Incidental Mutation 'R7080:Or6d15'
ID 549461
Institutional Source Beutler Lab
Gene Symbol Or6d15
Ensembl Gene ENSMUSG00000050654
Gene Name olfactory receptor family 6 subfamily D member 15
Synonyms GA_x54KRFPKN04-58217732-58216800, MOR119-2, Olfr215
MMRRC Submission 045174-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R7080 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 116558973-116559905 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 116559314 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 198 (F198I)
Ref Sequence ENSEMBL: ENSMUSP00000052425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061723]
AlphaFold Q8VF82
Predicted Effect probably damaging
Transcript: ENSMUST00000061723
AA Change: F198I

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000052425
Gene: ENSMUSG00000050654
AA Change: F198I

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5e-47 PFAM
Pfam:7TM_GPCR_Srsx 33 258 1.8e-5 PFAM
Pfam:7tm_1 39 288 2.9e-15 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 94% (47/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 A G 2: 25,336,116 (GRCm39) E2162G probably benign Het
Ackr4 A G 9: 103,976,761 (GRCm39) V62A probably damaging Het
Atox1 T A 11: 55,341,365 (GRCm39) K57* probably null Het
Atp6v1e1 G A 6: 120,799,350 (GRCm39) probably benign Het
Bmpr2 T C 1: 59,906,842 (GRCm39) V645A probably benign Het
Brwd1 T C 16: 95,810,730 (GRCm39) T1602A probably benign Het
Cdc42bpg T C 19: 6,365,219 (GRCm39) V692A probably damaging Het
Cdca2 T C 14: 67,935,551 (GRCm39) D388G probably damaging Het
Celsr1 G A 15: 85,816,652 (GRCm39) R1764C possibly damaging Het
Copz2 G T 11: 96,747,538 (GRCm39) V174L probably benign Het
Dnaaf1 T C 8: 120,309,335 (GRCm39) L141P probably damaging Het
Fam170a T A 18: 50,413,740 (GRCm39) probably null Het
Fshr A T 17: 89,404,539 (GRCm39) probably null Het
Gbx1 C T 5: 24,731,298 (GRCm39) A173T probably benign Het
Gm3604 G A 13: 62,518,109 (GRCm39) A83V probably damaging Het
Gpr19 A T 6: 134,847,419 (GRCm39) V88D probably damaging Het
Hnrnpd C T 5: 100,124,392 (GRCm39) probably null Het
Homez T C 14: 55,095,112 (GRCm39) S199G probably benign Het
Kit T C 5: 75,767,941 (GRCm39) I108T probably damaging Het
Lrrc34 A C 3: 30,688,705 (GRCm39) Y199D probably damaging Het
Mapk12 T C 15: 89,017,350 (GRCm39) D208G probably damaging Het
Mon1a A G 9: 107,778,985 (GRCm39) D403G probably damaging Het
Myo1d C T 11: 80,565,460 (GRCm39) E426K probably damaging Het
Nol11 G A 11: 107,070,878 (GRCm39) T307I probably damaging Het
Or10d5 A G 9: 39,861,444 (GRCm39) C208R probably damaging Het
Or52b4 A T 7: 102,184,172 (GRCm39) I73F possibly damaging Het
Or5aq1b A G 2: 86,902,083 (GRCm39) Y132H probably damaging Het
Or8k28 A T 2: 86,285,835 (GRCm39) L260* probably null Het
Pcdhb16 C T 18: 37,611,516 (GRCm39) Q159* probably null Het
Phf19 G A 2: 34,788,724 (GRCm39) probably null Het
Qrfpr C T 3: 36,234,198 (GRCm39) R381H probably benign Het
Rad51ap2 A G 12: 11,506,366 (GRCm39) D96G probably benign Het
Ranbp1 T C 16: 18,063,097 (GRCm39) D93G possibly damaging Het
Reep1 A G 6: 71,757,749 (GRCm39) D116G possibly damaging Het
Rinl T C 7: 28,496,101 (GRCm39) C361R probably damaging Het
Rps6kb1 T C 11: 86,397,666 (GRCm39) D393G probably damaging Het
Slc2a12 T C 10: 22,541,216 (GRCm39) V357A probably benign Het
Spryd3 T C 15: 102,026,627 (GRCm39) D348G probably benign Het
Syne2 G A 12: 76,099,501 (GRCm39) A569T probably benign Het
Tcstv5 T C 13: 120,411,270 (GRCm39) D112G probably benign Het
Thoc6 C T 17: 23,892,503 (GRCm39) R6Q probably null Het
Tyw3 G C 3: 154,299,426 (GRCm39) S94R probably benign Het
Unc13b C T 4: 43,171,926 (GRCm39) T918I unknown Het
Unc80 A T 1: 66,685,680 (GRCm39) H2268L possibly damaging Het
Urod C T 4: 116,849,838 (GRCm39) A187T probably damaging Het
Usp46 G T 5: 74,177,344 (GRCm39) N205K probably benign Het
Wapl T C 14: 34,414,313 (GRCm39) F392L probably benign Het
Zim1 T C 7: 6,680,305 (GRCm39) T453A possibly damaging Het
Other mutations in Or6d15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01666:Or6d15 APN 6 116,559,296 (GRCm39) missense possibly damaging 0.93
IGL02959:Or6d15 APN 6 116,559,505 (GRCm39) missense probably damaging 1.00
IGL03053:Or6d15 APN 6 116,559,206 (GRCm39) missense possibly damaging 0.50
R0078:Or6d15 UTSW 6 116,559,701 (GRCm39) missense probably damaging 0.96
R0277:Or6d15 UTSW 6 116,559,562 (GRCm39) missense probably damaging 0.99
R0323:Or6d15 UTSW 6 116,559,562 (GRCm39) missense probably damaging 0.99
R0399:Or6d15 UTSW 6 116,559,742 (GRCm39) missense probably benign 0.00
R0545:Or6d15 UTSW 6 116,559,617 (GRCm39) missense probably benign 0.01
R1213:Or6d15 UTSW 6 116,559,827 (GRCm39) missense probably benign 0.00
R1775:Or6d15 UTSW 6 116,559,925 (GRCm39) start gained probably benign
R1789:Or6d15 UTSW 6 116,559,658 (GRCm39) missense probably damaging 1.00
R4724:Or6d15 UTSW 6 116,559,898 (GRCm39) missense probably damaging 1.00
R5391:Or6d15 UTSW 6 116,559,808 (GRCm39) missense probably damaging 1.00
R5392:Or6d15 UTSW 6 116,559,379 (GRCm39) missense probably damaging 1.00
R5686:Or6d15 UTSW 6 116,559,890 (GRCm39) missense probably benign 0.00
R6124:Or6d15 UTSW 6 116,559,446 (GRCm39) missense probably benign 0.05
R7355:Or6d15 UTSW 6 116,559,916 (GRCm39) start gained probably benign
R9084:Or6d15 UTSW 6 116,559,232 (GRCm39) missense probably benign 0.03
Z1177:Or6d15 UTSW 6 116,559,514 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGTTCACAAGAGCAGCCTC -3'
(R):5'- AATTATGGCCTGCCTTGCTC -3'

Sequencing Primer
(F):5'- CAGCCTCTCGGTTGGATTCAAG -3'
(R):5'- CTGACCTTCACCCTGATCACG -3'
Posted On 2019-05-15