Incidental Mutation 'IGL01524:Trim17'
ID 89511
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim17
Ensembl Gene ENSMUSG00000036964
Gene Name tripartite motif-containing 17
Synonyms Rnf16, terf
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01524
Quality Score
Status
Chromosome 11
Chromosomal Location 58845511-58863923 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58861423 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 279 (T279A)
Ref Sequence ENSEMBL: ENSMUSP00000074639 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047697] [ENSMUST00000075141]
AlphaFold Q7TPM3
Predicted Effect silent
Transcript: ENSMUST00000047697
SMART Domains Protein: ENSMUSP00000037248
Gene: ENSMUSG00000036964

DomainStartEndE-ValueType
RING 16 65 1.17e-10 SMART
BBOX 94 135 4.1e-15 SMART
coiled coil region 143 180 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000075141
AA Change: T279A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074639
Gene: ENSMUSG00000036964
AA Change: T279A

DomainStartEndE-ValueType
RING 16 65 1.17e-10 SMART
BBOX 94 135 4.1e-15 SMART
coiled coil region 143 180 N/A INTRINSIC
PRY 294 347 8.95e-16 SMART
SPRY 348 472 2.54e-30 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131221
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadat A T 8: 60,969,106 (GRCm39) D117V probably damaging Het
Abca14 T C 7: 119,852,644 (GRCm39) Y870H possibly damaging Het
Ankrd36 T C 11: 5,585,092 (GRCm39) I301T probably benign Het
Atp10b T A 11: 43,150,672 (GRCm39) S1457T probably benign Het
Bltp1 A G 3: 36,996,531 (GRCm39) D1081G possibly damaging Het
Ccdc175 G A 12: 72,177,916 (GRCm39) probably benign Het
Ccdc93 A G 1: 121,389,628 (GRCm39) K224E probably benign Het
Cep131 C T 11: 119,956,786 (GRCm39) A886T probably damaging Het
Clip1 A C 5: 123,717,442 (GRCm39) H1282Q probably damaging Het
Ctcfl T G 2: 172,959,177 (GRCm39) D183A probably benign Het
Cyp17a1 C T 19: 46,659,495 (GRCm39) V112I probably benign Het
Fhod3 T C 18: 25,263,659 (GRCm39) I1521T probably damaging Het
Gipc2 A G 3: 151,843,214 (GRCm39) I141T probably damaging Het
Glo1 T C 17: 30,815,393 (GRCm39) R141G possibly damaging Het
Ipmk C A 10: 71,208,631 (GRCm39) A140E probably damaging Het
Kynu A G 2: 43,561,394 (GRCm39) D310G possibly damaging Het
Myo1f T A 17: 33,798,857 (GRCm39) I174N probably damaging Het
Nat10 T A 2: 103,588,102 (GRCm39) N8Y probably damaging Het
Nhlrc2 A G 19: 56,564,587 (GRCm39) I304V probably benign Het
Pdk4 T C 6: 5,491,979 (GRCm39) H31R probably damaging Het
Sema6d T C 2: 124,505,995 (GRCm39) V644A possibly damaging Het
Slc30a4 T A 2: 122,544,308 (GRCm39) K11N possibly damaging Het
Slc6a3 T C 13: 73,686,668 (GRCm39) S12P probably benign Het
Spats2 C T 15: 99,110,127 (GRCm39) A508V probably benign Het
Tinag A G 9: 76,952,820 (GRCm39) Y55H probably damaging Het
Topbp1 T C 9: 103,188,844 (GRCm39) I172T possibly damaging Het
Vmn1r216 C A 13: 23,283,519 (GRCm39) N67K probably benign Het
Washc4 T C 10: 83,411,996 (GRCm39) L709P probably benign Het
Xdh T C 17: 74,230,132 (GRCm39) probably null Het
Zfhx4 C T 3: 5,309,036 (GRCm39) P754L probably damaging Het
Zfp267 T C 3: 36,218,729 (GRCm39) Y251H possibly damaging Het
Zfp623 C A 15: 75,819,528 (GRCm39) S161R probably benign Het
Zmat3 G A 3: 32,395,827 (GRCm39) R227C possibly damaging Het
Other mutations in Trim17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02581:Trim17 APN 11 58,861,902 (GRCm39) nonsense probably null
P0026:Trim17 UTSW 11 58,862,084 (GRCm39) missense possibly damaging 0.83
R0518:Trim17 UTSW 11 58,859,320 (GRCm39) missense probably damaging 0.99
R0521:Trim17 UTSW 11 58,859,320 (GRCm39) missense probably damaging 0.99
R0765:Trim17 UTSW 11 58,862,195 (GRCm39) missense possibly damaging 0.73
R1165:Trim17 UTSW 11 58,862,041 (GRCm39) missense possibly damaging 0.92
R1441:Trim17 UTSW 11 58,856,018 (GRCm39) missense probably damaging 1.00
R2164:Trim17 UTSW 11 58,862,237 (GRCm39) missense probably damaging 1.00
R2320:Trim17 UTSW 11 58,857,624 (GRCm39) missense probably benign
R3436:Trim17 UTSW 11 58,856,059 (GRCm39) missense probably damaging 1.00
R4715:Trim17 UTSW 11 58,859,276 (GRCm39) intron probably benign
R4832:Trim17 UTSW 11 58,862,270 (GRCm39) missense probably damaging 0.97
R4928:Trim17 UTSW 11 58,845,127 (GRCm39) unclassified probably benign
R4950:Trim17 UTSW 11 58,861,254 (GRCm39) missense probably damaging 0.98
R5339:Trim17 UTSW 11 58,845,336 (GRCm39) splice site probably null
R5909:Trim17 UTSW 11 58,859,506 (GRCm39) missense probably damaging 1.00
R5915:Trim17 UTSW 11 58,859,388 (GRCm39) missense probably damaging 0.99
R5947:Trim17 UTSW 11 58,856,369 (GRCm39) missense probably damaging 1.00
R6732:Trim17 UTSW 11 58,861,851 (GRCm39) critical splice acceptor site probably null
R7027:Trim17 UTSW 11 58,859,442 (GRCm39) missense probably benign 0.08
R7143:Trim17 UTSW 11 58,856,010 (GRCm39) nonsense probably null
R7168:Trim17 UTSW 11 58,859,404 (GRCm39) missense probably benign
R7682:Trim17 UTSW 11 58,857,634 (GRCm39) missense possibly damaging 0.82
R7707:Trim17 UTSW 11 58,856,110 (GRCm39) nonsense probably null
R7972:Trim17 UTSW 11 58,859,394 (GRCm39) missense probably benign 0.01
R8543:Trim17 UTSW 11 58,862,281 (GRCm39) missense probably damaging 1.00
R8791:Trim17 UTSW 11 58,862,002 (GRCm39) missense probably benign 0.00
R8894:Trim17 UTSW 11 58,859,536 (GRCm39) missense probably benign 0.00
R9015:Trim17 UTSW 11 58,856,057 (GRCm39) missense probably damaging 0.99
R9026:Trim17 UTSW 11 58,862,273 (GRCm39) missense probably benign 0.01
R9269:Trim17 UTSW 11 58,862,257 (GRCm39) missense probably damaging 1.00
R9609:Trim17 UTSW 11 58,855,964 (GRCm39) missense probably damaging 1.00
Z1177:Trim17 UTSW 11 58,856,215 (GRCm39) missense probably damaging 0.99
Z1186:Trim17 UTSW 11 58,861,272 (GRCm39) missense probably benign
Z1186:Trim17 UTSW 11 58,856,331 (GRCm39) missense probably benign 0.00
Z1187:Trim17 UTSW 11 58,861,272 (GRCm39) missense probably benign
Z1187:Trim17 UTSW 11 58,856,331 (GRCm39) missense probably benign 0.00
Z1188:Trim17 UTSW 11 58,861,272 (GRCm39) missense probably benign
Z1188:Trim17 UTSW 11 58,856,331 (GRCm39) missense probably benign 0.00
Z1189:Trim17 UTSW 11 58,861,272 (GRCm39) missense probably benign
Z1189:Trim17 UTSW 11 58,856,331 (GRCm39) missense probably benign 0.00
Z1190:Trim17 UTSW 11 58,861,272 (GRCm39) missense probably benign
Z1190:Trim17 UTSW 11 58,856,331 (GRCm39) missense probably benign 0.00
Z1191:Trim17 UTSW 11 58,861,272 (GRCm39) missense probably benign
Z1191:Trim17 UTSW 11 58,856,331 (GRCm39) missense probably benign 0.00
Z1192:Trim17 UTSW 11 58,861,272 (GRCm39) missense probably benign
Z1192:Trim17 UTSW 11 58,856,331 (GRCm39) missense probably benign 0.00
Posted On 2013-12-03