Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01309:Vmn1r180'

73561

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r180

Ensembl Gene

ENSMUSG00000092473

Gene Name

vomeronasal 1 receptor 180

Synonyms

LOC232962, V1rd16

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL01309

Quality Score

Status

Chromosome

Chromosomal Location

23950632-23955691 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 23952999 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 196 (F196L)

Ref Sequence

ENSEMBL: ENSMUSP00000134362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000173816]

AlphaFold

B9EK86

Predicted Effect

probably damaging
Transcript: ENSMUST00000173816
AA Change: F196L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473
AA Change: F196L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	31	286	6.7e-9	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610318N02Rik	A	G	16: 17,113,546	V275A	possibly damaging	Het
Adamts2	A	G	11: 50,803,701	D1105G	probably benign	Het
Adgrb3	T	A	1: 25,112,271	M195L	possibly damaging	Het
Adrm1	A	G	2: 180,175,963		probably benign	Het
Atg13	T	A	2: 91,678,831	I457F	possibly damaging	Het
BC034090	T	C	1: 155,226,384	N45D	probably damaging	Het
C3	C	T	17: 57,209,652		probably benign	Het
Cacna1a	G	A	8: 84,523,028	G221D	probably damaging	Het
Calr	A	G	8: 84,846,706		probably null	Het
Chd3	C	T	11: 69,357,731	V825I	probably damaging	Het
Chdh	T	G	14: 30,035,804		probably benign	Het
Ckap5	T	C	2: 91,570,184	V627A	probably damaging	Het
Commd3	A	G	2: 18,672,478	E5G	probably benign	Het
Ddi1	T	C	9: 6,265,773	R199G	probably damaging	Het
Dennd4c	A	G	4: 86,805,487		probably benign	Het
Dok7	G	A	5: 35,079,568	G293D	possibly damaging	Het
Epm2aip1	T	C	9: 111,273,528	V523A	probably benign	Het
Fam171b	C	T	2: 83,879,447	Q488*	probably null	Het
Gabbr1	G	A	17: 37,048,607		probably null	Het
Gm5965	T	G	16: 88,778,331	S131A	possibly damaging	Het
Gpcpd1	T	C	2: 132,550,324	D235G	probably damaging	Het
Grip1	A	T	10: 119,931,302	K111*	probably null	Het
Itih4	G	T	14: 30,891,749	D308Y	probably damaging	Het
Kcnj6	A	G	16: 94,832,455	Y266H	probably damaging	Het
Lrrc41	T	C	4: 116,096,466	L783P	probably damaging	Het
Map4k5	T	C	12: 69,841,963	D298G	probably benign	Het
Mapkbp1	T	C	2: 120,018,942	F712L	probably damaging	Het
Mcoln2	T	C	3: 146,163,527		probably benign	Het
Megf11	T	A	9: 64,681,416	S532R	probably benign	Het
Mkx	T	C	18: 6,937,192	D284G	probably benign	Het
Mmp16	A	G	4: 18,116,185	I596M	probably damaging	Het
Msto1	C	A	3: 88,913,686	R34L	probably benign	Het
Mtmr9	A	G	14: 63,526,805	L491P	probably damaging	Het
Olfr1196	T	G	2: 88,700,966	Y121S	probably damaging	Het
Olfr12	T	C	1: 92,620,335	M143T	probably damaging	Het
Olfr917	T	A	9: 38,664,993	I284L	probably benign	Het
Otor	T	C	2: 143,078,612	V38A	possibly damaging	Het
Pcdhb12	G	T	18: 37,436,154	D118Y	probably damaging	Het
Prelp	T	C	1: 133,914,807	H200R	probably benign	Het
Prmt5	T	C	14: 54,509,877	Y481C	probably damaging	Het
Psg23	T	G	7: 18,614,540	D114A	probably damaging	Het
Ptger4	A	T	15: 5,242,758	Y127N	probably damaging	Het
Rabgap1l	C	A	1: 160,700,798	V385L	probably benign	Het
Rergl	T	A	6: 139,493,258	K191*	probably null	Het
Sart3	A	G	5: 113,759,250	F252S	probably damaging	Het
Sbno1	A	T	5: 124,381,706	S1169T	probably benign	Het
Serpinb8	C	T	1: 107,604,718	T180M	probably damaging	Het
Sipa1l1	G	A	12: 82,387,696	E747K	probably benign	Het
Sptb	T	A	12: 76,587,463	D2158V	probably benign	Het
Sycp2	T	G	2: 178,358,111	D1024A	probably benign	Het
Tbr1	T	G	2: 61,806,067	N262K	possibly damaging	Het
Tnrc6a	A	T	7: 123,171,494	I836F	probably benign	Het
Ttn	T	C	2: 76,938,747	E2823G	probably damaging	Het
Uqcrc1	T	A	9: 108,948,958	L441Q	possibly damaging	Het
Vmn2r111	T	C	17: 22,569,016	I451M	possibly damaging	Het
Zcchc7	A	T	4: 44,926,060	H353L	probably damaging	Het

Other mutations in Vmn1r180

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00487:Vmn1r180	APN	7	23952523	missense	probably benign	0.36
IGL01793:Vmn1r180	APN	7	23953243	missense	probably benign	0.00
IGL02653:Vmn1r180	APN	7	23953075	missense	probably damaging	1.00
IGL03277:Vmn1r180	APN	7	23953285	missense	probably damaging	0.99
IGL03352:Vmn1r180	APN	7	23952652	nonsense	probably null
R1298:Vmn1r180	UTSW	7	23953147	missense	possibly damaging	0.84
R1701:Vmn1r180	UTSW	7	23952970	missense	possibly damaging	0.84
R1702:Vmn1r180	UTSW	7	23952969	missense	possibly damaging	0.52
R2122:Vmn1r180	UTSW	7	23953141	missense	probably damaging	1.00
R4241:Vmn1r180	UTSW	7	23952873	missense	probably damaging	1.00
R5683:Vmn1r180	UTSW	7	23953210	missense	possibly damaging	0.58
R7241:Vmn1r180	UTSW	7	23952466	missense	probably damaging	0.96
R7522:Vmn1r180	UTSW	7	23953260	missense	probably damaging	1.00
R8749:Vmn1r180	UTSW	7	23952990	missense	probably damaging	1.00
R8991:Vmn1r180	UTSW	7	23952651	missense	probably benign	0.06
R9442:Vmn1r180	UTSW	7	23952195	start gained	probably benign

Posted On

2013-10-07