Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02162:Zfp541'

282517

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp541

Ensembl Gene

ENSMUSG00000078796

Gene Name

zinc finger protein 541

Synonyms

EG666528

Accession Numbers

Essential gene?

Probably essential (E-score: 0.750) question?

Stock #

IGL02162

Quality Score

Status

Chromosome

Chromosomal Location

15795739-15830259 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 15813393 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 682 (T682K)

Ref Sequence

ENSEMBL: ENSMUSP00000148143 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108509] [ENSMUST00000209369] [ENSMUST00000210805]

AlphaFold

Q0GGX2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000108509
AA Change: T682K

PolyPhen 2 Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000104149
Gene: ENSMUSG00000078796
AA Change: T682K

Domain	Start	End	E-Value	Type
low complexity region	48	65	N/A	INTRINSIC
ZnF_C2H2	140	162	2.24e-3	SMART
ZnF_C2H2	168	190	4.47e-3	SMART
ZnF_C2H2	196	221	2.36e-2	SMART
low complexity region	249	260	N/A	INTRINSIC
low complexity region	362	374	N/A	INTRINSIC
low complexity region	444	465	N/A	INTRINSIC
low complexity region	473	484	N/A	INTRINSIC
low complexity region	594	609	N/A	INTRINSIC
low complexity region	659	670	N/A	INTRINSIC
ZnF_C2H2	838	860	3.72e0	SMART
low complexity region	953	958	N/A	INTRINSIC
ELM2	1065	1122	4.46e-14	SMART
SANT	1171	1219	8.38e-7	SMART
low complexity region	1252	1263	N/A	INTRINSIC
ZnF_C2H2	1301	1323	1.01e-1	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000209369
AA Change: T682K

PolyPhen 2 Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000210805
AA Change: T682K

PolyPhen 2 Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ang5	T	C	14: 44,199,966 (GRCm39)	L10S	probably damaging	Het
Cdk5rap1	T	C	2: 154,177,489 (GRCm39)	T577A	probably damaging	Het
Clca3a1	G	T	3: 144,460,564 (GRCm39)	P297T	probably damaging	Het
Col9a2	A	T	4: 120,911,531 (GRCm39)		probably benign	Het
Ctss	A	G	3: 95,454,132 (GRCm39)	K227R	probably benign	Het
Dmxl1	G	A	18: 50,094,230 (GRCm39)	R2902Q	probably benign	Het
Dnah10	G	T	5: 124,881,810 (GRCm39)	A2862S	probably damaging	Het
Elp1	A	G	4: 56,796,502 (GRCm39)		probably null	Het
Fbxw5	C	A	2: 25,393,283 (GRCm39)	Q16K	probably damaging	Het
Fcgbp	G	A	7: 27,774,660 (GRCm39)	C78Y	probably damaging	Het
Gm20547	T	A	17: 35,076,003 (GRCm39)	Y688F	possibly damaging	Het
Gpaa1	T	C	15: 76,216,353 (GRCm39)		probably benign	Het
Grik2	T	C	10: 49,298,671 (GRCm39)	H63R	possibly damaging	Het
Ikbke	A	G	1: 131,201,452 (GRCm39)	S132P	possibly damaging	Het
Kirrel2	A	G	7: 30,153,089 (GRCm39)	I340T	probably benign	Het
Lipo5	A	T	19: 33,446,163 (GRCm39)		probably benign	Het
Nfkbie	T	G	17: 45,867,242 (GRCm39)		probably null	Het
Ntng1	G	T	3: 109,842,311 (GRCm39)	S154*	probably null	Het
Or6c208	C	T	10: 129,223,973 (GRCm39)	P157L	probably benign	Het
Or8b12b	A	G	9: 37,684,227 (GRCm39)	I91V	probably benign	Het
Pbld2	T	C	10: 62,907,179 (GRCm39)		probably benign	Het
Phaf1	C	T	8: 105,966,605 (GRCm39)		probably benign	Het
Plec	C	T	15: 76,064,360 (GRCm39)	M1971I	probably benign	Het
Ppp1r3a	A	T	6: 14,717,714 (GRCm39)	F1067I	probably damaging	Het
Qpctl	A	G	7: 18,878,606 (GRCm39)	F290L	possibly damaging	Het
Sorcs3	A	T	19: 48,523,970 (GRCm39)	Y288F	probably damaging	Het
St8sia3	A	G	18: 64,398,651 (GRCm39)	N37D	probably benign	Het
Vmn2r109	T	C	17: 20,774,422 (GRCm39)	D311G	probably benign	Het
Zbtb44	A	G	9: 30,964,688 (GRCm39)	I33V	probably benign	Het
Zfp267	T	C	3: 36,218,210 (GRCm39)	F78L	probably benign	Het

Other mutations in Zfp541

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02262:Zfp541	APN	7	15,813,620 (GRCm39)	missense	probably damaging	1.00
IGL02347:Zfp541	APN	7	15,817,390 (GRCm39)	missense	probably damaging	1.00
IGL02516:Zfp541	APN	7	15,816,918 (GRCm39)	splice site	probably null
R0101:Zfp541	UTSW	7	15,811,968 (GRCm39)	missense	probably damaging	1.00
R0412:Zfp541	UTSW	7	15,816,099 (GRCm39)	missense	possibly damaging	0.88
R0627:Zfp541	UTSW	7	15,829,607 (GRCm39)	splice site	probably benign
R0784:Zfp541	UTSW	7	15,816,917 (GRCm39)	intron	probably benign
R1083:Zfp541	UTSW	7	15,812,637 (GRCm39)	missense	probably benign	0.16
R1541:Zfp541	UTSW	7	15,812,437 (GRCm39)	missense	probably benign	0.04
R1575:Zfp541	UTSW	7	15,812,640 (GRCm39)	missense	possibly damaging	0.94
R1730:Zfp541	UTSW	7	15,811,898 (GRCm39)	missense	probably damaging	0.99
R1783:Zfp541	UTSW	7	15,811,898 (GRCm39)	missense	probably damaging	0.99
R1966:Zfp541	UTSW	7	15,812,996 (GRCm39)	missense	probably benign	0.02
R2022:Zfp541	UTSW	7	15,816,110 (GRCm39)	missense	probably damaging	1.00
R2048:Zfp541	UTSW	7	15,812,252 (GRCm39)	missense	possibly damaging	0.94
R2436:Zfp541	UTSW	7	15,810,373 (GRCm39)	missense	possibly damaging	0.94
R3973:Zfp541	UTSW	7	15,806,147 (GRCm39)	missense	probably damaging	1.00
R4081:Zfp541	UTSW	7	15,806,060 (GRCm39)	missense	probably benign	0.16
R4589:Zfp541	UTSW	7	15,817,261 (GRCm39)	missense	probably benign	0.35
R4724:Zfp541	UTSW	7	15,815,612 (GRCm39)	missense	probably damaging	0.99
R4812:Zfp541	UTSW	7	15,813,035 (GRCm39)	missense	probably benign	0.01
R4817:Zfp541	UTSW	7	15,824,307 (GRCm39)	missense	probably damaging	1.00
R5232:Zfp541	UTSW	7	15,829,104 (GRCm39)	missense	probably damaging	1.00
R5331:Zfp541	UTSW	7	15,829,683 (GRCm39)	missense	probably damaging	1.00
R5551:Zfp541	UTSW	7	15,824,786 (GRCm39)	missense	probably damaging	1.00
R5976:Zfp541	UTSW	7	15,810,344 (GRCm39)	missense	probably benign	0.34
R6259:Zfp541	UTSW	7	15,829,451 (GRCm39)	missense	probably benign	0.02
R6523:Zfp541	UTSW	7	15,829,445 (GRCm39)	missense	probably damaging	1.00
R6826:Zfp541	UTSW	7	15,812,907 (GRCm39)	missense	probably damaging	0.96
R7319:Zfp541	UTSW	7	15,813,294 (GRCm39)	missense	probably benign	0.21
R7428:Zfp541	UTSW	7	15,826,793 (GRCm39)	missense	probably damaging	1.00
R7594:Zfp541	UTSW	7	15,810,311 (GRCm39)	missense	probably damaging	0.96
R7724:Zfp541	UTSW	7	15,805,919 (GRCm39)	missense	probably damaging	1.00
R8276:Zfp541	UTSW	7	15,813,009 (GRCm39)	missense	possibly damaging	0.87
R8433:Zfp541	UTSW	7	15,805,999 (GRCm39)	missense	probably benign	0.16
R9068:Zfp541	UTSW	7	15,812,376 (GRCm39)	missense	probably damaging	0.96
R9086:Zfp541	UTSW	7	15,824,329 (GRCm39)	missense	probably damaging	1.00
R9132:Zfp541	UTSW	7	15,816,966 (GRCm39)	missense	probably benign	0.45
R9261:Zfp541	UTSW	7	15,816,029 (GRCm39)	missense	possibly damaging	0.94
R9408:Zfp541	UTSW	7	15,806,139 (GRCm39)	missense	probably damaging	1.00
R9518:Zfp541	UTSW	7	15,813,036 (GRCm39)	missense	possibly damaging	0.80
R9621:Zfp541	UTSW	7	15,805,892 (GRCm39)	missense	possibly damaging	0.94
Z1088:Zfp541	UTSW	7	15,813,720 (GRCm39)	missense	probably benign	0.16
Z1176:Zfp541	UTSW	7	15,812,191 (GRCm39)	missense	probably damaging	1.00
Z1177:Zfp541	UTSW	7	15,816,092 (GRCm39)	missense	probably damaging	0.98
Z1177:Zfp541	UTSW	7	15,812,954 (GRCm39)	missense	probably benign	0.26
Z1177:Zfp541	UTSW	7	15,812,688 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16