 K58E probably benign Het
Rnf43 A G 11: 87,732,025 R651G probably damaging Het
Scel A T 14: 103,608,170 L580F possibly damaging Het
Scn4b G A 9: 45,147,829 V133M probably damaging Het
Sipa1l3 T C 7: 29,377,635 N904S probably damaging Het
Tanc2 T C 11: 105,835,051 V347A probably benign Het
Tmem245 T C 4: 56,937,957 Y197C probably damaging Het
Usp30 C T 5: 114,111,180 R182* probably null Het
Vmn2r112 T A 17: 22,603,115 V258E probably damaging Het
Vps35 T C 8: 85,274,814 probably benign Het
Xkr7 G A 2: 153,054,398 V391M possibly damaging Het
Ythdf3 A T 3: 16,203,215 probably benign Het
Zfp110 T C 7: 12,849,186 V587A probably benign Het
Other mutations in Sun5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03404:Sun5 APN 2 153871004 unclassified probably benign
R0384:Sun5 UTSW 2 153858965 missense probably benign 0.43
R0442:Sun5 UTSW 2 153870952 missense possibly damaging 0.93
R0505:Sun5 UTSW 2 153870952 missense probably damaging 1.00
R0666:Sun5 UTSW 2 153859048 missense possibly damaging 0.93
R1889:Sun5 UTSW 2 153865995 missense probably benign 0.11
R3711:Sun5 UTSW 2 153867548 missense probably benign 0.00
R4751:Sun5 UTSW 2 153866016 splice site probably null
R4762:Sun5 UTSW 2 153865363 nonsense probably null
R4821:Sun5 UTSW 2 153869466 missense probably benign
R6018:Sun5 UTSW 2 153858443 missense probably damaging 1.00
R6248:Sun5 UTSW 2 153860669 missense probably damaging 1.00
X0023:Sun5 UTSW 2 153870964 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAAGCATTTCTTGGCCTCTGC -3'
(R):5'- CAGGCTAAGATTGCAGGTTGAG -3'

Sequencing Primer
(F):5'- GGCCTCTGCAACTAAATGTTC -3'
(R):5'- AGTGAGTCTGGAGGCCCTAG -3'
Posted On2014-10-30