Incidental Mutation 'R5317:Pan3'
ID 405867
Institutional Source Beutler Lab
Gene Symbol Pan3
Ensembl Gene ENSMUSG00000029647
Gene Name PAN3 poly(A) specific ribonuclease subunit
Synonyms 2700050F09Rik, A430027N15Rik
MMRRC Submission 042900-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.385) question?
Stock # R5317 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 147366971-147485312 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 147480020 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000031651] [ENSMUST00000031651] [ENSMUST00000031651] [ENSMUST00000031651] [ENSMUST00000175807] [ENSMUST00000175807] [ENSMUST00000175807] [ENSMUST00000175807] [ENSMUST00000176553] [ENSMUST00000176553] [ENSMUST00000176553] [ENSMUST00000176553] [ENSMUST00000176600] [ENSMUST00000176600] [ENSMUST00000176600] [ENSMUST00000176600]
AlphaFold Q640Q5
Predicted Effect probably null
Transcript: ENSMUST00000031651
SMART Domains Protein: ENSMUSP00000031651
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
ZnF_C3H1 51 76 2.24e-3 SMART
low complexity region 77 87 N/A INTRINSIC
low complexity region 93 120 N/A INTRINSIC
low complexity region 188 194 N/A INTRINSIC
low complexity region 318 335 N/A INTRINSIC
PDB:4BWP|B 391 829 1e-161 PDB
Blast:S_TKc 439 607 2e-8 BLAST
SCOP:d1pme__ 453 602 4e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000031651
SMART Domains Protein: ENSMUSP00000031651
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
ZnF_C3H1 51 76 2.24e-3 SMART
low complexity region 77 87 N/A INTRINSIC
low complexity region 93 120 N/A INTRINSIC
low complexity region 188 194 N/A INTRINSIC
low complexity region 318 335 N/A INTRINSIC
PDB:4BWP|B 391 829 1e-161 PDB
Blast:S_TKc 439 607 2e-8 BLAST
SCOP:d1pme__ 453 602 4e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000031651
SMART Domains Protein: ENSMUSP00000031651
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
ZnF_C3H1 51 76 2.24e-3 SMART
low complexity region 77 87 N/A INTRINSIC
low complexity region 93 120 N/A INTRINSIC
low complexity region 188 194 N/A INTRINSIC
low complexity region 318 335 N/A INTRINSIC
PDB:4BWP|B 391 829 1e-161 PDB
Blast:S_TKc 439 607 2e-8 BLAST
SCOP:d1pme__ 453 602 4e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000031651
SMART Domains Protein: ENSMUSP00000031651
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
ZnF_C3H1 51 76 2.24e-3 SMART
low complexity region 77 87 N/A INTRINSIC
low complexity region 93 120 N/A INTRINSIC
low complexity region 188 194 N/A INTRINSIC
low complexity region 318 335 N/A INTRINSIC
PDB:4BWP|B 391 829 1e-161 PDB
Blast:S_TKc 439 607 2e-8 BLAST
SCOP:d1pme__ 453 602 4e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000175807
SMART Domains Protein: ENSMUSP00000135729
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
PDB:4BWP|B 51 450 1e-134 PDB
Predicted Effect probably null
Transcript: ENSMUST00000175807
SMART Domains Protein: ENSMUSP00000135729
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
PDB:4BWP|B 51 450 1e-134 PDB
Predicted Effect probably null
Transcript: ENSMUST00000175807
SMART Domains Protein: ENSMUSP00000135729
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
PDB:4BWP|B 51 450 1e-134 PDB
Predicted Effect probably null
Transcript: ENSMUST00000175807
SMART Domains Protein: ENSMUSP00000135729
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
PDB:4BWP|B 51 450 1e-134 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176505
Predicted Effect probably null
Transcript: ENSMUST00000176553
SMART Domains Protein: ENSMUSP00000134911
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
PDB:4BWP|B 1 142 5e-66 PDB
low complexity region 161 171 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000176553
SMART Domains Protein: ENSMUSP00000134911
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
PDB:4BWP|B 1 142 5e-66 PDB
low complexity region 161 171 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000176553
SMART Domains Protein: ENSMUSP00000134911
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
PDB:4BWP|B 1 142 5e-66 PDB
low complexity region 161 171 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000176553
SMART Domains Protein: ENSMUSP00000134911
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
PDB:4BWP|B 1 142 5e-66 PDB
low complexity region 161 171 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000176596
Predicted Effect probably benign
Transcript: ENSMUST00000176596
Predicted Effect probably null
Transcript: ENSMUST00000176600
SMART Domains Protein: ENSMUSP00000135367
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
ZnF_C3H1 51 76 2.24e-3 SMART
low complexity region 77 87 N/A INTRINSIC
low complexity region 93 120 N/A INTRINSIC
low complexity region 188 194 N/A INTRINSIC
low complexity region 372 389 N/A INTRINSIC
PDB:4BWP|B 445 883 1e-161 PDB
Blast:S_TKc 493 661 2e-8 BLAST
SCOP:d1pme__ 507 656 4e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176600
SMART Domains Protein: ENSMUSP00000135367
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
ZnF_C3H1 51 76 2.24e-3 SMART
low complexity region 77 87 N/A INTRINSIC
low complexity region 93 120 N/A INTRINSIC
low complexity region 188 194 N/A INTRINSIC
low complexity region 372 389 N/A INTRINSIC
PDB:4BWP|B 445 883 1e-161 PDB
Blast:S_TKc 493 661 2e-8 BLAST
SCOP:d1pme__ 507 656 4e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176600
SMART Domains Protein: ENSMUSP00000135367
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
ZnF_C3H1 51 76 2.24e-3 SMART
low complexity region 77 87 N/A INTRINSIC
low complexity region 93 120 N/A INTRINSIC
low complexity region 188 194 N/A INTRINSIC
low complexity region 372 389 N/A INTRINSIC
PDB:4BWP|B 445 883 1e-161 PDB
Blast:S_TKc 493 661 2e-8 BLAST
SCOP:d1pme__ 507 656 4e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176600
SMART Domains Protein: ENSMUSP00000135367
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
ZnF_C3H1 51 76 2.24e-3 SMART
low complexity region 77 87 N/A INTRINSIC
low complexity region 93 120 N/A INTRINSIC
low complexity region 188 194 N/A INTRINSIC
low complexity region 372 389 N/A INTRINSIC
PDB:4BWP|B 445 883 1e-161 PDB
Blast:S_TKc 493 661 2e-8 BLAST
SCOP:d1pme__ 507 656 4e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176753
SMART Domains Protein: ENSMUSP00000134989
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 43 49 N/A INTRINSIC
low complexity region 173 190 N/A INTRINSIC
PDB:4BWP|B 246 684 1e-164 PDB
Blast:S_TKc 294 462 1e-8 BLAST
SCOP:d1pme__ 308 457 8e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176753
SMART Domains Protein: ENSMUSP00000134989
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 43 49 N/A INTRINSIC
low complexity region 173 190 N/A INTRINSIC
PDB:4BWP|B 246 684 1e-164 PDB
Blast:S_TKc 294 462 1e-8 BLAST
SCOP:d1pme__ 308 457 8e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176753
SMART Domains Protein: ENSMUSP00000134989
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 43 49 N/A INTRINSIC
low complexity region 173 190 N/A INTRINSIC
PDB:4BWP|B 246 684 1e-164 PDB
Blast:S_TKc 294 462 1e-8 BLAST
SCOP:d1pme__ 308 457 8e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000176753
SMART Domains Protein: ENSMUSP00000134989
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 43 49 N/A INTRINSIC
low complexity region 173 190 N/A INTRINSIC
PDB:4BWP|B 246 684 1e-164 PDB
Blast:S_TKc 294 462 1e-8 BLAST
SCOP:d1pme__ 308 457 8e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177465
SMART Domains Protein: ENSMUSP00000134810
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 43 49 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177465
SMART Domains Protein: ENSMUSP00000134810
Gene: ENSMUSG00000029647

DomainStartEndE-ValueType
low complexity region 43 49 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176856
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177496
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.6%
Validation Efficiency
Allele List at MGI

 All alleles(15) : Gene trapped(15)

Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arih1 A C 9: 59,300,619 (GRCm39) H542Q probably benign Het
Ccn4 T G 15: 66,789,131 (GRCm39) S206A probably benign Het
Cnot8 T C 11: 58,004,029 (GRCm39) S155P probably damaging Het
Dcc C T 18: 71,517,226 (GRCm39) E810K possibly damaging Het
Dmrt2 T C 19: 25,650,844 (GRCm39) V10A probably benign Het
Dnah17 G A 11: 118,018,109 (GRCm39) R129W possibly damaging Het
Eif4a3 G T 11: 119,185,490 (GRCm39) H117N probably damaging Het
Fhip2a T A 19: 57,370,141 (GRCm39) probably null Het
Gpr179 T A 11: 97,228,671 (GRCm39) Q1161H probably damaging Het
Grm1 T G 10: 10,622,443 (GRCm39) M427L possibly damaging Het
Grxcr2 T A 18: 42,131,916 (GRCm39) H51L probably damaging Het
Il1rn C T 2: 24,239,554 (GRCm39) T150I probably benign Het
Kcnc4 C T 3: 107,366,055 (GRCm39) R51H probably damaging Het
Kcnh3 T C 15: 99,125,822 (GRCm39) S160P probably benign Het
Lrrc37 T C 11: 103,504,971 (GRCm39) I2332M possibly damaging Het
Mcm9 G A 10: 53,414,330 (GRCm39) P250L probably damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Mtmr2 T C 9: 13,704,475 (GRCm39) F201L probably benign Het
Or8s5 G A 15: 98,238,246 (GRCm39) A208V probably benign Het
Pcdhgb7 T A 18: 37,885,887 (GRCm39) D352E probably benign Het
Pdgfa A G 5: 138,974,102 (GRCm39) probably null Het
Pkhd1 T C 1: 20,520,528 (GRCm39) D1938G probably damaging Het
Plac8 C T 5: 100,704,345 (GRCm39) probably null Het
Rab11fip3 T C 17: 26,287,052 (GRCm39) E367G possibly damaging Het
Sgo2a C T 1: 58,054,683 (GRCm39) P289L probably benign Het
Slc22a18 T C 7: 143,052,896 (GRCm39) Y374H probably damaging Het
Slco2a1 T C 9: 102,956,778 (GRCm39) V530A probably benign Het
Spty2d1 A T 7: 46,648,049 (GRCm39) S293R possibly damaging Het
Stt3b G T 9: 115,081,578 (GRCm39) Y569* probably null Het
Tas2r140 A G 6: 133,032,543 (GRCm39) Y72H probably benign Het
Usp35 C T 7: 96,960,846 (GRCm39) R860H probably damaging Het
Vmn2r130 T A 17: 23,282,557 (GRCm39) M79K probably benign Het
Vsig10l T C 7: 43,114,247 (GRCm39) S190P probably damaging Het
Wwc2 C T 8: 48,300,590 (GRCm39) D958N unknown Het
Zfp318 AAGAAGG A 17: 46,723,463 (GRCm39) probably benign Het
Other mutations in Pan3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01483:Pan3 APN 5 147,466,783 (GRCm39) missense probably benign 0.05
IGL01612:Pan3 APN 5 147,390,052 (GRCm39) splice site probably benign
IGL02187:Pan3 APN 5 147,463,398 (GRCm39) missense probably benign 0.21
IGL02324:Pan3 APN 5 147,466,933 (GRCm39) splice site probably null
IGL02328:Pan3 APN 5 147,466,933 (GRCm39) splice site probably null
IGL02507:Pan3 APN 5 147,463,406 (GRCm39) missense probably damaging 0.98
IGL03144:Pan3 APN 5 147,387,591 (GRCm39) splice site probably benign
3-1:Pan3 UTSW 5 147,463,385 (GRCm39) missense probably benign 0.14
R2145:Pan3 UTSW 5 147,466,908 (GRCm39) missense possibly damaging 0.87
R2174:Pan3 UTSW 5 147,387,463 (GRCm39) missense possibly damaging 0.63
R2504:Pan3 UTSW 5 147,463,846 (GRCm39) missense possibly damaging 0.87
R3106:Pan3 UTSW 5 147,476,189 (GRCm39) splice site probably benign
R3723:Pan3 UTSW 5 147,440,018 (GRCm39) intron probably benign
R3944:Pan3 UTSW 5 147,387,540 (GRCm39) missense probably damaging 1.00
R4589:Pan3 UTSW 5 147,479,983 (GRCm39) missense probably damaging 0.98
R4647:Pan3 UTSW 5 147,464,013 (GRCm39) missense probably damaging 1.00
R4811:Pan3 UTSW 5 147,466,868 (GRCm39) missense probably damaging 1.00
R5001:Pan3 UTSW 5 147,463,492 (GRCm39) critical splice donor site probably null
R5126:Pan3 UTSW 5 147,464,008 (GRCm39) missense probably benign 0.00
R5215:Pan3 UTSW 5 147,391,915 (GRCm39) splice site probably null
R5496:Pan3 UTSW 5 147,463,938 (GRCm39) critical splice acceptor site probably null
R5687:Pan3 UTSW 5 147,391,982 (GRCm39) missense probably damaging 1.00
R6147:Pan3 UTSW 5 147,485,093 (GRCm39) unclassified probably benign
R6539:Pan3 UTSW 5 147,387,463 (GRCm39) missense possibly damaging 0.63
R7008:Pan3 UTSW 5 147,482,503 (GRCm39) missense probably damaging 0.99
R7047:Pan3 UTSW 5 147,483,175 (GRCm39) missense probably damaging 0.97
R7226:Pan3 UTSW 5 147,463,802 (GRCm39) missense probably damaging 1.00
R7424:Pan3 UTSW 5 147,473,082 (GRCm39) splice site probably null
R7453:Pan3 UTSW 5 147,463,491 (GRCm39) critical splice donor site probably null
R8062:Pan3 UTSW 5 147,463,960 (GRCm39) missense probably benign 0.18
R8786:Pan3 UTSW 5 147,424,951 (GRCm39) missense possibly damaging 0.94
R8897:Pan3 UTSW 5 147,387,472 (GRCm39) missense probably benign 0.23
R9658:Pan3 UTSW 5 147,479,881 (GRCm39) missense probably benign 0.00
X0060:Pan3 UTSW 5 147,479,943 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCACTTTTCAGAGCCCTTC -3'
(R):5'- CCTTGTATGTGCACACAGGG -3'

Sequencing Primer
(F):5'- CCTTCCAATTTCTAATTAACTGGGG -3'
(R):5'- TATGTGCACACAGGGCAGGAG -3'
Posted On 2016-07-22