Incidental Mutation 'R2392:Krtap14'
ID247837
Institutional Source Beutler Lab
Gene Symbol Krtap14
Ensembl Gene ENSMUSG00000074928
Gene Namekeratin associated protein 14
SynonymsPmg1, mKAP13
MMRRC Submission 040360-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.089) question?
Stock #R2392 (G1)
Quality Score225
Status Not validated
Chromosome16
Chromosomal Location88818667-88826145 bp(-) (GRCm38)
Type of Mutationsplice site (10 bp from exon)
DNA Base Change (assembly) T to A at 88825709 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136883 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023648] [ENSMUST00000099562] [ENSMUST00000187823] [ENSMUST00000189774]
Predicted Effect probably benign
Transcript: ENSMUST00000023648
SMART Domains Protein: ENSMUSP00000023648
Gene: ENSMUSG00000022931

DomainStartEndE-ValueType
Pfam:PMG 1 126 1.8e-35 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000099562
SMART Domains Protein: ENSMUSP00000136883
Gene: ENSMUSG00000074928

DomainStartEndE-ValueType
Pfam:PMG 1 67 5.7e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000187823
SMART Domains Protein: ENSMUSP00000140888
Gene: ENSMUSG00000022931

DomainStartEndE-ValueType
Pfam:PMG 1 145 3.3e-38 PFAM
Predicted Effect silent
Transcript: ENSMUST00000189774
SMART Domains Protein: ENSMUSP00000139983
Gene: ENSMUSG00000074928

DomainStartEndE-ValueType
Pfam:PMG 1 166 1.3e-53 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232467
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency 96% (53/55)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,258,105 S2409T probably damaging Het
Acap2 A G 16: 31,139,640 F120S probably damaging Het
Akr1c6 A G 13: 4,434,478 probably null Het
Bptf C A 11: 107,072,747 A1874S probably damaging Het
Ccnl1 A G 3: 65,948,752 V244A probably damaging Het
Cenpe T G 3: 135,248,113 L1628R probably damaging Het
Cfap54 A G 10: 93,025,011 probably null Het
Chchd7 T A 4: 3,943,381 probably null Het
Col9a2 C G 4: 121,054,258 R599G probably damaging Het
Crybg2 G T 4: 134,072,614 V362L probably benign Het
Ddx11 T A 17: 66,149,973 V791E probably damaging Het
Disp1 G A 1: 183,087,167 P1230S probably benign Het
Elp5 T C 11: 69,975,102 H116R probably benign Het
Epb42 T C 2: 121,029,987 E177G possibly damaging Het
F13a1 T A 13: 36,943,997 I336F possibly damaging Het
Fabp3 C T 4: 130,312,387 T57I probably benign Het
Fuk A G 8: 110,889,724 M453T probably benign Het
Hacd2 A T 16: 35,106,378 E249V probably benign Het
Hnrnpf C A 6: 117,924,868 A371D possibly damaging Het
Jmjd1c A G 10: 67,229,904 T1703A probably damaging Het
Kcnj13 G A 1: 87,386,900 T200I possibly damaging Het
Kif1b G A 4: 149,220,620 T949M possibly damaging Het
Klhl35 G A 7: 99,473,824 A552T possibly damaging Het
Krt74 A G 15: 101,756,801 noncoding transcript Het
Lrrc45 A G 11: 120,719,539 N492S probably benign Het
Lrrcc1 T A 3: 14,536,520 N114K probably damaging Het
Mfsd2b T C 12: 4,865,164 D375G possibly damaging Het
Mgat4a A G 1: 37,498,704 L44P probably damaging Het
Mttp A C 3: 138,095,021 D774E probably damaging Het
Myo5a T C 9: 75,209,239 V1554A probably benign Het
Nes C T 3: 87,975,943 A503V probably benign Het
Nme8 A G 13: 19,688,943 probably null Het
Nr4a1 A G 15: 101,274,194 D583G possibly damaging Het
Olfr109 A G 17: 37,466,419 Y71C probably damaging Het
Olfr177 A G 16: 58,872,434 S239P probably damaging Het
Pnpla8 T A 12: 44,311,504 L746I probably damaging Het
Ppp1r7 A T 1: 93,354,341 I205F probably benign Het
Psd4 C A 2: 24,394,667 P181Q probably damaging Het
Ripor2 G A 13: 24,706,223 V694I probably benign Het
Scn10a A G 9: 119,627,202 S1185P possibly damaging Het
Sec23b T A 2: 144,585,587 probably null Het
Slfn2 A G 11: 83,065,328 N12S possibly damaging Het
Slfn4 A G 11: 83,185,422 K38R possibly damaging Het
Smarca2 G T 19: 26,640,650 probably null Het
Taar4 A G 10: 23,961,274 T261A possibly damaging Het
Tbl2 A G 5: 135,156,514 D159G probably benign Het
Tmem120a T C 5: 135,742,038 E55G probably damaging Het
Ttc21b A G 2: 66,207,450 probably null Het
Vill A T 9: 119,067,560 probably benign Het
Vmn2r28 A T 7: 5,484,131 M511K probably damaging Het
Vmn2r81 A T 10: 79,274,682 D543V probably damaging Het
Wdr95 A G 5: 149,580,670 T314A probably benign Het
Zbtb8b A G 4: 129,433,189 I61T probably damaging Het
Other mutations in Krtap14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01298:Krtap14 APN 16 88825727 missense probably benign 0.35
PIT4810001:Krtap14 UTSW 16 88825627 missense probably damaging 1.00
R1471:Krtap14 UTSW 16 88825627 missense probably damaging 1.00
R4927:Krtap14 UTSW 16 88826031 missense possibly damaging 0.90
R5339:Krtap14 UTSW 16 88825859 missense probably benign 0.05
Predicted Primers
Posted On2014-11-11