Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00487:Vmn1r180'

5310

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r180

Ensembl Gene

ENSMUSG00000092473

Gene Name

vomeronasal 1 receptor 180

Synonyms

LOC232962, V1rd16

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL00487

Quality Score

Status

Chromosome

Chromosomal Location

23950632-23955691 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23952523 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 37 (H37L)

Ref Sequence

ENSEMBL: ENSMUSP00000134362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000173816]

AlphaFold

B9EK86

Predicted Effect

probably benign
Transcript: ENSMUST00000173816
AA Change: H37L

PolyPhen 2 Score 0.363 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473
AA Change: H37L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	31	286	6.7e-9	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 15 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	T	A	11: 110,309,450		probably null	Het
Dusp23	T	C	1: 172,631,632		probably benign	Het
Invs	C	T	4: 48,407,689	Q555*	probably null	Het
Mak16	T	C	8: 31,166,750	N9D	probably benign	Het
Mrps7	T	C	11: 115,604,858	I74T	possibly damaging	Het
Nlrp4a	T	G	7: 26,449,985	V339G	possibly damaging	Het
Nucb1	A	G	7: 45,501,651	L102P	probably damaging	Het
Pdp2	T	C	8: 104,594,197	M226T	probably benign	Het
Pik3r2	T	C	8: 70,770,429	D449G	probably damaging	Het
Rnf157	G	A	11: 116,362,355	P76S	probably benign	Het
Senp6	C	A	9: 80,113,838	Q267K	probably damaging	Het
Slc9a2	A	G	1: 40,742,658	E349G	probably damaging	Het
Snx14	G	T	9: 88,402,190	S475Y	probably damaging	Het
Wdr66	T	G	5: 123,274,177	I84S	probably damaging	Het
Xrn1	A	T	9: 96,038,949	H1371L	probably benign	Het

Other mutations in Vmn1r180

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01309:Vmn1r180	APN	7	23952999	missense	probably damaging	1.00
IGL01793:Vmn1r180	APN	7	23953243	missense	probably benign	0.00
IGL02653:Vmn1r180	APN	7	23953075	missense	probably damaging	1.00
IGL03277:Vmn1r180	APN	7	23953285	missense	probably damaging	0.99
IGL03352:Vmn1r180	APN	7	23952652	nonsense	probably null
R1298:Vmn1r180	UTSW	7	23953147	missense	possibly damaging	0.84
R1701:Vmn1r180	UTSW	7	23952970	missense	possibly damaging	0.84
R1702:Vmn1r180	UTSW	7	23952969	missense	possibly damaging	0.52
R2122:Vmn1r180	UTSW	7	23953141	missense	probably damaging	1.00
R4241:Vmn1r180	UTSW	7	23952873	missense	probably damaging	1.00
R5683:Vmn1r180	UTSW	7	23953210	missense	possibly damaging	0.58
R7241:Vmn1r180	UTSW	7	23952466	missense	probably damaging	0.96
R7522:Vmn1r180	UTSW	7	23953260	missense	probably damaging	1.00
R8749:Vmn1r180	UTSW	7	23952990	missense	probably damaging	1.00
R8991:Vmn1r180	UTSW	7	23952651	missense	probably benign	0.06
R9442:Vmn1r180	UTSW	7	23952195	start gained	probably benign

Posted On

2012-04-20