Incidental Mutation 'R4746:Cxcl13'
ID 356720
Institutional Source Beutler Lab
Gene Symbol Cxcl13
Ensembl Gene ENSMUSG00000023078
Gene Name C-X-C motif chemokine ligand 13
Synonyms Scyb13, 4631412M08Rik, BCA-1, ANGIE2, BLC
MMRRC Submission 041968-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4746 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 96104810-96108927 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 96107756 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 71 (K71E)
Ref Sequence ENSEMBL: ENSMUSP00000023840 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023840]
AlphaFold O55038
Predicted Effect probably damaging
Transcript: ENSMUST00000023840
AA Change: K71E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023840
Gene: ENSMUSG00000023078
AA Change: K71E

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
SCY 29 90 4.14e-11 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
PHENOTYPE: B lymphocyte trafficking is impaired in homozygous mutant mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik G A 2: 152,282,685 (GRCm39) S180N probably benign Het
Atp5f1a G T 18: 77,866,442 (GRCm39) G165V probably benign Het
Cbfa2t2 A C 2: 154,365,845 (GRCm39) M352L possibly damaging Het
Ccser2 A T 14: 36,631,082 (GRCm39) D98E probably damaging Het
Cfap20 A G 8: 96,148,684 (GRCm39) probably null Het
Chuk A T 19: 44,077,210 (GRCm39) C379S possibly damaging Het
Cic G A 7: 24,987,905 (GRCm39) G1531E probably damaging Het
Ckap4 A G 10: 84,369,384 (GRCm39) V116A possibly damaging Het
Dmxl2 A T 9: 54,359,080 (GRCm39) I210N probably benign Het
Donson A C 16: 91,479,125 (GRCm39) V397G probably damaging Het
Dpy19l1 C A 9: 24,361,966 (GRCm39) V332L probably benign Het
Dsp T C 13: 38,379,080 (GRCm39) S1343P possibly damaging Het
Egflam A G 15: 7,254,120 (GRCm39) probably null Het
Eif2b4 A G 5: 31,344,997 (GRCm39) I550T probably damaging Het
Fbxo47 A T 11: 97,770,254 (GRCm39) V46D probably benign Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Folr1 T A 7: 101,513,184 (GRCm39) D37V probably damaging Het
Gm17333 AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA AAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAAGAGAA 16: 77,649,766 (GRCm39) noncoding transcript Het
Gnb1 C A 4: 155,627,531 (GRCm39) A104E probably damaging Het
Gnptg ATTGTTGATGATTT AT 17: 25,454,571 (GRCm39) probably benign Het
Htra4 A T 8: 25,523,713 (GRCm39) V284E probably damaging Het
Igkv3-3 A T 6: 70,664,308 (GRCm39) D50V probably benign Het
Irs3 A G 5: 137,642,209 (GRCm39) S410P probably benign Het
Kif26b C T 1: 178,701,546 (GRCm39) Q642* probably null Het
Klhl11 A T 11: 100,355,176 (GRCm39) M215K probably benign Het
Lamc3 A G 2: 31,795,626 (GRCm39) N337S possibly damaging Het
Lrrc55 G A 2: 85,026,514 (GRCm39) A170V probably damaging Het
Marchf3 A T 18: 56,909,144 (GRCm39) W214R probably damaging Het
Megf11 A C 9: 64,416,027 (GRCm39) T79P probably damaging Het
Mia3 A G 1: 183,126,663 (GRCm39) V26A possibly damaging Het
Myrf A G 19: 10,195,955 (GRCm39) F353S probably damaging Het
Obscn A G 11: 58,970,634 (GRCm39) probably null Het
Ocstamp T C 2: 165,238,208 (GRCm39) K352R probably benign Het
Or2t35 A T 14: 14,407,359 (GRCm38) I46F probably benign Het
Or8b12 G T 9: 37,657,453 (GRCm39) V8L probably benign Het
Osbpl3 T C 6: 50,305,654 (GRCm39) N434S probably damaging Het
Pign A C 1: 105,512,749 (GRCm39) L645V probably benign Het
Polr1has A T 17: 37,275,765 (GRCm39) I116L probably benign Het
Polr2a A G 11: 69,626,500 (GRCm39) S1540P probably benign Het
Ppp2r3c A T 12: 55,349,420 (GRCm39) probably null Het
Ptprf A G 4: 118,082,236 (GRCm39) V414A possibly damaging Het
Pyroxd2 G A 19: 42,740,839 (GRCm39) R22* probably null Het
Rab11fip2 G A 19: 59,925,542 (GRCm39) A225V probably damaging Het
Ranbp2 C T 10: 58,328,492 (GRCm39) A2836V probably damaging Het
Rimklb G A 6: 122,449,591 (GRCm39) R28* probably null Het
Scyl3 G A 1: 163,776,820 (GRCm39) R404Q probably damaging Het
Slc9a8 A T 2: 167,283,090 (GRCm39) K79* probably null Het
Sowaha A T 11: 53,370,163 (GRCm39) probably null Het
Tnk1 A G 11: 69,745,992 (GRCm39) V311A probably damaging Het
Tnrc6a T A 7: 122,789,220 (GRCm39) S1680T probably damaging Het
Tpp1 T C 7: 105,398,158 (GRCm39) Y335C probably damaging Het
Ttc39b A G 4: 83,162,340 (GRCm39) V308A probably benign Het
Ttll3 A C 6: 113,384,353 (GRCm39) Q557P probably damaging Het
Ulk3 G A 9: 57,500,201 (GRCm39) A266T probably benign Het
Wfdc6b C A 2: 164,459,353 (GRCm39) C138* probably null Het
Other mutations in Cxcl13
AlleleSourceChrCoordTypePredicted EffectPPH Score
ice UTSW 5 96,106,530 (GRCm39) missense probably damaging 1.00
pick UTSW 5 96,106,586 (GRCm39) missense probably benign 0.13
Sleet UTSW 5 96,104,861 (GRCm39) missense unknown
R0709:Cxcl13 UTSW 5 96,106,530 (GRCm39) missense probably damaging 1.00
R1669:Cxcl13 UTSW 5 96,106,600 (GRCm39) missense probably damaging 0.97
R2474:Cxcl13 UTSW 5 96,107,816 (GRCm39) nonsense probably null
R5278:Cxcl13 UTSW 5 96,106,586 (GRCm39) missense probably benign 0.13
R5457:Cxcl13 UTSW 5 96,104,830 (GRCm39) start codon destroyed unknown
R8055:Cxcl13 UTSW 5 96,107,763 (GRCm39) missense probably benign 0.08
R8854:Cxcl13 UTSW 5 96,104,861 (GRCm39) missense unknown
R9421:Cxcl13 UTSW 5 96,107,789 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGCCACTTGGATCTTGCTCC -3'
(R):5'- CCATGTGTGACAATAGCAGAAC -3'

Sequencing Primer
(F):5'- TGGATCTTGCTCCAACCCATATAAAG -3'
(R):5'- TAGCAGAACAGGCATTTGTCC -3'
Posted On 2015-11-11