Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02164:Tmem132c'

282576

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem132c

Ensembl Gene

ENSMUSG00000034324

Gene Name

transmembrane protein 132C

Synonyms

2810482M11Rik, 4632425D07Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

IGL02164

Quality Score

Status

Chromosome

Chromosomal Location

127318890-127642854 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 127613441 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 448 (T448K)

Ref Sequence

ENSEMBL: ENSMUSP00000113090 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000119026]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000119026
AA Change: T448K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000113090
Gene: ENSMUSG00000034324
AA Change: T448K

Domain	Start	End	E-Value	Type
low complexity region	14	21	N/A	INTRINSIC
Pfam:TMEM132D_N	58	187	1.2e-54	PFAM
Pfam:TMEM132	444	787	4.5e-143	PFAM
Pfam:TMEM132D_C	892	980	2.4e-39	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128068

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730480H06Rik	T	A	5: 48,537,524 (GRCm39)	V187E	probably benign	Het
Abcc12	T	A	8: 87,254,033 (GRCm39)	D917V	probably damaging	Het
Abhd15	A	T	11: 77,406,840 (GRCm39)	E272D	probably benign	Het
Adat3	T	A	10: 80,442,461 (GRCm39)	S100T	probably benign	Het
Adgrg6	T	C	10: 14,399,299 (GRCm39)		probably benign	Het
Alpl	C	T	4: 137,481,290 (GRCm39)	V121M	probably damaging	Het
Ano1	A	T	7: 144,190,918 (GRCm39)	Y388N	possibly damaging	Het
Arrdc4	C	T	7: 68,389,285 (GRCm39)		probably benign	Het
Asxl2	A	G	12: 3,552,079 (GRCm39)	M1274V	probably benign	Het
Bmt2	G	T	6: 13,628,878 (GRCm39)	N268K	possibly damaging	Het
Bpifb2	C	A	2: 153,725,482 (GRCm39)	L176M	probably damaging	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Cd14	T	C	18: 36,858,838 (GRCm39)	R206G	possibly damaging	Het
Cfap65	G	T	1: 74,967,304 (GRCm39)	T215K	possibly damaging	Het
Chd9	T	C	8: 91,659,849 (GRCm39)	S270P	possibly damaging	Het
Cidea	C	T	18: 67,499,581 (GRCm39)	S156L	probably damaging	Het
Col5a3	A	G	9: 20,703,939 (GRCm39)		probably null	Het
Cspg5	T	C	9: 110,080,104 (GRCm39)	V424A	probably damaging	Het
Ctc1	A	G	11: 68,916,922 (GRCm39)	H272R	probably damaging	Het
D5Ertd579e	A	T	5: 36,772,303 (GRCm39)	S697R	probably damaging	Het
Dennd3	T	C	15: 73,416,297 (GRCm39)	S516P	probably benign	Het
Dipk2b	T	A	X: 18,285,192 (GRCm39)	R421*	probably null	Het
Dlgap4	G	A	2: 156,553,059 (GRCm39)	R509H	probably damaging	Het
Dus3l	T	C	17: 57,074,943 (GRCm39)		probably benign	Het
Dync1h1	G	T	12: 110,628,993 (GRCm39)	W4183C	probably damaging	Het
Eif2s3x	A	T	X: 93,248,678 (GRCm39)	M152K	possibly damaging	Het
Epb41l1	C	T	2: 156,336,869 (GRCm39)		probably benign	Het
Ephx2	A	G	14: 66,341,169 (GRCm39)		probably benign	Het
Fabp12	T	A	3: 10,311,075 (GRCm39)	Y129F	probably damaging	Het
Fat3	A	G	9: 15,942,720 (GRCm39)		probably benign	Het
Fat4	T	C	3: 39,050,354 (GRCm39)		probably null	Het
Gnb1	T	A	4: 155,641,631 (GRCm39)		probably null	Het
Gpr107	C	A	2: 31,068,298 (GRCm39)	Y253*	probably null	Het
Grb10	C	T	11: 11,893,962 (GRCm39)	E320K	probably damaging	Het
Gucy2g	G	T	19: 55,226,455 (GRCm39)	H154N	probably benign	Het
H2bl1	T	C	13: 99,120,715 (GRCm39)	K104E	probably damaging	Het
Hemk1	T	A	9: 107,208,735 (GRCm39)	H154L	probably benign	Het
Hk2	A	T	6: 82,720,920 (GRCm39)		probably null	Het
Htr5a	A	G	5: 28,047,463 (GRCm39)	N6S	probably damaging	Het
Htra3	T	C	5: 35,810,410 (GRCm39)	D424G	probably benign	Het
Ift52	A	G	2: 162,867,384 (GRCm39)		probably null	Het
Igdcc4	A	G	9: 65,032,064 (GRCm39)		probably benign	Het
Itpr1	A	G	6: 108,366,444 (GRCm39)	K124E	probably benign	Het
Kcnc2	T	A	10: 112,291,590 (GRCm39)	N259K	possibly damaging	Het
Kics2	A	G	10: 121,586,675 (GRCm39)	Y194C	probably damaging	Het
Lmod2	A	T	6: 24,603,909 (GRCm39)	I295F	possibly damaging	Het
Lrp1	T	C	10: 127,399,536 (GRCm39)	E2324G	probably benign	Het
Lss	T	C	10: 76,372,094 (GRCm39)	S150P	probably damaging	Het
Macf1	T	C	4: 123,374,065 (GRCm39)	N1515S	probably benign	Het
Mapk11	T	C	15: 89,029,651 (GRCm39)		probably null	Het
Mc3r	T	A	2: 172,091,314 (GRCm39)	F179I	probably damaging	Het
Mtmr9	T	A	14: 63,767,737 (GRCm39)	N291Y	probably damaging	Het
Myo1h	T	C	5: 114,472,157 (GRCm39)	F396L	probably damaging	Het
Nek2	A	G	1: 191,559,416 (GRCm39)	K307R	probably benign	Het
Or12d2	C	A	17: 37,624,578 (GRCm39)	M232I	probably benign	Het
Osmr	G	A	15: 6,871,529 (GRCm39)	T296I	probably damaging	Het
Pcdhb11	T	G	18: 37,556,412 (GRCm39)	S581A	probably benign	Het
Pfkp	C	T	13: 6,647,951 (GRCm39)	V542M	probably damaging	Het
Pmpca	C	T	2: 26,285,581 (GRCm39)	S519L	probably benign	Het
Ptgds	A	T	2: 25,359,124 (GRCm39)	Y44N	probably damaging	Het
Raly	T	A	2: 154,701,849 (GRCm39)	Y116*	probably null	Het
Rock2	A	G	12: 17,015,530 (GRCm39)	D809G	probably damaging	Het
Sgsm2	T	G	11: 74,756,242 (GRCm39)	N369T	possibly damaging	Het
Slc6a15	A	G	10: 103,254,083 (GRCm39)	D673G	probably benign	Het
Spire2	A	T	8: 124,059,703 (GRCm39)	D67V	probably damaging	Het
St7l	T	C	3: 104,829,597 (GRCm39)		probably null	Het
Stau2	A	G	1: 16,416,052 (GRCm39)	L469P	probably damaging	Het
Tefm	A	G	11: 80,030,915 (GRCm39)	L107S	probably damaging	Het
Ticam1	A	T	17: 56,577,019 (GRCm39)	V692D	unknown	Het
Tipin	T	A	9: 64,201,631 (GRCm39)	D143E	probably damaging	Het
Trav8-1	A	T	14: 53,707,213 (GRCm39)	M1L	unknown	Het
Ttn	C	A	2: 76,569,141 (GRCm39)	V27251F	probably damaging	Het
Uvrag	A	T	7: 98,653,896 (GRCm39)	C31*	probably null	Het
Zap70	T	C	1: 36,810,267 (GRCm39)	Y126H	probably damaging	Het
Zfp644	A	G	5: 106,785,965 (GRCm39)	V194A	probably benign	Het
Zfp663	C	T	2: 165,200,968 (GRCm39)	W22*	probably null	Het

Other mutations in Tmem132c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00869:Tmem132c	APN	5	127,640,306 (GRCm39)	missense	possibly damaging	0.95
IGL00985:Tmem132c	APN	5	127,581,930 (GRCm39)	missense	probably damaging	0.99
IGL01599:Tmem132c	APN	5	127,436,616 (GRCm39)	splice site	probably benign
IGL01750:Tmem132c	APN	5	127,540,023 (GRCm39)	missense	possibly damaging	0.91
IGL01893:Tmem132c	APN	5	127,540,093 (GRCm39)	missense	possibly damaging	0.51
IGL02143:Tmem132c	APN	5	127,640,466 (GRCm39)	missense	probably benign	0.03
IGL02252:Tmem132c	APN	5	127,539,991 (GRCm39)	missense	possibly damaging	0.91
IGL02527:Tmem132c	APN	5	127,436,675 (GRCm39)	missense	possibly damaging	0.95
IGL02584:Tmem132c	APN	5	127,582,063 (GRCm39)	missense	probably damaging	1.00
IGL02878:Tmem132c	APN	5	127,640,154 (GRCm39)	missense	probably damaging	0.99
IGL03065:Tmem132c	APN	5	127,640,688 (GRCm39)	missense	probably damaging	1.00
IGL03120:Tmem132c	APN	5	127,640,448 (GRCm39)	missense	probably benign	0.06
IGL03380:Tmem132c	APN	5	127,613,506 (GRCm39)	missense	probably benign	0.00
IGL03387:Tmem132c	APN	5	127,640,784 (GRCm39)	missense	probably benign	0.00
R0106:Tmem132c	UTSW	5	127,631,733 (GRCm39)	missense	possibly damaging	0.94
R0106:Tmem132c	UTSW	5	127,631,733 (GRCm39)	missense	possibly damaging	0.94
R0415:Tmem132c	UTSW	5	127,640,769 (GRCm39)	missense	probably damaging	1.00
R0607:Tmem132c	UTSW	5	127,640,617 (GRCm39)	nonsense	probably null
R1413:Tmem132c	UTSW	5	127,640,631 (GRCm39)	missense	probably damaging	1.00
R1531:Tmem132c	UTSW	5	127,436,955 (GRCm39)	missense	probably damaging	1.00
R1648:Tmem132c	UTSW	5	127,540,120 (GRCm39)	splice site	probably benign
R2148:Tmem132c	UTSW	5	127,540,026 (GRCm39)	missense	probably damaging	1.00
R2149:Tmem132c	UTSW	5	127,540,026 (GRCm39)	missense	probably damaging	1.00
R2259:Tmem132c	UTSW	5	127,581,988 (GRCm39)	missense	probably benign	0.01
R3853:Tmem132c	UTSW	5	127,436,933 (GRCm39)	missense	probably benign	0.00
R4204:Tmem132c	UTSW	5	127,640,829 (GRCm39)	missense	possibly damaging	0.73
R4543:Tmem132c	UTSW	5	127,582,041 (GRCm39)	missense	probably benign	0.00
R4701:Tmem132c	UTSW	5	127,641,560 (GRCm39)	unclassified	probably benign
R5017:Tmem132c	UTSW	5	127,640,414 (GRCm39)	missense	probably benign	0.13
R5037:Tmem132c	UTSW	5	127,630,199 (GRCm39)	missense	probably benign	0.42
R5327:Tmem132c	UTSW	5	127,640,816 (GRCm39)	missense	possibly damaging	0.50
R5423:Tmem132c	UTSW	5	127,640,907 (GRCm39)	missense	probably benign	0.02
R5548:Tmem132c	UTSW	5	127,628,587 (GRCm39)	nonsense	probably null
R6425:Tmem132c	UTSW	5	127,630,329 (GRCm39)	missense	possibly damaging	0.95
R6717:Tmem132c	UTSW	5	127,641,093 (GRCm39)	missense	possibly damaging	0.93
R6899:Tmem132c	UTSW	5	127,628,744 (GRCm39)	missense	probably damaging	1.00
R7007:Tmem132c	UTSW	5	127,436,679 (GRCm39)	missense	probably damaging	1.00
R7297:Tmem132c	UTSW	5	127,437,281 (GRCm39)	missense	probably benign	0.06
R7326:Tmem132c	UTSW	5	127,641,123 (GRCm39)	missense	possibly damaging	0.51
R7386:Tmem132c	UTSW	5	127,640,990 (GRCm39)	missense	probably benign	0.16
R7504:Tmem132c	UTSW	5	127,631,696 (GRCm39)	missense	probably damaging	1.00
R7640:Tmem132c	UTSW	5	127,640,070 (GRCm39)	missense	probably damaging	1.00
R7718:Tmem132c	UTSW	5	127,640,504 (GRCm39)	missense	probably benign	0.06
R7762:Tmem132c	UTSW	5	127,631,760 (GRCm39)	missense	possibly damaging	0.90
R7818:Tmem132c	UTSW	5	127,641,152 (GRCm39)	makesense	probably null
R8117:Tmem132c	UTSW	5	127,437,176 (GRCm39)	missense	probably benign	0.22
R8425:Tmem132c	UTSW	5	127,641,421 (GRCm39)	missense
R8749:Tmem132c	UTSW	5	127,437,003 (GRCm39)	missense	possibly damaging	0.75
R8771:Tmem132c	UTSW	5	127,437,192 (GRCm39)	missense	probably benign	0.00
R8798:Tmem132c	UTSW	5	127,437,217 (GRCm39)	nonsense	probably null
R9372:Tmem132c	UTSW	5	127,640,145 (GRCm39)	missense	probably damaging	1.00
X0067:Tmem132c	UTSW	5	127,613,471 (GRCm39)	missense	possibly damaging	0.79
Z1088:Tmem132c	UTSW	5	127,581,985 (GRCm39)	missense	probably benign	0.14

Posted On

2015-04-16