Incidental Mutation 'IGL03005:Fmo9'
ID |
407525 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Fmo9
|
Ensembl Gene |
ENSMUSG00000026560 |
Gene Name |
flavin containing monooxygenase 9 |
Synonyms |
4831428F09Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.063)
|
Stock # |
IGL03005
|
Quality Score |
|
Status
|
|
Chromosome |
1 |
Chromosomal Location |
166489624-166509414 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 166502088 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Asparagine
at position 179
(S179N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000027843
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027843]
[ENSMUST00000148677]
|
AlphaFold |
Q8C116 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000027843
AA Change: S179N
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
SMART Domains |
Protein: ENSMUSP00000027843 Gene: ENSMUSG00000026560 AA Change: S179N
Domain | Start | End | E-Value | Type |
Pfam:FMO-like
|
3 |
535 |
1.2e-252 |
PFAM |
Pfam:Pyr_redox_2
|
4 |
262 |
2.9e-12 |
PFAM |
Pfam:Pyr_redox_3
|
7 |
221 |
2.3e-14 |
PFAM |
Pfam:NAD_binding_8
|
8 |
83 |
1.2e-6 |
PFAM |
Pfam:K_oxygenase
|
77 |
334 |
8.9e-11 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000148677
AA Change: S128N
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
SMART Domains |
Protein: ENSMUSP00000114750 Gene: ENSMUSG00000026560 AA Change: S128N
Domain | Start | End | E-Value | Type |
Pfam:FMO-like
|
1 |
484 |
1.6e-222 |
PFAM |
Pfam:Pyr_redox_3
|
3 |
170 |
1.2e-12 |
PFAM |
Pfam:K_oxygenase
|
28 |
283 |
6.2e-11 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Akt3 |
A |
T |
1: 176,894,793 (GRCm39) |
V268E |
probably damaging |
Het |
Aoc1l1 |
T |
A |
6: 48,953,480 (GRCm39) |
Y468* |
probably null |
Het |
Apob |
A |
G |
12: 8,043,059 (GRCm39) |
|
probably benign |
Het |
Arhgap19 |
T |
C |
19: 41,772,856 (GRCm39) |
|
probably benign |
Het |
C2cd2 |
A |
G |
16: 97,660,632 (GRCm39) |
L672P |
probably damaging |
Het |
Cars1 |
A |
G |
7: 143,112,906 (GRCm39) |
F774L |
probably damaging |
Het |
Cd200r3 |
T |
A |
16: 44,773,973 (GRCm39) |
S128R |
probably damaging |
Het |
Chd9 |
A |
G |
8: 91,738,075 (GRCm39) |
N1569S |
probably damaging |
Het |
Chmp7 |
G |
A |
14: 69,957,277 (GRCm39) |
R294C |
probably damaging |
Het |
Col10a1 |
A |
T |
10: 34,271,734 (GRCm39) |
I569F |
probably damaging |
Het |
Cspg4 |
T |
A |
9: 56,795,772 (GRCm39) |
V1169D |
probably damaging |
Het |
Emg1 |
G |
A |
6: 124,681,557 (GRCm39) |
T229I |
probably damaging |
Het |
Frem1 |
T |
C |
4: 82,912,371 (GRCm39) |
Y667C |
probably damaging |
Het |
Gpsm2 |
A |
G |
3: 108,594,322 (GRCm39) |
|
probably benign |
Het |
Gsdma |
A |
T |
11: 98,567,085 (GRCm39) |
E395V |
probably damaging |
Het |
Gsdmd |
C |
T |
15: 75,739,015 (GRCm39) |
T464M |
possibly damaging |
Het |
Iqschfp |
C |
A |
3: 68,526,010 (GRCm39) |
Q395K |
possibly damaging |
Het |
Lipo3 |
T |
C |
19: 33,763,136 (GRCm39) |
I36V |
possibly damaging |
Het |
Lrrtm1 |
A |
G |
6: 77,221,139 (GRCm39) |
S199G |
probably damaging |
Het |
Lypla1 |
C |
T |
1: 4,902,613 (GRCm39) |
|
probably benign |
Het |
Mst1r |
C |
T |
9: 107,791,748 (GRCm39) |
Q809* |
probably null |
Het |
Mtr |
T |
A |
13: 12,250,335 (GRCm39) |
|
probably benign |
Het |
Or4a39 |
G |
A |
2: 89,237,315 (GRCm39) |
T36I |
possibly damaging |
Het |
Pax7 |
T |
A |
4: 139,556,007 (GRCm39) |
I156F |
probably damaging |
Het |
Pcdhb8 |
T |
A |
18: 37,490,587 (GRCm39) |
L755Q |
probably damaging |
Het |
Pdzd2 |
G |
A |
15: 12,385,351 (GRCm39) |
P1140S |
probably damaging |
Het |
Pdzrn4 |
T |
C |
15: 92,668,272 (GRCm39) |
L808P |
probably damaging |
Het |
Pex1 |
G |
T |
5: 3,680,292 (GRCm39) |
Q971H |
probably null |
Het |
Pgap6 |
C |
T |
17: 26,337,911 (GRCm39) |
L432F |
probably benign |
Het |
Pld1 |
T |
A |
3: 28,141,402 (GRCm39) |
V655E |
possibly damaging |
Het |
Pnpla3 |
C |
T |
15: 84,058,469 (GRCm39) |
R163W |
probably damaging |
Het |
Rabgef1 |
T |
C |
5: 130,237,638 (GRCm39) |
L237P |
probably damaging |
Het |
Setbp1 |
A |
T |
18: 78,902,340 (GRCm39) |
N442K |
possibly damaging |
Het |
Sorl1 |
T |
G |
9: 41,968,621 (GRCm39) |
D544A |
probably damaging |
Het |
Spire2 |
C |
A |
8: 124,090,107 (GRCm39) |
P490T |
probably benign |
Het |
Zeb1 |
T |
A |
18: 5,767,150 (GRCm39) |
S554T |
probably benign |
Het |
|
Other mutations in Fmo9 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00886:Fmo9
|
APN |
1 |
166,507,714 (GRCm39) |
splice site |
probably null |
|
IGL01796:Fmo9
|
APN |
1 |
166,490,904 (GRCm39) |
missense |
probably benign |
0.31 |
IGL03115:Fmo9
|
APN |
1 |
166,505,220 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03163:Fmo9
|
APN |
1 |
166,502,019 (GRCm39) |
missense |
possibly damaging |
0.77 |
R0089:Fmo9
|
UTSW |
1 |
166,494,878 (GRCm39) |
missense |
probably benign |
0.05 |
R0570:Fmo9
|
UTSW |
1 |
166,502,031 (GRCm39) |
missense |
probably null |
0.00 |
R1520:Fmo9
|
UTSW |
1 |
166,495,024 (GRCm39) |
missense |
probably benign |
0.19 |
R1779:Fmo9
|
UTSW |
1 |
166,490,868 (GRCm39) |
missense |
probably benign |
0.18 |
R1783:Fmo9
|
UTSW |
1 |
166,501,217 (GRCm39) |
missense |
probably benign |
0.01 |
R2858:Fmo9
|
UTSW |
1 |
166,501,236 (GRCm39) |
missense |
probably damaging |
1.00 |
R2859:Fmo9
|
UTSW |
1 |
166,501,236 (GRCm39) |
missense |
probably damaging |
1.00 |
R3851:Fmo9
|
UTSW |
1 |
166,490,936 (GRCm39) |
missense |
probably benign |
0.00 |
R3924:Fmo9
|
UTSW |
1 |
166,492,221 (GRCm39) |
missense |
probably benign |
0.03 |
R4470:Fmo9
|
UTSW |
1 |
166,507,799 (GRCm39) |
missense |
probably damaging |
1.00 |
R4728:Fmo9
|
UTSW |
1 |
166,490,880 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5538:Fmo9
|
UTSW |
1 |
166,501,198 (GRCm39) |
missense |
probably benign |
0.01 |
R5650:Fmo9
|
UTSW |
1 |
166,491,015 (GRCm39) |
missense |
probably damaging |
1.00 |
R5820:Fmo9
|
UTSW |
1 |
166,492,170 (GRCm39) |
missense |
possibly damaging |
0.67 |
R6163:Fmo9
|
UTSW |
1 |
166,494,962 (GRCm39) |
missense |
probably benign |
|
R6229:Fmo9
|
UTSW |
1 |
166,505,126 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6243:Fmo9
|
UTSW |
1 |
166,494,938 (GRCm39) |
missense |
probably benign |
0.45 |
R6375:Fmo9
|
UTSW |
1 |
166,492,164 (GRCm39) |
critical splice donor site |
probably null |
|
R7144:Fmo9
|
UTSW |
1 |
166,505,189 (GRCm39) |
missense |
probably benign |
0.40 |
R7236:Fmo9
|
UTSW |
1 |
166,504,140 (GRCm39) |
missense |
probably damaging |
1.00 |
R7316:Fmo9
|
UTSW |
1 |
166,491,215 (GRCm39) |
missense |
probably benign |
0.21 |
R7341:Fmo9
|
UTSW |
1 |
166,504,115 (GRCm39) |
missense |
probably damaging |
1.00 |
R7382:Fmo9
|
UTSW |
1 |
166,491,229 (GRCm39) |
splice site |
probably null |
|
R7589:Fmo9
|
UTSW |
1 |
166,501,997 (GRCm39) |
missense |
possibly damaging |
0.61 |
R7679:Fmo9
|
UTSW |
1 |
166,495,058 (GRCm39) |
missense |
probably benign |
0.01 |
R8110:Fmo9
|
UTSW |
1 |
166,491,095 (GRCm39) |
missense |
probably benign |
0.03 |
R8500:Fmo9
|
UTSW |
1 |
166,502,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R9098:Fmo9
|
UTSW |
1 |
166,492,199 (GRCm39) |
missense |
possibly damaging |
0.48 |
R9301:Fmo9
|
UTSW |
1 |
166,494,794 (GRCm39) |
missense |
probably damaging |
1.00 |
R9400:Fmo9
|
UTSW |
1 |
166,505,243 (GRCm39) |
missense |
probably benign |
0.09 |
R9401:Fmo9
|
UTSW |
1 |
166,505,189 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1088:Fmo9
|
UTSW |
1 |
166,501,114 (GRCm39) |
critical splice donor site |
probably null |
|
|
Posted On |
2016-08-02 |