Incidental Mutation 'IGL01309:Vmn1r180'
ID 73561
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r180
Ensembl Gene ENSMUSG00000092473
Gene Name vomeronasal 1 receptor 180
Synonyms V1rd16, LOC232962
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL01309
Quality Score
Status
Chromosome 7
Chromosomal Location 23651812-23652781 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 23652424 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 196 (F196L)
Ref Sequence ENSEMBL: ENSMUSP00000134362 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173816]
AlphaFold B9EK86
Predicted Effect probably damaging
Transcript: ENSMUST00000173816
AA Change: F196L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473
AA Change: F196L

DomainStartEndE-ValueType
Pfam:TAS2R 8 298 2.9e-15 PFAM
Pfam:7tm_1 31 286 6.7e-9 PFAM
Pfam:V1R 41 297 1.4e-17 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik A G 16: 16,931,410 (GRCm39) V275A possibly damaging Het
Adamts2 A G 11: 50,694,528 (GRCm39) D1105G probably benign Het
Adgrb3 T A 1: 25,151,352 (GRCm39) M195L possibly damaging Het
Adrm1 A G 2: 179,817,756 (GRCm39) probably benign Het
Atg13 T A 2: 91,509,176 (GRCm39) I457F possibly damaging Het
BC034090 T C 1: 155,102,130 (GRCm39) N45D probably damaging Het
C3 C T 17: 57,516,652 (GRCm39) probably benign Het
Cacna1a G A 8: 85,249,657 (GRCm39) G221D probably damaging Het
Calr A G 8: 85,573,335 (GRCm39) probably null Het
Chd3 C T 11: 69,248,557 (GRCm39) V825I probably damaging Het
Chdh T G 14: 29,757,761 (GRCm39) probably benign Het
Ckap5 T C 2: 91,400,529 (GRCm39) V627A probably damaging Het
Commd3 A G 2: 18,677,289 (GRCm39) E5G probably benign Het
Ddi1 T C 9: 6,265,773 (GRCm39) R199G probably damaging Het
Dennd4c A G 4: 86,723,724 (GRCm39) probably benign Het
Dok7 G A 5: 35,236,912 (GRCm39) G293D possibly damaging Het
Epm2aip1 T C 9: 111,102,596 (GRCm39) V523A probably benign Het
Fam171b C T 2: 83,709,791 (GRCm39) Q488* probably null Het
Gabbr1 G A 17: 37,359,499 (GRCm39) probably null Het
Gm5965 T G 16: 88,575,219 (GRCm39) S131A possibly damaging Het
Gpcpd1 T C 2: 132,392,244 (GRCm39) D235G probably damaging Het
Grip1 A T 10: 119,767,207 (GRCm39) K111* probably null Het
Itih4 G T 14: 30,613,706 (GRCm39) D308Y probably damaging Het
Kcnj6 A G 16: 94,633,314 (GRCm39) Y266H probably damaging Het
Lrrc41 T C 4: 115,953,663 (GRCm39) L783P probably damaging Het
Map4k5 T C 12: 69,888,737 (GRCm39) D298G probably benign Het
Mapkbp1 T C 2: 119,849,423 (GRCm39) F712L probably damaging Het
Mcoln2 T C 3: 145,869,282 (GRCm39) probably benign Het
Megf11 T A 9: 64,588,698 (GRCm39) S532R probably benign Het
Mkx T C 18: 6,937,192 (GRCm39) D284G probably benign Het
Mmp16 A G 4: 18,116,185 (GRCm39) I596M probably damaging Het
Msto1 C A 3: 88,820,993 (GRCm39) R34L probably benign Het
Mtmr9 A G 14: 63,764,254 (GRCm39) L491P probably damaging Het
Or4a66 T G 2: 88,531,310 (GRCm39) Y121S probably damaging Het
Or8b52 T A 9: 38,576,289 (GRCm39) I284L probably benign Het
Or9s13 T C 1: 92,548,057 (GRCm39) M143T probably damaging Het
Otor T C 2: 142,920,532 (GRCm39) V38A possibly damaging Het
Pcdhb12 G T 18: 37,569,207 (GRCm39) D118Y probably damaging Het
Prelp T C 1: 133,842,545 (GRCm39) H200R probably benign Het
Prmt5 T C 14: 54,747,334 (GRCm39) Y481C probably damaging Het
Psg23 T G 7: 18,348,465 (GRCm39) D114A probably damaging Het
Ptger4 A T 15: 5,272,239 (GRCm39) Y127N probably damaging Het
Rabgap1l C A 1: 160,528,368 (GRCm39) V385L probably benign Het
Rergl T A 6: 139,470,256 (GRCm39) K191* probably null Het
Sart3 A G 5: 113,897,311 (GRCm39) F252S probably damaging Het
Sbno1 A T 5: 124,519,769 (GRCm39) S1169T probably benign Het
Serpinb8 C T 1: 107,532,448 (GRCm39) T180M probably damaging Het
Sipa1l1 G A 12: 82,434,470 (GRCm39) E747K probably benign Het
Sptb T A 12: 76,634,237 (GRCm39) D2158V probably benign Het
Sycp2 T G 2: 177,999,904 (GRCm39) D1024A probably benign Het
Tbr1 T G 2: 61,636,411 (GRCm39) N262K possibly damaging Het
Tnrc6a A T 7: 122,770,717 (GRCm39) I836F probably benign Het
Ttn T C 2: 76,769,091 (GRCm39) E2823G probably damaging Het
Uqcrc1 T A 9: 108,778,026 (GRCm39) L441Q possibly damaging Het
Vmn2r111 T C 17: 22,787,997 (GRCm39) I451M possibly damaging Het
Zcchc7 A T 4: 44,926,060 (GRCm39) H353L probably damaging Het
Other mutations in Vmn1r180
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00487:Vmn1r180 APN 7 23,651,948 (GRCm39) missense probably benign 0.36
IGL01793:Vmn1r180 APN 7 23,652,668 (GRCm39) missense probably benign 0.00
IGL02653:Vmn1r180 APN 7 23,652,500 (GRCm39) missense probably damaging 1.00
IGL03277:Vmn1r180 APN 7 23,652,710 (GRCm39) missense probably damaging 0.99
IGL03352:Vmn1r180 APN 7 23,652,077 (GRCm39) nonsense probably null
R1298:Vmn1r180 UTSW 7 23,652,572 (GRCm39) missense possibly damaging 0.84
R1701:Vmn1r180 UTSW 7 23,652,395 (GRCm39) missense possibly damaging 0.84
R1702:Vmn1r180 UTSW 7 23,652,394 (GRCm39) missense possibly damaging 0.52
R2122:Vmn1r180 UTSW 7 23,652,566 (GRCm39) missense probably damaging 1.00
R4241:Vmn1r180 UTSW 7 23,652,298 (GRCm39) missense probably damaging 1.00
R5683:Vmn1r180 UTSW 7 23,652,635 (GRCm39) missense possibly damaging 0.58
R7241:Vmn1r180 UTSW 7 23,651,891 (GRCm39) missense probably damaging 0.96
R7522:Vmn1r180 UTSW 7 23,652,685 (GRCm39) missense probably damaging 1.00
R8749:Vmn1r180 UTSW 7 23,652,415 (GRCm39) missense probably damaging 1.00
R8991:Vmn1r180 UTSW 7 23,652,076 (GRCm39) missense probably benign 0.06
R9442:Vmn1r180 UTSW 7 23,651,620 (GRCm39) start gained probably benign
Posted On 2013-10-07