Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03089:Ighg2b'

418286

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ighg2b

Ensembl Gene

ENSMUSG00000076613

Gene Name

immunoglobulin heavy constant gamma 2B

Synonyms

IgG2b, gamma2b

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL03089

Quality Score

Status

Chromosome

Chromosomal Location

113267934-113271553 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 113270298 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 240 (P240L)

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000103418
AA Change: P240L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100214
Gene: ENSMUSG00000076613
AA Change: P240L

Domain	Start	End	E-Value	Type
IGc1	22	92	6.9e-16	SMART
low complexity region	108	121	N/A	INTRINSIC
IG_like	145	220	4.02e-2	SMART
IGc1	251	324	1.64e-31	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000192188
AA Change: P240L

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl4	A	G	3: 95,584,556 (GRCm39)	S947P	probably damaging	Het
Agl	T	A	3: 116,574,672 (GRCm39)	H709L	probably damaging	Het
Alpi	T	A	1: 87,027,830 (GRCm39)	D250V	probably benign	Het
Anapc4	A	G	5: 53,023,740 (GRCm39)	S735G	probably benign	Het
Ank1	A	T	8: 23,594,848 (GRCm39)	I611L	probably benign	Het
Canx	A	G	11: 50,195,309 (GRCm39)	V253A	possibly damaging	Het
Cbfa2t3	A	T	8: 123,361,873 (GRCm39)	I383N	probably damaging	Het
Ccn3	C	T	15: 54,612,680 (GRCm39)	R230C	possibly damaging	Het
Cdc23	T	C	18: 34,767,513 (GRCm39)	Y519C	probably damaging	Het
Celsr3	T	A	9: 108,703,806 (GRCm39)	N96K	probably benign	Het
Clptm1	A	G	7: 19,371,072 (GRCm39)	Y355H	probably damaging	Het
Col6a5	C	T	9: 105,811,038 (GRCm39)	S827N	unknown	Het
Cyp21a1	G	T	17: 35,022,420 (GRCm39)		probably null	Het
Cyp24a1	T	G	2: 170,327,886 (GRCm39)	H452P	probably damaging	Het
Cyp2c39	T	A	19: 39,552,295 (GRCm39)	H329Q	probably benign	Het
D630003M21Rik	C	T	2: 158,058,664 (GRCm39)	R412Q	probably benign	Het
Dennd1b	G	A	1: 139,029,767 (GRCm39)	R308Q	possibly damaging	Het
Deup1	T	C	9: 15,519,096 (GRCm39)	S137G	possibly damaging	Het
Dmbt1	T	A	7: 130,712,778 (GRCm39)	I1583N	probably damaging	Het
Dvl1	G	A	4: 155,939,609 (GRCm39)	V320M	probably damaging	Het
Elmod3	A	G	6: 72,546,299 (GRCm39)	S254P	probably damaging	Het
Emsy	G	A	7: 98,286,473 (GRCm39)	Q226*	probably null	Het
Ephb6	C	A	6: 41,591,108 (GRCm39)	D88E	probably damaging	Het
Exoc1	A	G	5: 76,690,005 (GRCm39)	M182V	possibly damaging	Het
Fbxw4	T	G	19: 45,580,160 (GRCm39)		probably benign	Het
Fgr	A	G	4: 132,713,577 (GRCm39)	D35G	probably damaging	Het
Gm20547	A	T	17: 35,080,008 (GRCm39)	D366E	probably damaging	Het
Gucy1a1	T	C	3: 82,004,988 (GRCm39)	N599S	probably damaging	Het
Jak3	A	G	8: 72,138,727 (GRCm39)	D975G	probably benign	Het
Klhl26	A	T	8: 70,908,283 (GRCm39)	N24K	probably benign	Het
Letm1	T	A	5: 33,918,202 (GRCm39)	E314D	probably damaging	Het
Lin54	A	T	5: 100,598,852 (GRCm39)	F319L	probably damaging	Het
Lrp5	A	T	19: 3,670,314 (GRCm39)		probably null	Het
Lvrn	T	C	18: 47,013,776 (GRCm39)	F486S	probably damaging	Het
Or1e19	T	C	11: 73,316,009 (GRCm39)	T267A	probably benign	Het
Or2h1b	A	G	17: 37,462,534 (GRCm39)	C110R	probably damaging	Het
Or4c113	T	C	2: 88,885,357 (GRCm39)	R138G	probably benign	Het
Or51m1	A	C	7: 103,578,329 (GRCm39)	I100L	probably benign	Het
Or8g54	A	T	9: 39,706,977 (GRCm39)	Y102F	probably benign	Het
Pramel24	A	G	4: 143,452,703 (GRCm39)	T45A	probably benign	Het
Sap30bp	T	A	11: 115,848,214 (GRCm39)	M112K	possibly damaging	Het
Sbno1	A	G	5: 124,525,374 (GRCm39)		probably benign	Het
Slc30a5	T	C	13: 100,950,338 (GRCm39)	I307V	probably benign	Het
Trim37	T	A	11: 87,080,963 (GRCm39)	D21E	probably damaging	Het
Usp34	T	C	11: 23,396,958 (GRCm39)	F614S	possibly damaging	Het
Usp39	A	C	6: 72,305,622 (GRCm39)	F387C	probably damaging	Het
Vipas39	C	T	12: 87,300,028 (GRCm39)	C149Y	probably damaging	Het
Vmn2r107	C	A	17: 20,595,974 (GRCm39)	H842Q	probably benign	Het
Vps18	T	A	2: 119,123,658 (GRCm39)	V195E	probably benign	Het
Vsx1	A	G	2: 150,527,510 (GRCm39)		probably benign	Het

Other mutations in Ighg2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01366:Ighg2b	APN	12	113,270,656 (GRCm39)	missense	possibly damaging	0.79
IGL01837:Ighg2b	APN	12	113,270,065 (GRCm39)	missense	unknown
IGL01973:Ighg2b	APN	12	113,271,305 (GRCm39)	missense	unknown
IGL01998:Ighg2b	APN	12	113,270,709 (GRCm39)	missense	unknown
IGL02147:Ighg2b	APN	12	113,270,011 (GRCm39)	makesense	probably null
IGL02183:Ighg2b	APN	12	113,271,449 (GRCm39)	missense	unknown
PIT4453001:Ighg2b	UTSW	12	113,270,492 (GRCm39)	missense	unknown
R4199:Ighg2b	UTSW	12	113,270,907 (GRCm39)	missense	probably damaging	0.96
R4459:Ighg2b	UTSW	12	113,270,578 (GRCm39)	missense	unknown
R4577:Ighg2b	UTSW	12	113,270,512 (GRCm39)	missense	unknown
R4589:Ighg2b	UTSW	12	113,270,104 (GRCm39)	missense	unknown
R4807:Ighg2b	UTSW	12	113,267,965 (GRCm39)	unclassified	probably benign
R4822:Ighg2b	UTSW	12	113,270,011 (GRCm39)	makesense	probably null
R5424:Ighg2b	UTSW	12	113,271,550 (GRCm39)	missense	unknown
R5641:Ighg2b	UTSW	12	113,270,767 (GRCm39)	missense	unknown
R6297:Ighg2b	UTSW	12	113,270,512 (GRCm39)	missense	unknown
R6701:Ighg2b	UTSW	12	113,270,699 (GRCm39)	missense	unknown
R6703:Ighg2b	UTSW	12	113,268,653 (GRCm39)	unclassified	probably benign
R6880:Ighg2b	UTSW	12	113,270,726 (GRCm39)	missense
R7342:Ighg2b	UTSW	12	113,270,050 (GRCm39)	missense
R7505:Ighg2b	UTSW	12	113,268,600 (GRCm39)	missense
R7908:Ighg2b	UTSW	12	113,270,074 (GRCm39)	missense
R8543:Ighg2b	UTSW	12	113,270,552 (GRCm39)	missense	probably damaging	1.00
R8951:Ighg2b	UTSW	12	113,270,926 (GRCm39)	missense	probably benign
R9237:Ighg2b	UTSW	12	113,270,217 (GRCm39)	missense
R9539:Ighg2b	UTSW	12	113,270,498 (GRCm39)	missense
R9789:Ighg2b	UTSW	12	113,270,304 (GRCm39)	missense

Posted On

2016-08-02