Incidental Mutation 'R5998:Igkv15-103'
Institutional Source Beutler Lab
Gene Symbol Igkv15-103
Ensembl Gene ENSMUSG00000076523
Gene Nameimmunoglobulin kappa chain variable 15-103
MMRRC Submission 044177-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #R5998 (G1)
Quality Score225.009
Status Not validated
Chromosomal Location68437468-68437925 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 68437505 bp
Amino Acid Change Phenylalanine to Tyrosine at position 13 (F13Y)
Ref Sequence ENSEMBL: ENSMUSP00000100125 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103324]
Predicted Effect unknown
Transcript: ENSMUST00000103324
AA Change: F13Y
SMART Domains Protein: ENSMUSP00000100125
Gene: ENSMUSG00000076523
AA Change: F13Y

low complexity region 2 20 N/A INTRINSIC
IGv 38 110 1.51e-21 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.3%
  • 20x: 91.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 G A 11: 9,567,708 V4437I probably damaging Het
Acot12 T C 13: 91,757,534 I71T possibly damaging Het
Adcy10 A G 1: 165,541,649 I630V probably benign Het
Adcy3 T A 12: 4,198,348 V470E probably damaging Het
Adcy6 C A 15: 98,594,354 E1008* probably null Het
Adgrb3 A T 1: 25,431,501 probably null Het
Ahrr T A 13: 74,213,836 S515C probably damaging Het
Ankrd52 T C 10: 128,383,123 I416T probably damaging Het
Arhgap45 T C 10: 80,030,950 S1096P probably damaging Het
Atp8b4 A G 2: 126,433,867 probably null Het
Bcl6b A C 11: 70,228,183 I200M probably damaging Het
Btbd19 T A 4: 117,120,999 E234V probably benign Het
Csmd1 G A 8: 15,910,443 T3324I probably damaging Het
Cyp2a5 G A 7: 26,837,153 V186I probably benign Het
Glb1l2 G A 9: 26,766,003 T533I possibly damaging Het
Gm10471 T C 5: 26,084,706 D241G probably damaging Het
Gm8994 T C 6: 136,328,624 F28L probably benign Het
Helz G T 11: 107,685,534 E1851* probably null Het
Kcnq2 T C 2: 181,087,008 H548R probably damaging Het
Mcm3ap T C 10: 76,481,142 probably null Het
Micall2 T C 5: 139,706,911 probably null Het
Mill2 A G 7: 18,840,064 R25G probably benign Het
Mtcl1 G A 17: 66,368,280 H1041Y probably damaging Het
Olfr180 T C 16: 58,916,630 T4A probably benign Het
Olfr926 G A 9: 38,877,869 R231H probably damaging Het
Pigt A G 2: 164,507,454 E559G possibly damaging Het
Pkdrej A G 15: 85,815,453 V2094A probably benign Het
Ppp1r32 A T 19: 10,481,352 W105R possibly damaging Het
Prkdc T A 16: 15,783,157 L2894Q probably damaging Het
Tmem63b A G 17: 45,670,000 V256A possibly damaging Het
Zfp516 T C 18: 82,956,514 L279P probably damaging Het
Zfp780b T A 7: 27,964,622 K169N probably benign Het
Other mutations in Igkv15-103
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02851:Igkv15-103 APN 6 68437690 missense probably benign 0.13
R3957:Igkv15-103 UTSW 6 68437919 missense probably benign 0.00
R4165:Igkv15-103 UTSW 6 68437840 nonsense probably null
R4494:Igkv15-103 UTSW 6 68437796 missense probably benign 0.02
R6356:Igkv15-103 UTSW 6 68437457 start gained probably benign
R6610:Igkv15-103 UTSW 6 68437633 nonsense probably null
Predicted Primers PCR Primer

Sequencing Primer
Posted On2017-06-26