Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02090:Sgo2b'

279423

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sgo2b

Ensembl Gene

ENSMUSG00000094443

Gene Name

shugoshin 2B

Synonyms

Gm4975, Sgol2b

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL02090

Quality Score

Status

Chromosome

Chromosomal Location

64377728-64405204 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 64380123 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 903 (L903Q)

Ref Sequence

ENSEMBL: ENSMUSP00000136323 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179944]

AlphaFold

J3QMK1

Predicted Effect

probably damaging
Transcript: ENSMUST00000179944
AA Change: L903Q

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000136323
Gene: ENSMUSG00000094443
AA Change: L903Q

Domain	Start	End	E-Value	Type
coiled coil region	54	113	N/A	INTRINSIC
low complexity region	122	135	N/A	INTRINSIC
low complexity region	163	172	N/A	INTRINSIC
low complexity region	400	414	N/A	INTRINSIC
internal_repeat_1	528	618	9.12e-8	PROSPERO
internal_repeat_1	713	809	9.12e-8	PROSPERO
low complexity region	1009	1024	N/A	INTRINSIC
low complexity region	1059	1081	N/A	INTRINSIC
low complexity region	1112	1126	N/A	INTRINSIC
low complexity region	1130	1148	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210915

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ace2	A	G	X: 162,968,701 (GRCm39)	T482A	probably damaging	Het
Adh1	T	C	3: 137,988,546 (GRCm39)	I173T	possibly damaging	Het
Apoa1	T	C	9: 46,140,548 (GRCm39)	S60P	possibly damaging	Het
Blnk	A	G	19: 40,922,929 (GRCm39)	V396A	probably benign	Het
Borcs8	A	G	8: 70,619,030 (GRCm39)	D204G	probably damaging	Het
Calhm5	G	A	10: 33,972,261 (GRCm39)	P58L	probably damaging	Het
Cbfa2t2	A	G	2: 154,373,336 (GRCm39)		probably benign	Het
Cdkal1	T	G	13: 29,701,493 (GRCm39)	I319L	probably benign	Het
Celsr1	T	A	15: 85,791,922 (GRCm39)	T2560S	possibly damaging	Het
Chd8	A	G	14: 52,464,691 (GRCm39)		probably null	Het
Cyp4f39	T	C	17: 32,689,932 (GRCm39)		probably benign	Het
Dnah10	A	G	5: 124,866,876 (GRCm39)	N2265S	probably damaging	Het
Dnah5	C	T	15: 28,240,187 (GRCm39)		probably benign	Het
Epgn	G	A	5: 91,181,816 (GRCm39)	G133E	probably damaging	Het
Fdx2	C	A	9: 20,984,766 (GRCm39)	V13F	probably benign	Het
Gabarapl2	A	G	8: 112,667,831 (GRCm39)	Y25C	probably damaging	Het
Gigyf1	G	A	5: 137,523,826 (GRCm39)		probably null	Het
Gm6040	G	A	8: 21,407,169 (GRCm39)		probably benign	Het
Gm8229	T	C	14: 44,604,054 (GRCm39)	L81P	unknown	Het
Gstz1	A	G	12: 87,210,528 (GRCm39)	E137G	probably benign	Het
Htra1	T	C	7: 130,538,108 (GRCm39)	V36A	probably benign	Het
Ifnlr1	T	C	4: 135,432,578 (GRCm39)	V338A	probably benign	Het
Igsf8	A	G	1: 172,140,156 (GRCm39)		probably benign	Het
Khdc1a	T	A	1: 21,421,212 (GRCm39)	F132L	probably benign	Het
Kifc3	G	A	8: 95,829,108 (GRCm39)	S561L	probably damaging	Het
Mpi	T	C	9: 57,457,936 (GRCm39)	T89A	probably benign	Het
Ncor2	A	T	5: 125,111,467 (GRCm39)	M1281K	probably damaging	Het
Or4c117	T	C	2: 88,956,021 (GRCm39)	N18S	probably benign	Het
Or4k49	G	T	2: 111,495,333 (GRCm39)	C254F	probably damaging	Het
Or6c213	T	A	10: 129,574,181 (GRCm39)	I202L	probably benign	Het
Or6c66b	T	C	10: 129,377,176 (GRCm39)	Y257H	probably damaging	Het
Otog	G	A	7: 45,949,571 (GRCm39)	G2403D	probably damaging	Het
Pdgfb	C	A	15: 79,898,184 (GRCm39)	A6S	probably benign	Het
Pfkm	T	C	15: 98,021,121 (GRCm39)		probably null	Het
Plcb4	A	G	2: 135,789,041 (GRCm39)	M274V	probably benign	Het
Ppm1m	A	G	9: 106,074,001 (GRCm39)		probably null	Het
Rptn	A	G	3: 93,304,041 (GRCm39)	D458G	possibly damaging	Het
Sertad3	C	T	7: 27,175,950 (GRCm39)	S128F	probably benign	Het
Slc15a5	C	T	6: 138,020,598 (GRCm39)	R245H	probably benign	Het
Slc24a5	A	T	2: 124,910,218 (GRCm39)	T40S	probably benign	Het
Smchd1	T	C	17: 71,738,248 (GRCm39)	N539S	possibly damaging	Het
Tlr11	A	G	14: 50,600,489 (GRCm39)	D825G	probably damaging	Het
Top3b	T	G	16: 16,709,334 (GRCm39)	V674G	possibly damaging	Het
Urb2	G	A	8: 124,754,976 (GRCm39)	V228I	probably benign	Het
Usp24	C	T	4: 106,268,623 (GRCm39)	A2061V	possibly damaging	Het
Wdr72	C	A	9: 74,062,212 (GRCm39)	H453N	possibly damaging	Het
Xkr9	T	C	1: 13,771,600 (GRCm39)	M372T	probably damaging	Het
Zc3h12d	T	G	10: 7,743,096 (GRCm39)	S289A	probably benign	Het
Zfp607b	A	T	7: 27,398,140 (GRCm39)	M75L	possibly damaging	Het

Other mutations in Sgo2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01017:Sgo2b	APN	8	64,379,557 (GRCm39)	missense	probably benign
IGL01343:Sgo2b	APN	8	64,380,349 (GRCm39)	nonsense	probably null
IGL02027:Sgo2b	APN	8	64,379,863 (GRCm39)	missense	probably benign
IGL02121:Sgo2b	APN	8	64,384,316 (GRCm39)	missense	possibly damaging	0.94
IGL02206:Sgo2b	APN	8	64,394,118 (GRCm39)	missense	possibly damaging	0.94
IGL02554:Sgo2b	APN	8	64,379,571 (GRCm39)	missense	probably damaging	0.96
IGL02663:Sgo2b	APN	8	64,396,148 (GRCm39)	missense	probably damaging	0.97
IGL03149:Sgo2b	APN	8	64,379,617 (GRCm39)	missense	probably benign	0.14
floater	UTSW	8	64,391,451 (GRCm39)	nonsense	probably null
R0164:Sgo2b	UTSW	8	64,391,417 (GRCm39)	missense	possibly damaging	0.92
R0164:Sgo2b	UTSW	8	64,391,417 (GRCm39)	missense	possibly damaging	0.92
R0201:Sgo2b	UTSW	8	64,379,670 (GRCm39)	missense	probably benign
R0285:Sgo2b	UTSW	8	64,381,823 (GRCm39)	nonsense	probably null
R0325:Sgo2b	UTSW	8	64,381,410 (GRCm39)	missense	probably benign	0.20
R0727:Sgo2b	UTSW	8	64,380,816 (GRCm39)	missense	probably damaging	0.98
R0943:Sgo2b	UTSW	8	64,384,369 (GRCm39)	missense	possibly damaging	0.82
R1148:Sgo2b	UTSW	8	64,379,889 (GRCm39)	missense	probably damaging	0.99
R1266:Sgo2b	UTSW	8	64,381,455 (GRCm39)	missense	probably benign	0.00
R1484:Sgo2b	UTSW	8	64,384,507 (GRCm39)	missense	possibly damaging	0.77
R1493:Sgo2b	UTSW	8	64,379,889 (GRCm39)	missense	probably damaging	0.99
R1537:Sgo2b	UTSW	8	64,379,536 (GRCm39)	missense	possibly damaging	0.94
R1630:Sgo2b	UTSW	8	64,380,831 (GRCm39)	missense	possibly damaging	0.90
R1803:Sgo2b	UTSW	8	64,380,426 (GRCm39)	missense	probably benign	0.01
R1912:Sgo2b	UTSW	8	64,384,503 (GRCm39)	missense	probably damaging	0.98
R1993:Sgo2b	UTSW	8	64,379,867 (GRCm39)	missense	probably benign	0.36
R2042:Sgo2b	UTSW	8	64,381,561 (GRCm39)	missense	probably benign
R2130:Sgo2b	UTSW	8	64,380,181 (GRCm39)	missense	probably benign	0.09
R2146:Sgo2b	UTSW	8	64,381,057 (GRCm39)	missense	probably benign	0.00
R2881:Sgo2b	UTSW	8	64,380,570 (GRCm39)	missense	probably damaging	0.99
R3686:Sgo2b	UTSW	8	64,384,361 (GRCm39)	missense	probably benign	0.20
R3706:Sgo2b	UTSW	8	64,381,179 (GRCm39)	missense	probably damaging	0.98
R3889:Sgo2b	UTSW	8	64,380,777 (GRCm39)	missense	possibly damaging	0.82
R3894:Sgo2b	UTSW	8	64,381,767 (GRCm39)	missense	possibly damaging	0.91
R3895:Sgo2b	UTSW	8	64,381,767 (GRCm39)	missense	possibly damaging	0.91
R4058:Sgo2b	UTSW	8	64,379,981 (GRCm39)	missense	probably damaging	0.98
R4259:Sgo2b	UTSW	8	64,381,330 (GRCm39)	missense	probably benign	0.06
R4260:Sgo2b	UTSW	8	64,381,330 (GRCm39)	missense	probably benign	0.06
R4704:Sgo2b	UTSW	8	64,380,824 (GRCm39)	missense	probably damaging	0.98
R4815:Sgo2b	UTSW	8	64,384,448 (GRCm39)	missense	probably benign
R4922:Sgo2b	UTSW	8	64,379,664 (GRCm39)	missense	possibly damaging	0.66
R5232:Sgo2b	UTSW	8	64,381,636 (GRCm39)	missense	possibly damaging	0.55
R5262:Sgo2b	UTSW	8	64,396,171 (GRCm39)	missense	probably damaging	0.99
R5444:Sgo2b	UTSW	8	64,379,590 (GRCm39)	missense	possibly damaging	0.90
R5677:Sgo2b	UTSW	8	64,380,008 (GRCm39)	missense	possibly damaging	0.77
R5959:Sgo2b	UTSW	8	64,380,322 (GRCm39)	missense	probably benign	0.01
R6004:Sgo2b	UTSW	8	64,379,707 (GRCm39)	nonsense	probably null
R6267:Sgo2b	UTSW	8	64,380,827 (GRCm39)	missense	probably benign
R6296:Sgo2b	UTSW	8	64,380,827 (GRCm39)	missense	probably benign
R6328:Sgo2b	UTSW	8	64,381,345 (GRCm39)	nonsense	probably null
R6517:Sgo2b	UTSW	8	64,384,528 (GRCm39)	missense	probably damaging	0.99
R6523:Sgo2b	UTSW	8	64,380,538 (GRCm39)	missense	probably benign	0.11
R6726:Sgo2b	UTSW	8	64,380,769 (GRCm39)	nonsense	probably null
R6957:Sgo2b	UTSW	8	64,384,489 (GRCm39)	small deletion	probably benign
R7031:Sgo2b	UTSW	8	64,393,078 (GRCm39)	missense	possibly damaging	0.94
R7034:Sgo2b	UTSW	8	64,379,868 (GRCm39)	missense	probably benign	0.36
R7145:Sgo2b	UTSW	8	64,381,218 (GRCm39)	missense	probably damaging	1.00
R7289:Sgo2b	UTSW	8	64,394,192 (GRCm39)	missense	probably damaging	0.97
R7366:Sgo2b	UTSW	8	64,391,451 (GRCm39)	nonsense	probably null
R7660:Sgo2b	UTSW	8	64,393,108 (GRCm39)	missense	probably benign	0.27
R7761:Sgo2b	UTSW	8	64,379,946 (GRCm39)	missense	probably benign
R7762:Sgo2b	UTSW	8	64,379,531 (GRCm39)	missense	probably benign	0.03
R7822:Sgo2b	UTSW	8	64,380,318 (GRCm39)	missense	probably damaging	0.98
R8111:Sgo2b	UTSW	8	64,396,138 (GRCm39)	missense	probably damaging	0.98
R8129:Sgo2b	UTSW	8	64,381,834 (GRCm39)	missense	possibly damaging	0.90
R8273:Sgo2b	UTSW	8	64,377,735 (GRCm39)	missense	unknown
R8856:Sgo2b	UTSW	8	64,393,091 (GRCm39)	missense	probably null	0.99
R9249:Sgo2b	UTSW	8	64,391,407 (GRCm39)	nonsense	probably null
R9428:Sgo2b	UTSW	8	64,393,067 (GRCm39)	missense	probably damaging	0.99
R9616:Sgo2b	UTSW	8	64,380,274 (GRCm39)	missense	probably benign
R9621:Sgo2b	UTSW	8	64,380,651 (GRCm39)	missense	probably damaging	0.99
RF014:Sgo2b	UTSW	8	64,384,439 (GRCm39)	missense	possibly damaging	0.94
RF055:Sgo2b	UTSW	8	64,396,203 (GRCm39)	missense	probably damaging	1.00
Z1088:Sgo2b	UTSW	8	64,381,456 (GRCm39)	missense	possibly damaging	0.61
Z1088:Sgo2b	UTSW	8	64,380,039 (GRCm39)	missense	probably damaging	1.00
Z1177:Sgo2b	UTSW	8	64,381,419 (GRCm39)	missense	possibly damaging	0.82
Z1177:Sgo2b	UTSW	8	64,380,473 (GRCm39)	missense	probably benign	0.03

Posted On

2015-04-16