Incidental Mutation 'IGL02581:Trim17'
ID299342
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim17
Ensembl Gene ENSMUSG00000036964
Gene Nametripartite motif-containing 17
Synonymsterf, Rnf16
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02581
Quality Score
Status
Chromosome11
Chromosomal Location58954685-58973098 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 58971076 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 311 (Y311*)
Ref Sequence ENSEMBL: ENSMUSP00000074639 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047697] [ENSMUST00000075141]
Predicted Effect probably null
Transcript: ENSMUST00000047697
SMART Domains Protein: ENSMUSP00000037248
Gene: ENSMUSG00000036964

DomainStartEndE-ValueType
RING 16 65 1.17e-10 SMART
BBOX 94 135 4.1e-15 SMART
coiled coil region 143 180 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000075141
AA Change: Y311*
SMART Domains Protein: ENSMUSP00000074639
Gene: ENSMUSG00000036964
AA Change: Y311*

DomainStartEndE-ValueType
RING 16 65 1.17e-10 SMART
BBOX 94 135 4.1e-15 SMART
coiled coil region 143 180 N/A INTRINSIC
PRY 294 347 8.95e-16 SMART
SPRY 348 472 2.54e-30 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131221
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034H15Rik A G 1: 191,903,540 probably benign Het
Abca13 C T 11: 9,399,132 probably benign Het
Aga T C 8: 53,521,044 probably benign Het
Atp2a3 C A 11: 72,975,339 H262N probably benign Het
BC100530 T C 16: 36,359,498 T86A probably damaging Het
C1rl T C 6: 124,493,154 S2P possibly damaging Het
Dgkd T C 1: 87,918,002 probably benign Het
Dnajb11 A G 16: 22,871,018 N311D probably benign Het
Flg2 A C 3: 93,219,892 Q2037P unknown Het
Glyctk T C 9: 106,157,781 T29A probably benign Het
Gtf3c1 C A 7: 125,646,515 R1672L possibly damaging Het
Hps3 A T 3: 20,003,221 probably benign Het
Kcnh3 G T 15: 99,238,171 C683F possibly damaging Het
Lmtk2 T G 5: 144,148,348 F213V probably damaging Het
Malrd1 C A 2: 16,142,312 C1988* probably null Het
Map3k11 T A 19: 5,700,806 M684K probably benign Het
Mgea5 T A 19: 45,752,191 M902L possibly damaging Het
Pip5k1c C A 10: 81,317,321 probably null Het
Plekhh1 T C 12: 79,079,108 probably null Het
Rev3l C A 10: 39,821,281 N591K probably benign Het
Rrp9 T A 9: 106,483,628 N269K probably damaging Het
Sec14l4 T C 11: 4,039,941 I80T possibly damaging Het
Srpr G A 9: 35,215,032 probably null Het
Tmc8 G A 11: 117,783,888 R143H probably benign Het
Trank1 T C 9: 111,383,125 I1777T probably benign Het
Vps13a C T 19: 16,655,322 A2557T probably benign Het
Vps53 T G 11: 76,102,057 N106T probably damaging Het
Other mutations in Trim17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Trim17 APN 11 58970597 missense probably damaging 1.00
P0026:Trim17 UTSW 11 58971258 missense possibly damaging 0.83
R0518:Trim17 UTSW 11 58968494 missense probably damaging 0.99
R0521:Trim17 UTSW 11 58968494 missense probably damaging 0.99
R0765:Trim17 UTSW 11 58971369 missense possibly damaging 0.73
R1165:Trim17 UTSW 11 58971215 missense possibly damaging 0.92
R1441:Trim17 UTSW 11 58965192 missense probably damaging 1.00
R2164:Trim17 UTSW 11 58971411 missense probably damaging 1.00
R2320:Trim17 UTSW 11 58966798 missense probably benign
R3436:Trim17 UTSW 11 58965233 missense probably damaging 1.00
R4715:Trim17 UTSW 11 58968450 intron probably benign
R4832:Trim17 UTSW 11 58971444 missense probably damaging 0.97
R4928:Trim17 UTSW 11 58954301 unclassified probably benign
R4950:Trim17 UTSW 11 58970428 missense probably damaging 0.98
R5339:Trim17 UTSW 11 58954510 splice site probably null
R5909:Trim17 UTSW 11 58968680 missense probably damaging 1.00
R5915:Trim17 UTSW 11 58968562 missense probably damaging 0.99
R5947:Trim17 UTSW 11 58965543 missense probably damaging 1.00
R6732:Trim17 UTSW 11 58971025 critical splice acceptor site probably null
R7027:Trim17 UTSW 11 58968616 missense probably benign 0.08
R7143:Trim17 UTSW 11 58965184 nonsense probably null
R7168:Trim17 UTSW 11 58968578 missense probably benign
R7682:Trim17 UTSW 11 58966808 missense possibly damaging 0.82
R7707:Trim17 UTSW 11 58965284 nonsense probably null
R7972:Trim17 UTSW 11 58968568 missense probably benign 0.01
Z1177:Trim17 UTSW 11 58965389 missense probably damaging 0.99
Posted On2015-04-16