Incidental Mutation 'IGL02826:Zfp286'
ID361220
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp286
Ensembl Gene ENSMUSG00000047342
Gene Namezinc finger protein 286
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #IGL02826
Quality Score
Status
Chromosome11
Chromosomal Location62752577-62789462 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 62787960 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Arginine at position 47 (Q47R)
Ref Sequence ENSEMBL: ENSMUSP00000147022 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054654] [ENSMUST00000108705] [ENSMUST00000207597]
Predicted Effect possibly damaging
Transcript: ENSMUST00000054654
AA Change: Q47R

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000055517
Gene: ENSMUSG00000047342
AA Change: Q47R

DomainStartEndE-ValueType
KRAB 50 114 1.2e-17 SMART
ZnF_C2H2 241 263 2.75e-3 SMART
ZnF_C2H2 269 291 2.84e-5 SMART
ZnF_C2H2 296 318 1.03e-2 SMART
ZnF_C2H2 324 346 5.14e-3 SMART
ZnF_C2H2 352 374 4.24e-4 SMART
ZnF_C2H2 380 402 4.79e-3 SMART
ZnF_C2H2 408 430 1.06e-4 SMART
ZnF_C2H2 436 458 1.06e-4 SMART
ZnF_C2H2 464 486 3.95e-4 SMART
ZnF_C2H2 492 514 1.15e-5 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000108705
AA Change: Q47R

PolyPhen 2 Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000104345
Gene: ENSMUSG00000047342
AA Change: Q47R

DomainStartEndE-ValueType
KRAB 50 114 1.2e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139798
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140072
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145474
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149215
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149230
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152602
Predicted Effect probably damaging
Transcript: ENSMUST00000207597
AA Change: Q47R

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004E09Rik A C 16: 90,926,062 D261E probably benign Het
1810041L15Rik A G 15: 84,420,129 probably benign Het
4930404N11Rik A G 10: 81,364,736 probably benign Het
A3galt2 T C 4: 128,761,509 probably benign Het
Alk C T 17: 71,869,536 G1591D probably damaging Het
Angptl2 T C 2: 33,228,315 S34P probably benign Het
Atp2a2 A G 5: 122,489,291 V137A probably benign Het
Atp8b5 A G 4: 43,366,770 M845V probably damaging Het
Camk1d A G 2: 5,565,760 V30A possibly damaging Het
Ceacam19 G A 7: 19,882,610 T193I probably benign Het
Chst15 T A 7: 132,266,746 D315V probably damaging Het
Cux1 G T 5: 136,308,003 P885Q probably damaging Het
Cyth1 C T 11: 118,185,481 E88K possibly damaging Het
Dido1 A G 2: 180,683,958 V479A probably benign Het
Dlc1 G T 8: 36,570,275 probably benign Het
H2-Ab1 G A 17: 34,264,911 R82Q probably damaging Het
Hps6 T A 19: 46,006,041 *806K probably null Het
Ilf3 T C 9: 21,398,044 S486P probably benign Het
Kdm1b C A 13: 47,080,467 T759K probably damaging Het
Kirrel C A 3: 87,088,485 V381F probably damaging Het
Kmt2b A T 7: 30,577,144 V1701E probably damaging Het
Lrmda T C 14: 22,828,737 Y100H probably damaging Het
Mastl T C 2: 23,145,409 I169V probably damaging Het
Mroh2b A G 15: 4,962,148 E1576G probably damaging Het
Nek3 A T 8: 22,160,368 probably null Het
Nipal3 G T 4: 135,468,550 Y247* probably null Het
Nt5e A C 9: 88,355,705 K229N probably damaging Het
Olfr237-ps1 A G 6: 43,153,577 I91V possibly damaging Het
Olfr974 G T 9: 39,942,958 G233C probably damaging Het
Opa1 A G 16: 29,610,887 M290V probably null Het
Parp2 T A 14: 50,815,415 I155K probably benign Het
Pde4dip G T 3: 97,767,087 A171E probably damaging Het
Prom2 C T 2: 127,531,116 E678K probably benign Het
Rab12 A G 17: 66,498,116 probably benign Het
Rgs8 A T 1: 153,670,799 T13S probably damaging Het
Setd3 A G 12: 108,112,124 probably benign Het
Slx4ip G A 2: 137,004,973 V53I probably damaging Het
Stil A G 4: 115,024,098 D613G probably benign Het
Tjp3 T A 10: 81,273,689 S858C probably damaging Het
Tmem215 A G 4: 40,474,632 *236W probably null Het
Ttbk1 A G 17: 46,470,660 V389A probably benign Het
Wdfy4 A G 14: 32,971,750 F2706S possibly damaging Het
Xpo4 C A 14: 57,629,420 V222L possibly damaging Het
Zfc3h1 A G 10: 115,400,904 S428G probably benign Het
Zfp318 A G 17: 46,398,754 K468E probably damaging Het
Other mutations in Zfp286
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02659:Zfp286 APN 11 62783737 missense possibly damaging 0.54
IGL02745:Zfp286 APN 11 62780874 missense probably damaging 1.00
R0233:Zfp286 UTSW 11 62780393 missense possibly damaging 0.75
R0233:Zfp286 UTSW 11 62780393 missense possibly damaging 0.75
R0318:Zfp286 UTSW 11 62784962 missense probably damaging 1.00
R1954:Zfp286 UTSW 11 62783708 missense possibly damaging 0.46
R1994:Zfp286 UTSW 11 62779820 missense probably damaging 1.00
R2186:Zfp286 UTSW 11 62780461 missense probably damaging 0.97
R4258:Zfp286 UTSW 11 62781070 missense probably benign 0.07
R4327:Zfp286 UTSW 11 62780018 missense probably damaging 1.00
R4453:Zfp286 UTSW 11 62780204 missense probably damaging 1.00
R4479:Zfp286 UTSW 11 62780204 missense probably damaging 1.00
R4647:Zfp286 UTSW 11 62783733 nonsense probably null
R4667:Zfp286 UTSW 11 62780602 missense probably benign 0.00
R4883:Zfp286 UTSW 11 62780629 missense probably benign 0.01
R4978:Zfp286 UTSW 11 62788928 critical splice donor site probably null
R5120:Zfp286 UTSW 11 62780725 missense probably benign 0.40
R5533:Zfp286 UTSW 11 62780970 intron probably benign
R7236:Zfp286 UTSW 11 62783670 critical splice donor site probably null
R7464:Zfp286 UTSW 11 62780801 missense probably benign 0.00
R8065:Zfp286 UTSW 11 62753519 missense unknown
R8067:Zfp286 UTSW 11 62753519 missense unknown
R8716:Zfp286 UTSW 11 62780991 missense unknown
Z1186:Zfp286 UTSW 11 62784956 missense probably damaging 1.00
Z1186:Zfp286 UTSW 11 62787969 missense probably benign
Z1187:Zfp286 UTSW 11 62784956 missense probably damaging 1.00
Z1187:Zfp286 UTSW 11 62787969 missense probably benign
Z1188:Zfp286 UTSW 11 62784956 missense probably damaging 1.00
Z1188:Zfp286 UTSW 11 62787969 missense probably benign
Z1189:Zfp286 UTSW 11 62784956 missense probably damaging 1.00
Z1189:Zfp286 UTSW 11 62787969 missense probably benign
Z1190:Zfp286 UTSW 11 62784956 missense probably damaging 1.00
Z1190:Zfp286 UTSW 11 62787969 missense probably benign
Z1191:Zfp286 UTSW 11 62784956 missense probably damaging 1.00
Z1191:Zfp286 UTSW 11 62787969 missense probably benign
Z1192:Zfp286 UTSW 11 62784956 missense probably damaging 1.00
Z1192:Zfp286 UTSW 11 62787969 missense probably benign
Posted On2015-12-18